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List of works by Kapil Bhalla

"Loop" domain is necessary for taxol-induced mobility shift and phosphorylation of Bcl-2 as well as for inhibiting taxol-induced cytosolic accumulation of cytochrome c and apoptosis ⬇️

scientific article published on August 1, 1998

A phase 2 study of ruxolitinib in combination with azacitidine in patients with myelofibrosis

scientific article published on 05 September 2018

A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies

scientific article

A phase II study of omacetaxine mepesuccinate for patients with higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia after failure of hypomethylating agents

scientific article published on 15 November 2018

An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation

scientific article published on 26 December 2007

BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells

scientific article published on 28 September 2016

Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3 ⬇️

scientific article published on 01 March 1998

Characteristics and outcomes of older patients with secondary acute myeloid leukemia according to treatment approach

scientific article

Clinical Outcomes and Co-Occurring Mutations in Patients with RUNX1-Mutated Acute Myeloid Leukemia

scientific article published on 26 July 2017

Clinical experience with the BCL2-inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies

scientific article

Clonal Evolution and Treatment Outcomes in Hematopoietic Neoplasms Arising in Patients with Germline RUNX1 mutations

scientific article published on 17 August 2020

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics

scientific article published on 21 October 2020

Combination of Pan-Histone Deacetylase Inhibitor and Autophagy Inhibitor Exerts Superior Efficacy against Triple-Negative Human Breast Cancer Cells ⬇️

scientific article published on February 24, 2012

Deoxycytidine protects normal bone marrow progenitors against Ara-C and gemcitabine cytotoxicity without compromising their activity against cisplatin-resistant human ovarian cancer cells ⬇️

scientific article published on April 1, 1992

Dual Expression of TCF4 and CD123 Is Highly Sensitive and Specific For Blastic Plasmacytoid Dendritic Cell Neoplasm

scientific article published on 01 October 2019

Effect of Hemopoietic Growth Factors G-CSF and pIXY 321 on the Activity of High Dose ARA-C in Human Myeloid Leukemia Cells ⬇️

scientific article published on 01 January 1993

Effect of combined treatment with interleukin-3 and interleukin-6 on 4-hydroperoxycyclophosphamide-mediated reduction of glutathione levels and cytotoxicity in normal and leukemic bone marrow progenitor cells

scientific article published on August 1, 1992

Granulocyte-macrophage colony-stimulating factor/interleukin-3 fusion protein (pIXY 321) enhances high-dose Ara-C-induced programmed cell death or apoptosis in human myeloid leukemia cells ⬇️

scientific article (publication date: December 1992)

Heat Shock Protein 90 Inhibition Depletes TrkA Levels and Signaling in Human Acute Leukemia Cells ⬇️

scientific article published on July 27, 2010

High‐dose cytarabine induction is well tolerated and active in patients with de novo acute myeloid leukemia older than 60 years ⬇️

scientific article published on June 29, 2011

Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B ⬇️

scientific article published on October 1, 2003

Hsp90 Inhibitor–Mediated Disruption of Chaperone Association of ATR with Hsp90 Sensitizes Cancer Cells to DNA Damage ⬇️

scientific article published on May 12, 2011

Isolation and characterization of a deoxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-beta-D- arabinofuranosylcytosine ⬇️

scientific article published on November 1, 1984

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

scientific article published on 10 May 2021

MYC protein expression is an important prognostic factor in acute myeloid leukemia

scientific article published on 09 May 2018

Membrane glycoprotein changes associated with anthracycline resistance in HL-60 cells ⬇️

scientific article published on January 1, 1991

Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin granulocyte-macrophage colony-stimulating factor fusion protein ⬇️

scientific article published on 01 November 1997

Molecular and biologic determinants of neoadjuvant chemotherapy of locoregional breast cancer

scientific article published on April 1, 1998

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

scientific article (publication date: 15 June 2006)

Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results

scientific article published on 22 November 2010

Overexpression of Apaf-1 promotes apoptosis of untreated and paclitaxel- or etoposide-treated HL-60 cells ⬇️

scientific article published on October 15, 1998

Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists ⬇️

scientific article published on December 9, 2010

Phase 1 dose-finding study of rebastinib (DCC-2036) in patients with relapsed chronic myeloid leukemia and acute myeloid leukemia

scientific article

Phase II trial of paclitaxel, fluorouracil, and cisplatin in patients with advanced carcinoma of the esophagus ⬇️

scientific article published on 01 May 1998

Phase II trial of panobinostat, an oral pan‐deacetylase inhibitor in patients with primary myelofibrosis, post–essential thrombocythaemia, and post–polycythaemia vera myelofibrosis ⬇️

scientific article published on May 23, 2013

Phase I–II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo ⬇️

scientific article published on December 27, 2011

Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy

scientific article published on 27 September 2007

Preclinical and Phase I Results of Decitabine in Combination with Midostaurin (PKC412) for Newly Diagnosed Elderly or Relapsed/Refractory Adult Patients with Acute Myeloid Leukemia ⬇️

scientific article published on June 24, 2013

Publisher Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics

scientific article published on 19 November 2020

RETRACTED: Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas ⬇️

scientific article published on October 16, 2012

Role of Additional Novel Therapies in Myeloproliferative Neoplasms ⬇️

scientific article published on August 24, 2012

Successful lenalidomide treatment in high risk myelodysplastic syndrome with germline DDX41 mutation

scientific article published on 29 August 2019

Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells ⬇️

scientific article published on August 29, 2012

Superior efficacy of co-treatment with dual PI3K/mTOR inhibitor NVP-BEZ235 and pan-histone deacetylase inhibitor against human pancreatic cancer ⬇️

scientific article published on November 1, 2012

Targetable genetic alterations of () drive immunoglobulin expression in diffuse large B cell lymphoma

scientific article published on 01 June 2019

Taxol metabolism and disposition in cancer patients ⬇️

scientific article published on 01 April 1995

Treated secondary acute myeloid leukemia: a distinct high-risk subset of AML with adverse prognosis

scientific article published on 19 July 2017

Treatment with interleukin-3 plus granulocyte-macrophage colony-stimulating factors improves the selectivity of Ara-C in vitro against acute myeloid leukemia blasts ⬇️

scientific article published on November 15, 1991

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