Search filters

List of works by Alexey Rak

A combinatorial approach to crystallization of PX-BAR unit of the human Sorting Nexin 9

scientific article published on 01 November 2007

A size filtration approach to purify low affinity complexes for crystallization

scientific article

A structural model of the GDP dissociation inhibitor rab membrane extraction mechanism

scientific article

An Automated Microscale Thermophoresis Screening Approach for Fragment-Based Lead Discovery

scientific article published on 2 December 2015

Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation

scientific article

CODV-Ig, a universal bispecific tetravalent and multifunctional immunoglobulin format for medical applications.

scientific article

Chemical biology of protein lipidation: semi-synthesis and structure elucidation of prenylated RabGTPases

scientific article

Crystallization and preliminary X-ray diffraction analysis of monoprenylated Rab7 GTPase in complex with Rab escort protein 1

scientific article (publication date: 2003)

Discovery and Pharmacokinetic and Pharmacological Properties of the Potent and Selective MET Kinase Inhibitor 1-{6-[6-(4-Fluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylsulfanyl]benzothiazol-2-yl}-3-(2-morpholin-4-ylethyl)urea (SAR125844).

scientific article

Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers

scientific article

Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers

scientific article

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Recepto

scientific article published on 27 November 2019

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations

scientific article published on 04 June 2018

Extreme temperature tolerance of a hyperthermophilic protein coupled to residual structure in the unfolded state

scientific article

Farnesylation of the SNARE protein Ykt6 increases its stability and helical folding

scientific article

Fast NMR Methods for Measuring in the Direct and/or Competition Mode the Dissociation Constants of Chemical Fragments Interacting with a Receptor

scientific article published on 14 May 2019

Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases

scientific article published on 08 July 2008

Giantin interacts with both the small GTPase Rab6 and Rab1.

scientific article

In vitro assembly, purification, and crystallization of the rab geranylgeranyl transferase:substrate complex

scientific article

NMR structure of bacterial ribosomal protein l20: implications for ribosome assembly and translational control

scientific article

NMR structure of the ribosomal protein L23 from Thermus thermophilus

scientific article (publication date: June 2003)

Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4.

scientific article

Purification, crystallization and preliminary X-ray crystallographic analysis of mammalian MSS4-Rab8 GTPase protein complex

scientific article published on 27 January 2006

Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1.

scientific article published on 19 September 2007

Rab GTPases at a glance

scientific article published on 01 November 2007

Rab-subfamily-specific regions of Ypt7p are structurally different from other RabGTPases

scientific article

Sec2 is a Highly Efficient Exchange Factor for the Rab Protein Sec4

scientific article published on 03 November 2006

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

scientific article

Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule

scientific article published on 12 November 2014

Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coli

scientific article

Structure of Rab GDP-dissociation inhibitor in complex with prenylated YPT1 GTPase

scientific article

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase

scientific article (publication date: February 2003)

Structure of doubly prenylated Ypt1:GDI complex and the mechanism of GDI-mediated Rab recycling

scientific article

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease

scientific article

Structure of the extremely slow GTPase Rab6A in the GTP bound form at 1.8A resolution

scientific article

Structures of a pan-specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody-antigen interactions

scientific article published on 26 September 2014

The PX-BAR membrane-remodeling unit of sorting nexin 9

scientific article

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation

scientific article

The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold

scientific article

The use of virtual screening and differential scanning fluorimetry for the rapid identification of fragments active against MEK1

scientific article

Therapeutic Opportunities with Pharmacological Inhibition of CD38 with Isatuximab

scientific article published on 26 November 2019

[Developability assessment with case studies highlighting the decision taking]

scientific article published on 01 December 2019

Paulina is supported by:

About Paulina

Help