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List of works by Frank van de Veerdonk

967. Inhibition of Host Neuraminidase Increases Susceptibility to Invasive Pulmonary Aspergillosis

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans.

scientific article published on November 2016

A Genome-Wide Functional Genomics Approach Identifies Susceptibility Pathways to Fungal Bloodstream Infection in Humans

scientific article published on 01 July 2019

A guiding map for inflammation

scientific article published on July 2017

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist

scientific article (publication date: March 2014)

A systems genomics approach identifies SIGLEC15 as a susceptibility factor in recurrent vulvovaginal candidiasis

scientific article published on 01 June 2019

An anti-inflammatory property of Candida albicans β-glucan: Induction of high levels of interleukin-1 receptor antagonist via a Dectin-1/CR3 independent mechanism

scientific article

An exaggerated monocyte-derived cytokine response to Candida hyphae in patients with recurrent vulvovaginal candidiasis

scientific article published on 23 July 2020

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility

scientific article

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

scientific article published on 10 December 2020

Anti-Aspergillus human host defence relies on type 1 T helper (Th1), rather than type 17 T helper (Th17), cellular immunity.

scientific article published on 2 December 2009

Antifungal innate immunity: recognition and inflammatory networks

scientific article published on 20 December 2014

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

scientific article

Aspergillus fumigatus morphology and dynamic host interactions

scientific article published on 18 September 2017

Aspergillus fumigatus-induced IL-22 is not restricted to a specific Th cell subset and is dependent on complement receptor 3.

scientific article

Author Correction: Trained immunity, tolerance, priming and differentiation: distinct immunological processes

scientific article published in 2021

Autoimmune Regulator Deficiency Results in a Decrease in STAT1 Levels in Human Monocytes

scientific article

Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer

scientific article

Autophagy modulates Borrelia burgdorferi-induced production of interleukin-1β (IL-1β)

scientific article published on 5 February 2013

Basic Genetics and Immunology of Candida Infections

scientific article published on March 2016

Biology of IL-36 cytokines and their role in disease

scientific article

Blocking IL-1 to prevent respiratory failure in COVID-19

scientific article published on 18 July 2020

Borrelia species induce inflammasome activation and IL-17 production through a caspase-1-dependent mechanism

scientific article published on 09 December 2010

Borrelia-induced cytokine production is mediated by spleen tyrosine kinase (Syk) but is Dectin-1 and Dectin-2 independent.

scientific article published on 18 August 2015

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

scientific article

Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans

scientific article published in April 2009

CBLB ubiquitin ligase: a major regulator of antifungal immunity

scientific article published on August 2016

COVID-19 patients exhibit less pronounced immune suppression compared with bacterial septic shock patients

scientific article published on 06 April 2020

Candida albicans dampens host defense by downregulating IL-17 production.

scientific article published on 12 July 2010

Candida albicans morphogenesis and host defence: discriminating invasion from colonization. ⬇️

scientific article published on 12 December 2011

Caspase-1, but not ASC or NLRP3 inflammasome components, mediates IL-1beta activation and antifungal defense in disseminated candidiasis

scientific article published in 2009

Combination of biomarkers for the discrimination between bacterial and viral lower respiratory tract infections ⬇️

scientific article published on August 13, 2012

Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

scientific article published on 26 December 2020

Compartmentalized Cytokine Responses in Hidradenitis Suppurativa

scientific article published on 19 June 2015

Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting dectin-1/Syk kinase signaling

scientific article published on July 2013

Cytokine production assays reveal discriminatory immune defects in adults with recurrent infections and noninfectious inflammation

scientific article

Defects of pattern recognition: primary immunodeficiencies of the innate immune system

scientific article published on 16 April 2011

Deficient Candida-specific T-helper 17 response during sepsis

scientific article published on 14 September 2012

Deficient autophagy unravels the ROS paradox in chronic granulomatous disease

scientific article published on June 2014

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo

scientific article published on 11 December 2017

Differential Kinetics of Aspergillus nidulans and Aspergillus fumigatus Phagocytosis.

scientific article

Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages

scientific article published on 22 December 2008

Diversity: A Hallmark of Monocyte Society ⬇️

scientific article published on September 24, 2010

Effect of Convalescent Plasma on Organ Support-Free Days in Critically Ill Patients With COVID-19: A Randomized Clinical Trial

scientific article published on 01 November 2021

Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19: The REMAP-CAP COVID-19 Corticosteroid Domain Randomized Clinical Trial

scientific article published on 02 September 2020

Engagement of fatty acids with Toll-like receptor 2 drives interleukin-1β production via the ASC/caspase 1 pathway in monosodium urate monohydrate crystal-induced gouty arthritis

scientific article

Erratum: IL-1 family nomenclature

scholarly article by Charles A. Dinarello et al published March 2011 in Nature Immunology

Exposure to Candida albicans polarizes a T-cell driven arthritis model towards Th17 responses, resulting in a more destructive arthritis

scientific article (publication date: 2012)

FAVORABLE ANAKINRA RESPONSES IN SEVERE COVID-19 PATIENTS WITH SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS

scientific article published on 14 May 2020

Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations.

scientific article published on 17 July 2017

Gain-of-function STAT1 mutations impair STAT3 activity in patients with chronic mucocutaneous candidiasis (CMC).

scientific article

Genetic susceptibility to Candida infections

scientific article

Genome-Wide Association Study Reveals CLEC7A and PROM1 as Potential Regulators of Paracoccidioides brasiliensis-Induction of Cytokine Production in Peripheral Blood Mononuclear Cells

scientific article published in 2023

Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity

scientific article published on 16 November 2016

Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype

scientific article

Host-microbe interactions: innate pattern recognition of fungal pathogens

scientific article published on 17 July 2008

Human Neutrophils Use Different Mechanisms To Kill Aspergillus fumigatus Conidia and Hyphae: Evidence from Phagocyte Defects.

scientific article

Human recombinant interleukin-38 suppresses inflammation in mouse models of local and systemic disease

scientific article published on 28 October 2020

IL-1 family nomenclature

scientific article

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

scientific article published on 14 March 2016

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

scientific article published on 18 February 2014

IL-1-8 IL-1β and the development of Th17 responses

scientific article published in 2010

IL-18 Serum Concentration Is Markedly Elevated in Acute EBV Infection and Can Serve as a Marker for Disease Severity ⬇️

scientific article published on June 11, 2012

IL-1beta processing in host defense: beyond the inflammasomes

scientific article

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

scientific article

IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis

scientific article (publication date: November 2014)

IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist

scientific article published on 6 February 2012

IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation

scientific article published on 14 November 2014

Immune defects in patients with pulmonary <i>Mycobacterium abscessus</i> disease without cystic fibrosis

scientific article published on 01 October 2020

Immune defence against Candida fungal infections

scientific article published on 21 September 2015

Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidaemia.

scientific article published on 08 September 2014

Immunologic defects in severe mucocutaneous HSV-2 infections: Response to IFN-γ therapy

scientific article published on 7 April 2016

Immunotherapeutic approaches to treatment of fungal diseases.

scientific article

Immunotherapy: a potential adjunctive treatment for fungal infection

scientific article

In-host adaptation and acquired triazole resistance in Aspergillus fumigatus: a dilemma for clinical management

scientific article published on 13 September 2016

Inflammasome activation and IL-1β and IL-18 processing during infection

scientific article published on 18 February 2011

Inflammasome is a central player in the induction of obesity and insulin resistance

scientific article

Inflammasome-independent modulation of cytokine response by autophagy in human cells

scientific article

Inflammasome-independent regulation of IL-1-family cytokines

scientific article published on 10 December 2014

Inflammasome-independent role of apoptosis-associated speck-like protein containing a CARD (ASC) in T cell priming is critical for collagen-induced arthritis

scientific article

Influenza-Associated Aspergillosis in Critically Ill Patients.

scientific article

Inhibition of caspase-1 activation in Gram-negative sepsis and experimental endotoxemia

scientific article published on 18 January 2011

Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

scientific article

Invasive Aspergillus Tracheobronchitis Emerging as Highly Lethal Complication of Severe Influenza

scientific article published on 10 June 2020

Kallikrein-kinin blockade in patients with COVID-19 to prevent acute respiratory distress syndrome

scientific article published on 27 April 2020

LC3-associated phagocytosis: a crucial mechanism for antifungal host defence against Aspergillus fumigatus

scientific article published on 17 May 2016

Low interleukin-17A production in response to fungal pathogens in patients with chronic granulomatous disease

scientific article published on 22 December 2011

Metabolic Induction of Trained Immunity through the Mevalonate Pathway.

scientific article published in January 2018

Mimicking Behcet's disease: GM-CSF gain of function mutation in a family suffering from a Behcet's disease-like disorder marked by extreme pathergy

scientific article published on 22 December 2020

Modulation of inflammation by autophagy: Consequences for human disease

scientific article

Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19

scientific article published on 06 April 2022

Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.

scientific article published on 13 November 2012

Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1.

scientific article published on 18 March 2010

Neutrophil-mediated inhibition of proinflammatory cytokine responses

scientific article published on 10 October 2012

New Insights in the Immunobiology of IL-1 Family Members

scientific article published on 08 July 2013

Novel strategies for the prevention and treatment of Candida infections: the potential of immunotherapy

scientific article

Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity

scientific article published in 2023

Pathogenesis of invasive candidiasis

scientific article published on October 2010

Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra

scientific article

Pattern recognition receptors and their role in invasive aspergillosis ⬇️

scientific article published on 01 December 2012

Personalized medicine in influenza: a bridge too far or the near future?

scientific article published on 2 March 2017

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

scientific article published on 08 May 2020

Primary immunodeficiencies in cytosolic pattern-recognition receptor pathways: Toward host-directed treatment strategies

scientific article published on 08 July 2020

Primary immunodeficiencies of pattern recognition receptors ⬇️

scientific article published on September 12, 2012

Progressive multifocal leukoencephalopathy in an immunocompetent patient

scientific article published on 8 January 2016

Protective host defense against disseminated candidiasis is impaired in mice expressing human interleukin-37.

scientific article

Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease

scientific article

Receptor recognition of and immune intracellular pathways for Veillonella parvula lipopolysaccharide

scientific article published on 14 October 2009

Reduced concentrations of the B cell cytokine Interleukin 38 are associated with cardiovascular disease risk in overweight subjects

scientific article published on 30 October 2020

Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor

scientific article

Review of influenza-associated pulmonary aspergillosis in ICU patients and proposal for a case definition: an expert opinion

scientific article published on 22 June 2020

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

scientific article published on 18 September 2017

Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

scientific article published on 22 September 2017

Role of TLR1 and TLR6 in the host defense against disseminated candidiasis

scientific article published on 22 November 2007

Role of interleukin-23 (IL-23) receptor signaling for IL-17 responses in human Lyme disease

scientific article published on 6 September 2011

STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis

scientific article

STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis

scientific article

STAT3 phosphorylation mediates the stimulatory effects of interferon alpha on B cell differentiation and activation in SLE

scientific article published on 01 March 2020

Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

scientific article published on 05 August 2020

Severe Candida spp. infections: new insights into natural immunity

scientific article published on 03 December 2010

Skin microbiome imbalance in patients with STAT1/STAT3 defects impairs innate host defense responses

scientific article

T-cell Subsets and Antifungal Host Defenses ⬇️

scientific article published on September 30, 2010

TREML4 adds fuel to the TLR7 fire

scientific article

Th17 cytokine deficiency in patients with Aspergillus skull base osteomyelitis

scientific article

Th17 responses and host defense against microorganisms: an overview

scientific article published on December 2009

The BNT162b2 mRNA Vaccine Against SARS-CoV-2 Reprograms Both Adaptive and Innate Immune Responses

scientific article published in 2021

The Candida Th17 response is dependent on mannan- and beta-glucan-induced prostaglandin E2.

scientific article published on 8 November 2010

The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses

scientific article

The RIG-I-like helicase receptor MDA5 (IFIH1) is involved in the host defense against Candida infections

scientific article published on 13 January 2015

The Role of Dectin-2 for Host Defense Against Disseminated Candidiasis

scientific article published on 27 January 2016

The classical CD14⁺⁺ CD16⁻ monocytes, but not the patrolling CD14⁺ CD16⁺ monocytes, promote Th17 responses to Candida albicans

scientific article published on 30 August 2011

The dectin-1/inflammasome pathway is responsible for the induction of protective T-helper 17 responses that discriminate between yeasts and hyphae of Candida albicans

scientific article published on 29 April 2011

The discriminative capacity of soluble Toll-like receptor (sTLR)2 and sTLR4 in inflammatory diseases.

scientific article

The effects of in vivo B-cell depleting therapy on ex-vivo cytokine production

scientific article

The effects of signal transducer and activator of transcription three mutations on human platelets.

scientific article published on 29 September 2017

The immunopathology of sepsis and potential therapeutic targets

scientific article

The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis.

scientific article published on 04 July 2011

The interplay between inflammasome activation and antifungal host defense

scientific article published on May 2015

The macrophage mannose receptor induces IL-17 in response to Candida albicans.

scientific article published in April 2009

The potential impact of the pulmonary microbiome on immunopathogenesis of Aspergillus-related lung disease

scientific article

The role of interleukin-1 family members in the host defence against Aspergillus fumigatus

scientific article

Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics

scientific article published on 13 September 2017

Trained Immunity: a Tool for Reducing Susceptibility to and the Severity of SARS-CoV-2 Infection

scientific article published on 04 May 2020

Trained immunity, tolerance, priming and differentiation: distinct immunological processes

scientific article published on 08 December 2020

Treatment options for chronic mucocutaneous candidiasis

scientific article published on 6 May 2016

Two independent killing mechanisms of Candida albicans by human neutrophils: evidence from innate immunity defects.

scientific article published on 19 June 2014

Understanding human immune function using the resources from the Human Functional Genomics Project

scientific article published on August 2016

Uric acid priming in human monocytes is driven by the AKT-PRAS40 autophagy pathway

scientific article published on 8 May 2017

When the Fight against Fungi Goes Wrong

scientific article published on 4 February 2016

mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity.

scientific article

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