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List of works by Jeremy P E Spencer

(-)Epicatechin stimulates ERK-dependent cyclic AMP response element activity and up-regulates GluR2 in cortical neurons.

scientific article published on 7 February 2007

5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons

scientific article

A novel combined biomarker including plasma carotenoids, vitamin C, and ferric reducing antioxidant power is more strongly associated with fruit and vegetable intake than the individual components

scientific article published on 17 September 2014

A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats

scientific article

Absorption and metabolism of olive oil secoiridoids in the small intestine ⬇️

scientific article published on 17 March 2011

Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats

scientific article published in January 2006

Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury

scientific article published on 9 June 2006

Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons.

scientific article published in November 2007

Acute Effects of Hibiscus Sabdariffa Calyces on Postprandial Blood Pressure, Vascular Function, Blood Lipids, Biomarkers of Insulin Resistance and Inflammation in Humans

scholarly article by Salisu M Abubakar et al published 5 February 2019 in Nutrients

Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants

scientific article

Anthocyanins Promote Learning through Modulation of Synaptic Plasticity Related Proteins in an Animal Model of Ageing

article by David Vauzour et al published 31 July 2021 in Antioxidants (Basel, Switzerland)

Assessment of the dietary intake of total flavan-3-ols, monomeric flavan-3-ols, proanthocyanidins and theaflavins in the European Union.

scientific article published on 13 December 2013

Assessment of white grape pomace from winemaking as source of bioactive compounds, and its antiproliferative activity

scientific article published on 13 March 2015

Associations between flavan-3-ol intake and CVD risk in the Norfolk cohort of the European Prospective Investigation into Cancer (EPIC-Norfolk).

scientific article

Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain

scientific article published on 17 February 2010

Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research

scientific article published on August 2007

Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats

scientific article published on 9 October 2012

Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats

scientific article published on 9 May 2012

Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels

scientific article published on 5 May 2008

Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity

scientific article published on 31 March 2010

Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity

scientific article published on March 2004

Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury

scientific article published on 24 March 2007

Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults

scientific article

Cocoa flavanol intake improves endothelial function and Framingham Risk Score in healthy men and women: a randomised, controlled, double-masked trial: the Flaviola Health Study

scientific article

Cognitive tests used in chronic adult human randomised controlled trial micronutrient and phytochemical intervention studies

scientific article published on 12 August 2010

Composition and content of phenolic acids and avenanthramides in commercial oat products: Are oats an important polyphenol source for consumers?

scientific article published on 04 July 2019

Conjugates of Catecholamines with Cysteine and GSH in Parkinson's Disease: Possible Mechanisms of Formation Involving Reactive Oxygen Species ⬇️

scientific article published on November 1, 1998

Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients

scientific article published on March 2014

Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men.

scientific article

Dietary Levels of Pure Flavonoids Improve Spatial Memory Performance and Increase Hippocampal Brain-Derived Neurotrophic Factor

Dietary flavonoids as potential neuroprotectants

scientific article

Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor.

scientific article

Distribution of [3H]trans-resveratrol in rat tissues following oral administration

scientific article

Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?

scientific article published on 01 March 2008

Effect of cultivar type and ripening on the polyphenol content of date palm fruit.

scientific article published on 26 February 2013

Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin-rich extracts

scientific article published on 29 August 2017

Effects of pelargonidin-3-O-glucoside and its metabolites on lipopolysaccharide-stimulated cytokine production by THP-1 monocytes and macrophages

scientific article published on 8 January 2018

Epicatechin and its methylated metabolite attenuate UVA-induced oxidative damage to human skin fibroblasts ⬇️

scientific article published on October 15, 2003

Excretion of Avenanthramides, Phenolic Acids and their Major Metabolites Following Intake of Oat Bran.

scientific article published on 11 October 2017

Factors Affecting the Absorption, Metabolism, and Excretion of Cocoa Flavanols in Humans.

scientific article

Flavanol metabolites reduce monocyte adhesion to endothelial cells through modulation of expression of genes via p38-MAPK and p65-Nf-kB pathways

scientific article

Flavanol monomer-induced changes to the human faecal microflora.

scientific article published in November 2007

Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study

scientific article published on 9 January 2017

Flavanone-rich citrus beverages counteract the transient decline in postprandial endothelial function in humans: a randomised, controlled, double-masked, cross-over intervention study - CORRIGENDUM.

scientific article published in October 2017

Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments

scientific article published on 14 October 2013

Flavonoid intake in European adults (18 to 64 years).

scientific article

Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease--FLAVURS: a randomized controlled trial

scientific article

Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males

scientific article published on 18 August 2015

Flavonoids and brain health: multiple effects underpinned by common mechanisms

scientific article published on 15 August 2009

Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects.

scientific article published on 12 October 2009

Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies

scientific article published on 13 August 2009

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

scientific article published on 14 March 2012

Flavonoids, cognition, and dementia: Actions, mechanisms, and potential therapeutic utility for Alzheimer disease ⬇️

scientific article published on September 17, 2011

Flavonoids: antioxidants or signalling molecules?

scientific article (publication date: April 2004)

Flavonoids: modulators of brain function?

scientific article

Food for thought

scientific article published on 01 April 2009

Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance

scientific article

Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers

scientific article published on 16 February 2016

Glial metabolism of quercetin reduces its neurotoxic potential

scientific article published on 23 July 2008

Grape seed polyphenol extract and cognitive function in healthy young adults: a randomised, placebo-controlled, parallel-groups acute-on-chronic trial

scientific article published on 16 January 2020

Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

scientific article published on 27 July 2018

High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials

scientific article published on 27 October 2016

Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1.

scientific article

Impact of a (poly)phenol-rich extract from the brown algae Ascophyllum nodosum on DNA damage and antioxidant activity in an overweight or obese population: a randomized controlled trial

scientific article published on 01 October 2018

Impact of cocoa flavanol intake on age-dependent vascular stiffness in healthy men: a randomized, controlled, double-masked trial

scientific article published on 27 May 2015

Impact of cooking, proving, and baking on the (poly)phenol content of wild blueberry

scientific article published on 25 October 2013

Impact of palm date consumption on microbiota growth and large intestinal health: a randomised, controlled, cross-over, human intervention study.

scientific article published on October 2015

Impact of processing on the bioavailability and vascular effects of blueberry (poly)phenols

scientific article published on 22 August 2014

Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trial

scientific article published on 03 April 2012

In vitro colonic metabolism of coffee and chlorogenic acid results in selective changes in human faecal microbiota growth.

scientific article published on 26 March 2015

Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: A randomized, controlled, single blind, crossover human intervention trial

scientific article published on 08 August 2020

Inducible hydrogen sulfide synthesis in chondrocytes and mesenchymal progenitor cells: is H2S a novel cytoprotective mediator in the inflamed joint?

scientific article published on April 2012

Influence of age on the absorption, metabolism, and excretion of cocoa flavanols in healthy subjects.

scientific article published on 12 June 2015

Influence of sugar type on the bioavailability of cocoa flavanols

scientific article published on 7 March 2012

Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons.

scientific article

Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway.

scientific article published on 4 October 2007

Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects.

scientific article published on 17 August 2007

Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols

scientific article published on 07 August 2007

Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs

scientific article

Interactions between cocoa flavanols and inorganic nitrate: additive effects on endothelial function at achievable dietary amounts

scientific article published on 18 December 2014

Intracellular metabolism and bioactivity of quercetin and its in vivo metabolites.

scientific article published in May 2003

Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol

scientific article published in June 2010

Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo

scientific article published on 9 April 2008

MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide

scientific article

Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials

scientific article published on 30 November 2016

Metabolism of Anthocyanins by Human Gut Microflora and Their Influence on Gut Bacterial Growth

scientific article published on 4 April 2012

Metabolism of Tea Flavonoids in the Gastrointestinal Tract ⬇️

scientific article published on October 1, 2003

Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers

scientific article

Modulation of pro-survival Akt/protein kinase B and ERK1/2 signaling cascades by quercetin and its in vivo metabolites underlie their action on neuronal viability.

scientific article published on 24 June 2003

Neuroinflammation: modulation by flavonoids and mechanisms of action

scientific article

Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation

scientific article published on 20 April 2008

Nutrients and brain health: an overview

scientific article published on 3 September 2009

Nutrition and the ageing brain: Moving towards clinical applications

scientific article published on 24 May 2020

Nutrition for the ageing brain: Towards evidence for an optimal diet

scientific article

Oat bran, but not its isolated bioactive β-glucans or polyphenols, have a bifidogenic effect in an in vitro fermentation model of the gut microbiota

scientific article published on 28 January 2019

Olive Oil Phenolics Prevent Oxysterol-Induced Proinflammatory Cytokine Secretion and Reactive Oxygen Species Production in Human Peripheral Blood Mononuclear Cells, Through Modulation of p38 and JNK Pathways

scientific article

Olive Polyphenols and the Metabolic Syndrome.

scientific article

Orange pomace fibre increases a composite scoring of subjective ratings of hunger and fullness in healthy adults

scientific article

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Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols

scientific article published on 22 March 2008

Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activation

scientific article

Platelet-mediated metabolism of the common dietary flavonoid, quercetin

scientific article

Polyphenols

article from 2012

Polyphenols and human health: prevention of disease and mechanisms of action

scientific article published on 8 November 2010

Poor cognitive ageing: Vulnerabilities, mechanisms and the impact of nutritional interventions ⬇️

scientific article published on 14 December 2017

Potential Neuroprotective Actions of Dietary Flavonoids

Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study.

scientific article published on 10 November 2010

Prebiotic feeding elevates central brain derived neurotrophic factor, N-methyl-D-aspartate receptor subunits and D-serine.

scientific article published on 16 October 2013

Procyanidin, anthocyanin, and chlorogenic acid contents of highbush and lowbush blueberries.

scientific article

Recommending flavanols and procyanidins for cardiovascular health: current knowledge and future needs

scientific article published on 18 September 2010

Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations

scientific article published on 24 January 2012

Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial

scientific article published on 8 June 2015

Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase

scientific article published on 29 February 2008

Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes

scientific article published in April 2010

Synthetic, non-intoxicating 8,9-dihydrocannabidiol for the mitigation of seizures.

scientific article

The Effects of Flavonoids on Cardiovascular Health: A Review of Human Intervention Trials and Implications for Cerebrovascular Function

article

The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury.

scientific article

The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans

scientific article

The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial

scientific article

The effect of processing on chlorogenic acid content of commercially available coffee.

scientific article published on 13 June 2013

The effects of flavanone-rich citrus juice on cognitive function and cerebral blood flow: an acute, randomised, placebo-controlled cross-over trial in healthy, young adults

scientific article published on 16 January 2017

The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation

scientific article published on 01 June 2006

The genotypic variation of the antioxidant potential of different tomato varieties

scientific article published in September 2005

The impact of chronic blackberry intake on the neuroinflammatory status of rats fed a standard or high-fat diet

scientific article published on 30 June 2015

The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation.

scientific article published on 8 October 2014

The impact of flavonoids on memory: physiological and molecular considerations

scientific article published on 20 January 2009

The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms

scientific article published on 02 September 2009

The impact of fruit flavonoids on memory and cognition ⬇️

scientific article published on October 1, 2010

The interactions of flavonoids within neuronal signalling pathways

scientific article published on 16 October 2007

The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway.

scientific article published on 15 July 2006

The intracellular metabolism of isoflavones in endothelial cells

scientific article published on 20 November 2014

The mechanisms of action of flavonoids in the brain: Direct versus indirect effects.

scientific article published on 07 August 2015

The metabolome of [2-(14)C](-)-epicatechin in humans: implications for the assessment of efficacy, safety, and mechanisms of action of polyphenolic bioactives

scientific article

The neuroprotective potential of flavonoids: a multiplicity of effects

scientific article published on December 2008

The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling

scientific article

The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways

scientific article

The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth.

scientific article published on 11 October 2005

Thioflavones as novel neuroprotective agents

scientific article

Uptake and metabolism of (-)-epicatechin in endothelial cells

scientific article published on 6 April 2014

Zinc-histidine complex protects cultured cortical neurons against oxidative stress-induced damage.

scientific article published in November 2004

c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis

scientific article published in June 2003

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