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List of works by David Stokoe

A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.

scientific article

A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition.

scientific article

A comprehensive transcriptional portrait of human cancer cell lines

scientific article published on 08 December 2014

A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

scientific article published on May 2006

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

scientific article

A requirement for wild-type Ras isoforms in mutant KRas-driven signalling and transformation

scientific article published on June 2013

Activation of PI3K/mTOR pathway occurs in most adult low-grade gliomas and predicts patient survival

scientific article

Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication

scientific article

Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells

scientific article published on 23 April 2008

Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis.

scientific article published on 28 December 2015

Bioelectrical impedance vector analysis, phase-angle assessment and relationship with malnutrition risk in a cohort of frail older hospital patients in the United Kingdom

scientific article published on 23 June 2014

Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing.

scientific article

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes

scientific article published on 22 April 2014

DNA hypermethylation profiles associated with glioma subtypes and EZH2 and IGFBP2 mRNA expression.

scientific article

Disruption of PH–kinase domain interactions leads to oncogenic activation of AKT in human cancers ⬇️

scientific article published on November 7, 2012

Diverse somatic mutation patterns and pathway alterations in human cancers

scientific article (publication date: 12 August 2010)

EGFR signals to mTOR through PKC and independently of Akt in glioma

scientific article published on 27 January 2009

ERBB3 and IGF1R Signaling Are Required for Nrf2-Dependent Growth in KEAP1-Mutant Lung Cancer

scientific article published on 15 August 2019

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.

scientific article

Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes

scientific article published on May 2006

High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma

scientific article published on December 2005

Identification of Mutant K-Ras-dependent Phenotypes Using a Panel of Isogenic Cell Lines ⬇️

scientific article published on November 27, 2012

Inhibition of bromodomain-containing protein 9 for the prevention of epigenetically-defined drug resistance.

scientific article

Inhibition of phosphatidylinositol-3-kinase causes increased sensitivity to radiation through a PKB-dependent mechanism

scientific article published on November 2005

KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

scientific article published on 16 February 2017

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

scientific article (publication date: 2007)

Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

scientific article

New insights into PTEN.

scientific article published on December 2007

Oncogenic activating mutations are associated with local copy gain

scientific article

PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

scientific article published on October 2008

PTEN in brain tumors

scientific article published on April 2008

Pharmacological Inhibition of the Histone Lysine Demethylase KDM1A Suppresses the Growth of Multiple Acute Myeloid Leukemia Subtypes.

scientific article published on 2 February 2016

Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma

scientific article published on 15 December 2008

Phosphatase and tensin homologue growth suppression without phosphatase

scientific article

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

scientific article

Ras-MEK Signaling Mediates a Critical Chk1-Dependent DNA Damage Response in Cancer Cells

scientific article published on 30 January 2017

Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions.

scientific article published on 6 October 2006

Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers

scientific article published on 24 August 2016

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

scientific article

Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism.

scientific article published on September 2004

The p38 Mitogen-Activated Protein Kinase Pathway Links the DNA Mismatch Repair System to the G2 Checkpoint and to Resistance to Chemotherapeutic DNA-Methylating Agents ⬇️

scientific article published on November 1, 2003

The phosphoinositide 3-kinase pathway and cancer

scientific article

Translational deregulation in PDK-1-/- embryonic stem cells

scientific article

Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner

scientific article

ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction

scientific article

Zinc finger nucleases as tools to understand and treat human diseases

scientific article

mTOR-independent translational control of the extrinsic cell death pathway by RalA.

scientific article

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