List of works - Debra Luffer-Atlas

A decade of drug metabolite safety testing: industry and regulatory shared learning

scientific article published on 11 August 2017

A radiocalibration method with pseudo internal standard to estimate circulating metabolite concentrations

scientific article published on 01 July 2010

A strategy for the risk assessment of human genotoxic metabolites

scientific article published in February 2009

Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist

scientific article published on November 2003

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

scientific article published on 11 April 2016

Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain

scientific article published on 8 November 2012

Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated due to Clinical Drug-Induced Liver Injury.

scientific article published on 9 February 2018

Identification of 4-Aminopyrazolopyrimidine Metabolite That May Contribute to the Hypolipidemic Effects of LY2584702 in Long Evans Diet-Induced Obese Rats

scientific article published on 2 May 2017

Identification of cytochrome P4503A4 as the major enzyme responsible for the metabolism of ivermectin by human liver microsomes ⬇️

scientific article published on March 1, 1998

Olaratumab exerts anti-tumor activity in preclinical models of pediatric bone and soft tissue tumors through inhibition of platelet-derived growth factor receptor &alpha

scientific article published on 30 November 2017

Overview of metabolite safety testing from an industry perspective

scientific article published on July 2010

PDGFRα monoclonal antibody: Assessment of embryo-fetal toxicity and time-dependent placental transfer of a murine surrogate antibody of olaratumab in mice

scientific article published on 27 October 2018

Population Pharmacokinetic Modeling of Olaratumab, an Anti-PDGFRα Human Monoclonal Antibody, in Patients with Advanced and/or Metastatic Cancer

scientific article published on 15 June 2017

Predicting circulating human metabolites: how good are we?

scientific article published in February 2009

Serum Lipid and Protein Changes in Healthy Dyslipidemic Subjects Given a Selective Inhibitor of p70 S6 Kinase-1.

scientific article published on 26 November 2017

The early estimation of circulating drug metabolites in humans ⬇️

scientific article published on June 10, 2012

The effect of hepatic or renal impairment on the pharmacokinetics of edivoxetine, a selective norepinephrine transporter reuptake inhibitor

scientific article published on 17 August 2013

Unique/major human metabolites: why, how, and when to test for safety in animals

scientific article published on 01 January 2008

List of works by Debra Luffer-Atlas