List of works by Richard Harrigan

"Dynamic range" of inferred phenotypic HIV drug resistance values in clinical practice

scientific article

A Simple, Dynamic Measure of Antiretroviral Therapy Adherence Predicts Failure to Maintain HIV‐1 Suppression

article

A comparison of three computational modelling methods for the prediction of virological response to combination HIV therapy

scientific article

A compromise strategy for patients with multiple drug failure

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

scientific article

Adaptation of HIV-1 to human leukocyte antigen class I

scientific article published on 25 February 2009

Antiretroviral Concentrations in Untimed Plasma Samples Predict Therapy Outcome in a Population with Advanced Disease

article

Antiretroviral resistance among HIV-infected persons who have died in British Columbia, in the era of modern antiretroviral therapy

scientific article

Application and validation of case-finding algorithms for identifying individuals with human immunodeficiency virus from administrative data in British Columbia, Canada

scientific article

Association between HIV-1 RNA level and CD4 cell count among untreated HIV-infected individuals

article

Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study

scientific article

CD4-dependent characteristics of coreceptor use and HIV type 1 V3 sequence in a large population of therapy-naive individuals

scientific article published in February 2008

Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy

scientific article

Cohort Profile: HAART Observational Medical Evaluation and Research (HOMER) cohort

scientific article

Continued improvement in survival among HIV-infected individuals with newer forms of highly active antiretroviral therapy

scientific article

Correction: Evidence of Differential HLA Class I-Mediated Viral Evolution in Functional and Accessory/Regulatory Genes of HIV-1

article

Correction: Geographic and Temporal Trends in the Molecular Epidemiology and Genetic Mechanisms of Transmitted HIV-1 Drug Resistance: An Individual-Patient- and Sequence-Level Meta-Analysis

scientific article

Cost-Effectiveness of Antiretroviral Therapy for Multidrug-Resistant HIV: Past, Present, and Future

scientific article published on 8 November 2012

Development and validation of a composite programmatic assessment tool for HIV therapy

scientific article

Differential impact of adherence on long-term treatment response among naive HIV-infected individuals

article

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection

scientific article

Effect of Medication Adherence on Survival of HIV-Infected Adults Who Start Highly Active Antiretroviral Therapy When the CD4+ Cell Count Is 0.200 to 0.350 × 109 cells/L

scientific article published on November 18, 2003

Effects of Human Leukocyte Antigen Class I Genetic Parameters on Clinical Outcomes and Survival after Initiation of Highly Active Antiretroviral Therapy

article

Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART

scientific article

Epidemiology of treatment failure: a focus on recent trends

scientific article

Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1

scientific article

Expanded access to highly active antiretroviral therapy: a potentially powerful strategy to curb the growth of the HIV epidemic

scientific article

Expanded highly active antiretroviral therapy coverage among HIV-positive drug users to improve individual and public health outcomes

scientific article

Expansion of HAART coverage is associated with sustained decreases in HIV/AIDS morbidity, mortality and HIV transmission: the "HIV Treatment as Prevention" experience in a Canadian setting

scientific article (publication date: 2014)

Full suppression of viral load is needed to achieve an optimal CD4 cell count response among patients on triple drug antiretroviral therapy

article

Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient- and sequence-level meta-analysis

scientific article

HIV antiviral drug resistance: patient comprehension

scientific article published in July 2010

HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins

scientific article

HLA-associated viral mutations are common in human immunodeficiency virus type 1 elite controllers

scientific article published on 19 January 2009

Hepatitis C testing in Canada: don't leave baby boomers behind.

scientific article published in June 2017

Higher baseline levels of plasma human immunodeficiency virus type 1 RNA are associated with increased mortality after initiation of triple-drug antiretroviral therapy

scientific article published on 5 November 2003

Human leukocyte antigen-specific polymorphisms in HIV-1 Gag and their association with viral load in chronic untreated infection

article

Impact of baseline viral load and adherence on survival of HIV-infected adults with baseline CD4 cell counts ≥ 200 cells/μl

article

Improved virological outcomes in British Columbia concomitant with decreasing incidence of HIV type 1 drug resistance detection

scientific article

Increased Prevalence of Controlled Viremia and Decreased Rates of HIV Drug Resistance Among HIV-Positive People Who Use Illicit Drugs During a Community-wide Treatment-as-Prevention Initiative

scientific article published on 8 November 2015

Increased reporting of detectable plasma HIV-1 RNA levels at the critical threshold of 50 copies per milliliter with the Taqman assay in comparison to the Amplicor assay

scientific article published in May 2009

Increased resilience to the development of drug resistance with modern boosted protease inhibitor-based highly active antiretroviral therapy

scientific article

Initiation of antiretroviral therapy at high CD4+ cell counts is associated with positive treatment outcomes

scientific article

Is nevirapine-based therapy discontinuation in hepatitis C co-infected patients a more important mortality determinant than hypersensitivity: authors' reply

scientific article

Is there a baseline CD4 cell count that precludes a survival response to modern antiretroviral therapy?

scientific article

Longitudinal community plasma HIV-1 RNA concentrations and incidence of HIV-1 among injecting drug users: prospective cohort study.

scientific article published on 30 April 2009

Lower prevalence of drug resistance mutations at first-line virological failure to first-line therapy with atripla vs. tenofovir + emtricitabine/lamivudine + efavirenz administered on a multiple tablet therapy

scientific article published on November 2014

Magnitude of virologic blips is associated with a higher risk for virologic rebound in HIV-infected individuals: a recurrent events analysis

scientific article published in April 2012

Mitochondrial DNA somatic mutation burden and heteroplasmy are associated with chronological age, smoking, and HIV infection

scientific article published on 13 August 2019

Mitochondrial toxicity in the era of HAART: evaluating venous lactate and peripheral blood mitochondrial DNA in HIV-infected patients taking antiretroviral therapy

scientific article published on September 2003

Mitochondrial:nuclear DNA ratios in peripheral blood cells from human immunodeficiency virus (HIV)-infected patients who received selected HIV antiretroviral drug regimens

scientific article

Molecular and Clinical Epidemiology of CXCR4‐Using HIV‐1 in a Large Population of Antiretroviral‐Naive Individuals

article

Near real-time monitoring of HIV transmission hotspots from routine HIV genotyping: an implementation case study

scientific article published on 7 April 2016

Nucleoside-related mitochondrial toxicity among HIV-infected patients receiving antiretroviral therapy: insights from the evaluation of venous lactic acid and peripheral blood mitochondrial DNA.

scientific article published in March 2004

Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.

scientific article

Post-marketing experience with nevirapine extended release (XR) tablets: effectiveness and tolerability in a population-based cohort in British Columbia, Canada

scientific article

Predicting hospitalization among HIV-infected antiretroviral naïve patients starting HAART: determining clinical markers and exploring social pathways

scientific article published in March 2008

Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy

scientific article

Rates of antiretroviral resistance among HIV-infected patients with and without a history of injection drug use.

scientific article published in July 2005

Rates of disease progression among human immunodeficiency virus-infected persons initiating multiple-drug rescue therapy

scientific article published on 23 June 2003

Regional differences in rates of HIV-1 viral load monitoring in Canada: Insights and implications for antiretroviral care in high income countries

scientific article

Relative effects of antiretroviral therapy and harm reduction initiatives on HIV incidence in British Columbia, Canada, 1996-2013: a modelling study

scientific article

Risk of viral failure declines with duration of suppression on highly active antiretroviral therapy irrespective of adherence level

scientific article

Short communication. Association of the CCR5delta32 mutation with clinical response and >5-year survival following initiation of first triple antiretroviral regimen

article

Tenofovir and emtricitabine resistance among antiretroviral-naive patients in the Canadian Observational Cohort Collaboration: implications for PrEP

scientific article published on 01 January 2019

The Impact of Adherence on CD4 Cell Count Responses Among HIV-Infected Patients

article

The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic

scientific article

The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time

scientific article published on April 2009

The development of an expert system to predict virological response to HIV therapy as part of an online treatment support tool

scientific article published in September 2011

The development of artificial neural networks to predict virological response to combination HIV therapy.

scientific article published in January 2007

The impact of clinical, demographic and risk factors on rates of HIV transmission: a population-based phylogenetic analysis in British Columbia, Canada

scientific article

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation

scientific article

The relationship between resistance and adherence in drug-naive individuals initiating HAART is specific to individual drug classes

scientific article published on November 2008

Treatment interruption of highly active antiretroviral therapy in patients with nadir CD4 cell counts >200 cells/mm3.

scientific article

Trends in plasma HIV-RNA suppression and antiretroviral resistance in British Columbia, 1997-2010

scientific article

Uncommon pathways of immune escape attenuate HIV-1 integrase replication capacity

scientific article

Using baseline CD4 cell count and plasma HIV RNA to guide the initiation of highly active antiretroviral therapy

scientific article published in March 2004

When to initiate antiretroviral therapy in HIV-1-infected adults: a review for clinicians and patients

scientific article

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