List of works - Mark J. Zylka

A deep neural network to assess spontaneous pain from mouse facial expressions

scientific article published in January 2018

A high throughput assay to identify small molecule modulators of prostatic acid phosphatase

scientific article

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling

scientific article published in September 2005

AMP Is an Adenosine A1 Receptor Agonist ⬇️

scientific article published on January 3, 2012

Accurate and High Throughput Cell Segmentation Method for Mouse Brain Nuclei Using Cascaded Convolutional Neural Network

scholarly article by Qian Wang et al published 2017 in Lecture Notes in Computer Science

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A.

scientific article

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

scientific article

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family

scientific article

Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons

scientific article published on 8 September 2013

CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch ⬇️

scientific article published on January 1, 2012

Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA

scientific article published on 21 October 2020

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

scientific article published on 05 October 2020

Choice of vehicle affects pyraclostrobin toxicity in mice

scientific article published on 23 November 2018

Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research

scientific article published on 16 October 2020

Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord

scientific article

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

scientific article published on 23 April 2020

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C

scientific article published on 22 December 2014

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

scholarly article

Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits

scientific article published on February 2010

Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons ⬇️

scientific article published on January 1, 2011

Enhanced Nociception in Angelman Syndrome Model Mice

scientific article

Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8.

scientific article

Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice

scientific article published on 05 June 2019

Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2.

scientific article

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

scientific article published on 22 March 2016

Gene length matters in neurons

scientific article

High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase

scientific article

High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq

article

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.

scientific article published on 31 March 2016

Improving pain assessment in mice and rats with advanced videography and computational approaches

scientific article published on 01 April 2020

Lipid kinases as therapeutic targets for chronic pain

scientific article

Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice

scientific article published on 29 April 2019

Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact.

scientific article

Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors

scientific article published in January 2008

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

scientific article published on 8 July 2007

Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors

scientific article published on July 2009

Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons

scientific article published on October 2009

Needling adenosine receptors for pain relief

scientific article published in July 2010

Nonpeptidergic circuits feel your pain

scientific article

Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors ⬇️

scientific article published on June 1, 2011

Orally Active Adenosine A1 Receptor Agonists with Antinociceptive Effects in Mice ⬇️

scientific article published on July 16, 2012

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway

scientific article

Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling

scientific article published on 07 March 2014

PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

scientific article published on 19 October 2011

PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain

scientific article

Pain-relieving prospects for adenosine receptors and ectonucleotidases

scientific article

Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold ⬇️

scientific article published on March 21, 2013

Photochemical activation of TRPA1 channels in neurons and animals

scientific article

Prenatal treatment path for angelman syndrome and other neurodevelopmental disorders

scientific article published on 06 September 2019

Prostatic Acid Phosphatase Is Required for the Antinociceptive Effects of Thiamine and Benfotiamine ⬇️

scientific article published on October 31, 2012

Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine

scientific article

Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats

scientific article

Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate

scientific article published on August 2010

Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation

scientific article published on 14 April 2010

Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception

scientific article

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector

scientific journal article

Secretion and N-Linked Glycosylation Are Required for Prostatic Acid Phosphatase Catalytic and Antinociceptive Activity ⬇️

scientific article published on February 28, 2012

Sex, drugs and pain control

scientific article

Single-cell transcriptomic analysis of mouse neocortical development

scientific article published in Nature Communications

Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice

scientific article

Strobilurin fungicides in house dust: is wallboard a source?

scientific article published on 21 October 2019

The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently.

scientific article

The Troubled Touch of Autism.

scientific article

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

scientific article

The lipid kinase PIP5K1C regulates pain signaling and sensitization

scientific article published on May 2014

Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.

scientific article published on July 2013

Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd

scientific article published in January 2005

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

scientific article

Topoisomerase 1 inhibition reversibly impairs synaptic function.

scientific article

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons ⬇️

scientific article published on December 21, 2011

Topoisomerases facilitate transcription of long genes linked to autism

scientific article published on 28 August 2013

Zylka et al. reply

scientific article published on August 2014

[EXPRESS] Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization

scientific article published in January 2017

lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

scientific article published on 27 June 2019

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy

scientific article published on 20 December 2019

List of works by Mark J. Zylka

A deep neural network to assess spontaneous pain from mouse facial expressions

A high throughput assay to identify small molecule modulators of prostatic acid phosphatase

A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling

AMP Is an Adenosine A1 Receptor Agonist ⬇️

Accurate and High Throughput Cell Segmentation Method for Mouse Brain Nuclei Using Cascaded Convolutional Neural Network

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A.

Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypes

Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family

Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons

CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch ⬇️

Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA

Chd8 haploinsufficiency impairs early brain development and protein homeostasis later in life

Choice of vehicle affects pyraclostrobin toxicity in mice

Content and Performance of the MiniMUGA Genotyping Array, a New Tool To Improve Rigor and Reproducibility in Mouse Research

Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord

Deletion of Topoisomerase 1 in excitatory neurons causes genomic instability and early onset neurodegeneration

Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

Ecto-5'-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits

Emerging Roles for Ectonucleotidases in Pain-Sensing Neurons ⬇️

Enhanced Nociception in Angelman Syndrome Model Mice

Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8.

Enhanced histamine-induced itch in diacylglycerol kinase iota knockout mice

Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2.

GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility

Gene length matters in neurons

High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase

High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq

Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration.

Improving pain assessment in mice and rats with advanced videography and computational approaches

Lipid kinases as therapeutic targets for chronic pain

Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice

Maternal Ube3a Loss Disrupts Sleep Homeostasis But Leaves Circadian Rhythmicity Largely Intact.

Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors

Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch

Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors

Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons

Needling adenosine receptors for pain relief

Nonpeptidergic circuits feel your pain

Optimizing Promoters for Recombinant Adeno-Associated Virus-Mediated Gene Expression in the Peripheral and Central Nervous System Using Self-Complementary Vectors ⬇️

Orally Active Adenosine A1 Receptor Agonists with Antinociceptive Effects in Mice ⬇️

Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway

Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling

PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain

Pain-relieving prospects for adenosine receptors and ectonucleotidases

Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold ⬇️

Photochemical activation of TRPA1 channels in neurons and animals

Prenatal treatment path for angelman syndrome and other neurodevelopmental disorders

Prostatic Acid Phosphatase Is Required for the Antinociceptive Effects of Thiamine and Benfotiamine ⬇️

Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine

Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats

Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate

Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation

Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A(1)-adenosine receptors to mediate antinociception

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector

Secretion and N-Linked Glycosylation Are Required for Prostatic Acid Phosphatase Catalytic and Antinociceptive Activity ⬇️

Sex, drugs and pain control

Single-cell transcriptomic analysis of mouse neocortical development

Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice

Strobilurin fungicides in house dust: is wallboard a source?

The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently.

The Troubled Touch of Autism.

The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome

The lipid kinase PIP5K1C regulates pain signaling and sensitization

Tissue-nonspecific alkaline phosphatase acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.

Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd

Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms.

Topoisomerase 1 inhibition reversibly impairs synaptic function.

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons ⬇️

Topoisomerases facilitate transcription of long genes linked to autism

Zylka et al. reply

[EXPRESS] Conditional deletion of Pip5k1c in sensory ganglia and effects on nociception and inflammatory sensitization

lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy