Search filters

List of works by Jeffrey L. Wrana

A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis

scientific article (publication date: September 2007)

A critical role for NF2 and the Hippo pathway in branching morphogenesis

scientific article

A feed forward loop enforces YAP/TAZ signaling during tumorigenesis

scientific article published in Nature Communications

A high-content chemical screen identifies ellipticine as a modulator of p53 nuclear localization

scientific article

A high-throughput induction gene trap approach defines C4ST as a target of BMP signaling.

scientific article published in October 2002

A highly conserved program of neuronal microexons is misregulated in autistic brains

scientific article published on December 2014

A late transition in somatic cell reprogramming requires regulators distinct from the pluripotency network

scientific article published in December 2012

A lateral signalling pathway coordinates shape volatility during cell migration

scientific article

A role for the TGFbeta-Par6 polarity pathway in breast cancer progression

scientific article

A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening.

scientific article

Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis

scientific article

An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming

scientific article

An endogenous PI3K interactome promoting astrocyte mediated neuroprotection identifies a novel association with RNA binding protein ZC3H14

scientific article published on 24 November 2020

An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2

scientific article (publication date: 23 June 2006)

An experimentally derived confidence score for binary protein-protein interactions

scientific article

Analysis of Hippo and TGFβ signaling in polarizing epithelial cells and mouse embryos

scientific article published on 20 January 2016

Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway

scientific article

Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility.

scientific article published on 29 May 2019

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

scientific article

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development

scientific journal article

C4ST-1/CHST11-controlled chondroitin sulfation interferes with oncogenic HRAS signaling in Costello syndrome ⬇️

scientific article published on February 8, 2012

CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor

scientific article published on 19 February 2014

Caenorhabditis elegans SMA-10/LRIG is a conserved transmembrane protein that enhances bone morphogenetic protein signaling

scientific article

Cancer Cells Hijack PRC2 to Modify Multiple Cytokine Pathways

scientific article

Cell biology: an unexpected social servant

scientific article published on 01 September 2004

Cell competition during reprogramming gives rise to dominant clones

scientific article published on 21 March 2019

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.

scientific article published on 9 July 2009

Chemical enhancers of cytokine signaling that suppress microfilament turnover and tumor cell growth

scientific article

Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling

scientific article

Comparison of SARS-CoV-2 Indirect and Direct Detection Methods

scientific article published on 14 May 2020

Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding

scientific article

Coordinating developmental signaling: novel roles for the Hippo pathway.

scientific article published on 05 December 2011

Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

scientific article published on June 2015

Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity

scientific article

Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons

scientific article published on 01 June 2018

Degradation of RhoA by Smurf1 ubiquitin ligase

scientific article published on January 2006

Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity

scientific journal article

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover ⬇️

scientific article published on May 1, 2003

Distinct polarity cues direct Taz/Yap and TGFβ receptor localization to differentially control TGFβ-induced Smad signaling

scientific article published on March 2015

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

scientific article published on 22 March 2016

Dynamic modularity in protein interaction networks predicts breast cancer outcome

scientific article

Early endosomal regulation of Smad-dependent signaling in endothelial cells

scientific article

Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

scientific journal article

Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway

scientific article

Erlotinib synergizes with the poly(ADP-ribose) glycohydrolase inhibitor ethacridine in acute myeloid leukemia cells

scientific article published on September 2016

Essential gene profiles in breast, pancreatic, and ovarian cancer cells.

scientific article

Evidence for positive selection on a number of MicroRNA regulatory interactions during recent human evolution

scientific article

Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS.

scientific article published in July 2017

Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration.

scientific article published on December 2012

Foxh1 is essential for development of the anterior heart field

scientific journal article

Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development

scientific journal article

Functional genomics identifies new synergistic therapies for retinoblastoma

scientific article published on 22 June 2020

Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming

scientific article

GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations

scientific article

Gaining Insights into the Function of Post-Translational Protein Modification Using Genome Engineering and Molecular Cell Biology

scientific article published on 12 July 2019

Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development

scientific journal article

Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans

scientific article

High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer.

scientific article

High-throughput mapping of a dynamic signaling network in mammalian cells

scientific article (publication date: 11 March 2005)

Hippo signalling in intestinal regeneration and cancer

scientific article

Human ortholog of Drosophila Melted impedes SMAD2 release from TGF-β receptor I to inhibit TGF-β signaling

scientific article published on 26 May 2015

Identification of a non-phosphorylated, cell permeable, small molecule ligand for the Stat3 SH2 domain

scientific article

Image-based genome-wide siRNA screen identifies selective autophagy factors

scientific article

In or out? The dynamics of Smad nucleocytoplasmic shuttling ⬇️

scientific article published on May 1, 2003

Inhibition of SREBP1 sensitizes cells to death ligands.

scientific article

Inhibition of the sodium potassium adenosine triphosphatase pump sensitizes cancer cells to anoikis and prevents distant tumor formation

scientific article

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy

scientific journal article

Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network

scientific article

KATapulting toward Pluripotency and Cancer

scientific article

LUMIER: A Discovery Tool for Mammalian Protein Interaction Networks

scientific article published on January 2017

Looking into the black box: insights into the mechanisms of somatic cell reprogramming

scientific article published on 13 January 2011

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

scientific article published on 24 August 2014

MB-02SONIC HEDGEHOG INDUCES YB-1 IN A YAP-DEPENDENT MANNER TO REGULATE Igf2 EXPRESSION AND PROLIFERATION IN CEREBELLAR GRANULE NEURON PROGENITORS AND MEDULLOBLASTOMA CELLS.

scientific article published on 21 April 2015

MBNL proteins repress ES-cell-specific alternative splicing and reprogramming.

scientific article published on 05 June 2013

Maintenance of chondroitin sulfation balance by chondroitin-4-sulfotransferase 1 is required for chondrocyte development and growth factor signaling during cartilage morphogenesis

scientific journal article

Mink1 regulates β-catenin-independent Wnt signaling via Prickle phosphorylation

scientific article published on 28 October 2011

Modeling the Control of TGF-β/Smad Nuclear Accumulation by the Hippo Pathway Effectors, Taz/Yap

scientific article published on 29 July 2020

Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors

scientific article published in February 2017

Multiple roles for the hippo effector yap in gut regeneration and cancer initiation

scientific article published on 16 March 2016

Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming

scientific article

Next-generation RNA Sequencing of Archival Formalin-fixed Paraffin-embedded Urothelial Bladder Cancer

No effects of Smad2 (madh2) null mutation on malignant progression of intestinal polyps in Apc(delta716) knockout mice.

scientific article published in August 2002

Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks

scientific article published on 07 December 2013

On the wings of inhibition

scientific article published in Nature

Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019

scientific article published on 18 July 2020

PTEN regulates cilia through Dishevelled ⬇️

scientific article

Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients

scientific article published on 01 October 2020

Phosphoserine-dependent regulation of protein-protein interactions in the Smad pathway

scientific article published in January 2002

ProHits: integrated software for mass spectrometry-based interaction proteomics

scientific article

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions

scientific article

Protein interaction networks in medicine and disease

scientific article published on May 2012

Pulmonary pericytes regulate lung morphogenesis.

scientific article published on 22 June 2018

Recent advances in understanding contextual TGFβ signaling

scientific article

Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2.

scientific article published on 31 October 2016

Regulation of Par6 by extracellular signals

scientific article published on 20 February 2006

Regulation of Rho GTPases from the lateral sides of migrating cells.

scientific article published in November 2016

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

scientific article

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

scientific article (publication date: 5 December 2003)

Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.

scientific article

Regulation of planar cell polarity by Smurf ubiquitin ligases

scientific article

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

scientific article

Robust production of uniform human cerebral organoids from pluripotent stem cells

scientific article published on 17 April 2020

Seeing is believing: Wnt3 localization in the gut epithelium

scientific article published on 25 March 2016

Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells

scientific article published on July 2015

Selective targeting of neuroblastoma tumour-initiating cells by compounds identified in stem cell-based small molecule screens

scientific article

Signal integration in TGF-β, WNT, and Hippo pathways ⬇️

scientific article published on June 3, 2013

Signal transduction by the TGF-beta superfamily

scientific article

Signaling and endocytosis: a team effort for cell migration

scientific article

Signaling by the TGFβ superfamily

scientific article published on October 2013

Single-cell transcriptomes of the regenerating intestine reveal a revival stem cell

scientific article published on 24 April 2019

Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells

scientific article

SnapShot: The TGFbeta pathway interactome

scientific article published on 01 April 2008

Somatic driver mutation prevalence in 1844 prostate cancers identifies ZNRF3 loss as a predictor of metastatic relapse

scientific article published on 29 October 2021

Structural basis for specificity of TGFβ family receptor small molecule inhibitors

scientific article

Switch enhancers interpret TGF-β and Hippo signaling to control cell fate in human embryonic stem cells.

scientific article published on 12 December 2013

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

scientific article

TCF1 links GIPR signaling to the control of beta cell function and survival

scientific article published on 7 December 2015

TGF-beta and the Smad signal transduction pathway

scientific article

TGF-β Family Signaling in Embryonic and Somatic Stem-Cell Renewal and Differentiation

scientific article published on 20 January 2017

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

scientific article

TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling

scientific article published on 22 May 2020

Targeted mutations of the juxtamembrane tyrosines in the Kit receptor tyrosine kinase selectively affect multiple cell lineages

scientific journal article

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway

scientific article published in December 2010

The Hippo pathway regulates Wnt/beta-catenin signaling

scientific article

The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin

scientific article

The TGFbeta-Par6 polarity pathway: linking the Par complex to EMT and breast cancer progression

scientific article published on 01 February 2010

The TGFβ superfamily in stem cell biology and early mammalian embryonic development

scientific article published on 05 September 2012

The disparate role of BMP in stem cell biology

scientific article

The emerging role of exosomes in Wnt secretion and transport.

scientific article published on 08 May 2014

The extracellular domain of the TGFbeta type II receptor regulates membrane raft partitioning.

scientific article published on 12 June 2009

The return of Dr Jekyll in cancer metastasis

scientific article published on 27 November 2012

The secret life of Smad4

scientific article published on 01 January 2009

The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans

scientific article

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid-imidazolide alters transforming growth factor beta-dependent signaling and cell migration by affecting the cytoskeleton and the polarity complex

scientific article

The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated substrates

scientific article

Tissue-specific alternative splicing remodels protein-protein interaction networks

scientific article published in June 2012

Trafficking of Serine/Threonine Kinase Receptors and Smad Activation

Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA.

scientific article

Turning it up a Notch: cross-talk between TGF beta and Notch signaling

scientific article

UNC-129 regulates the balance between UNC-40 dependent and independent UNC-5 signaling pathways

scientific article

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

scientific article

YAP/TAZ Are Mechanoregulators of TGF-β-Smad Signaling and Renal Fibrogenesis.

scientific article published on 9 March 2016

Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer

scientific article

Paulina is supported by:

About Paulina

Help