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List of works by Björn Heindryckx

A maternally inherited autosomal point mutation in human phospholipase C zeta (PLCζ) leads to male infertility

scientific article published on 16 November 2011

A systematic analysis of the suitability of preimplantation genetic diagnosis for mitochondrial diseases in a heteroplasmic mitochondrial mouse model.

scientific article published on 12 February 2014

Activin A-derived human embryonic stem cells show increased competence to differentiate into primordial germ cell-like cells

scientific article published on 02 February 2021

Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells

scientific article published on 24 June 2015

Application Of Small Molecules Favoring Naïve Pluripotency during Human Embryonic Stem Cell Derivation

scientific article published on June 2015

Assessing the impact of minimizing arginine conversion in fully defined SILAC culture medium in human embryonic stem cells

scientific article published on 9 July 2016

Assessment of nuclear transfer techniques to prevent the transmission of heritable mitochondrial disorders without compromising embryonic development competence in mice

scientific article published on 16 September 2014

Assessment of the calcium releasing machinery in oocytes that failed to fertilize after conventional ICSI and assisted oocyte activation

scientific article published on 23 December 2018

Assisted oocyte activation following ICSI fertilization failure

scientific article published on 31 January 2014

Assisted oocyte activation significantly increases fertilization and pregnancy outcome in patients with low and total failed fertilization after intracytoplasmic sperm injection: a 17-year retrospective study

scientific article published on 24 May 2019

Bta-miR-10b Secreted by Bovine Embryos Negatively Impacts Preimplantation Embryo Quality

scientific article published on 22 August 2019

CRISPR/Cas9-mediated genome editing in naïve human embryonic stem cells

scientific article published on 30 November 2017

Cellular Heterogeneity in the Level of mtDNA Heteroplasmy in Mouse Embryonic Stem Cells.

scientific article

Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells

scientific article published on 24 May 2012

Chromosomal mosaicism in human blastocysts: the ultimate diagnostic dilemma

scientific article published on 06 March 2020

Comparative analysis of naive, primed and ground state pluripotency in mouse embryonic stem cells originating from the same genetic background.

scientific article

Contemporary pharmacogenetic assays in view of the PharmGKB database

scientific article published on 18 March 2019

Culture conditions affect Ca2+ release in artificially activated mouse and human oocytes

scientific article published on 12 January 2018

Culture medium preferences of pre-implantation cloned mouse embryos

scientific article published in January 2006

Derivation of human embryonic stem cells using a post-inner cell mass intermediate

scientific article published on 10 January 2013

Detailed method description for noninvasive monitoring of differentiation status of human embryonic stem cells

scientific article

Developmental competence of parthenogenetic mouse and human embryos after chemical or electrical activation ⬇️

scientific article published on November 3, 2010

Diagnosis and Treatment of Male Infertility-Related Fertilization Failure

scientific article published on 01 December 2020

Differential apoptotic staining of mammalian blastocysts based on double immunofluorescent CDX2 and active caspase-3 staining

scientific article published on 27 May 2011

Effect of two assisted oocyte activation protocols used to overcome fertilization failure on the activation potential and calcium releasing pattern.

scientific article published on 26 November 2015

Efficiency of assisted oocyte activation as a solution for failed intracytoplasmic sperm injection

scientific article

Erratum to: PLCζ disruption with complete fertilization failure in normozoospermia

scientific article published on July 2015

Erratum. Chromosomal mosaicism in human blastocysts: the ultimate diagnostic dilemma

scientific article published on 01 April 2020

Establishment and Characterization of Naïve Pluripotency in Human Embryonic Stem Cells.

scientific article

Exogenous supplementation of Activin A enhances germ cell differentiation of human embryonic stem cells.

scientific article

Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots.

scientific article

Hatching is modulated by microRNA-378a-3p derived from extracellular vesicles secreted by blastocysts

scientific article published on 17 March 2022

Human blastocyst outgrowths recapitulate primordial germ cell specification events

scientific article published on 01 September 2019

Human embryo research in Belgium: an overview.

scientific article published on June 2017

Human germline gene editing. Recommendations of ESHG and ESHRE

scientific article published on 12 January 2018

Human germline gene editing: Recommendations of ESHG and ESHRE.

scientific article published on 12 January 2018

Identification of histone H3 clipping activity in human embryonic stem cells

scientific article

Influence of activin A supplementation during human embryonic stem cell derivation on germ cell differentiation potential

scientific article published on 14 August 2013

Inhibition of transforming growth factor β signaling promotes epiblast formation in mouse embryos

scientific article

Language development of children born following intracytoplasmic sperm injection (ICSI) combined with assisted oocyte activation (AOA).

scientific article published on 26 May 2014

Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes

scientific article published on 18 October 2011

Metabolic plasticity complements the unique nature and demands of distinct pluripotency states

scientific article published on 13 February 2017

Modelling human embryogenesis: embryo-like structures spark ethical and policy debate

scientific article published on 26 July 2020

Mutation-free baby born from a mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome carrier after blastocyst trophectoderm preimplantation genetic diagnosis.

scientific article published on 23 August 2014

Neonatal and neurodevelopmental outcome of children aged 3-10 years born following assisted oocyte activation

scientific article published on 27 August 2013

Novel reproductive technologies to prevent mitochondrial disease

scientific article

PLCζ disruption with complete fertilization failure in normozoospermia

scientific article published on 19 May 2015

PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence

scientific article

Pan-cancer pharmacogenetics: targeted sequencing panels or exome sequencing?

scientific article published on 06 October 2020

Patients with a high proportion of immature and meiotically resistant oocytes experience defective nuclear oocyte maturation patterns and impaired pregnancy outcomes.

scientific article published on 31 January 2018

Polar body mutation load analysis in a patient with A3243G tRNALeu(UUR) point mutation

scientific article published on 6 April 2011

Poor correlation between polar bodies and blastomere mutation load in a patient with m.3243A>G tRNALeu(UUR) point mutation.

scientific article published on 3 May 2012

Preimplantation genetic diagnosis for chromosomal rearrangements with the use of array comparative genomic hybridization at the blastocyst stage

scientific article published on 25 October 2016

Procaine Induces Cytokinesis in Horse Oocytes via a pH-Dependent Mechanism

scientific article

Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions

scientific article published on 18 December 2020

Reference loci for RT-qPCR analysis of differentiating human embryonic stem cells

scientific article

Responsible innovation in human germline gene editing. Background document to the recommendations of ESHG and ESHRE

scientific article published on 12 January 2018

Responsible innovation in human germline gene editing: Background document to the recommendations of ESHG and ESHRE.

scientific article

Robust protocol for feeder-free adaptation of cryopreserved human pluripotent stem cells

scientific article published on 29 October 2019

Serial pronuclear transfer increases the developmental potential of in vitro-matured oocytes in mouse cloning

scientific article published in December 2002

Shallow whole genome sequencing is well suited for the detection of chromosomal aberrations in human blastocysts

scientific article published on 14 August 2015

Single Ca (2+) transients versus oscillatory Ca(2+) signalling: limitations and benefits

scientific article

Slow controlled-rate freezing of human in vitro matured oocytes: effects on maturation rate and kinetics and parthenogenetic activation

scientific article published on 20 July 2011

Sperm involved in recurrent partial hydatidiform moles cannot induce the normal pattern of calcium oscillations.

scientific article published on 12 June 2014

Strontium fails to induce Ca2+ release and activation in human oocytes despite the presence of functional TRPV3 channels

scientific article published on 09 April 2018

The combination of inhibitors of FGF/MEK/Erk and GSK3β signaling increases the number of OCT3/4- and NANOG-positive cells in the human inner cell mass, but does not improve stem cell derivation

scientific article published on 6 August 2012

The influence of early embryo traits on human embryonic stem cell derivation efficiency

scientific article published on 17 October 2010

The post-inner cell mass intermediate: implications for stem cell biology and assisted reproductive technology

scientific article published on 18 June 2015

Toxic effects of Hoechst staining and UV irradiation on preimplantation development of parthenogenetically activated mouse oocytes

scientific article

Tracking the progression of the human inner cell mass during embryonic stem cell derivation

scientific article published on 26 February 2012

Treatment of human embryos with the TGFβ inhibitor SB431542 increases epiblast proliferation and permits successful human embryonic stem cell derivation

scientific article published on 19 November 2013

Two decades of embryonic stem cells: a historical overview

scientific article published on 29 January 2019

Untargeted histone profiling during naive conversion uncovers conserved modification markers between mouse and human

scientific article published on 21 November 2019

Use of pluripotent stem cells for reproductive medicine: are we there yet?

scientific article published on 05 March 2014

Variance in total levels of phospholipase C zeta (PLC-ζ) in human sperm may limit the applicability of quantitative immunofluorescent analysis as a diagnostic indicator of oocyte activation capability

scientific article published on 3 October 2012

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes

scientific article published on 28 September 2019

WNT Inhibition and Increased FGF Signaling Promotes Derivation of Less Heterogeneous Primed Human Embryonic Stem Cells, Compatible with Differentiation

scientific article published on 02 April 2019

Whole genome amplification with SurePlex results in better copy number alteration detection using sequencing data compared to the MALBAC method

scientific article

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