List of works - Małgorzata Zygmunt

(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands

scientific article published on 10 August 2015

7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity

scientific article published on 13 April 2014

8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation

scientific article published on 19 June 2020

A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity

scientific article

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS.

scientific article published on May 2016

Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts

scientific article published on 03 April 2014

Analgesic activity of new 8-methoxy-1,3-dimethyl-2,6-dioxo-purin-7-yl derivatives with carboxylic, ester or amide moieties

scientific article published on 13 August 2014

Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones

scientific article published on 28 June 2014

Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity

scientific article published on 04 June 2019

Anti-inflammatory activity of lipoic acid in mice peritonitis model

Anti-inflammatory, antioxidant, and antiparkinsonian effects of adenosine A2A receptor antagonists.

scientific article

Antiarrhythmic activity in occlusion-reperfusion model of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino} propan-2-ol and its enantiomers.

scientific article published on 19 September 2015

Antiarrhythmic and α-Adrenoceptor Antagonistic Properties of Novel Arylpiperazine Derivatives of Pyrrolidin-2-one.

scientific article published on 2 November 2015

Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α₁-adrenoceptor affinities

scientific article published on 13 February 2012

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system.

scientific article

Antiparkinsonian Effects of Novel Adenosine A2A Receptor Antagonists

scientific article published on 18 November 2010

Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?

scientific article published in January 2013

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

scientific article

Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity.

scientific article published on 10 September 2016

Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

scientific article published on 3 August 2016

Contribution of the nitric oxide donor molsidomine and the antiparkinsonian drug l-DOPA to the modulation of the blood pressure in unilaterally 6-OHDA-lesioned rats.

scientific article published on 28 September 2016

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors ⬇️

scientific article published on 12 May 2020

Effect of selected drugs on zinc accumulation in teeth of laboratory animals

scientific article published on 05 February 2018

Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives

scientific article published on 06 March 2014

Evaluation of antidepressant-like and anxiolytic-like activity of purinedione-derivatives with affinity for adenosine A2A receptors in mice

scientific article

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

scientific article published on 27 April 2016

In vivo anti-inflammatory activity of lipoic acid derivatives in mice.

scientific article published on 24 April 2013

KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice

scientific article published on 18 June 2020

Methylprednisolone- acute spinal cord injury, benefits or risks?

scientific article published on 26 June 2013

Muscle relaxants--the current position in the treatment of spasticity in orthopedics.

scientific article published on September 2015

Nicotine affects hydrogen sulfide concentrations in mouse kidney and heart but not in brain and liver tissues.

scientific article published in January 2017

Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

scientific article published on 10 September 2018

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

scientific article published on 02 February 2019

Pharmacotherapy of Parkinson's disease: progress or regress?

scientific article

Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesity

scientific article published on 16 February 2016

Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

scientific article published on 13 March 2015

Structure-cardiovascular activity relationships in a group of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3-aminopropyl)-3,7-dihydro-1H-purine-2,6-diones

scientific article published on 01 March 2011

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

scientific article published on 6 August 2015

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α/α-Adrenergic Receptor Antagonist with Potential Uroselective Profile

scientific article published on 29 August 2018

Synthesis and cardiovascular activity of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3- piperazinopropyl)-3,7-dihydro-1H-purine-2,6-diones

scientific article published on 01 November 2004

Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.

scientific article published in December 2004

Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity.

scientific article published in March 2002

Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

scientific article published in June 2003

Synthesis, structure-activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives

scientific article

THE EFFECT OF SEROTONIN 5-HT1A, 5-HT2 RECEPTOR LIGANDS, KETOPROFEN AND THEIR COMBINATION IN MODELS OF INDUCED PAIN IN MICE

The effect of NaCl on the level of reduced sulfur compounds in rat liver. Implications for blood pressure increase.

scientific article

The influence of the route of administration of gold nanoparticles on their tissue distribution and basic biochemical parameters: In vivo studies

scientific article published on 08 November 2014

Tissue distribution of gold nanoparticles after single intravenous administration in mice.

scientific article published in January 2013

List of works by Małgorzata Zygmunt

(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands

7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity

8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation

A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS.

Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts

Analgesic activity of new 8-methoxy-1,3-dimethyl-2,6-dioxo-purin-7-yl derivatives with carboxylic, ester or amide moieties

Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones

Anti-Alzheimer's multitarget-directed ligands with serotonin 5-HT6 antagonist, butyrylcholinesterase inhibitory, and antioxidant activity

Anti-inflammatory activity of lipoic acid in mice peritonitis model

Anti-inflammatory, antioxidant, and antiparkinsonian effects of adenosine A2A receptor antagonists.

Antiarrhythmic activity in occlusion-reperfusion model of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino} propan-2-ol and its enantiomers.

Antiarrhythmic and α-Adrenoceptor Antagonistic Properties of Novel Arylpiperazine Derivatives of Pyrrolidin-2-one.

Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α₁-adrenoceptor affinities

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system.

Antiparkinsonian Effects of Novel Adenosine A2A Receptor Antagonists

Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity.

Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

Contribution of the nitric oxide donor molsidomine and the antiparkinsonian drug l-DOPA to the modulation of the blood pressure in unilaterally 6-OHDA-lesioned rats.

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors ⬇️

Effect of selected drugs on zinc accumulation in teeth of laboratory animals

Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives

Evaluation of antidepressant-like and anxiolytic-like activity of purinedione-derivatives with affinity for adenosine A2A receptors in mice

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

In vivo anti-inflammatory activity of lipoic acid derivatives in mice.

KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice

Methylprednisolone- acute spinal cord injury, benefits or risks?

Muscle relaxants--the current position in the treatment of spasticity in orthopedics.

Nicotine affects hydrogen sulfide concentrations in mouse kidney and heart but not in brain and liver tissues.

Novel amide derivatives of 1,3-dimethyl-2,6-dioxopurin-7-yl-alkylcarboxylic acids as multifunctional TRPA1 antagonists and PDE4/7 inhibitors: A new approach for the treatment of pain

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

Pharmacotherapy of Parkinson's disease: progress or regress?

Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesity

Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

Structure-cardiovascular activity relationships in a group of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3-aminopropyl)-3,7-dihydro-1H-purine-2,6-diones

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α/α-Adrenergic Receptor Antagonist with Potential Uroselective Profile

Synthesis and cardiovascular activity of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3- piperazinopropyl)-3,7-dihydro-1H-purine-2,6-diones

Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.

Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity.

Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

Synthesis, structure-activity relationship of some new anti-arrhythmic 5-arylidene imidazolidine-2,4-dione derivatives

THE EFFECT OF SEROTONIN 5-HT1A, 5-HT2 RECEPTOR LIGANDS, KETOPROFEN AND THEIR COMBINATION IN MODELS OF INDUCED PAIN IN MICE

The effect of NaCl on the level of reduced sulfur compounds in rat liver. Implications for blood pressure increase.

The influence of the route of administration of gold nanoparticles on their tissue distribution and basic biochemical parameters: In vivo studies

Tissue distribution of gold nanoparticles after single intravenous administration in mice.