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List of works by Robert Paine

"Modeling Residential Indoor Concentrations of PM2.5 , NO2 , NOx , and secondhand smoke in the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) Air Study"

scientific article published on 09 October 2020

A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography

scientific article published on 01 September 2019

Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.

scientific article published on 26 August 2016

Age-Related Differences in Health-Related Quality of Life in COPD: An Analysis of the COPDGene and SPIROMICS Cohorts

scientific article published on 17 December 2015

Airway Mucin Concentration as a Marker of Chronic Bronchitis

scientific article published on September 2017

Alignment of Inhaled Chronic Obstructive Pulmonary Disease Therapies with Published Strategies. Analysis of the Global Initiative for Chronic Obstructive Lung Disease Recommendations in SPIROMICS

scientific article published on 01 February 2019

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

scientific article

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

article

Aspirin Use and Respiratory Morbidity in COPD: A Propensity Score-Matched Analysis in Subpopulations and Intermediate Outcome Measures in COPD Study

scientific article published on 26 December 2018

Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults

scientific article published on 01 June 2020

Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers

scientific article published on 09 December 2019

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

scientific article published on 13 February 2020

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

scientific article

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.

scientific article

Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function

scientific article published on May 2016

Consequences of Hypoxia for the Pulmonary Alveolar Epithelial Cell Innate Immune Response

scientific article published on 31 October 2018

Contrasting effects of hyperoxia on GM-CSF gene transcription in alveolar epithelial cells and T cells

scientific article published on March 2015

Critical roles of inflammation and apoptosis in improved survival in a model of hyperoxia-induced acute lung injury in Pneumocystis murina-infected mice

scientific article published on 05 January 2009

Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects

scientific article published on 18 November 2020

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

scientific article

Disparate mechanisms of sICAM-1 production in the peripheral lung: contrast between alveolar epithelial cells and pulmonary microvascular endothelial cells

scientific article

Effect of alveolar epithelial cell plasticity on the regulation of GM-CSF expression ⬇️

scientific article published on January 6, 2012

Effect of naturally occurring ozone air pollution episodes on pulmonary oxidative stress and inflammation

scientific article published on 12 May 2015

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.

scientific article published on 15 November 2018

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

scientific article

GM-CSF and the impaired pulmonary innate immune response following hyperoxic stress

scientific article

GM-CSF provides autocrine protection for murine alveolar epithelial cells from oxidant-induced mitochondrial injury

scientific article

Genome-wide association study of lung function and clinical implication in heavy smokers

Heterogeneous burden of lung disease in smokers with borderline airflow obstruction

scientific article published on 20 November 2018

High-mobility group box-1 increases epithelial sodium channel activity and inflammation via the receptor for advanced glycation end products

scientific article published on 08 January 2020

Hyperoxia mediates acute lung injury and increased lethality in murine Legionella pneumonia: the role of apoptosis

scientific article published on 01 April 2003

ICAM-1 facilitates alveolar macrophage phagocytic activity through effects on migration over the AEC surface

scientific article published in July 2002

Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS)

scientific article published on 15 July 2019

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS

scientific article published on 29 June 2020

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.

scientific article published on 12 April 2018

Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis ⬇️

scientific article published on October 1, 2010

Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome

scientific article

Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers

scientific article published on 12 November 2020

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort

scientific article published on 05 June 2018

Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort

scientific article published on 04 August 2020

Occupational Exposures Influence CT Imaging Characteristics in the SPIROMICS Cohort

scientific article published on 01 December 2018

Overexpression of sICAM-1 in the alveolar epithelial space results in an exaggerated inflammatory response and early death in Gram negative pneumonia

scientific article published on 19 January 2011

Plasma Cathelicidin is Independently Associated with Reduced Lung Function in COPD: Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort

scientific article published on 01 October 2020

Pneumocystis pneumonia increases the susceptibility of mice to sublethal hyperoxia.

scientific article

Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS

scientific article published on 31 October 2019

Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort

scientific article published on May 2017

Respiratory effects of particulate air pollution episodes in former smokers with and without chronic obstructive pulmonary disease: a panel study

scholarly article published 19 August 2015

Reversible Airflow Obstruction Predicts Future Chronic Obstructive Pulmonary Disease Development in the SPIROMICS Cohort: An Observational Cohort Study

scientific article published in 2022

Rural Residence and COPD Exacerbations: Analysis of the SPIROMICS Cohort

scientific article published on 27 March 2018

SARS-CoV-2 Innate Effector Associations and Viral Load in Early Nasopharyngeal Infection

scientific article published on 04 November 2020

SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection

scientific article published on 01 February 2021

Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy

scientific article published on 01 April 2019

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study

scientific article published on 06 August 2019

Short-Term Air Pollution and Incident Pneumonia: A Case-Crossover Study

scientific article published on 28 December 2017

Sublethal hyperoxia impairs pulmonary innate immunity

scientific article

Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS

scientific article published on 23 January 2019

The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

scientific article published on 01 March 2020

Variability in objective and subjective measures affects baseline values in studies of patients with COPD.

scientific article published on 21 September 2017

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