List of works - Yajun Guo

A chimeric SM5-1 antibody inhibits hepatocellular carcinoma cell growth and induces caspase-dependent apoptosis

scientific article published on 23 October 2007

A functional motif QLYxxYP is essential for osteopontin induced T lymphocyte activation and migration

scientific article published on 29 January 2009

A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo

scientific article

A humanized anti-osteopontin antibody protects from Concanavalin A induced-liver injury in mice ⬇️

scientific article published on February 25, 2011

A novel functional motif of osteopontin for human lymphocyte migration and survival

scientific article published on 15 July 2008

Acid-induced aggregation propensity of nivolumab is dependent on the Fc.

scientific article published on 16 June 2016

Antibody-targeted immunoliposomes for cancer treatment

scientific article published on December 2013

Blockade of LIGHT/HVEM and B7/CD28 signaling facilitates long-term islet graft survival with development of allospecific tolerance

article

Cancer immunotherapy using in vitro genetically modified targeted dendritic cells

scientific article

Characterization of a humanized anti-CD20 antibody with potent antitumor activity against B-cell lymphoma

scientific article published on 6 January 2010

Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma

scientific article published on 14 October 2009

Characterization of alanine to valine sequence variants in the Fc region of nivolumab biosimilar produced in Chinese hamster ovary cells

scientific article published on 6 April 2016

Chemotherapy for gastric cancer by finely tailoring anti-Her2 anchored dual targeting immunomicelles ⬇️

scientific article published on April 28, 2012

Combating non-Hodgkin lymphoma by targeting both CD20 and HLA-DR through CD20-243 CrossMab

scientific article

Comparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular View

scientific article

Comparison of the inhibition mechanisms of Adalimumab and Infliximab in treating tumor necrosis factor α-associated diseases from a molecular view.

scientific article

Construction and characterization of a bispecific anti-CD20 antibody with potent antitumor activity against B-cell lymphoma

scientific article published on 14 July 2010

Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody

scientific article published on 17 April 2007

Construction and characterization of a humanized anti-human CD3 monoclonal antibody 12F6 with effective immunoregulation functions

scientific article published on 01 December 2005

Development and characterization of a fully functional small anti-HER2 antibody

scientific article published on October 2009

Development and characterization of a novel anti-IgE monoclonal antibody

scientific article

Development of SM5-1-conjugated ultrasmall superparamagnetic iron oxide nanoparticles for hepatoma detection

scientific article

Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity

scientific article published on 9 January 2008

Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity

scientific article

Enantiomeric separation of vilanterol trifenatate by chiral liquid chromatography

scientific article published on 08 August 2019

Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU.

scientific article

Eradication of non-Hodgkin lymphoma through the induction of tumor-specific T-cell immunity by CD20-Flex BiFP.

scientific article published on 31 October 2013

Expression, purification, and characterization of an immunotoxin containing a humanized anti-CD25 single-chain fragment variable antibody fused to a modified truncated Pseudomonas exotoxin A.

scientific article published on 19 September 2007

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

scientific article

Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab

scientific article

Functional and stable expression of recombinant human FOXP3 in bacterial cells and development of antigen-specific monoclonal antibodies

scientific article published on 30 August 2007

Generation and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency

scientific article

Genetically targeted T cells eradicate established breast cancer in syngeneic mice

scientific article

Humanization of an anti-CD34 monoclonal antibody by complementarity-determining region grafting based on computer-assisted molecular modelling

scientific article

Identification of a Novel Functional Domain of Ricin Responsible for Its Potent Toxicity ⬇️

scientific article published on February 8, 2011

In-Depth Characterization of a Pro-Antibody-Drug Conjugate by LC-MS.

scientific article published on 5 July 2016

Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA.

scientific article published on 20 September 2013

Lyophilized HER2-specific PEGylated immunoliposomes for active siRNA gene silencing

scientific article

Novel Dual-Control Poly( N -Isopropylacrylamide- Co -Chlorophyllin) Nanogels for Improving Drug Release ⬇️

scientific article published on March 1, 2012

PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumor progression with reduced toxicity and immunogenicity

scientific article

Phase 1 study of anti-epidermal growth factor receptor monoclonal antibody in patients with solid tumors

scientific article

Phase I trial of a humanized, Fc receptor nonbinding anti-CD3 antibody, hu12F6mu in patients receiving renal allografts

scientific article

Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

scholarly article by Qing An et al published 2019 in Drug Design, Development and Therapy

Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma

scientific article published on 31 May 2013

Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy

scientific article published on 13 January 2016

Preparation and Characterization of Paclitaxel-loaded PLGA nanoparticles coated with cationic SM5-1 single-chain antibody

scientific article

Preparation and characterization of recombinant protein ScFv(CD11c)-TRP2 for tumor therapy from inclusion bodies in Escherichia coli

scientific article

Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein

scientific article

Targeted delivery of tumor antigens to activated dendritic cells via CD11c molecules induces potent antitumor immunity in mice

scientific article

The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors ⬇️

scientific article published on March 5, 2011

The finely regulating well-defined functional polymeric nanocarriers for anti-tumor immunotherapy

scientific article published on April 2013

The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes ⬇️

scientific article published on May 1, 2011

The protein-protein interface evolution acts in a similar way to antibody affinity maturation.

scientific article

Therapeutic efficacy of an anti-PD-L1 antibody based immunocytokine in a metastatic mouse model of colorectal cancer

scientific article

Tolerability, pharmacokinetics and pharmacodynamics of CMAB007, a humanized anti-immunoglobulin E monoclonal antibody, in healthy Chinese subjects ⬇️

scientific article published on January 1, 2012

Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells

scientific article

Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome

scientific article published on 13 April 2007

Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab') fragments

scientific article published on 01 October 2008

Treatment of hepatocellular carcinoma with adenoviral vector-mediated Flt3 ligand gene therapy

scientific article

Two doses of humanized anti-CD25 antibody in renal transplantation: a preliminary comparative study

scientific article published on January 2009

List of works by Yajun Guo

A chimeric SM5-1 antibody inhibits hepatocellular carcinoma cell growth and induces caspase-dependent apoptosis

A functional motif QLYxxYP is essential for osteopontin induced T lymphocyte activation and migration

A humanized anti-osteopontin antibody inhibits breast cancer growth and metastasis in vivo

A humanized anti-osteopontin antibody protects from Concanavalin A induced-liver injury in mice ⬇️

A novel functional motif of osteopontin for human lymphocyte migration and survival

Acid-induced aggregation propensity of nivolumab is dependent on the Fc.

Antibody-targeted immunoliposomes for cancer treatment

Blockade of LIGHT/HVEM and B7/CD28 signaling facilitates long-term islet graft survival with development of allospecific tolerance

Cancer immunotherapy using in vitro genetically modified targeted dendritic cells

Characterization of a humanized anti-CD20 antibody with potent antitumor activity against B-cell lymphoma

Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma

Characterization of alanine to valine sequence variants in the Fc region of nivolumab biosimilar produced in Chinese hamster ovary cells

Chemotherapy for gastric cancer by finely tailoring anti-Her2 anchored dual targeting immunomicelles ⬇️

Combating non-Hodgkin lymphoma by targeting both CD20 and HLA-DR through CD20-243 CrossMab

Comparison of the Inhibition Mechanisms of Adalimumab and Infliximab in Treating Tumor Necrosis Factor α-Associated Diseases from a Molecular View

Comparison of the inhibition mechanisms of Adalimumab and Infliximab in treating tumor necrosis factor α-associated diseases from a molecular view.

Construction and characterization of a bispecific anti-CD20 antibody with potent antitumor activity against B-cell lymphoma

Construction and characterization of a high-affinity humanized SM5-1 monoclonal antibody

Construction and characterization of a humanized anti-human CD3 monoclonal antibody 12F6 with effective immunoregulation functions

Development and characterization of a fully functional small anti-HER2 antibody

Development and characterization of a novel anti-IgE monoclonal antibody

Development of SM5-1-conjugated ultrasmall superparamagnetic iron oxide nanoparticles for hepatoma detection

Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity

Development of novel tetravalent anti-CD20 antibodies with potent antitumor activity

Enantiomeric separation of vilanterol trifenatate by chiral liquid chromatography

Eradication of hepatoma and colon cancer in mice with Flt3L gene therapy in combination with 5-FU.

Eradication of non-Hodgkin lymphoma through the induction of tumor-specific T-cell immunity by CD20-Flex BiFP.

Expression, purification, and characterization of an immunotoxin containing a humanized anti-CD25 single-chain fragment variable antibody fused to a modified truncated Pseudomonas exotoxin A.

Feedback activation of STAT3 mediates trastuzumab resistance via upregulation of MUC1 and MUC4 expression

Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab

Functional and stable expression of recombinant human FOXP3 in bacterial cells and development of antigen-specific monoclonal antibodies

Generation and characterization of a target-selectively activated antibody against epidermal growth factor receptor with enhanced anti-tumor potency

Genetically targeted T cells eradicate established breast cancer in syngeneic mice

Humanization of an anti-CD34 monoclonal antibody by complementarity-determining region grafting based on computer-assisted molecular modelling

Identification of a Novel Functional Domain of Ricin Responsible for Its Potent Toxicity ⬇️

In-Depth Characterization of a Pro-Antibody-Drug Conjugate by LC-MS.

Inhibition of hepatocellular carcinoma growth using immunoliposomes for co-delivery of adriamycin and ribonucleotide reductase M2 siRNA.

Lyophilized HER2-specific PEGylated immunoliposomes for active siRNA gene silencing

Novel Dual-Control Poly( N -Isopropylacrylamide- Co -Chlorophyllin) Nanogels for Improving Drug Release ⬇️

PE38KDEL-loaded anti-HER2 nanoparticles inhibit breast tumor progression with reduced toxicity and immunogenicity

Phase 1 study of anti-epidermal growth factor receptor monoclonal antibody in patients with solid tumors

Phase I trial of a humanized, Fc receptor nonbinding anti-CD3 antibody, hu12F6mu in patients receiving renal allografts

Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

Polymer-lipid hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma

Preclinical studies of a Pro-antibody-drug conjugate designed to selectively target EGFR-overexpressing tumors with improved therapeutic efficacy

Preparation and Characterization of Paclitaxel-loaded PLGA nanoparticles coated with cationic SM5-1 single-chain antibody

Preparation and characterization of recombinant protein ScFv(CD11c)-TRP2 for tumor therapy from inclusion bodies in Escherichia coli

Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein

Targeted delivery of tumor antigens to activated dendritic cells via CD11c molecules induces potent antitumor immunity in mice

The fine-tuning of thermosensitive and degradable polymer micelles for enhancing intracellular uptake and drug release in tumors ⬇️

The finely regulating well-defined functional polymeric nanocarriers for anti-tumor immunotherapy

The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes ⬇️

The protein-protein interface evolution acts in a similar way to antibody affinity maturation.

Therapeutic efficacy of an anti-PD-L1 antibody based immunocytokine in a metastatic mouse model of colorectal cancer

Tolerability, pharmacokinetics and pharmacodynamics of CMAB007, a humanized anti-immunoglobulin E monoclonal antibody, in healthy Chinese subjects ⬇️

Treatment of collagen-induced arthritis with an anti-osteopontin monoclonal antibody through promotion of apoptosis of both murine and human activated T cells

Treatment of hepatocellular carcinoma in a mouse xenograft model with an immunotoxin which is engineered to eliminate vascular leak syndrome

Treatment of hepatocellular carcinoma in mice with PE38KDEL type I mutant-loaded poly(lactic-co-glycolic acid) nanoparticles conjugated with humanized SM5-1 F(ab') fragments

Treatment of hepatocellular carcinoma with adenoviral vector-mediated Flt3 ligand gene therapy

Two doses of humanized anti-CD25 antibody in renal transplantation: a preliminary comparative study