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List of works by Thota Ganesh

5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease

scientific article published on 01 January 2019

A Novel Second-Generation EP2 Receptor Antagonist Reduces Neuroinflammation and Gliosis After Status Epilepticus in Rats

scientific article published on 06 January 2021

A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition

scientific article published on 25 February 2019

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

scientific article

An Agonist Dependent Allosteric Antagonist of Prostaglandin EP2 Receptors

scientific article published on 23 April 2020

Asymmetric synthesis of the putative structure of (-)-oryzoxymycin

scientific article published on 01 February 2003

Azaindole therapeutic agents

scientific article published on 30 October 2020

Cancer and virus leads by HTS, chemical design and SEA data mining

scientific article published in January 2009

ChemInform Abstract: Novel Epothilone Lactones by an Unusual Diversion of the Grubbs′ Metathesis Reaction

Context-dependent GluN2B-selective inhibitors of NMDA receptor function are neuroprotective with minimal side effects

scientific article

Cyclooxygenase-2 in epilepsy.

scientific article

Design, synthesis and biological evaluation of bridged epothilone D analogues

scientific article

Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation

scientific article published on 24 January 2006

Development of second generation EP2 antagonists with high selectivity

scientific article

Discovery and characterization of carbamothioylacrylamides as EP2 selective antagonists.

scientific article published on July 2013

Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2.

scientific article published on 2 January 2018

Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling ⬇️

scientific article published on 27 May 2008

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells

scientific article published on 21 August 2015

EP2 Receptor Signaling Regulates Microglia Death.

scientific article published on 25 February 2015

Ebselen and Congeners Inhibit NADPH Oxidase 2-Dependent Superoxide Generation by Interrupting the Binding of Regulatory Subunits ⬇️

scientific article published on June 22, 2012

Enhanced microtubule binding and tubulin assembly properties of conformationally constrained paclitaxel derivatives

scientific article published on 25 September 2007

Ethylatropine Bromide as a Peripherally Restricted Muscarinic Antagonist.

scientific article

Evaluation of WO 2012/177618 A1 and US-2014/0179750 A1: novel small molecule antagonists of prostaglandin-E2 receptor EP2.

scientific article published on 15 March 2015

Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues

scientific article published on 31 January 2007

High-throughput assays for superoxide and hydrogen peroxide: design of a screening workflow to identify inhibitors of NADPH oxidases.

scientific article

Improved biochemical strategies for targeted delivery of taxoids

scientific article published on 18 March 2007

Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats

scientific article published on 28 July 2016

Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus

scientific article

Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

scientific article published on 11 February 2013

Lead optimization studies of cinnamic amide EP2 antagonists

scientific article

Modulating neuroinflammation and oxidative stress to prevent epilepsy and improve outcomes after traumatic brain injury

scientific article published on 06 December 2019

Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.

scientific article

Novel Microglia Cell Line Expressing the Human EP2 Receptor

scientific article published on 11 September 2019

Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction.

scientific article published on 9 February 2010

Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status epilepticus

scientific article published on 08 December 2020

Peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with anti-inflammatory properties

scientific article published on 15 November 2018

Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist for Use in Central Nervous System Disease Models

scientific article published on 16 January 2020

Promotion of tubulin assembly by poorly soluble taxol analogs

scientific article published on 30 October 2006

Prostaglandin dehydrogenase is a target for successful induction of cervical ripening

scientific article

Prostanoid receptor EP2 as a therapeutic target

scientific article

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

scientific article

Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

scientific article published on 14 August 2008

Synthesis and biological evaluation of fluorescently labeled epothilone analogs for tubulin binding studies

Synthesis of isotopically labeled epothilones

scientific article published on 05 December 2013

The COX-2/prostanoid signaling cascades in seizure disorders

scientific article published on 02 December 2018

The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.

scholarly article

Therapeutic window for cyclooxygenase-2 related anti-inflammatory therapy after status epilepticus

scientific article published on 17 January 2015

Thioxo-dihydroquinazolin-one Compounds as Novel Inhibitors of Myeloperoxidase

scientific article published on 31 August 2015

Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

scientific article

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