List of works by Özlem Türeci

A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity

scientific article published on 12 September 2019

A key regulatory role of the transcription factor NFATc2 in bronchial adenocarcinoma via CD8+ T lymphocytes.

scientific article published on 24 March 2009

A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice

scientific article published on 22 June 2020

A multicentre, phase IIa study of zolbetuximab as a single agent in patients with recurrent or refractory advanced adenocarcinoma of the stomach or lower oesophagus: the MONO study

scientific article published on 01 September 2019

A non-functional neoepitope specific CD8+ T-cell response induced by tumor derived antigen exposure in vivo

scientific article published on 24 December 2018

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

scientific article published on 01 January 2021

A novel tumour associated leucine zipper protein targeting to sites of gene transcription and splicing

scientific article

A phase I dose-escalation study of IMAB362 (Zolbetuximab) in patients with advanced gastric and gastro-oesophageal junction cancer

scientific article published on 21 June 2018

A placenta-specific gene ectopically activated in many human cancers is essentially involved in malignant cell processes

scientific article

A randomized study to evaluate safety and immunogenicity of the BNT162b2 COVID-19 vaccine in healthy Japanese adults

scientific article published on 14 December 2021

A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer

scientific article published on 20 December 2011

A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening

scientific article

Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer

article published in 2014

An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors

scientific article published on 02 January 2020

An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma

scientific article published on 29 July 2020

Antigen identification using SEREX.

scientific article

Antitumor vaccination with synthetic mRNA: strategies for in vitro and in vivo preclinical studies.

scientific article published on January 2013

Autoimmunity seen through the SEREX-scope.

scientific article published on October 2003

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T-cell responses

scientific article published on 30 September 2020

CXorf61 is a target for T cell based immunotherapy of triple-negative breast cancer

scientific article

Cascades of transcriptional induction during dendritic cell maturation revealed by genome-wide expression analysis

scientific article published on May 2003

Challenges towards the realization of individualized cancer vaccines

scientific article published on 01 August 2018

Characterization of human colon cancer antigens recognized by autologous antibodies

scientific article

Characterization of human colon cancer antigens recognized by autologous antibodies

Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6

scientific article published on 29 October 2015

Chromatin Immunoprecipitation Assay to Identify Genomic Binding Sites of Regulatory Factors

scientific article published in January 2016

Claudin 18.2 is a target for IMAB362 antibody in pancreatic neoplasms

scientific article

Claudin-18 gene structure, regulation, and expression is evolutionary conserved in mammals

scientific article published on 4 May 2011

Claudin-18 splice variant 2 is a pan-cancer target suitable for therapeutic antibody development

scientific article

Comparison of Claudin 18.2 expression in primary tumors and lymph node metastases in Japanese patients with gastric adenocarcinoma

scientific article published on 01 September 2019

Computational dissection of tissue contamination for identification of colon cancer-specific expression profiles

scientific article published on 01 March 2003

Confidence-based somatic mutation evaluation and prioritization

scientific article

CrELISA: a fast and robust enzyme-linked immunosorbent assay bypassing the need for purification of recombinant protein.

scientific article

Definition of tumor-associated antigens in hepatocellular carcinoma.

scientific article

Determinants of intracellular RNA pharmacokinetics: Implications for RNA-based immunotherapeutics

article

Dexamethasone premedication suppresses vaccine-induced immune responses against cancer

scientific article published on 13 May 2020

Discovery and Subtyping of Neo-Epitope Specific T-Cell Responses for Cancer Immunotherapy: Addressing the Mutanome.

scientific article published in January 2017

ERBB2-mediated transcriptional up-regulation of the alpha5beta1 integrin fibronectin receptor promotes tumor cell survival under adverse conditions.

scientific article published on April 2006

Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion.

scientific article published on 17 September 2015

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

scientific article published on 12 June 2017

Enhanced production of CCL18 by tolerogenic dendritic cells is associated with inhibition of allergic airway reactivity

scientific article

Enhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide.

scientific article published on 13 April 2018

Erratum: Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

scientific article published in October 2017

Erratum: Mutant MHC class II epitopes drive therapeutic immune responses to cancer

scientific article published in Nature

Exploitation of the antibody repertoire of cancer patients for the identification of human tumor antigens

scientific article

Exploiting the mutanome for tumor vaccination.

scientific article published on 11 January 2012

Expression of SSX genes in human tumors

scientific article published in July 1998

Expression of a novel transmembrane carbonic anhydrase isozyme XII in normal human gut and colorectal tumors

scientific article

Expression of cancer testis genes in human brain tumors.

scientific article published in October 2000

Expression of multiple cancer/testis (CT) antigens in breast cancer and melanoma: Basis for polyvalent CT vaccine strategies

scientific article published on 01 October 1998

Expression of multiple epigenetically regulated cancer/germline genes in nonsmall cell lung cancer

scientific article

Expression of serologically identified tumor antigens in acute leukemias.

scientific article

Expression of the membrane-associated carbonic anhydrase isozyme XII in the human kidney and renal tumors

scientific article (publication date: December 2000)

Expression profiling of autoimmune regulator AIRE mRNA in a comprehensive set of human normal and neoplastic tissues

scientific article published on 28 July 2006

FLT3 Ligand as a Molecular Adjuvant for Naked RNA Vaccines.

scientific article

FLT3 ligand enhances the cancer therapeutic potency of naked RNA vaccines.

scientific article

Frequent nonrandom activation of germ-line genes in human cancer.

scientific article published in September 2004

Functional TCR retrieval from single antigen-specific human T cells reveals multiple novel epitopes.

scientific article published on 22 September 2014

Genomic response of the rat brain to global ischemia and reperfusion.

scientific article published on 31 October 2008

HLA typing from RNA-Seq sequence reads

scientific article

HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory

scientific article published on 11 July 2019

Harnessing Tumor Mutations for Truly Individualized Cancer Vaccines

scientific article published on 01 January 2019

Highly specific auto-antibodies against claudin-18 isoform 2 induced by a chimeric HBcAg virus-like particle vaccine kill tumor cells and inhibit the growth of lung metastases.

scientific article published on 11 January 2011

Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells

scientific article

Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers

scientific article

Human neoplasms elicit multiple specific immune responses in the autologous host

scientific article

Humoral immune responses of lung cancer patients against the Transmembrane Phosphatase with TEnsin homology (TPTE).

scientific article published on 30 July 2015

Humoral immune responses of lung cancer patients against tumor antigen NY-ESO-1

article

Identification of a meiosis-specific protein as a member of the class of cancer/testis antigens

scientific article

Identification of carbonic anhydrase XII as the membrane isozyme expressed in the normal human endometrial epithelium

scientific article (publication date: 2000)

Identification of new claudin family members by a novel PSI-BLAST based approach with enhanced specificity.

scientific article

Identification of tumor-associated autoantigens with SEREX.

scientific article

Immunomic, genomic and transcriptomic characterization of CT26 colorectal carcinoma

scientific article

Improvement of in vivo expression of genes delivered by self-amplifying RNA using Vaccinia Virus immune evasion proteins

scientific article published on 6 September 2017

Improving mRNA-Based Therapeutic Gene Delivery by Expression-Augmenting 3' UTRs Identified by Cellular Library Screening

scientific article published on 18 December 2018

In silico strategy for detection of target candidates for antibody therapy of solid tumors.

scientific article

Increased Antigen Presentation Efficiency by Coupling Antigens to MHC Class I Trafficking Signals

scientific article published on 01 January 2008

Intranodal vaccination with naked antigen-encoding RNA elicits potent prophylactic and therapeutic antitumoral immunity.

scientific article published on 2 November 2010

Intravenous delivery of the toll-like receptor 7 agonist SC1 confers tumor control by inducing a CD8+ T cell response

scientific article published on 19 April 2019

Luciferase mRNA Transfection of Antigen Presenting Cells Permits Sensitive Nonradioactive Measurement of Cellular and Humoral Cytotoxicity.

scientific article published on 05 January 2016

MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes

scientific article

Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells.

scientific article

Molecular characterization of virus-induced autoantibody responses.

scientific article

Molecular definition of a novel human galectin which is immunogenic in patients with Hodgkin's disease

scientific article

Multiple splice variants of lactate dehydrogenase C selectively expressed in human cancer.

scientific article published in November 2002

Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

scientific article

Mutanome directed cancer immunotherapy

scientific article published on 21 December 2015

Mutant MHC class II epitopes drive therapeutic immune responses to cancer

scientific article published on 22 April 2015

Mutated tumor alleles are expressed according to their DNA frequency

scientific article published on 22 April 2014

NCOA3 is a selective co-activator of estrogen receptor α-mediated transactivation of PLAC1 in MCF-7 breast cancer cells

scientific article

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera

scientific article published on 19 January 2021

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera

scientific article

PLAC1 is essential for FGF7/FGFRIIIb-induced Akt-mediated cancer cell proliferation

scientific article published on 19 May 2020

Peptide microarrays enable rapid mimotope optimization for pharmacokinetic analysis of the novel therapeutic antibody IMAB362.

scientific article published on 7 March 2014

Personalized Neo-Epitope Vaccines for Cancer Treatment

scientific article published on 01 January 2020

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

scientific article published on 5 July 2017

Personalized vaccines for cancer immunotherapy.

scientific article published in March 2018

Phase 1/2 study of COVID-19 RNA vaccine BNT162b1 in adults

scientific article published on 12 August 2020

Phenotyping of peripheral blood mononuclear cells of patients with advanced heavily pre-treated adenocarcinoma of the stomach and gastro-esophageal junction

scientific article published on 28 August 2014

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

scientific article published on 22 April 2010

RNA-Based COVID-19 Vaccine BNT162b2 Selected for a Pivotal Efficacy Study

scientific article published on 20 August 2020

Rapid molecular dissection of viral and bacterial immunomes

scientific article published on April 2006

Retrieval of functional TCRs from single antigen-specific T cells: Toward individualized TCR-engineered therapies

scientific article published on 19 March 2015

SSX: a multigene family with several members transcribed in normal testis and human cancer

scientific article

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine ⬇️

scientific article published on 10 December 2020

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

scientific article published on 14 October 2020

Safety, Immunogenicity, and Efficacy of the BNT162b2 Covid-19 Vaccine in Adolescents

scientific article

Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2.

scientific article published on 03 August 2009

Selective activation of tumor growth-promoting Ca2+ channel MS4A12 in colon cancer by caudal type homeobox transcription factor CDX2.

scientific article published on 25 September 2009

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

scientific article published on 3 March 2011

SeroGRID: an improved method for the rapid selection of antigens with disease related immunogenicity.

scientific article

Serological analysis of human tumor antigens: molecular definition and implications

scientific article published on August 1997

Serological identification of human tumor antigens

scientific article published on October 1997

Simultaneous ex vivo quantification of antigen-specific CD4+ and CD8+ T cell responses using in vitro transcribed RNA

article

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

scientific article (publication date: June 2016)

T-cell receptor transfer into human T cells with ecotropic retroviral vectors.

scientific article published on 3 April 2014

Targeting the Heterogeneity of Cancer with Individualized Neoepitope Vaccines.

scientific article published on April 2016

Targeting the tumor mutanome for personalized vaccination therapy

scientific article published on August 2012

Targeting the tumor vasculature with engineered cystine-knot miniproteins

scientific article published on 15 January 2020

The European Regulatory Environment of RNA-Based Vaccines

scientific article published on January 2017

The Human Vaccines Project: A roadmap for cancer vaccine development

scientific article published on April 2016

The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40

scientific article

The human X chromosome is enriched for germline genes expressed in premeiotic germ cells of both sexes.

scientific article

Translation of genomics-guided RNA-based personalised cancer vaccines: towards the bedside

scientific article

Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK

scientific article published on 15 March 2013

Tumor vaccination using messenger RNA: prospects of a future therapy

scientific article published on 13 April 2011

Tumor-associated CpG demethylation augments hypoxia-induced effects by positive autoregulation of HIF-1α.

scientific article published on November 2010

Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice.

scientific article published on 15 July 2016

mRNA as a versatile tool for exogenous protein expression

scientific article published on October 2012

mRNA-based therapeutics--developing a new class of drugs

scientific article

mTOR inhibition improves antitumor effects of vaccination with antigen-encoding RNA.

scientific article published on 20 September 2013

rapmad: Robust analysis of peptide microarray data.

scientific article

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