List of works - Christopher J Ormandy

A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse

scientific article

Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

scientific article

Coexpression and Cross-Regulation of the Prolactin Receptor and Sex Steroid Hormone Receptors in Breast Cancer1 ⬇️

scientific article published on November 1, 1997

Coordinate regulation of oestrogen and prolactin receptor expression by sodium butyrate in human breast cancer cells ⬇️

scientific article published on January 31, 1992

Cyclin D1, EMS1 and 11q13 amplification in breast cancer

scientific article

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells

scientific article (publication date: December 2015)

ELF5 isoform expression is tissue-specific and significantly altered in cancer.

scientific article

ELF5 modulates the estrogen receptor cistrome in breast cancer

scientific article published on 02 January 2020

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

scientific article

Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion

scientific article published on August 2004

Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

scientific article

Elf5, hormones and cell fate

scientific article published on 30 March 2012

Gata-3 and mammary cell fate

scientific article

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

scientific article published on 23 October 2015

Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

scientific article

Human Growth Hormone Binds to Lactogenic Receptors in Bovine, Ovine and Rat Adrenals ⬇️

scientific article published on 01 May 1988

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

scientific article

Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer

scientific article

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

scientific article

Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants.

scientific article published on 15 October 2009

Interplay between progesterone and prolactin in mammary development and implications for breast cancer.

scientific article published on 16 September 2011

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

scientific article published on 22 December 2015

Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice

scientific article

KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling

scientific article

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility

scientific journal article

Lineage specific methylation of the Elf5 promoter in mammary epithelial cells.

scientific article

Long and short forms of the ovine prolactin receptor: cDNA cloning and genomic analysis reveal that the two forms arise by different alternative splicing mechanisms in ruminants and in rodents ⬇️

scientific article published on October 1, 1997

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

scientific article published on 08 December 2016

Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the "basal" breast cancer subgroup

scientific article

Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

scientific article published on 23 November 2017

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

scientific article published on 15 September 2021

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

scientific article

PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development

scientific article

Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.

scientific article

Prolactin and the prolactin receptor: new targets of an old hormone

scientific article

Prolactin regulation of mammary gland development.

scientific article published on 25 January 2008

Prolactin: A Hormone at the Crossroads of Neuroimmunoendocrinology ⬇️

scientific article published on May 1, 1998

Prostate development and carcinogenesis in prolactin receptor knockout mice

scientific journal article

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

scientific article

RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility

scientific article

Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice

scientific article published on January 2004

Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer

scientific article

Socs2 and elf5 mediate prolactin-induced mammary gland development

scientific journal article

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

scientific article

The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium

scientific article

The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.

scientific article

The mammary cellular hierarchy and breast cancer.

scientific article

The neuropeptide galanin augments lobuloalveolar development

scientific article

The role of prolactin and growth hormone in mammary gland development

scientific article

Transcriptional changes underlying the secretory activation phase of mammary gland development.

scientific article

Transcriptional regulation of prolactin receptor gene expression by sodium butyrate in MCF-7 human breast cancer cells ⬇️

scientific article published on 01 August 1992

Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice.

scientific article published on 29 April 2008

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

scientific article published in April 2017

Y4 receptor knockout rescues fertility in ob/ob mice.

scientific article published on May 2002

c-Myc overexpression and endocrine resistance in breast cancer

scientific article published on 18 October 2006

List of works by Christopher J Ormandy

A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse

Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease

Coexpression and Cross-Regulation of the Prolactin Receptor and Sex Steroid Hormone Receptors in Breast Cancer1 ⬇️

Coordinate regulation of oestrogen and prolactin receptor expression by sodium butyrate in human breast cancer cells ⬇️

Cyclin D1, EMS1 and 11q13 amplification in breast cancer

ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells

ELF5 isoform expression is tissue-specific and significantly altered in cancer.

ELF5 modulates the estrogen receptor cistrome in breast cancer

ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.

Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion

Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation

Elf5, hormones and cell fate

Gata-3 and mammary cell fate

HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse.

Hedgehog overexpression is associated with stromal interactions and predicts for poor outcome in breast cancer.

Human Growth Hormone Binds to Lactogenic Receptors in Bovine, Ovine and Rat Adrenals ⬇️

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer

Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice

Insulin, a key regulator of hormone responsive milk protein synthesis during lactogenesis in murine mammary explants.

Interplay between progesterone and prolactin in mammary development and implications for breast cancer.

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

Investigation of the transcriptional changes underlying functional defects in the mammary glands of prolactin receptor knockout mice

KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling

LRGUK-1 is required for basal body and manchette function during spermatogenesis and male fertility

Lineage specific methylation of the Elf5 promoter in mammary epithelial cells.

Long and short forms of the ovine prolactin receptor: cDNA cloning and genomic analysis reveal that the two forms arise by different alternative splicing mechanisms in ruminants and in rodents ⬇️

MCL-1 inhibition provides a new way to suppress breast cancer metastasis and increase sensitivity to dasatinib

Meta-analysis and gene set enrichment relative to er status reveal elevated activity of MYC and E2F in the "basal" breast cancer subgroup

Myeloid cell leukemia 1 (MCL-1), an unexpected modulator of protein kinase signaling during invasion.

NSG-Pro mouse model for uncovering resistance mechanisms and unique vulnerabilities in human luminal breast cancers

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development

Profiling the tyrosine phosphoproteome of different mouse mammary tumour models reveals distinct, model-specific signalling networks and conserved oncogenic pathways.

Prolactin and the prolactin receptor: new targets of an old hormone

Prolactin regulation of mammary gland development.

Prolactin: A Hormone at the Crossroads of Neuroimmunoendocrinology ⬇️

Prostate development and carcinogenesis in prolactin receptor knockout mice

RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly

RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility

Role of the CDK inhibitor p27 (Kip1) in mammary development and carcinogenesis: insights from knockout mice

Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer

Socs2 and elf5 mediate prolactin-induced mammary gland development

The Ets transcription factor Elf5 specifies mammary alveolar cell fate

The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium

The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.

The mammary cellular hierarchy and breast cancer.

The neuropeptide galanin augments lobuloalveolar development

The role of prolactin and growth hormone in mammary gland development

Transcriptional changes underlying the secretory activation phase of mammary gland development.

Transcriptional regulation of prolactin receptor gene expression by sodium butyrate in MCF-7 human breast cancer cells ⬇️

Transcriptome analysis identifies pathways associated with enhanced maternal performance in QSi5 mice.

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

Y4 receptor knockout rescues fertility in ob/ob mice.

c-Myc overexpression and endocrine resistance in breast cancer