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List of works by Costanza Emanueli

Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.

scientific article published on June 1998

Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia

scientific article published in August 2000

Adenovirus-mediated human tissue kallikrein gene delivery induces angiogenesis in normoperfused skeletal muscle

scientific article

Adenovirus-mediated human tissue kallikrein gene delivery inhibits neointima formation induced by interruption of blood flow in mice

scientific article published in June 2000

Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer

scientific article published on 13 September 2004

Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice

scientific article

Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth

scientific article

Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia

scientific article

BDNF (Brain-Derived Neurotrophic Factor) Promotes Embryonic Stem Cells Differentiation to Endothelial Cells Via a Molecular Pathway, Including MicroRNA-214, EZH2 (Enhancer of Zeste Homolog 2), and eNOS (Endothelial Nitric Oxide Synthase)

scientific article published on 01 September 2018

Blood pressure responses to acute or chronic captopril in mice with disruption of bradykinin B2-receptor gene

scientific article published in December 1997

Cardiac Nerve Growth Factor Overexpression Induces Bone Marrow-derived Progenitor Cells Mobilization and Homing to the Infarcted Heart

scientific article

Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice

scientific article published on 24 March 2003

Cardiovascular effects of nociceptin in unanesthetized mice

scientific article published on 01 March 1999

Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene

scientific article published in November 1997

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129

scientific article published on 29 March 2019

Circulating MicroRNAs as new biomarkers of ischaemia/reperfusion injury during cardiac surgery.

scientific article

Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair

scientific article published on 23 March 2015

Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization.

scientific article

Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia

scientific article

Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo

scientific article

Diabetes cardiovascular complications

scientific article published on 01 June 2012

Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA-Rho-associated kinase signaling pathway

scientific article published on 10 January 2013

Diabetes mellitus induces bone marrow microangiopathy

scientific article

Diabetes-induced epigenetic signature in vascular cells

scientific article published on June 2012

Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice

scientific article published in December 1999

EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia

scientific article published on 5 September 2014

Endogenous Nitric Oxide Inhibits Bronchoconstriction Induced by Cold-Air Inhalation in Guinea Pigs ⬇️

scientific article published on February 1, 1998

Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene

scientific article published in June 1998

Epigenetic Profile of Human Adventitial Progenitor Cells Correlates With Therapeutic Outcomes in a Mouse Model of Limb Ischemia

scientific article published on 08 January 2015

Expansion and characterization of neonatal cardiac pericytes provides a novel cellular option for tissue engineering in congenital heart disease.

scientific article

Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2.

scientific article published on 22 January 2015

Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway

scientific article published on 18 December 2012

Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling

scientific article

Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential

scientific article

Human tissue kallikrein: a new bullet for the treatment of ischemia

scientific article

In search of the best candidate for regeneration of ischemic tissues: are embryonic/fetal stem cells more advantageous than adult counterparts?

scientific article published on 01 October 2005

Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia

scientific article

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

scientific journal article

Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice

scientific article

Levels of human tissue kallikrein in the vitreous fluid of patients with severe proliferative diabetic retinopathy.

scientific article published in July 2004

Local delivery of human tissue kallikrein gene accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia

scientific article published in January 2001

Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction

scientific article published on 18 June 2013

Methodological Guidelines to Study Extracellular Vesicles

scientific article

MicroRNA regulation in angiogenesis ⬇️

scientific article published on July 14, 2011

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

scientific article published on 11 December 2012

MicroRNAs in Postischemic Vascular Repair

scientific article published on 15 March 2012

MicroRNAs in vascular biology, an introduction to the Vascular Pharmacology Special Issue on microRNAs ⬇️

scientific article published on October 26, 2011

Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs

scientific article published in October 2002

Nerve growth factor promotes cardiac repair following myocardial infarction

scientific article

Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles

scientific article published on 19 June 2008

Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia.

scientific article

Optimisation of laboratory methods for whole transcriptomic RNA analyses in human left ventricular biopsies and blood samples of clinical relevance

scientific article published on 14 March 2019

Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A.

scientific article

Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions

scientific article published on 25 October 2007

Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation) ⬇️

scientific article published on October 20, 2010

Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer

scientific article published in August 2002

Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia

scientific article

Ramipril improves hemodynamic recovery but not microvascular response to ischemia in spontaneously hypertensive rats.

scientific article published in May 2002

Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

scientific article

Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium

scientific article

Regulation of Vascular Endothelium Inflammatory Signalling by Shear Stress.

scientific article published in January 2016

Regulation of bradykinin B2‐receptor expression by oestrogen ⬇️

scientific article published on August 1, 1997

Regulatory RNAs in Heart Failure

scientific article published on 27 January 2020

Renin-angiotensin and kallikrein-kinin systems coordinately modulate angiogenesis

scientific article published on 01 June 2002

Renovascular hypertension in bradykinin B2-receptor knockout mice

scientific article published on 01 September 1998

Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer.

scientific article

Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects

scientific article published on 5 March 2012

Role of calcitonin gene-related peptide and kinins in post-ischemic intestinal reperfusion

scientific article

Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential

scientific article

Role of nitric oxide synthase inhibition in the acute hypertensive response to intracerebroventricular cadmium ⬇️

scientific article published on January 1, 1998

Role of the bradykinin B2 receptor in the maturation of blood pressure phenotype: lesson from transgenic and knockout mice

scientific article

Role of the kallikrein-kinin system in the maturation of cardiovascular phenotype

scientific article

S100A1: A novel and essential molecular component for postischemic angiogenesis

scientific article

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia

scientific article published on 11 October 2012

Studies of the cardiovascular effects of nociceptin and related peptides

scientific article

Targeting kinin receptors for the treatment of tissue ischaemia

scientific article

The biology of neurotrophins: cardiovascular function

scientific article published on January 2014

The control of microvascular permeability and blood pressure by neutral endopeptidase ⬇️

scientific article published on August 1, 1997

Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells.

scientific article published on 16 December 2010

Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction.

scientific article published on 22 January 2018

Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132

scientific article published on 25 August 2011

Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia

scientific article

Vascular differentiation from embryonic stem cells: Novel technologies and therapeutic promises ⬇️

scientific article published on 02 April 2012

miRNAs in post-ischaemic angiogenesis and vascular remodelling

scientific article

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