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List of works by Costanza Emanueli

Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.

scientific article published on June 1998

Adenovirus-mediated VEGF(121) gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia

scientific article published in August 2000

Adenovirus-mediated human tissue kallikrein gene delivery induces angiogenesis in normoperfused skeletal muscle

scientific article

Adenovirus-mediated human tissue kallikrein gene delivery inhibits neointima formation induced by interruption of blood flow in mice

scientific article published in June 2000

Akt/protein kinase B and endothelial nitric oxide synthase mediate muscular neovascularization induced by tissue kallikrein gene transfer

scientific article published on 13 September 2004

Altered baroreflex control of heart rate in bradykinin B2-receptor knockout mice

scientific article

Angiotensin AT(1) receptor signalling modulates reparative angiogenesis induced by limb ischaemia

scientific article

Antiangiogenesis mediates cisplatin-induced peripheral neuropathy: attenuation or reversal by local vascular endothelial growth factor gene therapy without augmenting tumor growth

scientific article

Apricot melanoidins prevent oxidative endothelial cell death by counteracting mitochondrial oxidation and membrane depolarization

scientific article

Arteriogenic therapy based on simultaneous delivery of VEGF-A and FGF4 genes improves the recovery from acute limb ischemia

scientific article

BDNF (Brain-Derived Neurotrophic Factor) Promotes Embryonic Stem Cells Differentiation to Endothelial Cells Via a Molecular Pathway, Including MicroRNA-214, EZH2 (Enhancer of Zeste Homolog 2), and eNOS (Endothelial Nitric Oxide Synthase)

scientific article published on 01 September 2018

Benfotiamine improves functional recovery of the infarcted heart via activation of pro-survival G6PD/Akt signaling pathway and modulation of neurohormonal response

scientific article published on 8 June 2010

Blood flow and stem cells in vascular disease

scientific article published on March 20, 2013

Blood pressure responses to acute or chronic captopril in mice with disruption of bradykinin B2-receptor gene

scientific article published in December 1997

Bridging Basic Science with Cardiac Surgery: The Bristol Heart Institute Experience

scientific article (publication date: 2015)

Cardiac Nerve Growth Factor Overexpression Induces Bone Marrow-derived Progenitor Cells Mobilization and Homing to the Infarcted Heart

scientific article

Cardiac hypertrophy and microvascular deficit in kinin B2 receptor knockout mice

scientific article published on 24 March 2003

Cardiovascular actions of neurotrophins

scientific article

Cardiovascular effects of nociceptin in unanesthetized mice

scientific article published on 01 March 1999

Cardiovascular phenotype of a mouse strain with disruption of bradykinin B2-receptor gene

scientific article published in November 1997

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129

scientific article published on 29 March 2019

Changing the logic of therapeutic angiogenesis for ischemic disease

scientific article

Circulating MicroRNAs as new biomarkers of ischaemia/reperfusion injury during cardiac surgery.

scientific article

Combined Intramyocardial Delivery of Human Pericytes and Cardiac Stem Cells Additively Improves the Healing of Mouse Infarcted Hearts Through Stimulation of Vascular and Muscular Repair

scientific article published on 23 March 2015

Copper Transport Protein Antioxidant-1 Promotes Inflammatory Neovascularization via Chaperone and Transcription Factor Function

scientific article

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery

scientific article

Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization.

scientific article

Data supporting the activation of autophagy genes in the diabetic heart

scientific article

Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia

scientific article

Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo

scientific article

Diabetes and vessel wall remodelling: from mechanistic insights to regenerative therapies.

scientific article

Diabetes cardiovascular complications

scientific article published on 01 June 2012

Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA-Rho-associated kinase signaling pathway

scientific article published on 10 January 2013

Diabetes mellitus induces bone marrow microangiopathy

scientific article

Diabetes-induced epigenetic signature in vascular cells

scientific article published on June 2012

Diagnostic tools for the study of vascular cognitive dysfunction in hypertension and antihypertensive drug research.

scientific article

Dilated and failing cardiomyopathy in bradykinin B(2) receptor knockout mice

scientific article published in December 1999

EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia

scientific article published on 5 September 2014

Endogenous Nitric Oxide Inhibits Bronchoconstriction Induced by Cold-Air Inhalation in Guinea Pigs

scientific article published on February 1, 1998

Enhanced blood pressure sensitivity to deoxycorticosterone in mice with disruption of bradykinin B2 receptor gene

scientific article published in June 1998

Epigenetic Profile of Human Adventitial Progenitor Cells Correlates With Therapeutic Outcomes in a Mouse Model of Limb Ischemia

scientific article published on 08 January 2015

Expansion and characterization of neonatal cardiac pericytes provides a novel cellular option for tissue engineering in congenital heart disease.

scientific article

Genetic deletion of the p66Shc adaptor protein protects from angiotensin II-induced myocardial damage

scientific article

Genetically engineered stem cell therapy for tissue regeneration

scientific article published on May 2004

Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2.

scientific article published on 22 January 2015

Global remodeling of the vascular stem cell niche in bone marrow of diabetic patients: implication of the microRNA-155/FOXO3a signaling pathway

scientific article published on 18 December 2012

Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling

scientific article

Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis.

scientific article

Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential

scientific article

Human fetal aorta contains vascular progenitor cells capable of inducing vasculogenesis, angiogenesis, and myogenesis in vitro and in a murine model of peripheral ischemia

scientific article published in June 2007

Human tissue kallikrein: a new bullet for the treatment of ischemia

scientific article

In search of the best candidate for regeneration of ischemic tissues: are embryonic/fetal stem cells more advantageous than adult counterparts?

scientific article published on 01 October 2005

Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia

scientific article

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

scientific journal article

Involvement of phosphoinositide 3-kinase gamma in angiogenesis and healing of experimental myocardial infarction in mice

scientific article

Levels of human tissue kallikrein in the vitreous fluid of patients with severe proliferative diabetic retinopathy.

scientific article published in July 2004

Local delivery of human tissue kallikrein gene accelerates spontaneous angiogenesis in mouse model of hindlimb ischemia

scientific article published in January 2001

Local inhibition of microRNA-24 improves reparative angiogenesis and left ventricle remodeling and function in mice with myocardial infarction

scientific article published on 18 June 2013

Methodological Guidelines to Study Extracellular Vesicles

scientific article

MicroRNA regulation in angiogenesis

scientific article published on July 14, 2011

MicroRNA transport in cardiovascular complication of diabetes

scientific article

MicroRNA-15a and microRNA-16 impair human circulating proangiogenic cell functions and are increased in the proangiogenic cells and serum of patients with critical limb ischemia

scientific article published on 11 December 2012

MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles

scientific article published on 03 March 2020

MicroRNA-503 and the extended microRNA-16 family in angiogenesis

scientific article

MicroRNAs as clinical biomarkers?

scientific article published on 14 July 2015

MicroRNAs in Postischemic Vascular Repair

scientific article published on 15 March 2012

MicroRNAs in congenital heart disease

scientific article

MicroRNAs in vascular biology, an introduction to the Vascular Pharmacology Special Issue on microRNAs

scientific article published on October 26, 2011

MicroRNAs in vascular tissue engineering and post-ischemic neovascularization

scientific article published on 14 May 2015

Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction

scientific article published on 11 April 2015

NEUROTROPHIN-3 (NT-3) PROMOTES REPARATIVE NEOVASCULARIZATION AND BLOOD FLOW RECOVERY IN A MOUSE MODEL OF LIMB ISCHEMIA

Nerve growth factor gene therapy using adeno-associated viral vectors prevents cardiomyopathy in type 1 diabetic mice

scientific article published on January 2012

Nerve growth factor promotes angiogenesis and arteriogenesis in ischemic hindlimbs

scientific article published in October 2002

Nerve growth factor promotes cardiac repair following myocardial infarction

scientific article

Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles

scientific article published on 19 June 2008

Neurotrophin-3 is a novel angiogenic factor capable of therapeutic neovascularization in a mouse model of limb ischemia.

scientific article

Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia

scientific article (publication date: November 2004)

Non coding RNAs in aortic aneurysmal disease

scientific article

Optimisation of laboratory methods for whole transcriptomic RNA analyses in human left ventricular biopsies and blood samples of clinical relevance

scientific article published on 14 March 2019

Oxidative stress-dependent activation of collagen synthesis is induced in human pulmonary smooth muscle cells by sera from patients with scleroderma-associated pulmonary hypertension.

scientific article

Paracrine control of vascularization and neurogenesis by neurotrophins

scientific article

Perivascular delivery of encapsulated mesenchymal stem cells improves postischemic angiogenesis via paracrine activation of VEGF-A.

scientific article

Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions

scientific article published on 25 October 2007

Pluripotent stem cell differentiation into vascular cells: A novel technology with promises for vascular re(generation)

scientific article published on October 20, 2010

Possible novel targets for therapeutic angiogenesis

scientific article published on 13 December 2008

Pre-emptive hypoxia-regulated HO-1 gene therapy improves post-ischaemic limb perfusion and tissue regeneration in mice

scientific article

Prevention of diabetes-induced microangiopathy by human tissue kallikrein gene transfer

scientific article published in August 2002

Protease-activated receptor-2 stimulates angiogenesis and accelerates hemodynamic recovery in a mouse model of hindlimb ischemia

scientific article

Ramipril improves hemodynamic recovery but not microvascular response to ischemia in spontaneously hypertensive rats.

scientific article published in May 2002

Rapid onset of cardiomyopathy in STZ-induced female diabetic mice involves the downregulation of pro-survival Pim-1

scientific article

Regional and global protective effects of tissue kallikrein gene delivery to the peri-infarct myocardium

scientific article

Regulation of Vascular Endothelium Inflammatory Signalling by Shear Stress.

scientific article published in January 2016

Regulation of bradykinin B2‐receptor expression by oestrogen

scientific article published on August 1, 1997

Regulatory RNAs in Heart Failure

scientific article published on 27 January 2020

Renin-angiotensin and kallikrein-kinin systems coordinately modulate angiogenesis

scientific article published on 01 June 2002

Renovascular hypertension in bradykinin B2-receptor knockout mice

scientific article published on 01 September 1998

Rescue of impaired angiogenesis in spontaneously hypertensive rats by intramuscular human tissue kallikrein gene transfer.

scientific article

Reversal of Angiogenic Growth Factor Upregulation by Revascularization of Lower Limb Ischemia

scientific article published on 01 January 2002

Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects

scientific article published on 5 March 2012

Role of calcitonin gene-related peptide and kinins in post-ischemic intestinal reperfusion

scientific article

Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential

scientific article

Role of microRNAs in diabetes and its cardiovascular complications.

scientific article

Role of nitric oxide synthase inhibition in the acute hypertensive response to intracerebroventricular cadmium

scientific article published on January 1, 1998

Role of the bradykinin B2 receptor in the maturation of blood pressure phenotype: lesson from transgenic and knockout mice

scientific article

Role of the kallikrein-kinin system in the maturation of cardiovascular phenotype

scientific article

S100A1: A novel and essential molecular component for postischemic angiogenesis

scientific article

Sensory neuropathy hampers nociception-mediated bone marrow stem cell release in mice and patients with diabetes.

scientific article published on 10 September 2015

Soluble ST2 is regulated by p75 neurotrophin receptor and predicts mortality in diabetic patients with critical limb ischemia

scientific article published on 11 October 2012

Studies of the cardiovascular effects of nociceptin and related peptides

scientific article

Switching on reparative angiogenesis: essential role of the vascular erythropoietin receptor

scientific article

Targeting kinin receptors for the treatment of tissue ischaemia

scientific article

The LINC00961 transcript and its encoded micropeptide SPAAR regulate endothelial cell function

scientific article published on 28 January 2020

The biology of neurotrophins: cardiovascular function

scientific article published on January 2014

The control of microvascular permeability and blood pressure by neutral endopeptidase

scientific article published on August 1, 1997

Therapeutic angiogenesis: translating experimental concepts to medically relevant goals

scientific article published on 23 August 2006

Tissue kallikrein is essential for invasive capacity of circulating proangiogenic cells.

scientific article published on 16 December 2010

Transplantation of Allogeneic Pericytes Improves Myocardial Vascularization and Reduces Interstitial Fibrosis in a Swine Model of Reperfused Acute Myocardial Infarction.

scientific article published on 22 January 2018

Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132

scientific article published on 25 August 2011

Type-2 diabetic Lepr(db/db) mice show a defective microvascular phenotype under basal conditions and an impaired response to angiogenesis gene therapy in the setting of limb ischemia

scientific article

Vascular differentiation from embryonic stem cells: Novel technologies and therapeutic promises

scientific article published on 02 April 2012

Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway

scientific article

You can teach an old dog new tricks: angiopoietin‐1 instructs Tie2 pos myeloid cells to promote neovascularization in ischemic limbs

scientific article published on June 1, 2013

miR-15a/-16 Inhibit Angiogenesis by Targeting the Tie2 Coding Sequence: Therapeutic Potential of a miR-15a/16 Decoy System in Limb Ischemia.

scientific article published on 17 May 2019

miRNAs in post-ischaemic angiogenesis and vascular remodelling

scientific article

p75(NTR)-dependent activation of NF-κB regulates microRNA-503 transcription and pericyte-endothelial crosstalk in diabetes after limb ischaemia

scientific journal article