Search filters

List of works by Roderick H Dashwood

3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells

scientific article published in 2012

3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells

scientific article

A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.

scientific article published on 13 March 2017

A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis ⬇️

scientific article published on September 24, 2012

Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract.

scientific article

Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition

scientific article published on 14 January 2019

Allyl mercaptan, a garlic-derived organosulfur compound, inhibits histone deacetylase and enhances Sp3 binding on the P21WAF1 promoter

scientific article published on 14 July 2008

Alpha-keto acid metabolites of organoselenium compounds inhibit histone deacetylase activity in human colon cancer cells

scientific article published on 15 June 2009

Amelioration of Ischemia–Reperfusion Injury in an Isolated Rabbit Lung Model Using OXANOH ⬇️

scientific article published on 01 October 2011

Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.

scientific article

Antimutagenic activity of spearmint

scientific article published in January 2004

Antimutagenic activity of tea towards 2-hydroxyamino-3-methylimidazo[4,5-f]quinoline: effect of tea concentration and brew time on electrophile scavenging ⬇️

scientific article published on June 18, 1998

Antioxidant and antigenotoxic activities of Angelica keiskei, Oenanthe javanica and Brassica oleracea in the Salmonella mutagenicity assay and in HCT116 human colon cancer cells

scientific article

Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure.

scientific article

A–Z of Epigenetic Readers: Targeting Alternative Splicing and Histone Modification Variants in Cancer

scientific article published in 2024

CCAR1 and CCAR2 as gene chameleons with antagonistic duality: Preclinical, human translational, and mechanistic basis

scientific article published on 09 August 2020

Cancer chemoprevention by dietary chlorophylls: a 12,000-animal dose-dose matrix biomarker and tumor study

scientific article

Cancer chemoprevention from the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ⬇️

scientific article published on August 31, 1998

Capsaicin represses transcriptional activity of β-catenin in human colorectal cancer cells ⬇️

scientific article published on July 20, 2011

Caspase-8 and apoptosis-inducing factor mediate a cytochrome c-independent pathway of apoptosis in human colon cancer cells induced by the dietary phytochemical chlorophyllin

scientific article published on 01 March 2003

Chemoprevention of dibenzo[a,l]pyrene transplacental carcinogenesis in mice born to mothers administered green tea: primary role of caffeine

scientific article published on 16 July 2008

Chemopreventive properties of chlorophylls towards aflatoxin B1: a review of the antimutagenicity and anticarcinogenicity data in rainbow trout ⬇️

scientific article published on March 20, 1998

Chemoprotection by sulforaphane: keep one eye beyond Keap1.

scientific article

Chlorophylls as anticarcinogens (review) ⬇️

scientific article published on April 1, 1997

Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters

scientific article

Comparison of white tea, green tea, epigallocatechin-3-gallate, and caffeine as inhibitors of PhIP-induced colonic aberrant crypts

scientific article published in January 2007

Development of a murine colonoscopic polypectomy model (with videos).

scientific article published on 30 November 2015

Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.

scientific article

Dietary Factors and Epigenetic Regulation for Prostate Cancer Prevention ⬇️

scientific article published on November 3, 2011

Dietary HDAC inhibitors: time to rethink weak ligands in cancer chemoprevention?

scientific article

Dietary Manipulation of Histone Structure and Function ⬇️

scientific article published on January 1, 2010

Dietary agents as histone deacetylase inhibitors

scientific article

Dietary agents as histone deacetylase inhibitors: sulforaphane and structurally related isothiocyanates

scientific article published on August 2008

Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells ⬇️

scientific article published on October 26, 2011

Dietary spinach reshapes the gut microbiome in an Apc-mutant genetic background: mechanistic insights from integrated multi-omics

scientific article published on 01 January 2021

Dietary sulforaphane, a histone deacetylase inhibitor for cancer prevention

scientific article

Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cells

scientific article published on 4 March 2011

Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane

scientific article (publication date: July 2013)

Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors

scientific article published on 20 February 2017

E2F4 and ribonucleotide reductase mediate S-phase arrest in colon cancer cells treated with chlorophyllin

scientific article

Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers

scientific article published on December 2009

Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells

scientific article published on 22 January 2014

Effects of tea and chlorophyllin on the mutagenicity ofN-hydroxy-IQ: Studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites ⬇️

scientific article published on January 1, 1997

Emerging crosstalk between long non-coding RNAs and Nrf2 signaling

scientific article published on 24 July 2020

Endothelins and their receptors in cancer: identification of therapeutic targets

scientific article published on 18 January 2011

Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention

scientific article published on April 2015

Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer

scientific article

HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates

scientific article published on 26 April 2013

HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells

scientific article published on 06 December 2015

Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs

scientific article published on 19 July 2018

Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors

scientific article published on 25 August 2015

Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly ⬇️

scientific article published on May 30, 2011

Identifying efficacious approaches to chemoprevention with chlorophyllin, purified chlorophylls and freeze-dried spinach in a mouse model of transplacental carcinogenesis

scientific article

Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin

scientific article published on October 2015

In utero exposure of mice to dibenzo[a,l]pyrene produces lymphoma in the offspring: role of the aryl hydrocarbon receptor

scientific article published in January 2006

Indole-3-carbinol: Anticarcinogen or tumor promoter in brassica vegetables? ⬇️

scientific article published on March 12, 1998

Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f] quinoline-induced tumorigenesis in the male F344 rat ⬇️

scientific article published on August 16, 1995

Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon ⬇️

scientific article published on November 1, 1997

Inhibition of beta-catenin/Tcf activity by white tea, green tea, and epigallocatechin-3-gallate (EGCG): minor contribution of H(2)O(2) at physiologically relevant EGCG concentrations

scientific article published on August 2002

Inhibitory Activity of Green and Black Tea in a Free Radical‐generating System Using 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline as Substrate ⬇️

scientific article published on June 1, 1997

Introduction to Nutrition and Physical Activity in Aging, Obesity, and Cancer ⬇️

scientific article published on 01 July 2011

Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout

scientific article published on 4 November 2007

Lysosomal trafficking of beta-catenin induced by the tea polyphenol epigallocatechin-3-gallate

scientific article published on 27 July 2005

Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice

scientific article

Metabolism as a key to histone deacetylase inhibition

scientific article published on 5 April 2011

MicroRNA profiling of carcinogen‐induced rat colon tumors and the influence of dietary spinach ⬇️

scientific article published on May 29, 2012

MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals

scientific article

Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds

scientific article published on April 2009

Molecular dosimetry in fish: quantitative target organ DNA adduction and hepatocarcinogenicity for four aflatoxins by two exposure routes in rainbow trout ⬇️

scientific article published on March 20, 1998

Multi-targeted prevention of cancer by sulforaphane

scientific article

Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun

scientific article published on April 2003

NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

scientific article published on 8 October 2010

Natural chlorophyll inhibits aflatoxin B1-induced multi-organ carcinogenesis in the rat

scientific article published on 08 February 2007

Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood

scientific article published on 30 December 2019

Nutritional Regulation of Epigenetic Changes ⬇️

scientific article published on September 1, 2012

Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam

scientific article published on 5 October 2016

Optimization of erlotinib plus sulindac dosing regimens for intestinal cancer prevention in an Apc-mutant model of Familial Adenomatous Polyposis

scientific article published on 04 December 2020

Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32.

scientific article published in June 2004

Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention

scientific article published on 26 June 2013

Promoter de-methylation of cyclin D2 by sulforaphane in prostate cancer cells ⬇️

scientific article published on October 26, 2011

Promotion versus suppression of rat colon carcinogenesis by chlorophyllin and chlorophyll: modulation of apoptosis, cell proliferation, and beta-catenin/Tcf signaling

scientific article published in February 2003

Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.

scientific article published on 17 February 2008

Reliable tumor detection by whole-genome methylation sequencing of cell-free DNA in cerebrospinal fluid of pediatric medulloblastoma

scientific article published on 16 October 2020

Response of Apc(min) and A33 (delta N beta-cat) mutant mice to treatment with tea, sulindac, and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

scientific article published on September 2002

Sequencing of the rat beta-catenin gene (Ctnnb1) and mutational analysis of liver tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline

scientific article published in January 2002

Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells

scientific article published on 9 November 2005

Sulforaphane inhibits histone deacetylase in vivo and suppresses tumorigenesis in Apc-minus mice

scientific article

Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.

scientific article

Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac

scientific article published on February 2003

Targeting Epigenetic 'Readers' with Natural Compounds for Cancer Interception

scientific article published on 01 December 2020

Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance

scientific article published on 04 August 2010

Tea catechins inhibit hepatocyte growth factor receptor (MET kinase) activity in human colon cancer cells: kinetic and molecular docking studies

scientific article published on November 2009

The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells

scientific article published in December 2004

The epigenome as a potential mediator of cancer and disease prevention in prenatal development

scientific article published on 15 May 2013

The importance of using pure chemicals in (anti)mutagenicity studies: chlorophyllin as a case in point ⬇️

scientific article published on November 28, 1997

The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.

scientific article

Tumor-suppressing effects of antioxidants from tea.

scientific article published in November 2004

Tumors from rats given 1,2-dimethylhydrazine plus chlorophyllin or indole-3-carbinol contain transcriptional changes in beta-catenin that are independent of beta-catenin mutation status

scientific article published on 24 July 2006

Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts.

scientific article published on 28 January 2018

beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet

scientific article published on 04 July 2008

p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance

scientific article published on 02 November 2018

Paulina is supported by:

About Paulina

Help