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List of works by Sofia Giorgetti

A FTIR microspectroscopy study of the structural and biochemical perturbations induced by natively folded and aggregated transthyretin in HL-1 cardiomyocytes

scientific article published in Scientific Reports

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

scientific article

A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo.

scientific article

Amyloid persistence in decellularized liver: biochemical and histopathological characterization.

scientific article published on 8 December 2015

Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic  2-microglobulin variant

scientific article

Benefit of doxycycline treatment on articular disability caused by dialysis related amyloidosis.

scientific article published on 4 June 2013

Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes

scientific article published on November 2016

C. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis

scientific article published on 27 December 2019

Citrate-stabilized gold nanoparticles hinder fibrillogenesis of a pathological variant of β2-microglobulin.

scientific article published on 7 March 2017

Class I Major Histocompatibility Complex, the Trojan Horse for Secretion of Amyloidogenic β 2 -Microglobulin

scientific article

Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis

scientific article published in Journal of Biological Chemistry

Conformational switching and fibrillogenesis in the amyloidogenic fragment of apolipoprotein a-I.

scientific article published on 5 November 2002

Effect of tetracyclines on the dynamics of formation and destructuration of beta2-microglobulin amyloid fibrils

scientific article

Effects of the Known Pathogenic Mutations on the Aggregation Pathway of the Amyloidogenic Peptide of Apolipoprotein A-I

article

Equilibrium unfolding thermodynamics of beta2-microglobulin analyzed through native-state H/D exchange

scientific article

Folding and fibrillogenesis: clues from beta2-microglobulin.

scientific article published on 15 June 2010

Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel.

scientific article

Interference of citrate-stabilized gold nanoparticles with β2-microglobulin oligomeric association

scientific article published on 01 May 2018

Lysine 58-cleaved beta2-microglobulin is not detectable by 2D electrophoresis in ex vivo amyloid fibrils of two patients affected by dialysis-related amyloidosis.

scientific article

Misidentification of transthyretin and immunoglobulin variants by proteomics due to methyl lysine formation in formalin-fixed paraffin-embedded amyloid tissue

scientific article

Molecular insights into cell toxicity of a novel familial amyloidogenic variant of β2-microglobulin

scientific article published on 18 March 2016

Monitoring the interaction between β2-microglobulin and the molecular chaperone αB-crystallin by NMR and mass spectrometry: αB-crystallin dissociates β2-microglobulin oligomers.

scientific article published on 03 May 2013

Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein beta2-microglobulin revealed by real-time two-dimensional NMR.

scientific article published on 22 December 2009

Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity.

scientific article published on 20 March 2018

Pharmaceutical strategies against amyloidosis: old and new drugs in targeting a "protein misfolding disease".

scientific article published on April 2004

Plasminogen activation triggers transthyretin amyloidogenesis

scientific article published in Journal of Biological Chemistry

Properties of Some Variants of Human β2-Microglobulin and Amyloidogenesis

scientific article published in Journal of Biological Chemistry

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

scientific article

Proteomics in protein misfolding diseases.

scientific article published in January 2009

Proteomics of beta2-microglobulin amyloid fibrils.

scientific article

Recombinant amyloidogenic domain of ApoA-I: Analysis of its fibrillogenic potential

article

Reduction of conformational mobility and aggregation in W60G β2-microglobulin: assessment by 15N NMR relaxation.

scientific article published on 18 October 2013

Solution structure of beta(2)-microglobulin and insights into fibrillogenesis.

scientific article

Structural and folding dynamic properties of the T70N variant of human lysozyme.

scientific article published on 22 April 2003

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin.

scientific article published on 06 September 2013

The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties

scientific article

The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease

scientific article published on 15 July 2010

Topological investigation of amyloid fibrils obtained from beta2-microglobulin.

scientific article