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List of works by Peter N. Devreotes

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

scientific article

Altering the threshold of an excitable signal transduction network changes cell migratory modes

scientific article published on 27 March 2017

An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells

scientific article published on 31 August 2020

An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration.

scientific article

Analysis of chemotaxis in Dictyostelium.

scientific article published on January 2012

Analyzing Chemotaxis Using Dictyostelium discoideum as a Model System

scientific article published on 01 January 2004

Assays for chemotaxis and chemoattractant-stimulated TorC2 activation and PKB substrate phosphorylation in Dictyostelium

scientific article published in January 2009

Assessment of Development and Chemotaxis in Dictyostelium discoideum Mutants ⬇️

scientific article published on January 1, 2011

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation

scientific article published on 9 November 2017

Automated characterization of cell shape changes during amoeboid motility by skeletonization

scientific article

Biased excitable networks: how cells direct motion in response to gradients.

scientific article

Cell migration directionality and speed are independently regulated by RasG and Gβ in Dictyostelium cells in electrotaxis

scientific article published on 04 July 2019

Cells navigate with a local-excitation, global-inhibition-biased excitable network.

scientific article

Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks

scientific article

Chemoattractant receptors activate, recruit and capture G proteins for wide range chemotaxis

scientific article published on 17 November 2018

Chemoattractant signaling in dictyostelium discoideum.

scientific article

Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton

scholarly article

Coupling traction force patterns and actomyosin wave dynamics reveals mechanics of cell motion

scientific article published on 01 December 2021

Dictyostelium RacH regulates endocytic vesicular trafficking and is required for localization of vacuolin

scientific article published in September 2006

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN.

scientific article

Ege A, a novel C2 domain containing protein, is essential for GPCR-mediated gene expression in dictyostelium

scientific article

Engineering PTEN function: membrane association and activity

scientific article

Engineering ePTEN, an enhanced PTEN with increased tumor suppressor activities

scientific article

Eukaryotic chemotaxis: a network of signaling pathways controls motility, directional sensing, and polarity

scientific article published on January 2010

Eukaryotic chemotaxis: distinctions between directional sensing and polarization

scientific article

Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis

scientific article

Excitable Signal Transduction Networks in Directed Cell Migration.

scientific article published on 9 August 2017

Generation of cells that ignore the effects of PIP3 on cytoskeleton ⬇️

scientific article published on September 1, 2011

Genetic analysis of the role of G protein-coupled receptor signaling in electrotaxis

scientific article published on 3 June 2002

Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration

scientific article

Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions

scientific article published in September 2003

Insight from the maximal activation of the signal transduction excitable network in Dictyostelium discoideum.

scientific article published on 30 March 2018

Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells

scientific article

Leading-edge research: PtdIns(3,4,5)P3 and directed migration

scientific article published in January 2007

Monitoring receptor-mediated activation of heterotrimeric G-proteins by fluorescence resonance energy transfer

scientific article published on 01 August 2002

Moving towards a paradigm: common mechanisms of chemotactic signaling in Dictyostelium and mammalian leukocytes

scientific article

Mutually inhibitory Ras-PI(3,4)P feedback loops mediate cell migration

article published in the Proceedings of the National Academy of Sciences of the United States of America

NKCC1 Regulates Migration Ability of Glioblastoma Cells by Modulation of Actin Dynamics and Interacting with Cofilin

scientific article published on 21 June 2017

Navigating signaling networks: chemotaxis in Dictyostelium discoideum

scientific article published on 19 June 2006

Navigating through models of chemotaxis.

scientific article published on 18 January 2008

Novel mechanism of PTEN regulation by its phosphatidylinositol 4,5-bisphosphate binding motif is critical for chemotaxis

scientific article (publication date: 16 April 2004)

Novel protein Callipygian defines the back of migrating cells

scientific article

Nucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer.

scientific article

Opening the conformation is a master switch for the dual localization and phosphatase activity of PTEN.

scientific article published on 28 July 2015

PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis

scientific article published on July 2008

PLA2 and PI3K/PTEN pathways act in parallel to mediate chemotaxis

scientific article published on April 2007

Phosphoinositide signaling plays a key role in cytokinesis

scientific article published on August 2006

RacG regulates morphology, phagocytosis, and chemotaxis

scientific article published on September 2006

Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis

scientific article

Receptor-mediated regulation of PI3Ks confines PI(3,4,5)P3 to the leading edge of chemotaxing cells

scientific article

Regulation of adenylyl cyclases by a region outside the minimally functional cytoplasmic domains

scientific article published on 2 November 2001

Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity

scientific article published on 28 August 2017

Signaling pathways mediating chemotaxis in the social amoeba, Dictyostelium discoideum

scientific article

Single-molecule analysis of chemoattractant-stimulated membrane recruitment of a PH-domain-containing protein.

scientific article published on 28 February 2006

Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects

scientific article published on 12 February 2020

Temporal and spatial regulation of chemotaxis

scientific article

Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis

scientific article

The GATA transcription factor GtaC regulates early developmental gene expression dynamics in Dictyostelium

scientific article published on 6 July 2015

The directional response of chemotactic cells depends on a balance between cytoskeletal architecture and the external gradient

scientific article

Three-dimensional stochastic simulation of chemoattractant-mediated excitability in cells

scientific article published on 14 July 2021

Traveling and standing waves mediate pattern formation in cellular protrusions

scientific article published on 07 August 2020

Tumor suppressor Hippo/MST1 kinase mediates chemotaxis by regulating spreading and adhesion

scientific article

Tumor suppressor PTEN acts through dynamic interaction with the plasma membrane

scholarly article

Tumor suppressor PTEN mediates sensing of chemoattractant gradients

scientific article published in May 2002

Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells.

scientific article

Two phases of actin polymerization display different dependencies on PI(3,4,5)P3 accumulation and have unique roles during chemotaxis

scientific article published on 31 October 2003

Visualization of G protein betagamma dimers using bimolecular fluorescence complementation demonstrates roles for both beta and gamma in subcellular targeting

scientific article published on 10 May 2004

Visualizing PI3 kinase-mediated cell-cell signaling during Dictyostelium development

scientific article published on 01 July 2002

Wave patterns organize cellular protrusions and control cortical dynamics

scientific article published on 11 March 2019

tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis

scientific article published on August 2008

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