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List of works by Johannes G van der Hoeven

A higher BMI is not associated with a different immune response and disease course in critically ill COVID-19 patients

scientific article published on 25 January 2021

A possible role for the cholinergic anti-inflammatory pathway in increased mortality observed in critically ill patients receiving nicotine replacement therapy

scientific article published in October 2007

Acetazolamide-mediated decrease in strong ion difference accounts for the correction of metabolic alkalosis in critically ill patients

scientific article

Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm

scientific article published in October 2004

Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial

scientific article

Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients.

scientific article

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

scientific article published on 10 December 2020

Appointing nurses trained in organ donation to improve family consent rates

scientific article published on 11 July 2019

Association between incident delirium and 28- and 90-day mortality in critically ill adults: a secondary analysis

scientific article published on 20 April 2020

Automated patient-ventilator interaction analysis during neurally adjusted non-invasive ventilation and pressure support ventilation in chronic obstructive pulmonary disease

scientific article

Biomarkers associated with delirium in critically ill patients and their relation with long-term subjective cognitive dysfunction; indications for different pathways governing delirium in inflamed and noninflamed patients

scientific article

Body mass index is not associated with cytokine induction during experimental human endotoxemia ⬇️

scientific article published on April 19, 2013

Brain resuscitation in the drowning victim

journal article published in 2012

C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia.

scientific article published in November 2010

Capturing early signs of deterioration: the dutch-early-nurse-worry-indicator-score and its value in the Rapid Response System

scientific article published on 16 November 2016

Cardiac troponin elevations among critically ill patients

scientific article published in October 2004

Cell-type-specific downregulation of heme oxygenase-1 by lipopolysaccharide via Bach1 in primary human mononuclear cells

scientific article published on 5 November 2014

Changes in frailty among ICU survivors and associated factors: Results of a one-year prospective cohort study using the Dutch Clinical Frailty Scale

scientific article published on 05 November 2019

Circulating adenosine increases during human experimental endotoxemia but blockade of its receptor does not influence the immune response and subsequent organ injury

scientific article published on 6 January 2011

Circulating angiopoietin-2 levels in the course of septic shock: relation with fluid balance, pulmonary dysfunction and mortality

scientific article published on 24 June 2009

Clinical review: The ABC of weaning failure - a structured approach ⬇️

scientific article published on December 8, 2010

Clinical value of an arterial pressure-based cardiac output measurement device

scientific article

Comparison and clinical suitability of eight prediction models for cardiac surgery-related acute kidney injury.

scientific article published on 4 December 2012

Comparison of cooling methods to induce and maintain normo- and hypothermia in intensive care unit patients: a prospective intervention study

scientific article

Comparison of two percutaneous tracheostomy techniques, guide wire dilating forceps and Ciaglia Blue Rhino: a sequential cohort study

scientific article

Contribution of alarm noise to average sound pressure levels in the ICU: An observational cross-sectional study

scientific article published on 10 July 2020

Contribution of various metabolites to the "unmeasured" anions in critically ill patients with metabolic acidosis

scientific article published in March 2008

Crew Resource Management in the trauma room: a prospective 3-year cohort study

scientific article published on 21 March 2017

Delirium in critically ill patients: impact on long-term health-related quality of life and cognitive functioning

scientific article published in January 2012

Development of Endotoxin Tolerance Does Not Influence the Response to a Challenge with the Mucosal Live-Attenuated Influenza Vaccine in Humans In Vivo

scientific article published on 11 December 2017

Development of endotoxin tolerance in humans in vivo

scientific article published in April 2009

Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers

scientific article published on 16 November 2020

Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia* ⬇️

scientific article published on August 1, 2011

Dipyridamole augments the antiinflammatory response during human endotoxemia ⬇️

scientific article published on November 30, 2011

Duration of antibiotic treatment: are even numbers odd?

scientific article published on 24 June 2005

Dynamic light application therapy to reduce the incidence and duration of delirium in intensive-care patients: a randomised controlled trial

scientific article published on 16 February 2016

Dynamic preload indicators decrease when the abdomen is opened

scientific article

Early and late outcome after single step dilatational tracheostomy versus the guide wire dilating forceps technique: a prospective randomized clinical trial ⬇️

scientific article published on April 12, 2011

Effect of Vasopressors on the Macro- and Microcirculation During Systemic Inflammation in Humans In Vivo

scientific article published on 01 February 2020

Effect of do-not-resuscitate orders on the penumbra of care ⬇️

scientific article published on January 19, 2012

Effect of preadmission sunlight exposure on intensive care unit-acquired delirium: a multicenter study.

scientific article published on 6 November 2013

Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans

scientific article

Effects of Vagus Nerve Stimulation and Vagotomy on Systemic and Pulmonary Inflammation in a Two-Hit Model in Rats ⬇️

scientific article published on April 6, 2012

Effects of a rapid response system on quality of life: a prospective cohort study in surgical patients before and after implementing a rapid response system ⬇️

scientific article published on May 1, 2013

Effects of prolonged mild hypothermia on cerebral blood flow after cardiac arrest ⬇️

scientific article published on August 1, 2012

Effects of the 34C>T Variant of the AMPD1 Gene on Immune Function, Multi-Organ Dysfunction, and Mortality in Sepsis Patients

scientific article published on 28 October 2015

Effects of the α7 Nicotinic Acetylcholine Receptor Agonist Gts-21 on the Innate Immune Response in Humans ⬇️

scientific article published on July 1, 2011

Effects of viscosity on cerebral blood flow after cardiac arrest

scientific article published in March 2014

Emphysema and pneumothorax after percutaneous tracheostomy: case reports and an anatomic study

scientific article published on May 2004

Endotoxemia-induced inflammation and the effect on the human brain

scientific article published on 5 May 2010

Endotoxin tolerance does not limit mild ischemia-reperfusion injury in humans in vivo

scientific article published in December 2009

Extravascular lung water index and global end-diastolic volume index should be corrected in children ⬇️

scientific article published on March 24, 2011

Extravascular lung water index measurement in critically ill children does not correlate with a chest x-ray score of pulmonary edema

scientific article

Extravascular lung water index measurement in critically ill children does not correlate with a chest x-ray score of pulmonary edema

F-18-fluorodeoxyglucose positron emission tomography combined with CT in critically ill patients with suspected infection

scientific article

Feasibility and safety of hydrotherapy in critically ill ventilated patients

scientific article published in February 2015

Financial consequences of the implementation of a rapid response system on a surgical ward

scientific article published on 29 April 2014

Flucloxacillin Results in Suboptimal Plasma Voriconazole Concentrations.

scientific article published on 17 July 2017

GTS-21 inhibits pro-inflammatory cytokine release independent of the Toll-like receptor stimulated via a transcriptional mechanism involving JAK2 activation.

scientific article

Gender differences in the innate immune response and vascular reactivity following the administration of endotoxin to human volunteers.

scientific article published on June 2007

Haloperidol prophylaxis in critically ill patients with a high risk for delirium

scientific article

Hematological indices, inflammatory markers and neutrophil CD64 expression: comparative trends during experimental human endotoxemia.

scientific article published in January 2007

Hemodynamic response to β-blockers in severe sepsis and septic shock: A review of current literature

scientific article published on 05 December 2018

How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo

scientific article

Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction.

scientific article

Hyperoxia after cardiac arrest may not increase ischemia-reperfusion injury ⬇️

scientific article published on June 22, 2011

Hypertonic fluid administration in patients with septic shock: a prospective randomized controlled pilot study

scientific article published on 01 March 2012

Hypothermia does not increase the risk of infection: a case control study ⬇️

scientific article published on February 3, 2011

Hypoxia attenuates inflammation-induced hepcidin synthesis during experimental human endotoxemia

scientific article published on 17 January 2019

Immunologic Consequences of Hypoxia during Critical Illness

scientific article published on 16 May 2016

Immunotherapy for the Adjunctive Treatment of Sepsis: From Immunosuppression to Immunostimulation. Time for a Paradigm Change? ⬇️

scientific article published on June 15, 2013

Impaired renal function is associated with greater urinary strong ion differences in critically ill patients with metabolic acidosis ⬇️

scientific article published on July 27, 2011

In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia.

scientific article

Inadequate Assessment of Patient-Ventilator Interaction Due to Suboptimal Diaphragm Electrical Activity Signal Filtering

scientific article published on 06 March 2020

Incidence and short-term consequences of delirium in critically ill patients: A prospective observational cohort study

scientific article

Incidence of cardiac arrests and unexpected deaths in surgical patients before and after implementation of a rapid response system ⬇️

scientific article published on June 20, 2012

Increased risk for secondary infections in trauma patients with viral reactivation

scientific article published on 8 August 2016

Inflammation-induced hepatotoxicity in humans

scientific article published in February 2009

Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study ⬇️

scientific article published on January 10, 2011

Influence of different breathing patterns on heart rate variability indices and reproducibility during experimental endotoxaemia in human subjects

scientific article published in September 2011

Influence of mild therapeutic hypothermia after cardiac arrest on hospital mortality

scientific article published on 01 January 2011

Intensive Insulin Therapy Increases the Risk of Hypoglycemia in Neurocritical Care Patients ⬇️

scientific article published on July 1, 2011

Intensive insulin therapy does not alter the inflammatory response in patients undergoing coronary artery bypass grafting: a randomized controlled trial [ISRCTN95608630].

scientific article

Interplay Between the Acute Inflammatory Response and Heart Rate Variability in Healthy Human Volunteers ⬇️

scientific article published on 01 August 2011

Interpretation of the transpulmonary thermodilution curve in the presence of a left-to-right shunt ⬇️

scientific article published on December 9, 2010

Interventions aimed at healthcare professionals to increase the number of organ donors: a systematic review.

scientific article published on 20 June 2019

Intravenous magnesium in subarachnoid hemorrhage ⬇️

scientific article published on May 24, 2011

Invasive pulmonary aspergillosis in influenza

scientific article

Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia.

scientific article

Lipopolysaccharide-stimulated whole blood cytokine production does not predict the inflammatory response in human endotoxemia.

scientific article

Low cerebral blood flow after cardiac arrest is not associated with anaerobic cerebral metabolism

scientific article published on 24 August 2017

Low-tidal-volume mechanical ventilation induces a toll-like receptor 4-dependent inflammatory response in healthy mice

scientific article published on September 2008

MONITOR-IC study, a mixed methods prospective multicentre controlled cohort study assessing 5-year outcomes of ICU survivors and related healthcare costs: a study protocol.

scientific article published on 14 November 2017

Mechanical ventilation in healthy mice induces reversible pulmonary and systemic cytokine elevation with preserved alveolar integrity: an in vivo model using clinical relevant ventilation settings

scientific article published on 01 September 2007

Mechanical ventilation induces a Toll/interleukin-1 receptor domain-containing adapter-inducing interferon beta-dependent inflammatory response in healthy mice

scientific article published on 01 October 2009

Mechanical ventilation-induced intrathoracic pressure distribution and heart-lung interactions*.

scientific article published in September 2014

Microcirculation and vascular reactivity during endotoxemia and endotoxin tolerance in humans

scientific article

Microvascular permeability during experimental human endotoxemia: an open intervention study

scientific article

Modulation of Innate Immunity by Adenosine Receptor Stimulation ⬇️

scientific article published on September 1, 2011

Monitoring of the Respiratory Muscles in the Critically Ill ⬇️

scientific article published on October 26, 2012

Monitoring patient-ventilator breath contribution in the critically ill during neurally adjusted ventilatory assist: reliability and improved algorithms for bedside use

scientific article published on 30 May 2019

Near-normal values of extravascular lung water in children

scientific article

Nitric oxide inhalation and glucocorticoids as combined treatment in human experimental endotoxemia: It takes not always two to tango

scientific article published in September 2009

Non-invasive mechanical ventilation for diagnostic bronchoscopy using a new face mask: an observational feasibility study

scientific article

Nonpharmacologic Interventions to Prevent or Mitigate Adverse Long-Term Outcomes Among ICU Survivors: A Systematic Review and Meta-Analysis

scientific article published on 01 November 2019

Nurses' 'worry' as predictor of deteriorating surgical ward patients: A prospective cohort study of the Dutch-Early-Nurse-Worry-Indicator-Score

scientific article published on 18 April 2016

Nurses' worry or concern and early recognition of deteriorating patients on general wards in acute care hospitals: a systematic review

scientific article published on 20 May 2015

Patient views regarding the impact of hydrotherapy on critically ill ventilated patients: A qualitative exploration study

scientific article published on 22 September 2018

Patient-Ventilator Interaction During Noninvasive Ventilation in Subjects With Exacerbation of COPD: Effect of Support Level and Ventilator Mode

scientific article published on 10 March 2020

Patterns in Bacterial- and Viral-Induced Immunosuppression and Secondary Infections in the ICU.

scientific article published on 2016

Physical, Mental, and Cognitive Health Status of ICU Survivors Before ICU Admission: A Cohort Study

scientific article published on 16 June 2020

Physician Experiences with Communicating Organ Donation with the Relatives: A Dutch Nationwide Evaluation on Factors that Influence Consent Rates

scientific article published on 01 October 2019

Plasma from septic shock patients induces loss of muscle protein.

scientific article published on 29 September 2011

Plasma obtained during human endotoxemia increases endothelial albumin permeability in vitro

scientific article published on 01 April 2006

Potentially Inadvertent Immunomodulation: Norepinephrine Use in Sepsis

scientific article published on 11 July 2016

Predictive value of neurologic prognostic indicators in hypothermia after cardiac arrest

scientific article published on 14 June 2011

Predictors of poor neurologic outcome in patients after cardiac arrest treated with hypothermia: A retrospective study ⬇️

scientific article published on March 17, 2011

Preserved metabolic coupling and cerebrovascular reactivity during mild hypothermia after cardiac arrest

scientific article

Prevention of ICU delirium and delirium-related outcome with haloperidol: a study protocol for a multicenter randomized controlled trial.

scientific article published on 21 November 2013

Prophylactic Haloperidol Effects on Long-term Quality of Life in Critically Ill Patients at High Risk for Delirium: Results of the REDUCE Study

scientific article published on 01 August 2019

Protective effects of adenosine A2A agonist during hemorrhagic shock: a simple intervention may result in a complex response

scientific article published on 01 December 2006

Rationing in the intensive care unit in case of full bed occupancy: a survey among intensive care unit physicians

scientific article

Recognizing and supporting morally injured ICU professionals during the COVID-19 pandemic

scientific article published on 28 May 2020

Reversal of immunoparalysis in humans in vivo: a double-blind, placebo-controlled, randomized pilot study.

scientific article published on 19 July 2012

Rewarming after hypothermia after cardiac arrest shifts the inflammatory balance* ⬇️

scientific article published on April 1, 2012

Risk factors for hypoglycaemia in neurocritical care patients ⬇️

scientific article published on August 21, 2012

Risk factors for the deterioration of oxygenation ratio in ventilated intensive care unit patients: a retrospective cohort study

scientific article published on 09 July 2009

Seventy-two hours of mild hypothermia after cardiac arrest is associated with a lowered inflammatory response during rewarming in a prospective observational study

scientific article

Severe vagal response after endotoxin administration in humans

scientific article published on 26 October 2004

Short-Term Hypoxia Dampens Inflammation in vivo via Enhanced Adenosine Release and Adenosine 2B Receptor Stimulation.

scientific article

Short-term beneficial effects of methylene blue on kidney damage in septic shock patients.

scientific article

Short-term hyperoxia does not exert immunologic effects during experimental murine and human endotoxemia.

scientific article

Short-term repeated HRV-16 exposure results in an attenuated immune response in vivo in humans

scientific article published on 15 February 2018

Strategies to optimize respiratory muscle function in ICU patients

scientific article

Surgical ward nurses' responses to worry: An observational descriptive study

scientific article published on 21 May 2018

Systemic inflammation decreases pain threshold in humans in vivo

scientific article

Temporal biomarker profiles and their association with ICU acquired delirium: a cohort study.

scientific article

The "cross-talk phenomenon" in transpulmonary thermodilution is flow dependent

scientific article published on 09 May 2006

The Effects of Brain Injury on Heart Rate Variability and the Innate Immune Response in Critically Ill Patients ⬇️

scientific article published on February 22, 2012

The Implementation of a Multidisciplinary Approach for Potential Organ Donors in the Emergency Department

scientific article published on 01 November 2019

The Influence of Concentration/Meditation on Autonomic Nervous System Activity and the Innate Immune Response

scientific article published on 01 June 2012

The Involvement of Danger-Associated Molecular Patterns in the Development of Immunoparalysis in Cardiac Arrest Patients

scientific article published on 20 July 2015

The association between ICU level of care and mortality in the Netherlands

scientific article published on 20 January 2015

The authors reply

The complement system is activated in a biphasic pattern after coronary artery bypass grafting

scientific article published on 01 March 2010

The effect of adenosine receptor agonists on cytokine release by human mononuclear cells depends on the specific Toll-like receptor subtype used for stimulation

scientific article published on 01 July 2006

The effect of iron loading and iron chelation on the innate immune response and subclinical organ injury during human endotoxemia: a randomized trial

scientific article

The effect of vasopressin on gastric perfusion in catecholamine-dependent patients in septic shock

scientific article

The effects of hypertonic fluid administration on the gene expression of inflammatory mediators in circulating leucocytes in patients with septic shock: a preliminary study ⬇️

scientific article published on November 1, 2011

The effects of methylene blue infusion on gastric tonometry and intestinal fatty acid binding protein levels in septic shock patients.

scientific article published on 8 April 2010

The impact of critical illness on the expiratory muscles and the diaphragm assessed by ultrasound in mechanical ventilated children

scientific article published on 27 August 2020

The impact of delirium on the prediction of in-hospital mortality in intensive care patients

scientific article

The influence of esmolol on right ventricular function in early experimental endotoxic shock

scientific article published on 01 September 2018

The nature of unmeasured anions in critically ill patients

scientific article published on 22 April 2008

The pulmonary artery catheter in the pediatric intensive care unit: not the way to go

scientific article published on 01 March 2012

The reliability of continuous noninvasive finger blood pressure measurement in critically ill children

scientific article

The role of cytokines and inducible nitric oxide synthase in endotoxemia-induced endothelial dysfunction

scientific article published in June 2010

The role of poly (ADP-ribose) polymerase in ventilator-induced lung injury

scientific article published on 22 October 2008

Titin and diaphragm dysfunction in mechanically ventilated rats ⬇️

scientific article published on February 11, 2012

Toll-like receptor 4 signaling in ventilator-induced diaphragm atrophy

scientific article published on 01 August 2012

Tracheostomy for long-term ventilated patients: a postal survey of ICU practice in The Netherlands

scientific article published on 22 July 2003

Transcriptome kinetics of circulating neutrophils during human experimental endotoxemia

scientific article

Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study

scientific article published on 7 June 2015

Unexpected left main stem bronchus cardiac output measurement

scientific article published on 12 June 2003

Upregulation of renal inducible nitric oxide synthase during human endotoxemia and sepsis is associated with proximal tubule injury.

scientific article

Urinary protein profiling in hyperactive delirium and non-delirium cardiac surgery ICU patients ⬇️

scientific article published on March 22, 2011

Use of recruitment maneuvers during mechanical ventilation in pediatric and neonatal intensive care units in the Netherlands

scientific article published on 13 March 2007

Validation of noninvasive pulse contour cardiac output using finger arterial pressure in cardiac surgery patients requiring fluid therapy

scientific article published on 01 February 2014

Validation of the Dutch language version of the Safety Attitudes Questionnaire (SAQ-NL).

scientific article

Variation in rates of ICU readmissions and post-ICU in-hospital mortality and their association with ICU discharge practices

scientific article

Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans

scientific article

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