List of works - Martin Knöfler

A novel combination of homeobox genes is expressed in mesenchymal chorionic stem/stromal cells in first trimester and term pregnancies

scientific article

AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans

scientific article published on 7 March 2013

Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast

scientific article

Administration of betaHCG leads to dose-dependent changes of gene expression signature of endometriotic stromal cells

scientific article published on 01 February 2010

Basic fibroblast growth factor and hypertensive disorders in pregnancy

scientific article published on 01 January 2002

Beta-hCG/LH receptor (b-HCG/LH-R) expression is increased in invasive versus preinvasive breast cancer: implications for breast carcinogenesis?

scientific article

Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth

scientific article published on 22 March 2017

Common oxytocin receptor gene polymorphisms and the risk for preterm birth ⬇️

scientific article published on January 1, 2013

Concentrations of estrogens in patients with preeclampsia

scientific article published in June 2002

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors

scientific article

Densities of decidual high endothelial venules correlate with T-cell influx in healthy pregnancies and idiopathic recurrent pregnancy losses

scientific article published on 17 September 2020

Detection of corticotropin-releasing hormone receptors R1 and R2 (CRH-R1, CRH-R2) using fluorescence immunohistochemistry in the myometrium of women delivering preterm or at term

scientific article published on 01 October 2003

Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo

scientific article

Elevated serum concentrations of androgens in women with pregnancy-induced hypertension ⬇️

scientific article published on March 31, 2003

Elevated serum concentrations of the angiogenesis inhibitor endostatin in preeclamptic women

scientific article published on 01 October 2003

Endostatin suppresses IGF-II-mediated signaling and invasion of human extravillous trophoblasts.

scientific article

Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B.

scientific article

Epithelial-mesenchymal transition during extravillous trophoblast differentiation.

scientific article published on 12 April 2016

Estrogen Signaling Drives Ciliogenesis in Human Endometrial Organoids

scientific article published on 01 October 2019

Evaluation of human first trimester decidual and telomerase-transformed endometrial stromal cells as model systems of in vitro decidualization

scientific article published on 7 December 2011

Expression of the human Hand1 gene in trophoblastic cells is transcriptionally regulated by activating and repressing specificity protein (Sp)-elements

scientific article published in January 2003

Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions

scientific article

Extravillous trophoblast-associated ADAM12 exerts pro-invasive properties, including induction of integrin beta 1-mediated cellular spreading

scientific article published on 2 April 2014

Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal control.

scientific article published on 29 September 2015

Genome amplification and cellular senescence are hallmarks of human placenta development

article

Governing the invasive trophoblast: current aspects on intra- and extracellular regulation.

scientific article published on 17 March 2010

Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains

scientific article

Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling

scientific article

Human placenta and trophoblast development: key molecular mechanisms and model systems

scientific article published on 03 May 2019

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling.

scientific article published on 26 September 2013

IFPA meeting 2016 workshop report III: Decidua-trophoblast interactions; trophoblast implantation and invasion; immunology at the maternal-fetal interface; placental inflammation.

scientific article published on 25 April 2017

Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma

scientific article

Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells

scientific article published on 01 November 2020

Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts

scientific article

Kisspeptins and the placenta: regulation of trophoblast invasion

scientific article published on March 2007

Macrophage-derived IL-33 is a critical factor for placental growth

scientific article published on 30 August 2013

Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

scientific article published on 28 December 2015

Metabolism of cholesterol and progesterone is differentially regulated in primary trophoblastic subtypes and might be disturbed in recurrent miscarriages

scientific article published on 17 September 2019

Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation.

scientific article published on 21 October 2015

New frontiers in placenta stem cell research, translation, and clinical application

scientific article published on 26 July 2017

Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts.

scientific article published on 20 December 2013

Notch1 controls development of the extravillous trophoblast lineage in the human placenta.

scientific article

Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy

scientific article

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta

scientific article published on 01 June 2020

Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia

scientific article published on 17 January 2020

Preeclampsia - a risk factor for osteoporosis? Analysis of maternal Sclerostin levels and markers of bone turnover in patients with pre-eclampsia

scientific article published on 25 February 2014

Pregnancy-associated diamine oxidase originates from extravillous trophoblasts and is decreased in early-onset preeclampsia

scientific article published on 20 April 2018

Production of oxytocin receptor and cytokines in primary uterine smooth muscle cells cultivated under inflammatory conditions

scientific article

Redistribution of corticotropin-releasing hormone receptor R2 using fluorescence immunohistochemistry in fetal membranes of women delivering preterm or at term

scientific article published on 01 December 2002

Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment

scientific article published in 2018

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

scientific article published on 02 August 2018

Serum levels of heat shock protein 70 in patients with preeclampsia: a pilot-study

scientific article published on 01 August 2002

The first trimester human trophoblast cell line ACH-3P: a novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations--TNF-alpha stimulates MMP15 expression

scientific article

The role of the invasive, placental trophoblast in human pregnancy ⬇️

scientific article published on May 1, 2012

Transcription factor AP-2α promotes EGF-dependent invasion of human trophoblast.

scientific article published on 8 February 2011

Transcriptional regulation of the human chorionic gonadotropin beta gene during villous trophoblast differentiation

scientific article

Transcriptome analysis of human cancer reveals a functional role of heme oxygenase-1 in tumor cell adhesion

scientific article

Transcriptome profiling reveals unique spectra of macrophage activation in decidua basalis and parietalis.

scholarly article

Trophoblast subtype-specific EGFR/ERBB4 expression correlates with cell cycle progression and hyperplasia in complete hydatidiform moles.

scientific article published on 03 March 2015

Trophoblast- and vascular smooth muscle cell-derived MMP-12 mediates elastolysis during uterine spiral artery remodeling

scientific article

Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures

scientific article published on 01 February 2004

Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids

scientific article published on 17 November 2020

Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation

scientific article

Wingless ligand 5a is a critical regulator of placental growth and survival

scientific article

Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility

scientific article published on 26 February 2014

Wnt1 is anti-lymphangiogenic in a melanoma mouse model

scientific article

List of works by Martin Knöfler

A novel combination of homeobox genes is expressed in mesenchymal chorionic stem/stromal cells in first trimester and term pregnancies

AKT isoforms 1 and 3 regulate basal and epidermal growth factor-stimulated SGHPL-5 trophoblast cell migration in humans

Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast

Administration of betaHCG leads to dose-dependent changes of gene expression signature of endometriotic stromal cells

Basic fibroblast growth factor and hypertensive disorders in pregnancy

Beta-hCG/LH receptor (b-HCG/LH-R) expression is increased in invasive versus preinvasive breast cancer: implications for breast carcinogenesis?

Chymase-producing cells of the innate immune system are required for decidual vascular remodeling and fetal growth

Common oxytocin receptor gene polymorphisms and the risk for preterm birth ⬇️

Concentrations of estrogens in patients with preeclampsia

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors

Densities of decidual high endothelial venules correlate with T-cell influx in healthy pregnancies and idiopathic recurrent pregnancy losses

Detection of corticotropin-releasing hormone receptors R1 and R2 (CRH-R1, CRH-R2) using fluorescence immunohistochemistry in the myometrium of women delivering preterm or at term

Effect of highly purified human chorionic gonadotropin preparations on the gene expression signature of stromal cells derived from endometriotic lesions: potential mechanisms for the therapeutic effect of human chorionic gonadotropin in vivo

Elevated serum concentrations of androgens in women with pregnancy-induced hypertension ⬇️

Elevated serum concentrations of the angiogenesis inhibitor endostatin in preeclamptic women

Endostatin suppresses IGF-II-mediated signaling and invasion of human extravillous trophoblasts.

Endothelin-1 down-regulates matrix metalloproteinase 14 and 15 expression in human first trimester trophoblasts via endothelin receptor type B.

Epithelial-mesenchymal transition during extravillous trophoblast differentiation.

Estrogen Signaling Drives Ciliogenesis in Human Endometrial Organoids

Evaluation of human first trimester decidual and telomerase-transformed endometrial stromal cells as model systems of in vitro decidualization

Expression of the human Hand1 gene in trophoblastic cells is transcriptionally regulated by activating and repressing specificity protein (Sp)-elements

Extravillous trophoblast invasion of venous as well as lymphatic vessels is altered in idiopathic, recurrent, spontaneous abortions

Extravillous trophoblast-associated ADAM12 exerts pro-invasive properties, including induction of integrin beta 1-mediated cellular spreading

Function and control of human invasive trophoblast subtypes: Intrinsic vs. maternal control.

Genome amplification and cellular senescence are hallmarks of human placenta development

Governing the invasive trophoblast: current aspects on intra- and extracellular regulation.

Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains

Human chorionic gonadotropin stimulates trophoblast invasion through extracellularly regulated kinase and AKT signaling

Human placenta and trophoblast development: key molecular mechanisms and model systems

Human placental trophoblast invasion and differentiation: a particular focus on Wnt signaling.

IFPA meeting 2016 workshop report III: Decidua-trophoblast interactions; trophoblast implantation and invasion; immunology at the maternal-fetal interface; placental inflammation.

Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma

Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells

Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts

Kisspeptins and the placenta: regulation of trophoblast invasion

Macrophage-derived IL-33 is a critical factor for placental growth

Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters

Metabolism of cholesterol and progesterone is differentially regulated in primary trophoblastic subtypes and might be disturbed in recurrent miscarriages

Neuregulin-1-mediated ErbB2-ErbB3 signalling protects human trophoblasts against apoptosis to preserve differentiation.

New frontiers in placenta stem cell research, translation, and clinical application

Notch signaling plays a critical role in motility and differentiation of human first-trimester cytotrophoblasts.

Notch1 controls development of the extravillous trophoblast lineage in the human placenta.

Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy

Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta

Placenta-Specific Genes, Their Regulation During Villous Trophoblast Differentiation and Dysregulation in Preterm Preeclampsia

Preeclampsia - a risk factor for osteoporosis? Analysis of maternal Sclerostin levels and markers of bone turnover in patients with pre-eclampsia

Pregnancy-associated diamine oxidase originates from extravillous trophoblasts and is decreased in early-onset preeclampsia

Production of oxytocin receptor and cytokines in primary uterine smooth muscle cells cultivated under inflammatory conditions

Redistribution of corticotropin-releasing hormone receptor R2 using fluorescence immunohistochemistry in fetal membranes of women delivering preterm or at term

Regulation of Placental Extravillous Trophoblasts by the Maternal Uterine Environment

Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta

Serum levels of heat shock protein 70 in patients with preeclampsia: a pilot-study

The first trimester human trophoblast cell line ACH-3P: a novel tool to study autocrine/paracrine regulatory loops of human trophoblast subpopulations--TNF-alpha stimulates MMP15 expression

The role of the invasive, placental trophoblast in human pregnancy ⬇️

Transcription factor AP-2α promotes EGF-dependent invasion of human trophoblast.

Transcriptional regulation of the human chorionic gonadotropin beta gene during villous trophoblast differentiation

Transcriptome analysis of human cancer reveals a functional role of heme oxygenase-1 in tumor cell adhesion

Transcriptome profiling reveals unique spectra of macrophage activation in decidua basalis and parietalis.

Trophoblast subtype-specific EGFR/ERBB4 expression correlates with cell cycle progression and hyperplasia in complete hydatidiform moles.

Trophoblast- and vascular smooth muscle cell-derived MMP-12 mediates elastolysis during uterine spiral artery remodeling

Tumor necrosis factor-alpha inhibits trophoblast migration through elevation of plasminogen activator inhibitor-1 in first-trimester villous explant cultures

Ultra-high-resolution 3D optical coherence tomography reveals inner structures of human placenta-derived trophoblast organoids

Wingless (Wnt)-3A induces trophoblast migration and matrix metalloproteinase-2 secretion through canonical Wnt signaling and protein kinase B/AKT activation

Wingless ligand 5a is a critical regulator of placental growth and survival

Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility

Wnt1 is anti-lymphangiogenic in a melanoma mouse model