List of works - Rafaela Holtappels

Adoptive CD8 T cell control of pathogens cannot be improved by combining protective epitope specificities

scientific article published on 01 February 2008

Antigen presentation under the influence of 'immune evasion' proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

scientific article published on 09 September 2012

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

scientific article published in June 2011

CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation

scientific article

CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model

CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model

scientific article published on 15 March 2008

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells

scientific article published on 07 March 2019

Control of murine cytomegalovirus infection by γδ T cells

scientific article

Correlation of dendritic cell maturation and the formation of aggregates of poly-ubiquitinated proteins in the cytosol

scientific article published on 14 March 2008

Cytomegalovirus encodes a positive regulator of antigen presentation

scientific article

Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues

scientific article published on 29 December 2003

Early gene m18, a novel player in the immune response to murine cytomegalovirus

scientific article

Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy

scientific article

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

scientific article published on 15 August 2016

Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting

scientific article

Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities.

scientific article published on 25 March 2015

Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

scientific article published on 14 September 2012

Immune evasion proteins enhance cytomegalovirus latency in the lungs.

scientific article published on 15 July 2009

In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.

scientific article published on 08 October 2010

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation

scientific article published on 15 April 2020

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs

scientific article

Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions

scientific article published on 09 September 2012

Non-cognate bystander cytolysis by clonal epitope-specific CTL lines through CD28-CD80 interaction inhibits antibody production: A potential caveat to CD8 T-cell immunotherapy.

scientific article

Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.

scientific article published on 14 February 2014

Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.

scientific article published on 13 September 2012

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

scientific article

Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues

scientific article published on 26 March 2008

Processing and presentation of murine cytomegalovirus pORFm164-derived peptide in fibroblasts in the face of all viral immunosubversive early gene functions

scientific article

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.

scientific article published on 14 June 2016

Refinement of strategies for the development of a human cytomegalovirus dense body vaccine

scientific article published on 5 March 2008

Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

scientific article published on 22 July 2020

Spatial distribution and structural arrangement of a murine cytomegalovirus glycoprotein detected by SPDM localization microscopy.

scientific article published on 7 February 2014

Stalemating a clever opportunist: lessons from murine cytomegalovirus

scientific article published on May 2004

Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination

scientific article published on 26 March 2008

Superresolution imaging of biological nanostructures by spectral precision distance microscopy.

scientific article published on September 2011

TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer

scientific article

The efficacy of antigen processing is critical for protection against cytomegalovirus disease in the presence of viral immune evasion proteins.

scientific article published on 24 June 2009

The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance priming of CD8 T cells by preventing negative feedback regulation.

scientific article published on 24 September 2008

Thy‐1 (CD90) regulates the extravasation of leukocytes during inflammation ⬇️

scientific article published on January 25, 2011

Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype

scientific article

List of works by Rafaela Holtappels

Adoptive CD8 T cell control of pathogens cannot be improved by combining protective epitope specificities

Antigen presentation under the influence of 'immune evasion' proteins and its modulation by interferon-gamma: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

Antigen-presenting cells of haematopoietic origin prime cytomegalovirus-specific CD8 T-cells but are not sufficient for driving memory inflation during viral latency.

CD8 T cells control cytomegalovirus latency by epitope-specific sensing of transcriptional reactivation

CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model

CD8 T-cell-based immunotherapy of cytomegalovirus infection: "proof of concept" provided by the murine model

Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells

Control of murine cytomegalovirus infection by γδ T cells

Correlation of dendritic cell maturation and the formation of aggregates of poly-ubiquitinated proteins in the cytosol

Cytomegalovirus encodes a positive regulator of antigen presentation

Cytomegalovirus misleads its host by priming of CD8 T cells specific for an epitope not presented in infected tissues

Early gene m18, a novel player in the immune response to murine cytomegalovirus

Epitope-specific in vivo protection against cytomegalovirus disease by CD8 T cells in the murine model of preemptive immunotherapy

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Highly protective in vivo function of cytomegalovirus IE1 epitope-specific memory CD8 T cells purified by T-cell receptor-based cell sorting

Identification of an atypical CD8 T cell epitope encoded by murine cytomegalovirus ORF-M54 gaining dominance after deletion of the immunodominant antiviral CD8 T cell specificities.

Immune control in the absence of immunodominant epitopes: implications for immunotherapy of cytomegalovirus infection with antiviral CD8 T cells

Immune evasion proteins enhance cytomegalovirus latency in the lungs.

In vivo impact of cytomegalovirus evasion of CD8 T-cell immunity: facts and thoughts based on murine models.

Insufficient Antigen Presentation Due to Viral Immune Evasion Explains Lethal Cytomegalovirus Organ Disease After Allogeneic Hematopoietic Cell Transplantation

Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs

Murine cytomegalovirus immune evasion proteins operative in the MHC class I pathway of antigen processing and presentation: state of knowledge, revisions, and questions

Non-cognate bystander cytolysis by clonal epitope-specific CTL lines through CD28-CD80 interaction inhibits antibody production: A potential caveat to CD8 T-cell immunotherapy.

Noncanonical expression of a murine cytomegalovirus early protein CD8 T-cell epitope as an immediate early epitope based on transcription from an upstream gene.

Parameters determining the efficacy of adoptive CD8 T-cell therapy of cytomegalovirus infection.

Peptide Processing Is Critical for T-Cell Memory Inflation and May Be Optimized to Improve Immune Protection by CMV-Based Vaccine Vectors

Polyclonal cytomegalovirus-specific antibodies not only prevent virus dissemination from the portal of entry but also inhibit focal virus spread within target tissues

Processing and presentation of murine cytomegalovirus pORFm164-derived peptide in fibroblasts in the face of all viral immunosubversive early gene functions

Reconstitution of CD8 T Cells Protective against Cytomegalovirus in a Mouse Model of Hematopoietic Cell Transplantation: Dynamics and Inessentiality of Epitope Immunodominance.

Refinement of strategies for the development of a human cytomegalovirus dense body vaccine

Revisiting CD8 T-cell 'Memory Inflation': New Insights with Implications for Cytomegaloviruses as Vaccine Vectors

Spatial distribution and structural arrangement of a murine cytomegalovirus glycoprotein detected by SPDM localization microscopy.

Stalemating a clever opportunist: lessons from murine cytomegalovirus

Subdominant CD8 T-cell epitopes account for protection against cytomegalovirus independent of immunodomination

Superresolution imaging of biological nanostructures by spectral precision distance microscopy.

TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer

The efficacy of antigen processing is critical for protection against cytomegalovirus disease in the presence of viral immune evasion proteins.

The immune evasion paradox: immunoevasins of murine cytomegalovirus enhance priming of CD8 T cells by preventing negative feedback regulation.

Thy‐1 (CD90) regulates the extravasation of leukocytes during inflammation ⬇️

Two antigenic peptides from genes m123 and m164 of murine cytomegalovirus quantitatively dominate CD8 T-cell memory in the H-2d haplotype

Virally Infected Mouse Liver Endothelial Cells Trigger CD8+ T-Cell Immunity