List of works - Jason K Kim

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

scientific article published on September 2017

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

scientific article published on 01 May 2020

A major role of insulin in promoting obesity-associated adipose tissue inflammation

scientific article published on May 2015

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

scientific article published on December 2008

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming

scientific article

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance

scientific article published on 28 September 2016

Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance

scientific article published in June 2005

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans

scientific article published on 01 March 2019

Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity

scientific article published in July 2002

Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance

scientific article published on 19 September 2016

An alternative splicing program promotes adipose tissue thermogenesis

scientific article published on 16 September 2016

Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver

scientific article published on 10 March 2020

Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation

scientific article

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

scientific article published on 08 February 2022

CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance

scientific article published on 12 March 2013

COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice

scientific article published on 2 June 2009

CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 () in adipose cells to enhance energy expenditure

scientific article published in Journal of Biological Chemistry

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

scientific article published on 26 November 2021

Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism

scientific journal article

Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice

scientific journal article

Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice

scientific article published on 16 July 2013

Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice

scientific article published on April 2016

Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression

scientific article published on 17 March 2004

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver

scientific article published in September 2005

Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle

scientific article published on 2 February 2005

ChREBP regulates fructose-induced glucose production independently of insulin signaling

scientific article published on 26 September 2016

Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice

scientific article published on 18 November 2020

Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice

scientific article published on 14 November 2007

Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance

scientific article

Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance

scientific article

Deficiency of the tumor promoter gene wip1 induces insulin resistance

scientific article

Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway

scientific article

Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

scientific article published in April 2004

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice

scientific article published in June 2003

Effects of chronic Akt activation on glucose uptake in the heart

scientific article published on 13 December 2005

Endocrine regulation of energy metabolism by the skeleton

scientific article

Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity.

scientific article published on 14 December 2017

Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

scientific article published on 24 February 2016

Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice

scientific article published on 12 March 2020

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

scientific article published on 7 October 2008

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

scientific article published on 13 May 2015

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

scientific article

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

scientific article published in March 2010

GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity

scientific article published on 03 June 2019

GRP78 plays an essential role in adipogenesis and postnatal growth in mice

scientific article published on 24 November 2012

Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance

scientific article published on 7 December 2015

Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity

scientific article published in October 2003

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice

scientific article published on 28 May 2017

Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain

scientific article published on 26 October 2012

Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

scientific article

Gut-derived serotonin is a multifunctional determinant to fasting adaptation

scientific article published on 18 October 2012

Hepatic NADH reductive stress underlies common variation in metabolic traits

scientific article published on 27 May 2020

Hepatic Src homology phosphatase 2 regulates energy balance in mice.

scientific article

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart

scientific article published on 8 February 2005

Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice

scientific article published on 25 January 2016

Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes

scientific article published on 01 July 2007

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis

scientific article published on 19 January 2019

Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma

scientific article published in July 2004

IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis

scientific article

IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle

scientific article published on 3 November 2016

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

scientific article

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

scientific journal article

Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2).

scientific article

Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase

scientific article

Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues

scientific article published on July 2015

Insulin resistance in tetracycline-repressible Munc18c transgenic mice

scientific article published in August 2003

Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

scientific article published on 18 August 2009

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation

scientific article published on 06 December 2012

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance

scientific article

Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans ⬇️

scientific article

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

scientific article published on 15 December 2008

Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice

scientific article published on 14 September 2017

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

scientific article

Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice

article

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

scholarly article

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

scientific article

Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.

scientific article

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.

scientific article

MicroRNA-378 controls classical brown fat expansion to counteract obesity

scientific article

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice

scientific article published on 20 May 2013

Mss51 deletion enhances muscle metabolism and glucose homeostasis in mice

scientific article published on 17 October 2019

Muscle Specific Insulin Receptor Overexpression Protects Mice from Diet-Induced Glucose Intolerance but Leads to Post-Receptor Insulin Resistance

scientific article published on 31 August 2020

Muscle-generated BDNF is a sexually dimorphic myokine that controls metabolic flexibility

scientific article published on 13 August 2019

Myeloid-Specific Deletion of Zfp36 Protects Against Insulin Resistance and Fatty Liver in Diet-Induced Obese Mice.

scientific article published on 6 March 2018

Myeloid-specific Acat1 ablation attenuates inflammatory responses in macrophages, improves insulin sensitivity, and suppresses diet-induced obesity.

scientific article

New insights into insulin resistance in the diabetic heart

scientific article

Nonacute effects of H-FABP deficiency on skeletal muscle glucose uptake in vitro

scientific article

Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders.

scientific article

Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart

scientific article published on 18 August 2009

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

scientific article published in July 2007

PKC-theta knockout mice are protected from fat-induced insulin resistance

scientific article

Prevention of steatosis by hepatic JNK1

scientific article

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia

scientific article published on 20 May 2016

Regulation of gluconeogenesis by Krüppel-like factor 15

scientific article published in April 2007

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice

scientific article published on July 2006

Requirement of JIP1-mediated c-Jun N-terminal kinase activation for obesity-induced insulin resistance

scientific article

Requirement of the ATM/p53 tumor suppressor pathway for glucose homeostasis

scientific article published on 18 October 2010

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

scientific article published on August 2005

Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance

scientific article

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1

scientific article

Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity

scientific article

Safety of Striatal Infusion of siRNA in a Transgenic Huntington's Disease Mouse Model

scientific article published on September 2015

Short-term weight loss attenuates local tissue inflammation and improves insulin sensitivity without affecting adipose inflammation in obese mice

scientific article published on 12 March 2013

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues

scientific article published on 24 October 2008

Syntaxin 4 transgenic mice exhibit enhanced insulin-mediated glucose uptake in skeletal muscle

scientific article

TRPM2 Ca2+ channel regulates energy balance and glucose metabolism

scientific article published on 24 January 2012

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion

scientific article published on 16 February 2016

The PPARα-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway

scientific article

The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

scientific article published on 16 April 2006

The effect of salicylates on insulin sensitivity.

scientific article published in December 2001

The proinflammatory cytokine macrophage migration inhibitory factor regulates glucose metabolism during systemic inflammation

scientific article published in October 2007

The transcription factor ATF4 regulates glucose metabolism in mice through its expression in osteoblasts

scientific article published on 10 August 2009

Thioredoxin Interacting Protein Is Required for a Chronic Energy-Rich Diet to Promote Intestinal Fructose Absorption

scientific article published on 02 September 2020

Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action

scientific article published on 18 March 2004

Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance

scientific article published on 17 April 2015

Txnip balances metabolic and growth signaling via PTEN disulfide reduction

scholarly article

Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice

scientific article published in December 2005

List of works by Jason K Kim

A Protein Scaffold Coordinates SRC-Mediated JNK Activation in Response to Metabolic Stress.

A big-data approach to understanding metabolic rate and response to obesity in laboratory mice

A major role of insulin in promoting obesity-associated adipose tissue inflammation

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming

Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance

Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans

Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity

Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance

An alternative splicing program promotes adipose tissue thermogenesis

Arrestin domain-containing 3 (Arrdc3) modulates insulin action and glucose metabolism in liver

Baf60c drives glycolytic metabolism in the muscle and improves systemic glucose homeostasis through Deptor-mediated Akt activation

Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance

CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance

COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice

CRISPR-delivery particles targeting nuclear receptor-interacting protein 1 () in adipose cells to enhance energy expenditure

CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease

Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism

Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice

Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice

Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice

Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression

Cardiac-specific overexpression of peroxisome proliferator-activated receptor-alpha causes insulin resistance in heart and liver

Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle

ChREBP regulates fructose-induced glucose production independently of insulin signaling

Characterization of Viral Insulins Reveals White Adipose Tissue Specific Effects in Mice

Comparison between surrogate indexes of insulin sensitivity and resistance and hyperinsulinemic euglycemic clamp estimates in mice

Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance

Deficiency of phosphoinositide 3-kinase enhancer protects mice from diet-induced obesity and insulin resistance

Deficiency of the tumor promoter gene wip1 induces insulin resistance

Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway

Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice

Effects of chronic Akt activation on glucose uptake in the heart

Endocrine regulation of energy metabolism by the skeleton

Endoplasmic reticulum chaperone GRP78 regulates macrophage function and insulin resistance in diet-induced obesity.

Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress

Exogenous GDF11, but not GDF8, reduces body weight and improves glucose homeostasis in mice

Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice

Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice

GABA-stimulated adipose-derived stem cells suppress subcutaneous adipose inflammation in obesity

GRP78 plays an essential role in adipogenesis and postnatal growth in mice

Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance

Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity

Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice

Glucose Tolerance in Mice is Linked to the Dose of the p53 Transactivation Domain

Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance

Gut-derived serotonin is a multifunctional determinant to fasting adaptation

Hepatic NADH reductive stress underlies common variation in metabolic traits

Hepatic Src homology phosphatase 2 regulates energy balance in mice.

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart

Human 'brite/beige' adipocytes develop from capillary networks, and their implantation improves metabolic homeostasis in mice

Hyperglycemia, maturity-onset obesity, and insulin resistance in NONcNZO10/LtJ males, a new mouse model of type 2 diabetes

Hyperinsulinemia drives hepatic insulin resistance in male mice with liver-specific Ceacam1 deletion independently of lipolysis

Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma

IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis

IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcinoembryonic Antigen-related Cell Adhesion Molecule 2 (CEACAM2).

Increased hepatic insulin action in diet-induced obese mice following inhibition of glucosylceramide synthase

Inducible Deletion of Protein Kinase Map4k4 in Obese Mice Improves Insulin Sensitivity in Liver and Adipose Tissues

Insulin resistance in tetracycline-repressible Munc18c transgenic mice

Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation

KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance

Links between insulin resistance, adenosine A2B receptors, and inflammatory markers in mice and humans ⬇️

Liver-specific deletion of protein-tyrosine phosphatase 1B (PTP1B) improves metabolic syndrome and attenuates diet-induced endoplasmic reticulum stress

Liver-specific reconstitution of CEACAM1 reverses the metabolic abnormalities caused by its global deletion in male mice

Long-term, efficient inhibition of microRNA function in mice using rAAV vectors

Loss of Nuclear and Membrane Estrogen Receptor-α Differentially Impairs Insulin Secretion and Action in Male and Female Mice

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.

MicroRNA-378 controls classical brown fat expansion to counteract obesity