Search filters

List of works by Douglas G Walker

A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease

scientific article

ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease

scientific article

ABCG2 is upregulated in Alzheimer's brain with cerebral amyloid angiopathy and may act as a gatekeeper at the blood-brain barrier for Abeta(1-40) peptides.

scientific article published on April 2009

Absence of effect of chronic nicotine administration on amyloid beta peptide levels in transgenic mice overexpressing mutated human APP (Sw, Ind).

scientific article

Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues

scientific article published on November 2006

Altered Expression Patterns of Inflammation-Associated and Trophic Molecules in Substantia Nigra and Striatum Brain Samples from Parkinson's Disease, Incidental Lewy Body Disease and Normal Control Cases

scientific article

Alzheimer's Disease Research Using Human Microglia

scientific article published on 05 August 2019

Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging ⬇️

scientific article published on November 7, 2011

Amyloid Beta and Tau as Alzheimer's Disease Blood Biomarkers: Promise From New Technologies

scientific article

Amyloid load in nondemented brains correlates with APOE e4.

scientific article

Anti-inflammatory and immune therapy for Alzheimer's disease: current status and future directions

scientific article published on December 2007

Apolipoprotein E Isoforms Differentially Regulate Alzheimer's Disease and Amyloid-β-Induced Inflammatory Response in vivo and in vitro

scientific article published on 29 March 2017

Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program

scientific article

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

scientific article

Atherosclerosis, vascular amyloidosis and brain hypoperfusion in the pathogenesis of sporadic Alzheimer's disease

scientific article published in July 2004

BACE1 levels by APOE genotype in non-demented and Alzheimer's post-mortem brains

scientific article

Biochemical Increase in Phosphorylated Alpha‐Synuclein Precedes Histopathology of Lewy‐Type Synucleinopathies ⬇️

scientific article published on April 12, 2012

Biochemical assessment of precuneus and posterior cingulate gyrus in the context of brain aging and Alzheimer's disease

scientific article

Brain biochemistry in autopsied patients with essential tremor

scientific article published on 28 October 2011

Broad-Based Nutritional Supplementation in 3xTg Mice Corrects Mitochondrial Function and Indicates Sex-Specificity in Response to Alzheimer's Disease Intervention ⬇️

scientific article published on January 1, 2012

Case series of clinically probable dementia with Lewy bodies in two Native Americans

scientific article published in October 2004

Cerebral blood flow in Alzheimer's disease

scientific article

Cerebrospinal fluid biomarkers of neuropathologically diagnosed Parkinson’s disease subjects ⬇️

scientific article published on September 1, 2012

Changes in CD200 and intercellular adhesion molecule-1 (ICAM-1) levels in brains of Lewy body disorder cases are associated with amounts of Alzheimer's pathology not α-synuclein pathology

scientific article published on 16 March 2017

Changes in properties of serine 129 phosphorylated α-synuclein with progression of Lewy-type histopathology in human brains

scientific article

Characterization of RNA isolated from eighteen different human tissues: results from a rapid human autopsy program

scientific article published on 16 April 2016

Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer's disease and aged brains: increased levels correlate with neuropathology

scientific article published on 21 December 2019

Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production

scientific article

Circle of Willis atherosclerosis: association with Alzheimer's disease, neuritic plaques and neurofibrillary tangles

scientific article published on 20 September 2006

Converging mediators from immune and trophic pathways to identify Parkinson disease dementia

scientific article published on 27 January 2016

Cortical phosphorylated α-Synuclein levels correlate with brain wave spectra in Parkinson's disease

scientific article published on 08 April 2016

Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: a potential mechanism leading to chronic inflammation

scientific article published on 24 September 2008

Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin

article

Effects of FTMT Expression by Retinal Pigment Epithelial Cells on Features of Angiogenesis ⬇️

scientific article published on 21 May 2020

Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease

scientific article published on 04 February 2009

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.

scientific article published on 31 December 2008

F1F0 ATP Synthase-Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline

scientific article published on 23 August 2016

Faster Cognitive Decline in Dementia due to Alzheimer Disease with Clinically Undiagnosed Lewy Body Disease

Faster cognitive decline in dementia due to Alzheimer disease with clinically undiagnosed Lewy body disease

scientific article published on 25 June 2019

Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes

scientific article published on 19 December 2005

Gene expression correlates of neurofibrillary tangles in Alzheimer's disease

scientific article

Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain

scientific article

Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models

scientific article published on 13 June 2016

Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models

article

Hippocampal sclerosis dementia with tauopathy.

scientific article

Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations

scientific article

Human postmortem brain-derived cerebrovascular smooth muscle cells express all genes of the classical complement pathway: a potential mechanism for vascular damage in cerebral amyloid angiopathy and Alzheimer's disease

scientific article

Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains

scientific article (publication date: 2015)

Impaired platelet mitochondrial activity in Alzheimer's disease and mild cognitive impairment

scientific article published on 27 October 2006

Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease

scientific article published on September 2002

Increased Alzheimer's disease neuropathology is associated with type 2 diabetes and ApoE ε.4 carrier status

scientific article

Increased expression of the urokinase plasminogen-activator receptor in amyloid beta peptide-treated human brain microglia and in AD brains

scientific article published in February 2002

Increased expression of toll-like receptor 3, an anti-viral signaling molecule, and related genes in Alzheimer's disease brains

scientific article published on 01 August 2018

Is There Inflammatory Synergy in Type II Diabetes Mellitus and Alzheimer’s Disease? ⬇️

scientific article published on June 21, 2012

Localization of Thioredoxin-Interacting Protein in Aging and Alzheimer’s Disease Brains

scientific article published in 2022

Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits

scientific article

Microglia activation and anti-inflammatory regulation in Alzheimer's disease

scientific article

Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin

scientific article published on 23 July 2019

Microglial Progranulin: Involvement in Alzheimer's Disease and Neurodegenerative Diseases

scholarly article by Anarmaa Mendsaikhan et al published 11 March 2019 in Cells

Modeling Alzheimer's disease immune therapy mechanisms: interactions of human postmortem microglia with antibody-opsonized amyloid beta peptide

scientific article published in November 2002

Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

scientific article

PINK1 signalling rescues amyloid pathology and mitochondrial dysfunction in Alzheimer's disease

scientific article published on 25 October 2017

Parkinson disease with dementia: comparing patients with and without Alzheimer pathology

scientific article published on July 2009

Parkinson's Disease Dementia and Potential Therapeutic Strategies ⬇️

scientific article published on December 28, 2010

Parkinson's disease, cortical dysfunction, and alpha-synuclein

scientific article

Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer's Disease Brains

scientific article published on 20 January 2020

Peripheral Synucleinopathy in Early Parkinson's Disease: Submandibular Gland Needle Biopsy Findings

scientific article published on 22 January 2016

Peripheral synucleinopathy in early Parkinson's disease: Submandibular gland needle biopsy findings

scientific article published on 01 May 2017

Perturbations in calcium-mediated signal transduction in microglia from Alzheimer's disease patients

scientific article published on August 2005

Phosphorylated α-synuclein in the retina is a biomarker of Parkinson's disease pathology severity

scientific article published on 08 May 2018

Plasma Levels of Aβ42 and Tau Identified Probable Alzheimer's Dementia: Findings in Two Cohorts

scientific article published on 24 July 2017

Postmortem interval effect on RNA and gene expression in human brain tissue

scientific article

Pre- and post-synaptic cortical cholinergic deficits are proportional to amyloid plaque presence and density at preclinical stages of Alzheimer's disease

scientific article

Presence of Striatal Amyloid Plaques in Parkinson's Disease Dementia Predicts Concomitant Alzheimer's Disease: Usefulness for Amyloid Imaging ⬇️

scientific article published on January 1, 2012

Quantitative appraisal of ventricular cerebrospinal fluid biomarkers in neuropathologically diagnosed Parkinson's disease cases lacking Alzheimer's disease pathology

scientific article published on 12 March 2013

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice

scientific article published on 30 September 2004

RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease

scientific article published on 11 November 2009

RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease

scientific article published in December 2007

Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's disease

scientific article

Reduced clinical and postmortem measures of cardiac pathology in subjects with advanced Alzheimer's Disease ⬇️

scientific article published on January 25, 2011

Reduced striatal tyrosine hydroxylase in incidental Lewy body disease

scientific article

Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease

scientific article

Sorl1 as an Alzheimer's disease predisposition gene?

scientific article published on 01 November 2007

Striatal Amyloid Plaque Density Predicts Braak Neurofibrillary Stage and Clinicopathological Alzheimer's Disease: Implications for Amyloid Imaging ⬇️

scientific article published on January 1, 2012

Studies on Colony Stimulating Factor Receptor-1 and Ligands Colony Stimulating Factor-1 and Interleukin-34 in Alzheimer's Disease Brains and Human Microglia

scientific article published on 09 August 2017

Submandibular gland needle biopsy for the diagnosis of Parkinson disease

scientific article published on 05 February 2014

Substantia nigra Marinesco bodies are associated with decreased striatal expression of dopaminergic markers

scientific article published in April 2004

TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices

scientific article published on 11 November 2014

Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy

scientific article published on 3 July 2008

The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease

scientific article published in October 2016

The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease

scientific article published on 3 February 2016

The Sun Health Research Institute Brain Donation Program: description and experience, 1987-2007

scientific article published on 18 March 2008

The influence of Apolipoprotein E genotype on regional pathology in Alzheimer's disease

scientific article

Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases

scientific article published on 08 December 2020

Thiorphan-induced neprilysin inhibition raises amyloid beta levels in rabbit cortex and cerebrospinal fluid

scientific article published in October 2003

Understanding the neurobiology of CD200 and the CD200 receptor: a therapeutic target for controlling inflammation in human brains?

scientific article published on May 2013

Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction

scientific article published on 28 April 2009

Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus

scientific article published in November 2006

Paulina is supported by:

About Paulina

Help