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List of works by Lyle L Moldawer

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

scientific article

A Novel Drug for Treatment of Necrotizing Soft-Tissue Infections: A Randomized Clinical Trial

scientific article published on 16 April 2014

A Novel Single Cell RNA-seq Analysis of Non-Myeloid Circulating Cells in Late Sepsis

scientific article published on 16 August 2021

A Review of GM-CSF Therapy in Sepsis

scientific article

A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients

scientific article published on 25 November 2020

A better understanding of why murine models of trauma do not recapitulate the human syndrome

scientific article

A checkpoint on innate myeloid cells in pulmonary arterial hypertension

scientific article published on 18 December 2018

A community approach to mortality prediction in sepsis via gene expression analysis.

scientific article published on 15 February 2018

A critical role of CpG motifs in a murine peritonitis model by their binding to highly expressed toll-like receptor-9 on liver NKT cells

scientific article published on 22 September 2006

A dynamic network of transcription in LPS-treated human subjects

scientific article published on 28 July 2009

A genomic score prognostic of outcome in trauma patients

scientific article published on 10 April 2009

A genomic storm in critically injured humans

scientific article published on 21 November 2011

A mouse model for investigating the molecular pathogenesis of adenovirus pneumonia ⬇️

scientific article published on March 1, 1991

A new family of synthetic diterpenes that regulates cytokine synthesis by inhibiting IkappaBalpha phosphorylation

scientific article

A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma

scientific article

A regionalised strategy for improving motor vehicle-related highway driver deaths using a weighted averages method

scientific article

A roadmap from single-cell transcriptome to patient classification for the immune response to trauma

scientific article published on 15 December 2020

Abdominal sepsis patients have a high incidence of chronic critical illness with dismal long-term outcomes

scientific article published on 25 July 2020

Aberrant signaling in the TNFalpha/TNF receptor 1 pathway of the NZM2410 lupus-prone mouse

scientific article published in February 2004

Acute kidney injury is associated with early cytokine changes after trauma

scientific article published on April 2013

Adenoviral gene transfer of an NF-kappaB super-repressor increases collagen deposition in rodent cutaneous wound healing

scientific article

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

scientific article

Age and Sex Influence the Hippocampal Response and Recovery Following Sepsis

scientific article published on 05 July 2019

Aged mice are unable to mount an effective myeloid response to sepsis

scientific article published on 13 December 2013

Aluminum Adjuvant Improves Survival via NLRP3 Inflammasome and Myeloid Non-Granulocytic Cells in a Murine Model of Neonatal Sepsis

scientific article published on 04 August 2020

Analysis of Gene Expression Patterns in Human Postburn Hypertrophic Scars

article

Analysis of factorial time-course microarrays with application to a clinical study of burn injury

scientific article

Anorectic Effects of the Cytokine, Ciliary Neurotropic Factor, Are Mediated by Hypothalamic Neuropeptide Y: Comparison with Leptin* ⬇️

scientific article published on February 1, 1998

Anti-TNF-alpha therapies: the next generation

scientific article

Anti-cytokine and anti-inflammatory therapies for the treatment of severe sepsis: progress and pitfalls

scientific article published in August 2004

Antineoplastic therapy in colorectal cancer through proteasome inhibition

scientific article

Application of genome-wide expression analysis to human health and disease

scientific article

Arginine‐Enhanced Enteral Nutrition Augments the Growth of a Nitric Oxide‐Producing Tumor ⬇️

scientific article published on July 1, 1997

B cells enhance early innate immune responses during bacterial sepsis

scientific article

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

scientific article published on 14 December 2017

Benchmarking outcomes in the critically injured trauma patient and the effect of implementing standard operating procedures.

scientific article published in May 2012

Bioglass attenuates a proinflammatory response in mouse peritoneal endotoxicosis

scientific article published on 01 February 2002

Biological measures for the formulation of a hospital prognostic index ⬇️

scientific article published on 01 October 1981

Biology of interleukin-10 and its regulatory roles in sepsis syndromes

scientific article

Biology of tumor necrosis factor-alpha- implications for psoriasis

scientific article published on April 2004

Blocking interleukin-18: a tumor necrosis factor-alpha lesson already learned

scientific article published on 01 August 2003

CD11c+ dendritic cells are required for survival in murine polymicrobial sepsis

scientific article published in September 2005

CD14 receptor occupancy in severe sepsis: results of a phase I clinical trial with a recombinant chimeric CD14 monoclonal antibody (IC14).

scientific article published in May 2004

CXCR3 blockade: a novel anti-sepsis approach?

scientific article published on 21 November 2012

Cancer-induced expansion and activation of CD11b+ Gr-1+ cells predispose mice to adenoviral-triggered anaphylactoid-type reactions

scientific article

Cecal Slurry Injection in Neonatal and Adult Mice

scientific article published on 01 January 2021

Cecal ligation and puncture.

scientific article

Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma

scientific article published on 20 September 2019

Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways

scholarly article

Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis

scientific article published in September 2004

Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome

scientific article published on 02 July 2018

Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study

scientific article published on 13 November 2020

Clinical microfluidics for neutrophil genomics and proteomics.

scientific article

Comparative proteome analyses of human plasma following in vivo lipopolysaccharide administration using multidimensional separations coupled with tandem mass spectrometry.

scientific article published on February 2005

Continuous flow microfluidic device for rapid erythrocyte lysis

scientific article published in November 2004

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F Osuchowski et al published October 2018 in Infection

Cost and Mortality Associated With Postoperative Acute Kidney Injury.

scientific article

Critical role for CXC ligand 10/CXC receptor 3 signaling in the murine neonatal response to sepsis.

scientific article

Current Epidemiology of Surgical Sepsis: Discordance Between Inpatient Mortality and 1-year Outcomes

scientific article published on 01 September 2019

Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling

scientific article published on 03 February 2010

Cytokine profile after lung transplantation: correlation with allograft injury

scientific article published on 01 May 2006

Cytokines and wound healing: the role of cytokine and anticytokine therapy in the repair response

scientific article published on March 2004

DAMPs, PAMPs, and the origins of SIRS in bacterial sepsis

scientific article published on January 2013

DISTINCT IMMUNOLOGIC ENDOTYPES ARE ASSOCIATED WITH CLINICAL TRAJECTORY AFTER SEVERE BLUNT TRAUMA AND HEMORRHAGIC SHOCK

scientific article published on 17 November 2020

Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists.

scientific article published on 30 June 2008

Delayed emergency myelopoiesis following polymicrobial sepsis in neonates

scientific article

Delayed neutralization of interferon-gamma prevents lethality in primate Gram-negative bacteremic shock.

scientific article

Determination of burn patient outcome by large-scale quantitative discovery proteomics

scientific article published on June 2013

Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients

scientific article published on May 2013

Development of a novel, nonimmunogenic, soluble human TNF receptor type I (sTNFR-I) construct in the baboon ⬇️

scientific article published on November 1, 2001

Differences in outcome between obese and nonobese patients following severe blunt trauma are not consistent with an early inflammatory genomic response

scientific article

Differential toll-like receptor expression after ex vivo lipopolysaccharide exposure in patients with sepsis and following surgical stress

scientific article published on 06 March 2006

Direct evidence for tumor necrosis factor-alpha signaling in arteriogenesis

scientific article

Do Tregs link sepsis to tumor growth?

scientific article published on 01 June 2010

Downstream mediators of the intratumoral interferon response suppress antitumor immunity, induce gemcitabine resistance and associate with poor survival in human pancreatic cancer.

scientific article published on 30 September 2015

Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult

scientific article published on 13 October 2017

Early blood biomarkers predict organ injury and resource utilization following complex cardiac surgery

scientific article

Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress

scientific article published on 28 October 2019

Effect of ibuprofen on fever and metabolic changes induced by continuous infusion of leukocytic pyrogen (interleukin 1) or endotoxin ⬇️

scientific article published on December 1, 1983

Enhanced Collagen Accumulation Following Direct Transfection of the Inducible Nitric Oxide Synthase Gene in Cutaneous Wounds ⬇️

scientific article published on May 29, 1998

Evidence for Persistent Immune Suppression in Patients WHO Develop Chronic Critical Illness After Sepsis

scientific article published on 6 September 2017

Evidence that brief stress may induce the acute phase response in rats ⬇️

scientific article published on December 1, 1997

Exogenous Human Recombinant Interleukin-10 Attenuates Hindlimb Ischemia–Reperfusion Injury ⬇️

scientific article published on 01 May 1997

Exogenously administered interleukin-10 decreases pulmonary neutrophil infiltration in a tumor necrosis factor–dependent murine model of acute visceral ischemia ⬇️

scientific article published on 01 July 1997

Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions

scientific article published on 20 July 2005

Functional genomics and gene expression profiling in sepsis: beyond class prediction

scientific article

Functional modification of dendritic cells with recombinant adenovirus encoding interleukin 10 for the treatment of sepsis.

scientific article published in June 2005

GENOME-WIDE MONOCYTIC mRNA EXPRESSION IN POLYTRAUMA PATIENTS FOR IDENTIFICATION OF CLINICAL OUTCOME

scientific article published on 01 July 2005

Gene Expression Patterns in Peripheral Blood Leukocytes in Patients with Recurrent Ciguatera Fish Poisoning: Preliminary Studies

scientific article published on July 2016

Genetic determinants of lipopolysaccharide and D-galactosamine-mediated hepatocellular apoptosis and lethality ⬇️

scientific article published on January 1, 2001

Genetic polymorphisms, functional genomics and the host inflammatory response to injury and inflammation.

scientific article

Genomic and proteomic determinants of lower extremity revascularization failure: rationale and study design

scientific article

Genomic and proteomic determinants of outcome in patients undergoing thoracoabdominal aortic aneurysm repair

scientific article published in June 2004

Genomic responses in mouse models poorly mimic human inflammatory diseases

scientific article (publication date: 26 February 2013)

HMGB1 as a therapeutic target for sepsis: it's all in the timing!

scientific article published on 30 January 2014

High dynamic range characterization of the trauma patient plasma proteome

scientific article published on 9 May 2006

Histological chorioamnionitis shapes the neonatal transcriptomic immune response.

scientific article published on 15 June 2016

Host responses to sepsis vary in different low-lethality murine models

scientific article

Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock

scientific article

Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment.

scientific article published on 18 November 2016

Human leukocyte antigen expression in sepsis: what have we learned?

scientific article published on 01 January 2005

Human transcriptome array for high-throughput clinical studies.

scientific article

Hyperacute Monocyte Gene Response Patterns Are Associated With Lower Extremity Vein Bypass Graft Failure

scientific article published on 01 March 2018

Hypothermia induces interleukin-10 and attenuates injury in the lungs of endotoxemic rats.

scientific article

ICU-Acquired Weakness, Chronic Critical Illness, and the Persistent Inflammation-Immunosuppression and Catabolism Syndrome

scientific article published in November 2017

Identification and interpretation of longitudinal gene expression changes in trauma

scientific article

Immediate postoperative inflammatory response predicts long-term outcome in lung-transplant recipients

scientific article

Immune Checkpoint Inhibition in Sepsis: A Phase 1b Randomized, Placebo-Controlled, Single Ascending Dose Study of Antiprogrammed Cell Death-Ligand 1 Antibody (BMS-936559)

scientific article published on 01 May 2019

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab

scientific article published on 01 October 2019

Immunological Defects in Neonatal Sepsis and Potential Therapeutic Approaches.

scientific article published on 07 February 2017

Immunotherapies for COVID-19: lessons learned from sepsis

scientific article published on 28 April 2020

Immunotherapy: It is not just for cancer anymore

scientific article published on 3 January 2018

Impact of Early-Life Exposures to Infections, Antibiotics, and Vaccines on Perinatal and Long-term Health and Disease.

scientific article

Impact of exogenous growth hormone on host preservation and tumor cell-cycle distribution in a rat sarcoma model ⬇️

scientific article published on 01 August 1991

Impact of toll-like receptor 4 stimulation on human neonatal neutrophil spontaneous migration, transcriptomics, and cytokine production

scientific article published on 28 May 2018

Impaired autophagy: A mechanism of mitochondrial dysfunction in anoxic rat hepatocytes

scientific article published on May 2008

Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation

scientific article published on June 2015

In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen

scientific article published in October 2007

Incidence, clinical predictors, genomics, and outcome of acute kidney injury among trauma patients.

scientific article

Increased Leptin Expression in Mice with Bacterial Peritonitis is Partially Regulated by Tumor Necrosis Factor Alpha ⬇️

scientific article published on April 1, 1998

Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor ⬇️

scientific article published on September 25, 1998

Increased lymphoid tissue apoptosis in baboons with bacteremic shock

scientific article published in June 2004

Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis

scientific article published in December 2007

Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis.

scientific article

Increased survival in sepsis by in vivo adenovirus-induced expression of IL-10 in dendritic cells

scientific article published on 01 April 2002

Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer

scientific article published on August 2004

Influence of age and sex on microRNA response and recovery in the hippocampus following sepsis

scientific article published on 30 January 2022

Influence of recombinant adenovirus on liver injury in endotoxicosis and its modulation by IL-10 expression

scientific article published in January 2004

Inhibition of NF-kappa B augments sensitivity to 5-fluorouracil/folinic acid in colon cancer.

scientific article published on August 2004

Inhibition of transforming growth factor alpha stimulation of human squamous cell carcinoma of the head and neck with anti-TGF-α antibodies and tyrphostin ⬇️

scientific article published on 01 December 1997

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

scientific article published on 4 April 2018

Insulin-like growth factor I preserves host lean tissue mass in cancer cachexia

scientific article published on 01 March 1992

Integrating "big data" into surgical practice.

scientific article

Interleukin 1 receptor blockade attenuates the host inflammatory response ⬇️

scientific article published on July 1, 1990

Interleukin 1: an important mediator of host resistance against Pneumocystis carinii ⬇️

scientific article published on September 1, 1992

Interleukin 6, but not ciliary neurotrophic factor or leukaemia inhibitory factor, is responsible for the acute phase response to turpentine-induced myositis ⬇️

scientific article published on June 1, 1998

Interleukin-1 and interleukin-1 antagonism in sepsis, systemic inflammatory response syndrome, and septic shock ⬇️

scientific article published on 01 April 1995

Interleukin-10 fails to modulate low shear stress-induced neointimal hyperplasia

scientific article published in February 2002

Interleukin-10: a complex role in the pathogenesis of sepsis syndromes and its potential as an anti-inflammatory drug

scientific article

Interleukin-18: a novel prognostic cytokine in bacteria-induced sepsis

scientific article

Interleukin-6 and STAT3 protect the liver from hepatic ischemia and reperfusion injury during ischemic preconditioning

scientific article published on 23 August 2006

Interleukin-6: Still crazy after all these years

scientific article published on 01 October 2006

Is there value in plasma cytokine measurements in patients with severe trauma and sepsis?

scientific article published on 11 May 2013

LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock

scientific article published on 18 September 2019

LPS Stimulation of Cord Blood Reveals a Newborn-Specific Neutrophil Transcriptomic Response and Cytokine Production.

scientific article published on May 2017

Large-scale multiplexed quantitative discovery proteomics enabled by the use of an (18)O-labeled "universal" reference sample

scientific article published on January 2009

Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y ⬇️

scientific article published on January 2, 1998

Leptin produces anorexia and weight loss without inducing an acute phase response or protein wasting ⬇️

scientific article published on June 1, 1998

Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice

scientific article published on 2 February 2006

Longitudinal studies of inter-alpha inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis

scientific article published on 01 February 2007

Magic bullets and surrogate biomarkers circa 2009.

scientific article published on May 2009

Maintenance of anti-Sm/RNP autoantibody production by plasma cells residing in ectopic lymphoid tissue and bone marrow memory B cells.

scientific article published on 18 March 2013

Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes

scientific article published on 22 April 2009

Maturation of murine bone marrow-derived dendritic cells with poly(I:C) produces altered TLR-9 expression and response to CpG DNA.

scientific article published on 22 September 2006

Metalloproteinase inhibitors and wound healing: A novel enhancer of wound strength ⬇️

scientific article published on 01 August 1998

Mice are not men.

scientific article published on 24 December 2014

Microbial recognition and danger signals in sepsis and trauma

scientific article published on 20 January 2017

Microfluidic isolation of leukocytes from whole blood for phenotype and gene expression analysis

scientific article

Microfluidic leukocyte isolation for gene expression analysis in critically ill hospitalized patients

scientific article

Microfluidics-based capture of human neutrophils for expression analysis in blood and bronchoalveolar lavage

scientific article published on 19 September 2011

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

scholarly article by Marcin F. Osuchowski et al published 14 August 2018 in Infection

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis

Molecular characterization of the acute inflammatory response to infections with gram-negative versus gram-positive bacteria

scientific article

Monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations

scientific article

Mopeds and Scooters: Crash Outcomes in a High Traffic State ⬇️

scientific article published on July 1, 2011

Mouse Injury Model of Polytrauma and Shock.

scientific article published in January 2018

Murine Models of Sepsis and Trauma: Can We Bridge the Gap?

scientific article

MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis

scientific article

MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery

scientific article published on 27 February 2018

Myeloid-Derived Suppressor Cells and Pulmonary Hypertension

scholarly article by Andrew J Bryant published in August 2018

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis

scientific article published on 13 November 2019

Myeloid-derived suppressor cells in cancer cachexia syndrome: a new explanation for an old problem.

scientific article

Myeloid-derived suppressor cells in sepsis: friend or foe?

scientific article published on 03 May 2012

Neutrophil chemotaxis and transcriptomics in term and preterm neonates

scientific article published in September 2017

Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.

scientific article

Neutrophil mobilization from the bone marrow during polymicrobial sepsis is dependent on CXCL12 signaling

scientific article

Nitric Oxide Contributes to Adriamycin's Antitumor Effect ⬇️

scientific article published on 01 May 1997

Novel role for tumor-induced expansion of myeloid-derived cells in cancer cachexia

scientific article

Obese patients show a depressed cytokine profile following severe blunt injury.

scientific article published on March 2012

Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model

scientific article published on 01 November 2019

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival

scientific article published on 15 April 2020

Opening the window on genome-wide expression analyses in sepsis

scientific article published on 01 October 2007

Parallels between cancer and infectious disease

scientific article published on July 2014

Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis

scientific article published on 17 November 2015

Peaks of endogenous G-CSF serum concentrations are followed by an increase in respiratory burst activity of granulocytes in patients with septic shock

scientific article published in March 2002

Persistent Inflammation, Immunosuppression and Catabolism Syndrome.

scientific article published on April 2017

Persistent inflammation and anemia among critically ill septic patients

scientific article published on 01 February 2019

Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care

scientific article published on June 2012

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery

scientific article published on 26 May 2018

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma

scientific article

Persistently Elevated Glucagon-Like Peptide-1 Levels among Critically Ill Surgical Patients after Sepsis and Development of Chronic Critical Illness and Dismal Long-Term Outcomes

scientific article published on 13 April 2019

Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness

scientific article published on 31 December 2019

Pharmacokinetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon ⬇️

scientific article published on 01 April 1998

Phenotypic heterogeneity by site of infection in surgical sepsis: a prospective longitudinal study

scientific article published on 07 May 2020

Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis.

scientific article

Plasma proteome response to severe burn injury revealed by 18O-labeled "universal" reference-based quantitative proteomics

scientific article

Pleiotropic IFN-dependent and -independent effects of IRF5 on the pathogenesis of experimental lupus

scientific article published on 14 March 2012

Postnatal Age Is a Critical Determinant of the Neonatal Host Response to Sepsis

scientific article

Preclinical models of shock and sepsis: what can they tell us?

scientific article

Premise for Standardized Sepsis Models

scientific article published on 01 January 2019

Pro- and antiinflammatory cytokine production after radiofrequency ablation of unresectable hepatic tumors

scientific article

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

scientific article published on 24 June 2019

Prospective Validation of a Transcriptomic Metric in Severe Trauma

scientific article published on 24 January 2019

Protective immunity and defects in the neonatal and elderly immune response to sepsis

scientific article published on 03 March 2014

Quantitative proteome analysis of human plasma following in vivo lipopolysaccharide administration using 16O/18O labeling and the accurate mass and time tag approach.

scientific article

Reply to "Do Not Blame the Rodent for the Failure of Developing Sepsis Therapies"

scientific article published on 04 November 2020

Revisiting the Role of Tumor Necrosis Factor α and the Response to Surgical Injury and Inflammation ⬇️

scientific article published on May 1, 1998

Role of Innate Immunity in Neonatal Infection ⬇️

scientific article published on January 7, 2013

Role of Toll-like receptors in the development of sepsis

scientific article published on March 2008

Role of endogenous interleukin-10 in local and distant organ injury after visceral ischemia-reperfusion

scientific article

Roles of vaccinia virus genes E3L and K3L and host genes PKR and RNase L during intratracheal infection of C57BL/6 mice

scientific article

Selective activation of peripheral blood T cell subsets by endotoxin infusion in healthy human subjects corresponds to differential chemokine activation

scientific article published on 01 November 2005

Sepsis Diagnostics: From Discovery to Application

scientific article published in January 2017

Sepsis Pathophysiology, Chronic Critical Illness, and Persistent Inflammation-Immunosuppression and Catabolism Syndrome

scientific article published on 14 September 2016

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients

scientific article

Sepsis and septic shock

Sepsis and the dendritic cell

scientific article published on November 2003

Sepsis induces early alterations in innate immunity that impact mortality to secondary infection

scientific article

Sepsis is associated with reduced spontaneous neutrophil migration velocity in human adults

scientific article published in PLoS ONE

Septic Stability? Gut Microbiota in Young Adult MICE Maintains Overall Stability After Sepsis Compared to Old Adult MICE

scientific article published on 20 August 2020

Severe immunosuppression and not a cytokine storm characterize COVID-19 infections

scientific article published on 20 July 2020

Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock

scientific article published on 14 June 2016

Single Cell RNA-SEQ of Human Myeloid Derived Suppressor Cells in Late Sepsis Reveals Multiple Subsets with Unique Transcriptional Responses: A Pilot Study

scientific article published on 05 October 2020

Soluble human p55 and p75 tumor necrosis factor receptors reverse spontaneous arthritis in transgenic mice expressing transmembrane tumor necrosis factor alpha

scientific article published in September 2006

Splenic transposition is superior to caudal shunt as a model of murine total hepatic ischemia

scientific article published on 01 January 2005

Stored packed red blood cell transfusion up-regulates inflammatory gene expression in circulating leukocytes

scientific article published in July 2007

Structural basis for the proinflammatory cytokine activity of high mobility group box 1

scientific article

Superoxide production by macrophages and T cells is critical for the induction of autoreactivity and type 1 diabetes

scientific article

Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents

scientific article

TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis

scientific article

Targeting IL-17A attenuates neonatal sepsis mortality induced by IL-18.

scientific article published on 25 April 2016

Temporal patterns of gene expression in murine cutaneous burn wound healing

scientific article published on 13 February 2004

The Effect of Aging Physiology on Critical Care

scientific article published on 28 October 2020

The Epidemiology of Chronic Critical Illness After Severe Traumatic Injury at Two-Level One Trauma Centers

scientific article

The Postinjury Inflammatory State and the Bone Marrow Response to Anemia

scientific article published on 01 September 2018

The Role of Cytokines in Cancer Cachexia ⬇️

scientific article published on 01 November 1992

The authors reply

The authors reply

The changing pattern and implications of multiple organ failure after blunt injury with hemorrhagic shock.

scientific article

The future of murine sepsis and trauma research models

scientific article

The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients

scientific article published on 01 August 2018

The inflammatory milieu within the pancreatic cancer microenvironment correlates with clinicopathologic parameters, chemoresistance and survival

scientific article published on 24 October 2015

The metabolic effects of pokeweek mitogen in mice ⬇️

scientific article published on January 1, 1998

The origins of cachexia in acute and chronic inflammatory diseases.

scientific article

The role of NIGMS P50 sponsored team science in our understanding of multiple organ failure

scientific article published on 22 May 2017

Tolerance to endotoxin prevents mortality in infected thermal injury: association with attenuated cytokine responses

scientific article published on 01 May 1992

Traditional resuscitative practices fail to resolve metabolic acidosis in morbidly obese patients after severe blunt trauma.

scientific article published on February 2010

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis

scientific article published on 02 November 2020

Transfection of the Type II TGF-β Receptor Into Colon Cancer Cells Increases Receptor Expression, Inhibits Cell Growth, and Reduces the Malignant Phenotype ⬇️

scientific article published on June 1, 1998

Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis

scientific article

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo ⬇️

scientific article published on June 1, 1992

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.

scientific article

Unique transcriptomic response to sepsis is observed among patients of different age groups.

scientific article published on 8 September 2017

Using innate immunity to characterize the host response to microbial invasion in severe sepsis

scientific article published on April 2008

Variable requirement of dendritic cells for recruitment of NK and T cells to different TLR agonists

scientific article published on 01 March 2007

Varying blood monocyte and dendritic cell responses after laparoscopic versus open gastric bypass surgery

scientific article published on 01 November 2005

What is the role for the inflammasome in burn injury and sepsis?

scientific article published on January 2012

What's New in Shock, February 2019?

scientific article published on 01 February 2019

What's New in Shock, January 2016?

scientific article published on 01 January 2016

What's New in Shock, September 2016?

scientific article

What's new in Shock, June 2006?

scientific article published on 01 June 2006

What's new in Shock, October 2014?

scientific article published on 01 October 2014

What’s New in Shock? February 2013 ⬇️

scientific article published on February 1, 2013

β-Blockade use for Traumatic Injuries and Immunomodulation: A Review of Proposed Mechanisms and Clinical Evidence

scientific article published on 11 May 2016

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