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List of works by Roger F Butterworth

"PAINFUL LEG" FOLLOWING STROKES ⬇️

scientific article published on 01 November 1963

"Peripheral-type" (mitochondrial) benzodiazepine receptors in hepatic encephalopathy

scientific article published on January 1993

A DEVICE FOR TREATING PRESSURE SORES AROUND THE ANKLES

scientific article published on 01 May 1965

A NEW X-RAY CONTRAST MEDIUM FOR DISPLAYING CADAVER VESSELS ⬇️

scientific article published on 01 September 1964

A PNEUMATIC DEVICE FOR CORRECTING KNEE-JOINT CONTRACTURES ⬇️

scientific article published on 01 May 1965

A case of tick typhus.

scientific article published in October 1952

A device for producing realistic pulsation of a dead heart

scientific article published on 01 September 1951

A device for treating pressure sores around the ankle ⬇️

scientific article published on November 27, 1971

A high-affinity [3H]tryptamine binding site in human brain

scientific article published on 01 January 1995

A new operating cardioscope

scientific article published on 01 September 1951

A new type of eye endoscope

scientific article

A new x-ray contrast medium for displaying cadaver vessels

scientific article published on 01 January 1966

A profile of cerebral and hepatic carnitine, ammonia, and energy metabolism in a model of organic aciduria: BALB/cByJ mouse with short-chain acyl-CoA dehydrogenase deficiency

scientific article published in October 1993

A quantitative autoradiographic study of muscarinic cholinergic receptor subtypes in the brains of pyrithiamine-treated rats

scientific article published on 01 August 1995

A reliable method for the simultaneous estimation of dopamine, noradrenaline and serotonin in discrete areas of brain ⬇️

scientific article published on October 1, 1975

Abnormalities of peripheral nerve conduction in relation to thiamine status in alcoholic patients

scientific article published on 01 May 1991

Accumulation and Removal of Hg203 in Different Regions of the Rat Brain ⬇️

scientific article published on November 1, 1978

Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pathogenesis of hepatic encephalopathy?

scientific article published on 01 December 1995

Active pyruvate dehydrogenase in platelets from Friedreich's ataxia patients

scientific article published on 01 November 1980

Activities of monoamine oxidase-A and -B are altered in the brains of congenitally hyperammonemic sparse-fur (spf) mice

scientific article

Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy

scientific article published in December 1987

Activities of thiamine-dependent enzymes in two experimental models of thiamine deficiency encephalopathy: 3. Transketolase

scientific article published on 01 March 1987

Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy. 2. alpha-Ketoglutarate dehydrogenase

scientific article published in April 1986

Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 1. The pyruvate dehydrogenase complex

scientific article published in October 1985

Acute liver failure: a critical appraisal of available animal models

scientific article

Affinities and densities of high-affinity [3H]muscimol (GABA-A) binding sites and of central benzodiazepine receptors are unchanged in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

scientific article published in September 1988

Alcohol-thiamine interactions: an update on the pathogenesis of Wernicke encephalopathy

scientific article

Alterations in expression of genes coding for key astrocytic proteins in acute liver failure ⬇️

scientific article published on December 1, 2001

Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure

scientific article

Alterations in serotonin parameters in brain of thiamine-deficient rats are evident prior to the appearance of neurological symptoms.

scientific article published in September 1996

Alterations in soluble guanylate cyclase content and modulation by nitric oxide in liver disease.

scientific article published in November 2004

Alterations of [3H]8-OH-DPAT and [3H]ketanserin binding sites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

scientific article published on 01 November 1994

Alterations of neurotransmitter-related gene expression in human and experimental portal-systemic encephalopathy

scientific article

Alterations of thiamine phosphorylation and of thiamine-dependent enzymes in Alzheimer's disease

scientific article published on March 1996

Altered expression of tight junction proteins and matrix metalloproteinases in thiamine-deficient mouse brain.

scientific article

Altered glial-neuronal crosstalk: cornerstone in the pathogenesis of hepatic encephalopathy

scientific article published on 27 March 2010

Amino Acid Changes in Thiamine-Deficient Encephalopathy: Some Implications for the Pathogenesis of Friedreich's Ataxia ⬇️

scientific article published on 01 May 1979

Amino acid changes in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

scientific article published in September 1987

Amino acid changes in regions of the CNS in relation to function in experimental portal-systemic encephalopathy ⬇️

scientific article published on September 1, 1984

Amino acids in autopsied human spinal cord. Selective changes in Friedreich's ataxia

scientific article published on 01 January 1984

Aminoglycoside antibiotics: chemical transformation of paromamine into 3'-epiparomamine.

scientific article

Ammonia and hepatic encephalopathy: the more things change, the more they remain the same.

scientific article

Ammonia and proinflammatory cytokines modify expression of genes coding for astrocytic proteins implicated in brain edema in acute liver failure

scientific article published on 10 March 2010

Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats

scientific article published in March 1992

Ammonia induces MK-801-sensitive nitration and phosphorylation of protein tyrosine residues in rat astrocytes

scientific article

Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis

scientific article

Ammonia-induced swelling of rat cerebral cortical slices: implications for the pathogenesis of brain edema in acute hepatic failure

scientific article published on 01 September 1989

Ammonia: key factor in the pathogenesis of hepatic encephalopathy

scientific article published on February 1987

Ammonium acetate challenge in experimental chronic hepatic encephalopathy induces a transient increase of brain 5-HT release in vivo

scientific article

An image of the brain in patients with liver disease ⬇️

scientific article published on December 1, 1997

An interaction between benzodiazepines and neuroactive steroids at GABA A receptors in cultured hippocampal neurons

scientific article published on 17 February 2006

An update on the role of brain glutamine synthesis and its relation to cell-specific energy metabolism in the hyperammonemic brain: further studies using NMR spectroscopy

scientific article

Antioxidant and anti-inflammatory effects of mild hypothermia in the attenuation of liver injury due to azoxymethane toxicity in the mouse.

scientific article published on 3 March 2010

Antipyretics and Reye's syndrome

scientific article published on 01 August 1998

Apomorphine and piribedil in rats: biochemical and pharmacologic studies

scientific article published on January 1, 1975

Apomorphine: sterotyped behavior and regional distribution in rat brain

scientific article published in March 1975

Arginine-related guanidino compounds and nitric oxide synthase in the brain of ornithine transcarbamylase deficient spf mutant mouse: effect of metabolic arginine deficiency

scientific article published in September 1996

Aromatic and branched-chain amino acids in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

scientific article

Assessment of bioaccumulation and neurotoxicity in rats with portacaval anastomosis and exposed to manganese phosphate: a pilot study ⬇️

scientific article published on December 1, 2001

Assessment of bioaccumulation, neuropathology, and neurobehavior following subchronic (90 days) inhalation in Sprague-Dawley rats exposed to manganese phosphate

scientific article published in September 2002

Beneficial effects of L-ornithine L-aspartate for prevention of overt hepatic encephalopathy in patients with cirrhosis: a systematic review with meta-analysis

scientific article published on 23 July 2019

Benzodiazepine receptors and hepatic encephalopathy

scientific article published on March 1990

Bilirubin metabolism - preliminary investigation

scientific article published in November 1976

Bioaccumulation and locomotor effect of manganese dust in rats

scientific article published in July 2001

Brain GABA and benzodiazepine receptors in hepatic encephalopathy

scientific article published on July 1990

Brain edema and encephalopathy in acute liver failure: a primary neurogliopathy? ⬇️

scientific article published on February 27, 2012

Brain edema in acute liver failure.

scientific article published on December 2003

Brain extracellular quinolinic acid in chronic experimental hepatic encephalopathy as assessed by in vivo microdialysis: acute effects of L-tryptophan

scientific article published in October 1996

Brain histamine in experimental acute liver failure: effects of L-histidine loading

scientific article published on 5 March 2004

Brain lactate synthesis in thiamine deficiency: a re-evaluation using 1H-13C nuclear magnetic resonance spectroscopy

scientific article published in January 2005

Brain tryptophan hydroxylation in the portacaval shunted rat: a hypothesis for the regulation of serotonin turnover in vivo

scientific article published on March 1991

Cell-selective effects of ammonia on glutamate transporter and receptor function in the mammalian brain ⬇️

scientific article published on September 1, 2003

Central muscarinic cholinergic M1 and M2 receptor changes in congenital ornithine transcarbamylase deficiency

scientific article

Cerebellar ataxia produced by 3-acetyl pyridine in rat.

scientific article

Cerebral GABA-ergic and glutamatergic function in hepatic encephalopathy

scientific article published on February 1987

Cerebral aminoacids in portal-systemic encephalopathy: lack of evidence for altered gamma-aminobutyric acid (GABA) function

scientific article

Cerebral dysfunction in chronic alcoholism: role of alcoholic liver disease

scientific article

Cerebral inflammation contributes to encephalopathy and brain edema in acute liver failure: protective effect of minocycline

scientific article published on 7 February 2009

Cerebral thiamine-dependent enzyme changes in experimental Wernicke's encephalopathy

scientific article

Cerebral vulnerability is associated with selective increase in extracellular glutamate concentration in experimental thiamine deficiency

scientific article published on 01 September 1993

Cerebrospinal fluid amino acids in relation to neurological status in experimental portal-systemic encephalopathy ⬇️

scientific article published on June 1, 1991

Characterization of binding sites for the ω3 receptor ligands []PK11195 and []RO5-4864 in human brain ⬇️

scientific article published on December 4, 1997

Choline acetyltransferase and acetylcholinesterase activities are unchanged in brain in human and experimental portal-systemic encephalopathy

scientific article published on 01 December 1994

Chronic exposure of rat primary astrocyte cultures to manganese results in increased binding sites for the 'peripheral-type' benzodiazepine receptor ligand 3H-PK 11195.

scientific article published in August 1999

Clinical laboratory findings in Friedreich's ataxia

scientific article published on 01 November 1976

Complications of cirrhosis III. Hepatic encephalopathy

scientific article

Current theories on the pathogenesis of hepatic encephalopathy

scientific article published on September 1994

Decreased activities of thiamine diphosphatase in frontal and temporal cortex in Alzheimer's disease

scientific article

Decreased beta-actin mRNA expression in hyperglycemic focal cerebral ischemia in the rat.

scientific article published in March 2004

Decreased glutamate transporter (GLT-1) expression in frontal cortex of rats with acute liver failure.

scientific article published in July 1997

Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat.

scientific article published in April 2005

Dehydroepiandrosterone sulphate improves cholestasis-associated fatigue in bile duct ligated rats.

scientific article published on 8 July 2009

Densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand 3H-PK11195 are increased in brain 24 hours following portacaval anastomosis

scientific article published on 01 September 1994

Determination of muscular pyruvate dehydrogenase in 2 experimental ataxia models

scientific article published on 01 April 1977

Developmental deficiency of the cholinergic system in congenitally hyperammonemic spf mice: effect of acetyl-L-carnitine.

scientific article published in July 1995

Diencephalic and cerebellar pathology in alcoholic and nonalcoholic patients with end-stage liver disease ⬇️

scientific article published on October 1, 1997

Differential effects of ammonia on the benzodiazepine modulatory site on the GABA-A receptor complex of human brain

scientific article published in July 2005

Direct evidence for central proinflammatory mechanisms in rats with experimental acute liver failure: protective effect of hypothermia

scientific article published on 4 March 2009

Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure.

scientific article published on 4 January 2006

Distinctive pattern of Bergmann glial pathology in human hepatic encephalopathy ⬇️

scientific article published on August 1, 1997

Early microglial response in experimental thiamine deficiency: an immunohistochemical analysis

scientific article

Editorial: rifaximin and minimal hepatic encephalopathy

scientific article published on 01 February 2011

Effect of Ammonia on Brain Serotonin Metabolism in Relation to Function in the Portacaval Shunted Rat ⬇️

scientific article published on July 1, 1990

Effect of L-carnitine on cerebral and hepatic energy metabolites in congenitally hyperammonemic sparse-fur mice and its role during benzoate therapy

scientific article published in August 1993

Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

scientific article published on January 2006

Effect of alloxan diabetes on cerebellar amino acids

scientific article published on February 1, 1978

Effect of ammonium ions on synaptic transmission in the mammalian central nervous system

scientific article published on August 1, 1992

Effect of asparagine, glutamine and insulin on cerebral amino acid neurotransmitters

scientific article published on 01 November 1980

Effect of portacaval anastomosis on electrically stimulated release of glutamate from rat hippocampal slices

scientific article published in May 1991

Effect of portacaval anastomosis on glutamine synthetase activities in liver, brain, and skeletal muscle

scientific article published on July 1, 1992

Effect of portacaval anastomosis on glutamine synthetase protein and gene expression in brain, liver and skeletal muscle

scientific article published on 01 December 1999

Effect of probenecid on 5-hydroxyindoleacetic acid in cisternal cerebrospinal fluid of rats with portacaval anastomosis

scientific article published on 01 August 1995

Effect of pyrithiamine treatment and subsequent thiamine rehabilitation on regional cerebral amino acids and thiamine-dependent enzymes

scientific article published on 01 April 1989

Effect of sodium benzoate on cerebral and hepatic energy metabolites in spf mice with congenital hyperammonemia

scientific article published in January 1993

Effect of taurine on calcium binding to microsomes isolated from rat cerebral cortex

scientific article published on March 1977

Effect of thiamine deficiency on levels of putative amino acid transmitters in affected regions of the rat brain ⬇️

scientific article published on August 1, 1979

Effects of Glutamate and Aspartate on Ataxic Gait Induced by 3-Acetyl Pyridine in Rats ⬇️

scientific article published on 01 November 1980

Effects of ammonia on glutamate transporter (GLAST) protein and mRNA in cultured rat cortical astrocytes

scientific article published on 01 August 2000

Effects of ammonia on high affinity glutamate uptake and glutamate transporter EAAT3 expression in cultured rat cerebellar granule cells

scientific article published in July 2003

Effects of congenital hyperammonemia on the cerebral and hepatic levels of the intermediates of energy metabolism in spf mice

scientific article published in April 1992

Effects of hyperammonaemia on brain function ⬇️

scientific article published on January 1, 1998

Effects of hypothermia on brain glucose metabolism in acute liver failure: a H/C-nuclear magnetic resonance study.

scientific article published in September 2003

Effects of maternal thiamine deficiency on the development of thiamine-dependent enzymes in regions of the rat brain

scientific article published on 01 January 1989

Effects of ornithine aminotransferase inactivation by 5-fluoromethylornithine in rats following portacaval anastomosis

scientific article published on 01 September 1994

Effects of thiamine deficiency on brain metabolism: implications for the pathogenesis of the Wernicke-Korsakoff syndrome

scientific article

Effects of thiamine deficiency on thiamine-dependent enzymes in regions of the brain of pregnant rats and their offspring

scientific article

Efficacy of l-Ornithine l-Aspartate for the Treatment of Hepatic Encephalopathy and Hyperammonemia in Cirrhosis: Systematic Review and Meta-Analysis of Randomized Controlled Trials

scholarly article by Roger F Butterworth et al published September 2018 in Journal of clinical and experimental hepatology

Epidemic of seasonal ataxia in Nigeria following ingestion of the African SilkwormAnaphe venata: Role of thiamine deficiency? ⬇️

scientific article published on December 1, 1997

Etiology of cirrhosis predicts deterioration of "brain reserve" after hepatic encephalopathy or transjugular intrahepatic portosystemic shunt

scientific article published on 13 June 2015

Evaluation of the Role of NMDA-Mediated Excitotoxicity in the Selective Neuronal Loss in Experimental Wernicke Encephalopathy ⬇️

scientific article published on January 1, 1998

Evidence for a central cholinergic deficit in congenital ornithine transcarbamylase deficiency

scientific article published in January 1998

Evidence for a serotonin transporter deficit in experimental acute liver failure

scientific article

Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.

scientific article published in February 1998

Evidence for an astrocytic glutamate transporter deficit in hepatic encephalopathy

scientific article

Evidence for cholinergic neuronal loss in brain in congenital ornithine transcarbamylase deficiency

scientific article published on 01 August 1994

Evidence for forebrain cholinergic neuronal loss in congenital ornithine transcarbamylase deficiency

scientific article

Evidence for oxidative/nitrosative stress in the pathogenesis of hepatic encephalopathy

scientific article published on 02 March 2010

Excitatory neurons and schizophrenia

scientific article published in November 1998

Experimental models of hepatic encephalopathy: ISHEN guidelines.

scientific article published on July 2009

Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure.

scientific article

Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat.

scientific article published in December 2004

Factors related to age-grade trends and sex differences in children's preferences for comic books

scientific article published on 01 March 1951

Familial Hyperbilirubinemia in Friedreich's Ataxia ⬇️

scientific article published on February 1, 1978

Flumazenil in cirrhotic patients in hepatic coma: a randomized double-blind placebo-controlled crossover trial

scientific article

Glucose and insulin metabolism in Friedreich's ataxia

scientific article published in November 1976

Glucose loading precipitates focal lactic acidosis in the vulnerable medial thalamus of thiamine-deficient rats

scientific article

Glutamate transporter and receptor function in disorders of ammonia metabolism ⬇️

scientific article published on January 1, 2001

Glutamate transporters in hyperammonemia

scientific article

Glutamatergic synaptic dysfunction in hyperammonemic syndromes

scientific article

Glutamic Acid in Spinal-Cord Gray Matter in Friedreich's Ataxia ⬇️

scientific article published on September 30, 1982

Hepatic Encephalopathy in Acute Liver Failure: Role of the Glutamate System ⬇️

scientific article published on January 1, 1997

Hepatic Encephalopathy in Cirrhosis: Pathology and Pathophysiology

article published in 2019

Hepatic encephalopathy

scientific article published on 01 January 2003

Hepatic encephalopathy and brain edema in acute hepatic failure: does glutamate play a role?

scientific article published in April 1997

Hepatic encephalopathy in alcoholic cirrhosis

scientific article

Hepatic encephalopathy in cirrhotic and portacaval shunted dogs: lack of changes in brain GABA uptake, brain GABA levels, brain glutamic acid decarboxylase activity and brain postsynaptic GABA receptors

scientific article published on 01 July 1988

Hepatic encephalopathy--a serious complication of alcoholic liver disease.

scientific article published in January 2003

Hepatic encephalopathy: A central neuroinflammatory disorder? ⬇️

scientific article published on April 1, 2011

Hepatic encephalopathy: An update of pathophysiologic mechanisms

scientific article

Hepatic encephalopathy: a neuropsychiatric disorder involving multiple neurotransmitter systems

scientific article

Hepatoprotection by L-Ornithine L-Aspartate in Non-Alcoholic Fatty Liver Disease.

scientific article

How important are brain banks for alcohol research?

scientific article published in February 2003

Hypokinesia produced by anterolateral hypothalamic 6-hydroxydopamine lesions and its reversal by some antiparkinson drugs ⬇️

scientific article published on January 1, 1978

Hypothermia attenuates oxidative/nitrosative stress, encephalopathy and brain edema in acute (ischemic) liver failure

scientific article

IL-1 or TNF receptor gene deletion delays onset of encephalopathy and attenuates brain edema in experimental acute liver failure

scientific article published on 17 November 2009

Images of the brain in chronic liver failure ⬇️

scientific article published on November 1, 2001

Immunohistochemical detection of inducible nitric oxide synthase, nitrotyrosine and manganese superoxide dismutase following hyperglycemic focal cerebral ischemia.

scientific article published in November 2001

Impaired oxidation of branched-chain amino acids in the medial thalamus of thiamine-deficient rats

scientific article

In vivo microdialysis in an animal model of neurological disease: thiamine deficiency (Wernicke) encephalopathy

scientific article

Increased "peripheral-type" benzodiazepine receptor sites and mRNA in thalamus of thiamine-deficient rats

scientific journal article

Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo

scientific article published on 4 May 2010

Increased activities of MAOA and MAOB in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

scientific article published on 01 September 1993

Increased blood manganese in cirrhotic patients: relationship to pallidal magnetic resonance signal hyperintensity and neurological symptoms

scientific article

Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy

scientific article published in July 2005

Increased brain concentrations of endogenous (non-benzodiazepine) GABA-A receptor ligands in human hepatic encephalopathy

scientific article published in December 2004

Increased brain content of the endogenous benzodiazepine receptor ligand, octadecaneuropeptide (ODN), following portacaval anastomosis in the rat.

scientific article published in January 1991

Increased brain endothelial nitric oxide synthase expression in thiamine deficiency: relationship to selective vulnerability

scientific article published in July 2004

Increased brain serotonin turnover correlates with the degree of shunting and hyperammonemia in rats following variable portal vein stenosis

scientific article published in May 2004

Increased cerebrospinal fluid lactate reflects deterioration of neurological status in experimental portal-systemic encephalopathy

scientific article published in December 1991

Increased concentrations of histamine and its metabolite, tele-methylhistamine and down-regulation of histamine H3 receptor sites in autopsied brain tissue from cirrhotic patients who died in hepatic coma

scientific article

Increased densities of binding sites for the "peripheral-type" benzodiazepine receptor ligand [3H]PK11195 in vulnerable regions of the rat brain in thiamine deficiency encephalopathy

scientific article

Increased densities of binding sites for the 'peripheral-type' benzodiazepine receptor ligand [3H]PK 11195 in rat brain following portacaval anastomosis

scientific article published on July 10, 1992

Increased densities of binding sites for the peripheral-type benzodiazepine receptor ligand [3H]PK 11195 in congenital ornithine transcarbamylase-deficient sparse fur mouse

scientific article published on 01 December 1993

Increased densities of peripheral-type benzodiazepine receptors in brain autopsy samples from cirrhotic patients with hepatic encephalopathy

scientific article

Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy

scientific article published on March 1997

Increased endogenous neuropeptide ligand for benzodiazepine receptors in hepatic encephalopathy

scientific article published on 01 April 1990

Increased expression of glyceraldehyde-3-phosphate dehydrogenase in cultured astrocytes following exposure to manganese

scientific article published on July 1999

Increased expression of the peripheral-type benzodiazepine receptor-isoquinoline carboxamide binding protein mRNA in brain following portacaval anastomosis

scientific article published in May 1997

Increased levels of pregnenolone and its neuroactive metabolite allopregnanolone in autopsied brain tissue from cirrhotic patients who died in hepatic coma

scientific article published on 24 March 2006

Increased manganese concentrations in pallidum of cirrhotic patients

scientific article published on 01 March 1995

Increased neuronal cell survival after L-deprenyl treatment in experimental thiamine deficiency ⬇️

scientific article published on April 15, 1998

Increased neuronal nitric oxide synthase expression in brain following portacaval anastomosis ⬇️

scientific article published on August 8, 1997

Increased nitric oxide synthase activities and L-[3H]arginine uptake in brain following portacaval anastomosis

scientific article published on 01 August 1995

Indomethacin improves locomotor deficit and reduces brain concentrations of neuroinhibitory steroids in rats following portacaval anastomosis

scientific article published on 8 May 2008

Induction of astrocytic cyclooxygenase-2 in epileptic patients with hippocampal sclerosis

scientific article published in March 2003

Inflammatory Cascades Driven by Tumor Necrosis Factor-Alpha Play a Major Role in the Progression of Acute Liver Failure and Its Neurological Complications ⬇️

scientific article published on November 15, 2012

Intracellular pH rises and astrocytes swell after portacaval anastomosis in rats ⬇️

scientific article published on December 1, 1991

Investigation of the relationship between some brain peptides and neurotransmitters

scientific article published on January 1, 1979

Keeping cool in acute liver failure: rationale for the use of mild hypothermia

scientific article

Kinetics, pharmacology, and autoradiographic distribution of L-[3H]nitroarginine binding sites in rat cerebellum.

scientific article published in February 1996

L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses

L-Ornithine L-Aspartate (LOLA) for the Treatment of Hepatic Encephalopathy in Cirrhosis: Novel Insights and Translation to the Clinic

scientific article published on 01 February 2019

L-Ornithine L-Aspartate for the Treatment of Sarcopenia in Chronic Liver Disease: The Taming of a Vicious Cycle.

scientific article published on 28 April 2019

L-[3H]nitroarginine and L-[3H]arginine uptake into rat cerebellar synaptosomes: kinetics and pharmacology.

scientific article published in September 1996

L-ornithine-L-aspartate in experimental portal-systemic encephalopathy: therapeutic efficacy and mechanism of action.

scientific article published in June 1998

L-ornithine-L-aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure

scientific article published in September 1999

Lack of assessment of body temperature in mice with acetaminophen toxicity

scientific article published on 01 July 2006

Lipopolysaccharide precipitates hepatic encephalopathy and increases blood–brain barrier permeability in mice with acute liver failure ⬇️

scientific article published on August 2, 2013

Liver-brain proinflammatory signalling in acute liver failure: role in the pathogenesis of hepatic encephalopathy and brain edema.

scientific article published on 05 December 2012

Localized oesophagitis due to drugs

scientific article published on 01 September 1958

Loss of [3H]MK801 binding sites in brain in congenital ornithine transcarbamylase deficiency

scientific article published on 01 September 1995

Loss of [3H]kainate and of NMDA-displaceable [3H]glutamate binding sites in brain in thiamine deficiency: results of a quantitative autoradiographic study

scientific article published in October 1995

Loss of expression of glial fibrillary acidic protein in acute hyperammonemia

scientific article published in August 2002

Loss of noradrenaline transporter sites in frontal cortex of rats with acute (ischemic) liver failure.

scientific article

Manganese deposition in basal ganglia structures results from both portal-systemic shunting and liver dysfunction

scientific article published in September 1999

Manganese distribution in the brain and neurobehavioral changes following inhalation exposure of rats to three chemical forms of manganese

scientific article published on 01 March 2004

Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy

scientific article published on December 1995

Maternal thiamine deficiency. A factor in intrauterine growth retardation

scientific article

Maternal thiamine deficiency: still a problem in some world communities ⬇️

scientific article published on 01 December 2001

Measurement of Ataxia and Related Neurological Signs in the Laboratory Rat ⬇️

scientific article published on 01 May 1979

Mechanisms of brain edema in acute liver failure and impact of novel therapeutic interventions.

scientific article published on October 2007

Mechanisms of neuronal cell death in Wernicke's encephalopathy

scientific article published on June 1, 1998

Mechanisms of selective neuronal cell death due to thiamine deficiency

scientific article published on 01 January 1999

Metal toxicity, liver disease and neurodegeneration

scientific article published on 06 April 2010

Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity

scientific article published on 18 November 2006

Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure

scientific article published on 01 April 2000

Mild hypothermia for the treatment of acute liver failure--what are we waiting for?

scientific article published on 01 October 2007

Mild hypothermia in the prevention of brain edema in acute liver failure: mechanisms and clinical prospects.

scientific article published in December 2002

Mild hypothermia prevents brain edema and attenuates up-regulation of the astrocytic benzodiazepine receptor in experimental acute liver failure

scientific article published in May 2005

Mild hypothermia prevents cerebral edema and CSF lactate accumulation in acute liver failure.

scientific article

Mild hypothermia prevents cerebral edema in acute liver failure

scientific article

Minimal hepatic encephalopathy: consensus statement of a working party of the Indian National Association for Study of the Liver

scientific article published on June 2010

Minocycline attenuates oxidative/nitrosative stress and cerebral complications of acute liver failure in rats.

scientific article

Missed opportunities in the post-mortem room

scientific article published on 01 November 1955

Mitochondrial dysfunction in acute hyperammonemia

scientific article

Molecular Neurobiology of Acute Liver Failure ⬇️

scientific article published on August 1, 2003

Monitoring of neurotransmitter amino acids by means of an indwelling cisterna magna catheter: a comparison of two rodent models of fulminant liver failure

scientific article published on October 1, 1992

Monoamines and metabolites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy

scientific article

N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms.

scientific article published on 30 April 2010

Na+,K(+)-ATPase activities are increased in brain in both congenital and acquired hyperammonemic syndromes

scientific article published on 01 September 1995

Na+,K(+)-ATPase activity is selectively increased in thalamus in thiamine deficiency prior to the appearance of neurological symptoms

scientific article published in April 1996

Nature of the Lung Enzyme which inactivates Serum Vasoconstrictor

scientific article published in Nature

Neuroactive amino acids and glutamate (NMDA) receptors in frontal cortex of rats with experimental acute liver failure

scientific article published in October 1996

Neuroactive amino acids in hepatic encephalopathy

scientific article published on 01 June 1996

Neuroactive steroids and fatigue severity in patients with primary biliary cirrhosis and hepatitis C.

scientific article

Neurobiological characterization of an azoxymethane mouse model of acute liver failure

scientific article published on 23 March 2006

Neurobiology of ammonia.

scientific article

Neurochemical and electrophysiological studies on the inhibitory effect of ammonium ions on synaptic transmission in slices of rat hippocampus: evidence for a postsynaptic action

scientific article published on 01 January 1990

Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets

scientific article published on August 16, 2011

Neuronal cell death in Wernicke's encephalopathy: pathophysiologic mechanisms and implications for PET imaging

scientific article published on March 1996

Neuronal nitric oxide synthase and Hepatic Encephalopathy

scientific article published on September 1, 1998

Neurosteroids in hepatic encephalopathy: Novel insights and new therapeutic opportunities

scientific article

Neurotransmitter dysfunction in hepatic encephalopathy: new approaches and new findings

scientific article published on June 1, 2001

Neurotransmitter function in thiamine-deficiency encephalopathy

scientific article published in January 1982

New insights into mechanisms of gamma-diketone-induced axonopathy

scientific article published on 29 April 2009

Nitric oxide synthase activities are selectively decreased in vulnerable brain regions in thiamine deficiency

scientific article published in April 1996

Normal coupling of brain benzodiazepine and neurosteroid modulatory sites on the GABA-A receptor complex in human hepatic encephalopathy

scientific article

Nutrition in the management of cirrhosis and its neurological complications.

scientific article

Ornithine transcarbamylase deficiency: Pathogenesis of the cerebral disorder and new prospects for therapy ⬇️

scientific article published on September 1, 1997

Ouabain Induced Stereotyped Behavior in Rats ⬇️

scientific article published on November 1, 1978

Parkinsonism in cirrhosis: pathogenesis and current therapeutic options ⬇️

scientific article published on October 20, 2012

Pathogenesis and treatment of portal-systemic encephalopathy: an update

scientific article

Pathogenesis of Acute Hepatic Encephalopathy ⬇️

scientific article published on 01 July 1998

Pathogenesis of alcoholic peripheral neuropathy: direct effect of ethanol or nutritional deficit?

scientific article published on June 1994

Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure

scientific article

Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure: Role of glutamine redefined ⬇️

scientific article published on February 21, 2012

Pathogenesis of hepatic encephalopathy in cirrhosis: the concept of synergism revisited

scientific article published on 2 November 2015

Pathogenesis of hepatic encephalopathy: new insights from neuroimaging and molecular studies

scientific article published in August 2003

Pathogenesis of hepatic encephalopathy: update on molecular mechanisms.

scientific article

Pathophysiologic mechanisms responsible for the reversible (thiamine-responsive) and irreversible (thiamine non-responsive) neurological symptoms of Wernicke's encephalopathy

scientific article

Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease ⬇️

scientific article published on March 1, 1995

Pathophysiology of brain dysfunction in hyperammonemic syndromes: The many faces of glutamine

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Pathophysiology of cerebellar dysfunction in the Wernicke-Korsakoff syndrome.

scientific article

Pathophysiology of hepatic encephalopathy: The concept of synergism

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Pathophysiology of hepatic encephalopathy: a new look at GABA from the molecular standpoint

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Pathophysiology of hepatic encephalopathy: a new look at ammonia

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Pathophysiology of hepatic encephalopathy: studies in autopsied brain tissue from hepatic coma patients.

scientific article published on July 1990

Peripheral benzodiazepine binding sites in Alzheimer's disease frontal and temporal cortex ⬇️

scientific article published on May 1, 1991

Perispinal etanercept for post-stroke neurological and cognitive dysfunction: scientific rationale and current evidence

scientific article

Pharmacokinetics of benzodiazepine antagonist Ro 15-1788 in cirrhotic patients with moderate or severe liver dysfunction

scientific article published in December 1989

Pilot Studies on Membranes and some Transport Mechanisms in Friedreich's Ataxia ⬇️

scientific article published on 01 May 1979

Plasma and CSF benzodiazepine receptor ligand concentrations in cirrhotic patients with hepatic encephalopathy: relationship to severity of encephalopathy and to pharmaceutical benzodiazepine intake

scientific article published on September 1, 1998

Platelet Dopamine Uptake in Huntington's Chorea and Gilles de la Tourette's Syndrome: Effect of Haloperidol ⬇️

scientific article published on November 1, 1977

Platelet taurine uptake in spinocerebellar degeneration

scientific article published on 01 February 1978

Portacaval anastomosis causes selective alterations of peripheral-type benzodiazepine receptor expression in rat brain and peripheral tissues

scientific article

Portacaval anastomosis induces region-selective alterations of the endogenous opioid system in the rat brain

scientific article

Portacaval anastomosis results in altered neuron--astrocytic metabolic trafficking of amino acids: evidence from 13C-NMR studies.

scientific article published in October 1996

Portacaval anastomosis results in more widespread alterations of cerebral metabolism in old versus young adult rats: implications for post-shunt encephalopathy

scientific article published on March 1, 1998

Portacaval shunting and hyperammonemia stimulate the uptake of L-[3H] arginine but not of L-[3H]nitroarginine into rat brain synaptosomes

scientific article published in January 1997

Portal-systemic encephalopathy: a disorder of multiple neurotransmitter systems.

scientific article published on January 1994

Portal-systemic encephalopathy: a disorder of multiple neurotransmitter systems.

scientific article published on April 1994

Portal-systemic encephalopathy: a disorder of neuron-astrocytic metabolic trafficking

scientific article published on January 1993

Possible serotonin-agonist action of veratramine ⬇️

scientific article published on May 1, 1978

Postoperative course after portacaval anastomosis in rats is determined by the portacaval pressure gradient ⬇️

scientific article published on December 1, 1991

Primary cultures of rat astrocytes respond to thiamine deficiency-induced swelling by downregulating aquaporin-4 levels

scientific article

Protective effect of L-carnitine in ammonia-precipitated encephalopathy in the portacaval shunted rat.

scientific article

Pyrithiamine-induced thiamine deficiency results in decreased Ca2+-dependent release of glutamate from rat hippocampal slices ⬇️

scientific article published on September 1, 1991

Pyruvate dehydrogenase activity in regions of the rat brain during postnatal development

scientific article published in July 1984

Pyruvate dehydrogenase complex in Friedreich's ataxia

scientific article published on January 1, 1978

Pyruvate metabolism in Friedreich's ataxia

scientific article published on November 1, 1976

Quantitative autoradiography using selective radioligands for central and peripheral-type benzodiazepine receptors in experimental Wernicke's encephalopathy: implications for positron emission tomography imaging

scientific article published on 01 May 1996

Reduced activities of thiamine-dependent enzymes in brains of alcoholics in the absence of Wernicke's encephalopathy

scientific article published on August 1995

Reduced brain levels of DHEAS in hepatic coma patients: Significance for increased GABAergic tone in hepatic encephalopathy ⬇️

scientific article published on April 3, 2012

Reduced expression of astrocytic glycine transporter (Glyt-1) in acute liver failure

scientific article published in December 2002

Reduced plasma dehydroepiandrosterone sulfate levels are significantly correlated with fatigue severity in patients with primary biliary cirrhosis

scientific article published on 19 June 2007

Reduced sensory and motor nerve conduction velocities in moderate drinkers

scientific article published on 01 January 2000

Region selective alterations of soluble guanylate cyclase content and modulation in brain of cirrhotic patients.

scientific article published in November 2002

Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using 1H/13C nuclear magnetic resonance spectroscopy

scientific article published on 12 April 2008

Region-selective decreases in densities of [3H]tryptamine binding sites in autopsied brain tissue from cirrhotic patients with hepatic encephalopathy.

scientific article published on February 1994

Region-selective permeability of the blood-brain barrier to α-aminoisobutyric acid during thiamine deficiency and following its reversal

scientific article published on 27 November 2020

Region-selective reductions in activities of glutamine synthetase in rat brain following portacaval anastomosis

scientific article published on 01 December 1993

Regional Amino Acid Distribution in Relation to Function in Insulin Hypoglycaemia ⬇️

scientific article published on May 1, 1982

Regional alterations of dopamine and its metabolites in rat brain following portacaval anastomosis

scientific article published in January 1995

Regional alterations of thiamine phosphate esters and of thiamine diphosphate-dependent enzymes in relation to function in experimental Wernicke's encephalopathy

scientific article published in January 1995

Regional amino acid neurotransmitter changes in brains of spf/Y mice with congenital ornithine transcarbamylase deficiency

scientific article

Regional differences in the capacity for ammonia removal by brain following portocaval anastomosis

scientific article published on 01 August 1988

Regional distribution of binding sites for the nitric oxide synthase inhibitor L-[3H]nitroarginine in rat brain

scientific article

Reprint of: Neuroinflammation in acute liver failure: mechanisms and novel therapeutic targets

scientific article published on 11 April 2012

Reprint of: Nutrition in the Management of Cirrhosis and its Neurological Complications

scientific article

Reversible Alterations of Cerebral ?-Aminobutyric Acid in Pyrithiamine-Treated Rats: Implications for the Pathogenesis of Wernicke's Encephalopathy ⬇️

scientific article published on 01 October 1988

Review article: the design of clinical trials in hepatic encephalopathy--an International Society for Hepatic Encephalopathy and Nitrogen Metabolism (ISHEN) consensus statement.

scientific article published on 09 February 2011

Risk of falls in cirrhosis predicted by psychometric testing ⬇️

scientific article published on February 21, 2012

Role of circulating neurotoxins in the pathogenesis of hepatic encephalopathy: potential for improvement following their removal by liver assist devices

scientific article

Role of endogenous benzodiazepine ligands and their GABA-A--associated receptors in hepatic encephalopathy

scientific article

Role of manganese in the pathogenesis of portal-systemic encephalopathy

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Role of mitochondrial dysfunction and oxidative stress in the pathogenesis of selective neuronal loss in Wernicke's encephalopathy

scientific article

Role of nutrition in the management of hepatic encephalopathy in end-stage liver failure.

scientific article published on 22 December 2010

Selective Alterations of Extracellular Brain Amino Acids in Relation to Function in Experimental Portal‐Systemic Encephalopathy: Results of an In Vivo Microdialysis Study ⬇️

scientific article published on 01 September 1995

Selective alterations of brain dopamine D(2) receptor binding in cirrhotic patients: results of a (11)C-N-methylspiperone PET study.

scientific article published on 7 August 2008

Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia

scientific article

Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy

scientific article published in August 2001

Selective increase of brain lactate synthesis in experimental acute liver failure: results of a [H-C] nuclear magnetic resonance study

scientific article

Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide

scientific article published on 15 May 2008

Selective increases of extracellular brain concentrations of aromatic and branched-chain amino acids in relation to deterioration of neurological status in acute (ischemic) liver failure ⬇️

scientific article published on December 1, 1997

Selective loss of N-methyl-D-aspartate-sensitive L-[3H]glutamate binding sites in rat brain following portacaval anastomosis

scientific article published in August 1990

Selective loss of binding sites for the glutamate receptor ligands [3H]kainate and (S)-[3H]5-fluorowillardiine in the brains of rats with acute liver failure

scientific article

Selective loss of expression of glutamate GluR2/R3 receptor subunits in cerebellar tissue from a patient with olivopontocerebellar atrophy

scientific article published in June 2002

Selective loss of pallidal dopamine D2 receptor density in hepatic encephalopathy

scientific article published on 01 November 1993

Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure

scientific article published in April 2006

Serum and platelet lipoamide dehydrogenase in Friedreich's ataxia

scientific article published on 01 February 1978

Taurine in hepatic encephalopathy

scientific article

The "peripheral-type" benzodiazepine (omega 3) receptor in hyperammonemic disorders

scientific article

The Role of Liver Disease in Alcohol-Induced Cognitive Defects

scientific article published on 01 January 1995

The [3H]tryptamine receptor in human brain: kinetics, distribution, and pharmacologic profile

scientific article published on 01 September 1994

The astrocytic ("peripheral-type") benzodiazepine receptor: role in the pathogenesis of portal-systemic encephalopathy

scientific article

The biosynthesis of ascorbate protects isolated rat hepatocytes from cumene hydroperoxide-mediated oxidative stress

scientific article

The brain glutamate system in liver failure

scientific article published on 12 June 2006

The burning skin syndrome: treatment with hydroxychloroquine

scientific article published on September 1960

The concept of "the inflamed brain" in acute liver failure: mechanisms and new therapeutic opportunities

scientific article published on 20 October 2015

The liver–brain axis in liver failure: neuroinflammation and encephalopathy ⬇️

scientific article published on 02 July 2013

The neurobiology of hepatic encephalopathy

scientific article

The neuropharmacology of taurine ⬇️

scientific article published on September 1, 1975

The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy

scientific article published on December 2007

The neurosteroid system: implication in the pathophysiology of hepatic encephalopathy

scientific article published on 17 May 2007

The nutritional management of hepatic encephalopathy in patients with cirrhosis: International Society for Hepatic Encephalopathy and Nitrogen Metabolism Consensus

scientific article published on 31 May 2013

The portacaval-shunted rat: a new model for the study of the mechanisms controlling voluntary ethanol consumption and ethanol preference?

scientific article published in April 1997

The venous drainage of the left atrium

scientific article published on April 1954

Thiamin deficiency and brain disorders

scientific article

Thiamine deficiency and wernicke's encephalopathy in AIDS ⬇️

scientific article published on December 1, 1991

Thiamine deficiency in AIDS ⬇️

scientific article published on October 26, 1991

Thiamine deficiency results in metabolic acidosis and energy failure in cerebellar granule cells: an in vitro model for the study of cell death mechanisms in Wernicke's encephalopathy

scientific article published on 01 October 2000

Thiamine deficiency-related brain dysfunction in chronic liver failure

scientific article published on 06 December 2008

Thiamine phosphatases in human brain: regional alterations in patients with alcoholic cirrhosis

scientific article published on 01 April 1995

Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

scientific article published in December 1990

Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome

scientific article published on 01 October 1993

Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis

scientific article published in May 1994

Trace amines in hepatic encephalopathy.

scientific article published on January 1995

Up-regulation of caveolin-1 and blood–brain barrier breakdown are attenuated by N-acetylcysteine in thiamine deficiency ⬇️

scientific article published on September 21, 2010

Update of cell damage mechanisms in thiamine deficiency: focus on oxidative stress, excitotoxicity and inflammation

scientific article published on 16 January 2009

Uptake and efflux of 14C-dopamine in platelets: Evidence for a generalized defect in Parkinson's disease ⬇️

scientific article published on January 1, 1975

Vesicular dysfunction during experimental thiamine deficiency is indicated by alterations in dopamine metabolism

scientific article published in December 1996

eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain

scientific article published on 17 August 2009

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