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List of works by Spencer Phillips Hey

A Comparison of Response Patterns for Progression-Free Survival and Overall Survival Following Treatment for Cancer With PD-1 Inhibitors: A Meta-analysis of Correlation and Differences in Effect Sizes

scientific article published on 01 June 2018

A Framework for Assessing Scientific Merit in Ethical Review of Clinical Research

scientific article published on 01 March 2019

A Systematic Review Of The Food And Drug Administration's 'Exception From Informed Consent' Pathway

scientific article published on 01 October 2018

A Systematic Review and Meta-Analysis of Bevacizumab in First-Line Metastatic Breast Cancer: Lessons for Research and Regulatory Enterprises

scientific article published on 25 October 2019

A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology

scientific article published on 05 December 2018

Accumulating Evidence and Research Organization (AERO) model: a new tool for representing, analyzing, and planning a translational research program.

scientific article published on 30 May 2013

Adaptive trials, efficiency, and ethics

scientific article published on 22 October 2019

An Uninformative Truth: The Logic of Amarin's Off-Label Promotion

scientific article

Are outcome-adaptive allocation trials ethical?

scientific article published on 3 February 2015

Assay sensitivity and the epistemic contexts of clinical trials

scientific article published in January 2013

Assessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval

scientific article published on 01 July 2019

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis

scholarly article published 5 April 2019

BIOMEDICAL RESEARCH. Countering imprecision in precision medicine

scientific article published on 01 July 2016

Benefit, Risk, and Outcomes in Drug Development: A Systematic Review of Sunitinib

scientific article

Cell and Gene Therapy Trials: Are We Facing an ‘Evidence Crisis’?

article

Challenges and Opportunities for Biomarker Validation

scientific article published on 01 September 2019

Cluster over individual randomization: are study design choices appropriately justified? Review of a random sample of trials

scientific article published on 05 May 2020

Community-engaged Evidence Synthesis to Inform Public Health Policy and Clinical Practice: A Case Study

scientific article published on 01 October 2019

Data Sharing For Research-Encouraging Signs Amid Ethical Tensions

scientific article published on 02 August 2019

Defining "True and Non-Misleading" for Pharmaceutical Promotion

scientific article published on 01 June 2018

Developing a framework for the ethical design and conduct of pragmatic trials in healthcare: a mixed methods research protocol

article

Do We Know Whether Researchers and Reviewers are Estimating Risk and Benefit Accurately?

scientific article published on 16 May 2016

Epistemology, Ethics, and Progress in Precision Medicine

scientific article published on 01 January 2016

Ethical Challenges in Biomarker-Driven Drug Development

scientific article published on 25 September 2017

Ethical and Regulatory Issues for Embedded Pragmatic Trials Involving People Living with Dementia

scientific article published on 01 July 2020

Ethics and epistemology of accurate prediction in clinical research.

scientific article

Ethics, Error, and Initial Trials of Efficacy ⬇️

scientific article published on May 8, 2013

Evaluating the evidence behind the surrogate measures included in the FDA's table of surrogate endpoints as supporting approval of cancer drugs

scientific article published on 13 April 2020

Heterogeneity of antidiabetic treatment effect on the risk of major adverse cardiovascular events in type 2 diabetes: a systematic review and meta-analysis

scientific article published on 29 September 2020

Heuristics and Explanation in Translational Medicine

scientific article published on 01 January 2019

Influence, integrity, and the FDA: An ethical framework

scientific article published in September 2017

Is the concept of clinical equipoise still relevant to research?

scientific article

Priority, prediction and the ethical research enterprise

scientific article published on 06 February 2017

Public Approval of Exception From Informed Consent in Emergency Clinical Trials: A Systematic Review of Community Consultation Surveys

scientific article published on 03 July 2019

Rejoinder

scientific article published on 03 February 2015

Reprioritizing Research Activity for the Post-Antibiotic Era: Ethical, Legal, and Social Considerations

scientific article published in March 2017

Research ethics for emerging trial designs: does equipoise need to adapt?

scientific article published on 25 January 2018

Stakeholder views regarding ethical issues in the design and conduct of pragmatic trials: study protocol

scientific article published on 20 November 2018

Success, Failure, and Transparency in Biomarker-Based Drug Development: A Case Study of Cholesteryl Ester Transfer Protein Inhibitors

scientific article published on June 2017

Surrogate Endpoints and Drug Regulation: What Is Needed to Clarify the Evidence

scientific article published on 01 September 2019

The Challenges of Validating in Precision Medicine: The Case of Excision Repair Cross-Complement Group 1 Diagnostic Testing

scientific article

The FDA, Juno Therapeutics, and the ethical imperative of transparency.

scientific article published on 15 August 2016

The Question of Clinical Equipoise and Patients' Best Interests

scientific article

The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders

scientific article published on 23 December 2019

The evidence landscape in precision medicine

scientific article published on 01 April 2020

The importance of decision intent within descriptions of pragmatic trials

scientific article published on 15 May 2020

The risk-escalation model: a principled design strategy for early-phase trials

scientific article published on June 2014

Thinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers

scholarly article by Austin R Horn et al published September 2018 in Journal of Medical Ethics

Thinking clearly about the FIRST trial: addressing ethical challenges in cluster randomised trials of policy interventions involving health providers

scholarly article by Austin R Horn et al published 27 April 2018 in Journal of Medical Ethics

US Food and Drug Administration Recommendations on the Use of Surrogate Measures as End Points in New Anti-infective Drug Approvals

scientific article published on 11 November 2019

What questions can a placebo answer?

scientific article published on 17 May 2016

Why High Drug Pricing Is A Problem for Research Ethics

scientific article published on 19 December 2019

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