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List of works by Sean F Brady

A semi-synthetic kanglemycin shows in vivo efficacy against high-burden rifampicin resistant pathogens

scientific article published on 10 August 2020

Accessing Bioactive Natural Products from the Human Microbiome

scientific article published on 01 June 2018

Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis ⬇️

scientific article published on 24 February 2011

An Optimized Synthetic-Bioinformatic Natural Product Antibiotic Sterilizes Multidrug-Resistant Acinetobacter baumannii-Infected Wounds

scientific article

An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin

scientific article published on January 2009

Antibacterial enzymes from the functional screening of metagenomic libraries hosted in Ralstonia metallidurans

scientific article

Antimicrobials Inspired by Nonribosomal Peptide Synthetase Gene Clusters

scientific article published on 5 January 2017

Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes ⬇️

scientific article

Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols

scientific article published on 30 April 2014

Atolypenes, Tricyclic Bacterial Sesterterpenes Discovered Using a Multiplexed In Vitro Cas9-TAR Gene Cluster Refactoring Approach. ⬇️

scientific article published on 21 December 2018

Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale

scientific article published on 18 October 2017

Bacterial printing press that regenerates its ink: contact-printing bacteria using hydrogel stamps

scientific article published on 01 July 2005

Bioactive Synthetic-Bioinformatic Natural Product Cyclic Peptides Inspired by Nonribosomal Peptide Synthetase Gene Clusters from the Human Microbiome

scientific article published on 27 September 2019

Biocatalysts and small molecule products from metagenomic studies ⬇️

scientific article published on March 26, 2012

Cadasides, Calcium-Dependent Acidic Lipopeptides from the Soil Metagenome That Are Active against Multidrug-Resistant Bacteria.

scientific article

Characterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubin

scientific article

Chemical-biogeographic survey of secondary metabolism in soil

scientific article

Cloning and Characterization of an Environmental DNA-Derived Gene Cluster That Encodes the Biosynthesis of the Antitumor Substance BE-54017 ⬇️

scientific article published on May 4, 2011

Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary

scientific article

Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA.

scientific article

Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. ⬇️

scientific article published on September 2010

Commensal bacteria make GPCR ligands that mimic human signalling molecules

scientific article published on 30 August 2017

Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis

scientific article published on 25 October 2016

Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules

scientific article

Correction: Singh, M.P., et al. Cytoskyrins and Cytosporones Produced by Cytospora sp. CR200: Taxonomy, Fermentation and Biological Activities

scientific article published on 14 April 2009

Corrigendum: Commensal bacteria make GPCR ligands that mimic human signalling molecules

scientific article published in Nature

Crystal Structures of the Glycopeptide Sulfotransferase Teg12 in a Complex with the Teicoplanin Aglycone

scientific article

Culture-independent discovery of natural products from soil metagenomes

scientific article

Culture-independent discovery of the malacidins as calcium-dependent antibiotics with activity against multidrug-resistant Gram-positive pathogens

scientific article published on 12 February 2018

Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium

scientific article published on 22 June 2007

Cytoskyrins and cytosporones produced by Cytospora sp. CR200: taxonomy, fermentation and biological activities

scientific article published on 19 July 2007

Discovery and synthetic refactoring of tryptophan dimer gene clusters from the environment

scientific article

Discovery of MRSA active antibiotics using primary sequence from the human microbiome.

scientific article

Discovery of a Metagenome‐Derived Enzyme that Produces Branched‐Chain Acyl‐(Acyl‐Carrier‐Protein)s from Branched‐Chain α‐Keto Acids ⬇️

scientific article published on June 28, 2011

Discovery of indolotryptoline antiproliferative agents by homology-guided metagenomic screening.

scientific article

Environmental DNA-encoded antibiotics fasamycins A and B inhibit FabF in type II fatty acid biosynthesis

scientific article

Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria

scientific article

Fluostatins Produced by the Heterologous Expression of a TAR Reassembled Environmental DNA Derived Type II PKS Gene Cluster ⬇️

scientific article published on September 1, 2010

Functional Multigenomic Screening of Human-Associated Bacteria for NF-κB-Inducing Bioactive Effectors

scientific article published on 19 November 2019

Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites ⬇️

scientific article published on July 18, 2011

Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132 agonist

scientific article published on 17 August 2015

Global biogeographic sampling of bacterial secondary metabolism

scientific article

Guanacastepene, a Fungal-Derived Diterpene Antibiotic with a New Carbon Skeleton

scientific article (publication date: March 2000)

Human Microbiome Inspired Antibiotics with Improved β-Lactam Synergy against MDR Staphylococcus aureus

scientific article

Identification of biosynthetic gene clusters from metagenomic libraries using PPTase complementation in a Streptomyces host ⬇️

scientific article published in September 2017

Identification of the Colicin V Bacteriocin Gene Cluster by Functional Screening of a Human Microbiome Metagenomic Library.

scientific article published on 15 August 2017

Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA

scientific article

Long-chain N-acyl amino acid synthases are linked to the putative PEP-CTERM/exosortase protein-sorting system in Gram-negative bacteria

scientific article

Long-chain N-acyltyrosine synthases from environmental DNA

scientific article

Malleilactone, a polyketide synthase-derived virulence factor encoded by the cryptic secondary metabolome of Burkholderia pseudomallei group pathogens. ⬇️

scientific article

Mapping Interactions of Microbial Metabolites with Human G-Protein-Coupled Receptors

scientific article published on 01 August 2019

Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products

scientific article

Meeting report: 1st international functional metagenomics workshop may 7-8, 2012, st. Jacobs, ontario, Canada

scientific article

Metabolites from the induced expression of cryptic single operons found in the genome of Burkholderia pseudomallei ⬇️

scientific article published on 19 January 2011

Metagenomic approaches to natural products from free-living and symbiotic organisms

scientific article published on 16 September 2009

Metagenomic small molecule discovery methods

scientific article

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Mining soil metagenomes to better understand the evolution of natural product structural diversity: pentangular polyphenols as a case study

scientific article published on 18 December 2014

Mining the metabiome: identifying novel natural products from microbial communities

scientific article

Multiplexed CRISPR/Cas9- and TAR-Mediated Promoter Engineering of Natural Product Biosynthetic Gene Clusters in Yeast

scientific article published on 20 May 2016

Multiplexed metagenome mining using short DNA sequence tags facilitates targeted discovery of epoxyketone proteasome inhibitors

scientific article

Multiplexed mobilization and expression of biosynthetic gene clusters ⬇️

scientific article published in 2022

Mutations in the proteolipid subunits of the vacuolar H+-ATPase provide resistance to indolotryptoline natural products

scientific article

N-acyl derivatives of arginine and tryptophan isolated from environmental DNA expressed in Escherichia coli.

scientific article

Natural Product Discovery through Improved Functional Metagenomics in Streptomyces ⬇️

scientific article published on 22 July 2016

Natural product biosynthetic gene diversity in geographically distinct soil microbiomes.

scientific article

Natural products from environmental DNA hosted in Ralstonia metallidurans

scientific article

Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria.

scientific article published on 19 September 2007

New natural product families from an environmental DNA (eDNA) gene cluster

scientific article

Paerucumarin, a new metabolite produced by the pvc gene cluster from Pseudomonas aeruginosa ⬇️

scientific article

Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water

scientific article

Pantocin B, an Antibiotic fromErwinia herbicolaDiscovered by Heterologous Expression of Cloned Genes

scientific article published on 26 July 2002

Phaeosphaeride A, an inhibitor of STAT3-dependent signaling isolated from an endophytic fungus ⬇️

scientific article published on August 2006

Reassembly of functionally intact environmental DNA-derived biosynthetic gene clusters

scientific article

Recent application of metagenomic approaches toward the discovery of antimicrobials and other bioactive small molecules ⬇️

scientific article published on September 29, 2010

Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism

scientific article published in Nature Communications

Selective enrichment of environmental DNA libraries for genes encoding nonribosomal peptides and polyketides by phosphopantetheine transferase-dependent complementation of siderophore biosynthesis.

scientific article

Synthesis of long-chain fatty acid enol esters isolated from an environmental DNA clone

scientific article

Synthetic-bioinformatic natural product antibiotics with diverse modes of action

scientific article published on 22 July 2020

Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom.

scientific article

Tailoring enzyme-rich environmental DNA clones: a source of enzymes for generating libraries of unnatural natural products

scientific article

Targeted metagenomics: finding rare tryptophan dimer natural products in the environment

scientific article (publication date: 13 May 2015)

Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters

scientific article published on 27 November 2012

The 2.7 Å resolution structure of the glycopeptide sulfotransferase Teg14

scientific article

The chemical arsenal of Burkholderia pseudomallei is essential for pathogenicity.

scientific article

The pvc operon regulates the expression of the Pseudomonas aeruginosa fimbrial chaperone/usher pathway (cup) genes ⬇️

scientific article

Total Synthesis of Malacidin A by β-Hydroxyaspartic Acid Ligation Mediated Cyclization and Absolute Structure Establishment

scientific article published on 29 July 2020

Uncovering the biosynthetic potential of rare metagenomic DNA using co-occurrence network analysis of targeted sequences ⬇️

scientific article published on 26 August 2019

Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity

scientific article published on 28 November 2016

Utahmycins a and B, azaquinones produced by an environmental DNA clone ⬇️

scientific article published on May 2010

Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters.

scientific article published on 6 July 2015

eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes

scientific article

phylogeo: an R package for geographic analysis and visualization of microbiome data

scientific article

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