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List of works by Lillian Siu

A Multi-Arm Phase I Study of the PI3K/mTOR Inhibitors PF-04691502 and Gedatolisib (PF-05212384) plus Irinotecan or the MEK Inhibitor PD-0325901 in Advanced Cancer

scientific article published on 24 October 2017

A Phase I First-in-Human Study of Nesvacumab (REGN910), a Fully Human Anti-Angiopoietin-2 (Ang2) Monoclonal Antibody, in Patients with Advanced Solid Tumors

scientific article published on 21 October 2015

A Phase I Study of Dinaciclib in Combination With MK-2206 in Patients With Advanced Pancreatic Cancer ⬇️

scientific article published on 01 August 2020

A Phase I study of olaparib and irinotecan in patients with colorectal cancer: Canadian Cancer Trials Group IND 187.

scientific article

A Phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy in patients with advanced solid malignancies and peritoneal carcinomatosis

scientific article

A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix

scientific article published on 22 January 2005

A Phase II trial of erlotinib as maintenance treatment after gemcitabine plus platinum-based chemotherapy in patients with recurrent and/or metastatic nasopharyngeal carcinoma.

scientific article published in June 2012

A classification system for clinical relevance of somatic variants identified in molecular profiling of cancer.

scientific article published on 16 April 2015

A comparison of weekly versus 3-weekly cisplatin during adjuvant radiotherapy for high-risk head and neck cancer.

scientific article published on August 2016

A cost-effectiveness analysis of human papillomavirus vaccination of boys for the prevention of oropharyngeal cancer

scientific article published on 13 April 2015

A dose-escalation phase I trial of nimotuzumab, an antibody against the epidermal growth factor receptor, in patients with advanced solid malignancies.

scientific article published on 8 May 2010

A final report of a phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy (LDFWAR) in patients with advanced solid malignancies and peritoneal carcinomatosis with a dose escalation in ovaria

scientific article

A multicenter phase 1 study of γ -secretase inhibitor RO4929097 in combination with capecitabine in refractory solid tumors

scientific article

A multicenter phase II study of "adjuvant" irinotecan following resection of colorectal hepatic metastases

scientific article published in December 2005

A multicenter, phase 3, randomized trial of concurrent chemoradiotherapy plus adjuvant chemotherapy versus radiotherapy alone in patients with regionally advanced nasopharyngeal carcinoma: 10-year outcomes for efficacy and toxicity

scientific article

A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies

scientific article published in June 2008

A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment

scientific article published on 14 May 2020

A phase 2 study of platinum and gemcitabine in patients with advanced salivary gland cancer: a trial of the NCIC Clinical Trials Group

scientific article published in January 2010

A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma

scientific article

A phase I and pharmacokinetic study of SAM486A, a novel polyamine biosynthesis inhibitor, administered on a daily-times-five every-three-week schedule in patients with Advanced solid malignancies.

scientific article

A phase I study of OGX-011, a 2'-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer

scientific article

A phase I study of VS-6063, a second-generation focal adhesion kinase inhibitor, in patients with advanced solid tumors

scientific article published on 4 September 2015

A phase I study of oral LY293111 given daily in combination with irinotecan in patients with solid tumours.

scientific article published on 5 December 2006

A phase I study of pivaloyloxymethyl butyrate, a prodrug of the differentiating agent butyric acid, in patients with advanced solid malignancies.

scientific article

A phase I study of the oral gamma secretase inhibitor R04929097 in combination with gemcitabine in patients with advanced solid tumors (PHL-078/CTEP 8575).

scientific article published on 05 May 2013

A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041).

scientific article

A phase I trial of pantoprazole in combination with doxorubicin in patients with advanced solid tumors: evaluation of pharmacokinetics of both drugs and tissue penetration of doxorubicin

scientific article published on 12 September 2014

A phase I trial of two sequence-specific schedules of decitabine and vorinostat in patients with acute myeloid leukemia.

scientific article

A phase I, open-label, two-stage study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral AKT inhibitor GSK2141795 in patients with solid tumors

scientific article published on 3 April 2018

A phase II trial with pharmacodynamic endpoints of the proteasome inhibitor bortezomib in patients with metastatic colorectal cancer

scientific article published in August 2005

A phase Ib combination study of RO4929097, a gamma-secretase inhibitor, and temsirolimus in patients with advanced solid tumors

scientific article published on 17 July 2013

A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients

scientific article

A randomized trial on addition of concurrent-adjuvant chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma

article

A risk stratification model for toxicities in phase 1 immunotherapy trials

scientific article published in 2022

A six-weekly dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation

scientific article published on 15 April 2020

Abstract 3141: The relationship between BRAF/NRAS/KIT genomic driver mutations and anti-PD1 immunotherapy responses in patients with advanced melanoma

scholarly article

Abstract 3161: Identification of HPV/p16-associated microRNAs in primary oropharyngeal carcinoma

Abstract CT014: Initial results from the Phase I study of MSC-1, a humanized anti-LIF monoclonal antibody, in patients with advanced solid tumors

scholarly article

Abstract CT124: Sitravatinib and nivolumab in oral cavity cancer window of opportunity study (SNOW)

scholarly article

Abstract CT190: A Phase II basket study of hypomethylating agent oral cc-486 and durvalumab in advanced solid tumors (METADUR)

scholarly article

Additional germline findings from a tumor profiling program

scientific article published on 9 August 2018

Adherence to surveillance guidelines after curative resection for stage II/III colorectal cancer

scientific article published in May 2008

An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

scientific article published on 13 March 2019

An open-label, phase II multicohort study of an oral hypomethylating agent CC-486 and durvalumab in advanced solid tumors

scientific article published on 01 August 2020

Analysis of treatment practices for elderly cancer patients in Ontario, Canada

scientific article

Approaches to modernize the combination drug development paradigm

scientific article

Approaches to phase 1 clinical trial design focused on safety, efficiency, and selected patient populations: a report from the clinical trial design task force of the national cancer institute investigational drug steering committee

scientific article published on 09 March 2010

Are older cancer patients being referred to oncologists? A mail questionnaire of Ontario primary care practitioners to evaluate their referral patterns

scientific article published in December 2003

Association of Neurocognitive Deficits With Radiotherapy or Chemoradiotherapy for Patients With Head and Neck Cancer.

scientific article published on 22 November 2017

Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy

scientific article

Barriers in phase I cancer clinical trials referrals and enrollment: five-year experience at the Princess Margaret Hospital

scientific article

Bugs as drugs: The role of microbiome in cancer focusing on immunotherapeutics

scientific article published on 10 November 2020

Cancer genomics: technology, discovery, and translation

scientific article published on 23 January 2012

Cancer genomics: the challenge of drug accessibility

scientific article

Cancer patients' acceptability of incorporating an epidemiology questionnaire within a clinical trial

scientific article published on 29 January 2015

Cancer patients' experiences with immune checkpoint modulators: A qualitative study

scientific article published on 02 March 2020

Cardiovascular toxicity of molecularly targeted agents.

scientific article

Centromeric cohesion failure invokes a conserved choreography of chromosomal mis-segregations in pancreatic neuroendocrine tumor

scientific article published on 28 April 2020

Challenges and Opportunities in Adapting Clinical Trial Design for Immunotherapies

scientific article published in September 2017

Characterization and outcomes of patients enrolled to multiple phase I cancer trials

scientific article published on 08 November 2019

Chemoradiotherapy regimens for locoregionally advanced nasopharyngeal carcinoma: A Bayesian network meta-analysis

scientific article published on June 2015

Chemotherapy with gemcitabine-containing regimens for locally recurrent or metastatic nasopharyngeal carcinoma

scientific article published in December 2002

Choice of Starting Dose for Biopharmaceuticals in First-in-Human Phase I Cancer Clinical Trials

scientific article

Choice of starting dose for molecularly targeted agents evaluated in first-in-human phase I cancer clinical trials

scientific article published on February 2010

Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment

scientific article

Clinical genomics information management software linking cancer genome sequence and clinical decisions

scientific article published in September 2013

Clinical trial designs for targeted agents

scientific article

Cognitive functioning after radiotherapy or chemoradiotherapy for head-and-neck cancer

scientific article

Combined-modality treatment of solid tumors using radiotherapy and molecular targeted agents

scientific article

Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trial

scientific article

Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma.

scientific article

Comparison of outcomes of phase II studies and subsequent randomized control studies using identical chemotherapeutic regimens

scientific article published on 01 October 2005

Concurrent-Adjuvant Chemoradiation Therapy for Stage III-IVB Nasopharyngeal Carcinoma-Exploration for Achieving Optimal 10-Year Therapeutic Ratio

scientific article published on 02 May 2018

Conformal radiotherapy in the adjuvant treatment of gastric cancer: Review of 82 cases.

scientific article

Correlation of Epstein-Barr virus DNA in cell-free plasma, functional imaging and clinical course in locally advanced nasopharyngeal cancer: a pilot study

scientific article published in September 2004

Corrigendum to "A six-weekly (Q6W) dosing schedule for pembrolizumab in patients with cancer based on evaluation using modelling and simulation" [Eur J Canc 131 (2020) 68-75]

scientific article published on 04 January 2021

Could the human papillomavirus vaccination be cost-effective in males for the prevention of oropharyngeal cancer?

scientific article published on 6 August 2014

Current Treatment Landscape of Nasopharyngeal Carcinoma and Potential Trials Evaluating the Value of Immunotherapy

scientific article published on 26 March 2019

Customized autoantibodies (autoAbs) profiling to predict and monitor immune-related adverse events (irAEs) in patients receiving immune checkpoint inhibitors (ICI).

scientific article published on 06 June 2022

Cyclin-dependent kinase inhibitors as potential targeted anticancer agents

scientific article published on 05 March 2009

Defining dose-limiting toxicity for phase 1 trials of molecularly targeted agents: results of a DLT-TARGETT international survey.

scientific article

Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis

scientific article

Demonstrating Noninferiority of Accelerated Radiotherapy With Panitumumab vs Standard Radiotherapy With Cisplatin in Locoregionally Advanced Squamous Cell Head and Neck Carcinoma-Reply

scientific article published on 01 October 2017

Determinants of the recommended phase 2 dose of molecular targeted agents

scientific article published on 9 February 2017

Development of Fibroblast Growth Factor Receptor Inhibitors: Kissing Frogs to Find a Prince?

scientific article

Development of the Functional Assessment of Cancer Therapy-Immune Checkpoint Modulator (FACT-ICM): A toxicity subscale to measure quality of life in patients with cancer who are treated with ICMs

scientific article published on 08 January 2020

Dose escalation methods in phase I cancer clinical trials

scientific article published on 12 May 2009

Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 expression who have progressed on platinum-based chemotherapy

scientific article published on 18 December 2018

Early mortality and overall survival in oncology phase I trial participants: can we improve patient selection?

scientific article

Early phase clinical trials to identify optimal dosing and safety

scientific article

Effect of Standard Radiotherapy With Cisplatin vs Accelerated Radiotherapy With Panitumumab in Locoregionally Advanced Squamous Cell Head and Neck Carcinoma: A Randomized Clinical Trial

scientific article published on 08 December 2016

Epidermal growth factor receptor targeting in head and neck cancer: have we been just skimming the surface?

scientific article published on 4 March 2013

Epstein-Barr virus DNA measured in nasopharyngeal brushings in patients with nasopharyngeal carcinoma: pilot study.

scientific article published in October 2004

Evaluation of adverse events experienced by older patients participating in studies of molecularly targeted agents alone or in combination

scientific article published on 01 April 2006

Evaluation of the pharmacodynamic effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay

scientific article

Evolution of clinical trial design in early drug development: systematic review of expansion cohort use in single-agent phase I cancer trials

scientific article published on 14 October 2013

Exposure and Tumor Fn14 Expression as Determinants of Pharmacodynamics of the Anti-TWEAK Monoclonal Antibody RG7212 in Patients with Fn14-Positive Solid Tumors.

scientific article published on 7 October 2015

Factors contributing to the efficacy of concurrent–adjuvant chemotherapy for locoregionally advanced nasopharyngeal carcinoma: Combined analyses of NPC-9901 and NPC-9902 Trials

scientific article published on 26 November 2010

Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer

scientific article published on 14 October 2018

Feasibility Assessment of Using the Complete Patient-Reported Outcomes Version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) Item Library

scientific article published on 06 February 2019

Feasibility of real time next generation sequencing of cancer genes linked to drug response: results from a clinical trial

scientific article

Fluorescence in situ hybridization gene amplification analysis of EGFR and HER2 in patients with malignant salivary gland tumors treated with lapatinib

scientific article published on August 2009

Genomic testing in cancer: patient knowledge, attitudes, and expectations

scientific article published on 24 June 2014

Genomically personalized therapy in head and neck cancer

scientific article published on 09 June 2016

Giant Prolactinoma Presenting As a Base of Skull Tumor With Nasopharyngeal Extension: A Potential Diagnostic Pitfall in Neuroendocrine Lesions of the Base of Skull

scientific article published on 14 February 2017

Hyperprogressive disease in early-phase immunotherapy trials: Clinical predictors and association with immune-related toxicities

scientific article published on 15 February 2019

Hypofractionated radiotherapy alone with 2.4 Gy per fraction for head and neck cancer during the COVID-19 pandemic: The Princess Margaret experience and proposal

scientific article published on 01 June 2020

Identifying actionable variants using next generation sequencing in patients with a historical diagnosis of undifferentiated pleomorphic sarcoma.

scientific article published on 10 September 2017

Imatinib mesylate in patients with adenoid cystic cancers of the salivary glands expressing c-kit: a Princess Margaret Hospital phase II consortium study

scientific article published in January 2005

Impact and perceptions of mandatory tumor biopsies for correlative studies in clinical trials of novel anticancer agents

scientific article published on October 2006

Impact of cisplatin dose and smoking pack-years in human papillomavirus-positive oropharyngeal squamous cell carcinoma treated with chemoradiotherapy

scientific article published on 19 July 2019

Impact of cisplatin dose intensity on human papillomavirus-related and -unrelated locally advanced head and neck squamous cell carcinoma

scientific article published on 23 September 2016

Impact of cumulative cisplatin dose and adjuvant chemotherapy in locally-advanced nasopharyngeal carcinoma treated with definitive chemoradiotherapy

scientific article published on 06 April 2020

Impact of multi-gene mutational profiling on clinical trial outcomes in metastatic breast cancer.

scientific article published on 24 November 2017

Important early advances in squamous cell carcinoma of the head and neck

scientific article published on 01 January 2012

Improving the quality of abstract reporting for phase I cancer trials

scientific article published in March 2008

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

scientific article published on 23 July 2015

Incidental germline findings identified in a somatic genomic sequencing program for advanced cancer patients

Increasing operational and scientific efficiency in clinical trials

scientific article published on 21 July 2020

Intratumoral Transcriptome Heterogeneity Is Associated With Patient Prognosis and Sidedness in Patients With Colorectal Cancer Treated With Anti-EGFR Therapy From the CO.20 Trial

scientific article published on 29 September 2020

Latency and interval therapy affect the evolution in metastatic colorectal cancer

scientific article published on 17 January 2020

Less Than Ideal: How Oncologists Practice With Limited Drug Access ⬇️

scientific article published on January 10, 2012

Lung cancer in never smokers from the Princess Margaret Cancer Centre.

scientific article published on 27 April 2018

MG-131 Incidental germline findings in tumour molecular profiling by next generation sequencing

scientific article

Magnetic resonance imaging of nasopharyngeal carcinoma

article

Minimally Invasive Real-Time Detection of Actionable Mutations in Patients With Metastatic Solid Tumors Using Fine-Needle and Liquid Biopsies

scholarly article

Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience

scientific article published on 23 October 2017

Molecular profiling for precision cancer therapies

scientific article published on 14 January 2020

Molecular profiling of advanced solid tumors and patient outcomes with genotype-matched clinical trials: the Princess Margaret IMPACT/COMPACT trial.

scientific article published on 25 October 2016

Molecular targeted therapies in all histologies of head and neck cancers: an update

scientific article published on May 2010

Molecular targeted therapy of head and neck cancer: review and clinical development challenges

scientific article published on 27 September 2007

Molecular-targeted therapies in the treatment of squamous cell carcinomas of the head and neck

scientific article published on May 2008

Molecularly targeted oncology therapeutics and prolongation of the QT interval

scientific article published on August 2007

Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck

scientific article

Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling

scientific article published in November 2006

Nasopharyngeal carcinoma: the next challenges

scientific article published on 05 May 2010

Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer

scientific article published on 20 August 2012

Natural history and chemotherapy effectiveness for advanced adenocarcinoma of the small bowel: a retrospective review of 113 cases

scientific article

Neuroendocrine tumors of the gastrointestinal tract: a decade of experience at the Princess Margaret Hospital

scientific article published on February 2008

Nomograms to predict serious adverse events in phase II clinical trials of molecularly targeted agents

scientific article published in March 2008

Novel combinations of PI3K-mTOR inhibitors with dacomitinib or chemotherapy in PTEN-deficient patient-derived tumor xenografts.

scientific article published on 8 July 2017

Ocular toxicity of targeted therapies

scientific article published on 29 May 2012

Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation

scientific article published on 10 March 2012

Outcomes of Older Patients (≥ 70 Years) Treated With Targeted Therapy in Metastatic Chemorefractory Colorectal Cancer: Retrospective Analysis of NCIC CTG CO.17 and CO.20

scientific article published on 28 November 2018

PD-L1 Testing in Cancer: Challenges in Companion Diagnostic Development

scientific article published on 01 January 2016

Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412

scientific article published on 03 June 2020

Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients.

scientific article

Pharmacokinetic assessment of dacomitinib (pan-HER tyrosine kinase inhibitor) in patients with locally advanced head and neck squamous cell carcinoma (LA SCCHN) following administration through a gastrostomy feeding tube (GT).

scientific article published on 5 May 2015

Phase 1 study of ixazomib, an investigational proteasome inhibitor, in advanced non-hematologic malignancies

scientific article

Phase 1 study of the immunotoxin LMB-100 in patients with mesothelioma and other solid tumors expressing mesothelin

scientific article published on 01 September 2020

Phase 1 trial design: is 3 + 3 the best?

scientific article

Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors

scientific article published on 03 January 2014

Phase 1/2 Study of the Addition of Cisplatin to Adjuvant Chemotherapy With Image Guided High-Precision Radiation Therapy for Completely Resected Gastric Cancer

scientific article published on 31 August 2016

Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies

scientific article published on 01 February 2019

Phase I Study of Decitabine in Combination with Vorinostat in Patients with Advanced Solid Tumors and Non-Hodgkin's Lymphomas ⬇️

scientific article published on January 28, 2011

Phase I and Pharmacokinetic Study of Romidepsin in Patients with Cancer and Hepatic Dysfunction: A National Cancer Institute Organ Dysfunction Working Group Study

scientific article published on 14 August 2020

Phase I and pharmacokinetic study of Bay 38-3441, a camptothecin glycoconjugate, administered as a 30-minute infusion daily for five days every 3 weeks in patients with advanced solid malignancies

scientific article published in October 2005

Phase I and pharmacokinetic study of novel L-nucleoside analog troxacitabine given as a 30-minute infusion every 21 days

scientific article

Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks

scientific article published on 01 February 2003

Phase I combination of sorafenib and erlotinib therapy in solid tumors: safety, pharmacokinetic, and pharmacodynamic evaluation from an expansion cohort

scientific article

Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma

scientific article published on 10 June 2010

Phase I dose-escalation and -expansion study of buparlisib (BKM120), an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors

scientific article published on 21 March 2014

Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.

scientific article

Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors

scientific article

Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas.

scientific article

Phase I study of the multidrug resistance inhibitor zosuquidar administered in combination with vinorelbine in patients with advanced solid tumours

scientific article

Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors

scientific article published on 01 August 2007

Phase I trial of dacomitinib, a pan-human epidermal growth factor receptor (HER) inhibitor, with concurrent radiotherapy and cisplatin in patients with locoregionally advanced squamous cell carcinoma of the head and neck (XDC-001).

scientific article published on 11 June 2016

Phase I trial of gemcitabine, doxorubicin and cisplatin (GAP) in patients with advanced solid tumors

scientific article

Phase I trial of sorafenib and gemcitabine in advanced solid tumors with an expanded cohort in advanced pancreatic cancer

scientific article

Phase I/II trial of erlotinib and cisplatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck: a Princess Margaret Hospital phase II consortium and National Cancer Institute of Canada Clinical Trials Group Study

scientific article published on 01 June 2007

Phase II Study of Lapatinib in Recurrent or Metastatic Epidermal Growth Factor Receptor and/or erbB2 Expressing Adenoid Cystic Carcinoma and Non–Adenoid Cystic Carcinoma Malignant Tumors of the Salivary Glands

article by Mark Agulnik et al published September 2007 in Journal of Clinical Oncology

Phase II randomised discontinuation trial of brivanib in patients with advanced solid tumours

scientific article published on 12 September 2019

Phase II study of activated charcoal to prevent irinotecan-induced diarrhea

scientific article published in November 2004

Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck

scientific article

Phase II trial of sorafenib in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or nasopharyngeal carcinoma

scientific article published in August 2007

Phase III randomized, placebo-controlled study of cetuximab plus brivanib alaninate versus cetuximab plus placebo in patients with metastatic, chemotherapy-refractory, wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO

scientific article

Phase Ib Trial With Birabresib, a Small-Molecule Inhibitor of Bromodomain and Extraterminal Proteins, in Patients With Selected Advanced Solid Tumors

scientific article published on 07 May 2018

Pre-clinical characterization of Dacomitinib (PF-00299804), an irreversible pan-ErbB inhibitor, combined with ionizing radiation for head and neck squamous cell carcinoma

scientific article

Preclinical development of molecular-targeted agents for cancer

scientific article published on 07 December 2010

Predicting response and toxicity to PD-1 inhibition using serum autoantibodies identified from immuno-mass spectrometry

scientific article published on 07 May 2020

Predictive and pharmacodynamic biomarker studies in tumor and skin tissue samples of patients with recurrent or metastatic squamous cell carcinoma of the head and neck treated with erlotinib

scientific article published on June 2007

Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally advanced nasopharyngeal carcinoma

scientific article published in September 2006

Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group

scientific article

Preoperative radiation with concurrent chemotherapy for resectable rectal cancer: effect of dose escalation on pathologic complete response, local recurrence-free survival, disease-free survival, and overall survival

scientific article

Pretreatment neurocognitive function and self-reported symptoms in patients with newly diagnosed head and neck cancer compared with noncancer cohort

scientific article published on 17 April 2018

Principles of clinical trial design

scientific article

Prognostic importance of radiologic extranodal extension in HPV-positive oropharyngeal carcinoma and its potential role in refining TNM-8 cN-classification

scientific article published on 08 November 2019

Progress and challenges in the identification of biomarkers for EGFR and VEGFR targeting anticancer agents

scientific article published on 02 June 2008

Promising SINEs for embargoing nuclear-cytoplasmic export as an anticancer strategy

scientific article published on 17 April 2014

Quality of life and swallowing with standard chemoradiotherapy versus accelerated radiotherapy and panitumumab in locoregionally advanced carcinoma of the head and neck: A phase III randomised trial from the Canadian Cancer Trials Group (HN.6).

scientific article

Quality of life in patients with K-RAS wild-type colorectal cancer: the CO.20 phase 3 randomized trial

scientific article published on 11 October 2013

Radiation Therapy for Oropharyngeal Squamous Cell Carcinoma: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline

scientific article published on 24 October 2017

Raf kinase as a target for anticancer therapeutics

scientific article (publication date: April 2005)

Randomized phase II trials: inevitable or inadvisable?

scientific article published on 20 April 2010

Randomized trial of radiotherapy plus concurrent-adjuvant chemotherapy vs radiotherapy alone for regionally advanced nasopharyngeal carcinoma

scientific article published on 15 July 2010

Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520

scientific article published on 01 February 2019

Rational design and identification of immuno-oncology drug combinations.

scientific article published on 6 April 2018

Referrals to a Phase I Clinic and Trial Enrollment in the Molecular Screening Era

scientific article published on 04 March 2019

Refining American Joint Committee on Cancer/Union for International Cancer Control TNM stage and prognostic groups for human papillomavirus-related oropharyngeal carcinomas

scientific article published on 9 February 2015

Reporting of time-to-event end points and tracking of failures in randomized trials of radiotherapy with or without any concomitant anticancer agent for locally advanced head and neck cancer

scientific article published on 05 October 2009

Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1-Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinical Trial

scientific article published on 01 February 2019

Safety and clinical activity of intratumoral MEDI9197 alone and in combination with durvalumab and/or palliative radiation therapy in patients with advanced solid tumors

scientific article published on 01 October 2020

Safety and pharmacokinetics of motesanib in combination with gemcitabine and erlotinib for the treatment of solid tumors: a phase 1b study.

scientific article

Safety, Tolerability, and Potential Clinical Activity of a Glucocorticoid-Induced TNF Receptor-Related Protein Agonist Alone or in Combination With Nivolumab for Patients With Advanced Solid Tumors: A Phase 1/2a Dose-Escalation and Cohort-Expansion

scientific article published on 07 November 2019

Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors

scientific article

Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology

scientific article published on 01 February 2019

Significance of dysregulated metadherin and microRNA-375 in head and neck cancer.

scientific article

Simultaneous determination of OSI-774 and its major metabolite OSI-420 in human plasma by using HPLC with UV detection

scientific article published in January 2005

Somatic Tumor Variant Filtration Strategies to Optimize Tumor-Only Molecular Profiling Using Targeted Next-Generation Sequencing Panels

scientific article published on 19 December 2018

Sucralfate mouthwash for prevention and treatment of 5-fluorouracil-induced mucositis: a randomized, placebo-controlled trial

scientific article

Surrogate end points for median overall survival in metastatic colorectal cancer: literature-based analysis from 39 randomized controlled trials of first-line chemotherapy.

scientific article published on 17 September 2007

Survival in Early Phase Immuno-Oncology Trials: Development and Validation of a Prognostic Index

scientific article published on 19 September 2019

Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials

scientific article

TP53 mutations in high grade serous ovarian cancer and impact on clinical outcomes: a comparison of next generation sequencing and bioinformatics analyses

scientific article published on 18 January 2019

Talimogene Laherparepvec and Pembrolizumab in Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck (MASTERKEY-232): A Multicenter, Phase 1b Study

scientific article published on 15 July 2020

Testing ERBB2 p.L755S kinase domain mutation as a druggable target in a patient with advanced colorectal cancer

scientific article published on September 2016

Testing personalized medicine: patient and physician expectations of next-generation genomic sequencing in late-stage cancer care

scientific article published on 17 July 2013

The Utility of Hedgehog Signaling Pathway Inhibition for Cancer ⬇️

scientific article published on July 31, 2012

The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck

scientific article

The contents and readability of informed consent forms for oncology clinical trials

The effect of circadian rhythm on clinical outcome in patients receiving pembrolizumab in the INSPIRE pan-cancer trial.

scientific article published in 2022

The impact of an educational DVD on cancer patients considering participation in a phase I clinical trial

The influence of mentorship on research productivity in oncology

scientific article published in October 2007

The statins as anticancer agents

scientific article

Tilting the Balance of Dose Modification for Oral Anticancer Drugs?

scientific article published on 07 April 2014

Tolerability of the Intergroup 0099 (INT 0099) regimen in locally advanced nasopharyngeal cancer with a focus on patients' nutritional status

scientific article

Towards new methods for the determination of dose limiting toxicities and the assessment of the recommended dose for further studies of molecularly targeted agents--dose-Limiting Toxicity and Toxicity Assessment Recommendation Group for Early Trials

scientific article

Treatment implications of postoperative chemoradiotherapy for squamous cell carcinoma of the oral cavity with minor and major extranodal extension

scientific article published on 29 June 2020

Troxacitabine, an L-stereoisomeric nucleoside analog, on a five-times-daily schedule: a phase I and pharmacokinetic study in patients with advanced solid malignancies

scientific article

Tumour heterogeneity in the clinic

scientific article

Two-Target Quantitative PCR To Predict Library Composition for Shallow Shotgun Sequencing

scientific article published on 13 July 2021

Understanding the attitudes of the elderly towards enrolment into cancer clinical trials

scientific article

Use of Expansion Cohorts in Phase I Trials and Probability of Success in Phase II for 381 Anticancer Drugs

scientific article published on 4 April 2017

Validation of CyTOF Against Flow Cytometry for Immunological Studies and Monitoring of Human Cancer Clinical Trials

scientific article published on 17 May 2019

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