List of works - Elizabeth J. Goldsmith

A Phosphorylated Intermediate in the Activation of WNK Kinases

scientific article published on 21 April 2020

Characterization of mitogen-activated protein kinase (MAPK) dimers

scientific article published in November 2006

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

scientific article

Crystal structure of domain-swapped STE20 OSR1 kinase domain

scientific article

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

scientific journal article

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

scientific article published in July 2004

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

scientific article

Crystallization of MAP kinases

scientific article published on November 2006

Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening

scientific article published on 6 July 2016

Docking interactions induce exposure of activation loop in the MAP kinase ERK2

scientific article published on 01 June 2006

Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry

scientific article

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

scientific article

Functional divergence caused by mutations in an energetic hotspot in ERK2

scientific article published on 11 July 2019

How activating mutations affect MEK1 regulation and function

scientific article

Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule.

scientific article

MAP kinase modules: the excursion model and the steps that count

scientific article

Modeling of the spatial structure of eukaryotic ornithine decarboxylases ⬇️

scientific article published on July 1, 1995

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase

scientific article published in October 2004

Mutations in ERK2 Binding Sites Affect Nuclear Entry

scientific article published in Journal of Biological Chemistry

Precisely Ordered Phosphorylation Reactions in the p38 Mitogen-activated Protein (MAP) Kinase Cascade ⬇️

scientific article published on 06 June 2013

Properties of WNK1 and implications for other family members

scientific article

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

scientific article (publication date: 13 December 2002)

Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain

scientific article

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

scientific article

Structural Studies of MAP Kinase Cascade Components ⬇️

scientific article published on January 1, 2010

Structure of MAPKs.

scientific article

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

scientific article

Substrate and docking interactions in serine/threonine protein kinases

scientific article

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

scientific article

The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution

scientific article

Unique MAP Kinase binding sites

scientific article

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

scientific article

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension

scientific article

X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity †

scientific article

List of works by Elizabeth J. Goldsmith

A Phosphorylated Intermediate in the Activation of WNK Kinases

Characterization of mitogen-activated protein kinase (MAPK) dimers

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

Crystal structure of domain-swapped STE20 OSR1 kinase domain

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension

Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

Crystallization of MAP kinases

Discovery of novel TAOK2 inhibitor scaffolds from high-throughput screening

Docking interactions induce exposure of activation loop in the MAP kinase ERK2

Docking motif interactions in MAP kinases revealed by hydrogen exchange mass spectrometry

Domain-Swapping Switch Point in Ste20 Protein Kinase SPAK

Functional divergence caused by mutations in an energetic hotspot in ERK2

How activating mutations affect MEK1 regulation and function

Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule.

MAP kinase modules: the excursion model and the steps that count

Modeling of the spatial structure of eukaryotic ornithine decarboxylases ⬇️

Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase

Mutations in ERK2 Binding Sites Affect Nuclear Entry

Precisely Ordered Phosphorylation Reactions in the p38 Mitogen-activated Protein (MAP) Kinase Cascade ⬇️

Properties of WNK1 and implications for other family members

Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

Structural Studies of MAP Kinase Cascade Components ⬇️

Structure of MAPKs.

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

Substrate and docking interactions in serine/threonine protein kinases

The Structure of the MAP2K MEK6 Reveals an Autoinhibitory Dimer

The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution

Unique MAP Kinase binding sites

WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding

WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension

X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity †