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List of works by Timothy M Miller

A Phase 2, Double-Blind, Randomized, Dose-Ranging Trial Of Reldesemtiv In Patients With ALS

scientific article published on 24 September 2020

A viral toolkit for recording transcription factor-DNA interactions in live mouse tissues

scientific article published on 16 April 2020

ALS-linked mutant superoxide dismutase 1 (SOD1) alters mitochondrial protein composition and decreases protein import.

scientific article

Amyotrophic Lateral Sclerosis Care and Research in the USA During the COVID-19 Pandemic: Challenges and Opportunities

scientific article published on 23 May 2020

Amyotrophic lateral sclerosis and gene therapy.

scientific article published on September 2006

Amyotrophic lateral sclerosis onset is influenced by the burden of rare variants in known amyotrophic lateral sclerosis genes.

scientific article

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

scientific article published on 29 March 2013

An endogenous peptide marker differentiates SOD1 stability and facilitates pharmacodynamic monitoring in SOD1 amyotrophic lateral sclerosis

scientific article published on 16 May 2019

Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases

scientific article

Antisense Reduction of Tau in Adult Mice Protects against Seizures ⬇️

scientific article published on July 31, 2013

Antisense oligonucleotide therapy for neurodegenerative disease.

scientific article

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

scientific article published on 16 July 2018

Burst mitofusin activation reverses neuromuscular dysfunction in murine CMT2A

scientific article published on 19 October 2020

CK-2127107 amplifies skeletal muscle response to nerve activation in humans.

scientific article published on 18 November 2017

CNS microRNA profiles: a database for cell type enriched microRNA expression across the mouse central nervous system

scientific article published on 18 March 2020

Familial ALS with extreme phenotypic variability due to the I113T SOD1 mutation

article

Fibroblast bioenergetics to classify amyotrophic lateral sclerosis patients.

scientific article published on 24 October 2017

Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis

scholarly article

Gene-targeted therapies for the central nervous system

scientific article published on 11 February 2008

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

scientific article published in March 2018

Has gene therapy for ALS arrived?

scientific article published in October 2003

Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

scientific article published on 01 December 2019

Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model

scientific article published on 18 May 2016

Long-Term Survival of Participants in the CENTAUR Trial of Sodium Phenylbutyrate-Taurursodiol in ALS

scientific article published on 16 October 2020

Management of amyotrophic lateral sclerosis

scientific article published on September 2013

Medicine. Treating neurodegenerative diseases with antibiotics.

scientific article published in January 2005

Method for widespread microRNA-155 inhibition prolongs survival in ALS-model mice ⬇️

scientific article published on 04 June 2013

MicroRNA Profiling Reveals Marker of Motor Neuron Disease in ALS Models.

scientific article published on 17 April 2017

Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis

scientific article published on 01 September 2018

Peripheral neuropathy in an outpatient cohort of patients with Sjögren's syndrome

scientific article published on 01 May 2006

Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

scientific article published on 01 July 2020

Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis

scientific article published on 19 June 2017

Plasma neurofilament light predicts mortality in patients with stroke

scientific article published on 01 November 2020

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

scientific article published on March 2017

Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis

scientific article

Progressive spinal axonal degeneration and slowness in ALS2-deficient mice

scientific article published in July 2006

Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers

scientific article published on 02 October 2019

RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia

scientific article

RCADiA: simple automation platform for comparative multidimensional protein identification technology

scientific article

Reply: To PMID 25900666

scientific article published on 19 August 2015

SOD1 in Cerebral Spinal Fluid as a Pharmacodynamic Marker for Antisense Oligonucleotide Therapy ⬇️

scientific article published on February 1, 2013

Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria.

scholarly article

Smartphone data during the COVID-19 pandemic can quantify behavioral changes in people with ALS

scientific article published on 29 October 2020

Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

scientific article published on 7 December 2017

TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration

scientific article

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

scientific article

Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria.

scientific article

Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis

scientific article published on 01 September 2020

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

scientific article published on 13 July 2018

Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis

scientific article

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