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List of works by John E Landers

A Drosophila model of ALS reveals a partial loss of function of causative human PFN1 mutants.

scientific article published on 3 April 2017

A blinded international study on the reliability of genetic testing for GGGGCC-repeat expansions in C9orf72 reveals marked differences in results among 14 laboratories

scientific article

A common haplotype within the PON1 promoter region is associated with sporadic ALS.

scientific article published on October 2008

A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis

scientific article

A large genome scan for rare CNVs in amyotrophic lateral sclerosis

scientific article

A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS

scientific article published on 25 March 2009

A loss of FUS/TLS function leads to impaired cellular proliferation

scientific article

A novel phosphorylation site mutation in profilin 1 revealed in a large screen of US, Nordic, and German amyotrophic lateral sclerosis/frontotemporal dementia cohorts.

scientific article

ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function

scientific article published on 01 April 2022

ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function

scientific article published on 25 June 2018

ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation

scientific article

ATXN1 repeat expansions confer risk for amyotrophic lateral sclerosis and contribute to TDP-43 mislocalization

scientific article published on 19 May 2020

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

scientific article

Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort

scientific article published on 09 September 2009

Analysis of hnRNPA1, A2/B1, and A3 genes in patients with amyotrophic lateral sclerosis.

scientific article published on 2 July 2013

Analysis of the KIFAP3 gene in amyotrophic lateral sclerosis: a multicenter survival study

scientific article

Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

scientific article published on December 2011

Association of NIPA1 repeat expansions with amyotrophic lateral sclerosis in a large international cohort

scientific article published on 22 September 2018

Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis

scientific article published on 31 May 2016

Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scientific article

C9orf72 and UNC13A are shared risk loci for amyotrophic lateral sclerosis and frontotemporal dementia: a genome-wide meta-analysis

scientific article

CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia

scientific article published on 15 April 2016

CYLD is a causative gene for frontotemporal dementia - amyotrophic lateral sclerosis

scientific article published on 01 March 2020

Characterization of FUS mutations in amyotrophic lateral sclerosis using RNA-Seq

scientific article

Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study

scientific article published on October 2010

Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

preprint

Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

scholarly article

Comparative analysis of C9orf72 and sporadic disease in an ALS clinic population

scientific article published on 3 August 2016

DNA sequence analysis of the conserved region around the SOD1 gene locus in recessively inherited ALS.

scientific article published on 9 July 2009

Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.

scientific article

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

scientific article published on 19 February 2015

Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.

scientific article published on 22 October 2014

Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets

scientific article

Genome complexity reduction for SNP genotyping analysis

scientific article

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

scientific article published in March 2018

Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

scientific article published on 25 July 2016

Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis

scientific article published on 28 April 2013

Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis

scientific article

Human genetics and neuropathology suggest a link between miR-218 and amyotrophic lateral sclerosis pathophysiology

scientific article published on 01 December 2019

Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients

scientific article published on 22 April 2015

Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.

scientific article

Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis

scientific article published on 23 August 2019

Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele.

scientific article published on 8 August 2007

Mutant PFN1 causes ALS phenotypes and progressive motor neuron degeneration in mice by a gain of toxicity

scientific article

Mutational analysis of TARDBP in neurodegenerative diseases

scientific article

Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis.

scientific article

Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis

scientific article (publication date: 27 February 2009)

Mutations in the Glycosyltransferase Domain of GLT8D1 Are Associated with Familial Amyotrophic Lateral Sclerosis

scientific article published on 01 February 2019

Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy

scientific article

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

scientific article

Mutations in the vesicular trafficking protein annexin A11 are associated with amyotrophic lateral sclerosis

scientific article

NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

scientific article

New VAPB deletion variant and exclusion of VAPB mutations in familial ALS.

scientific article published on 5 March 2008

No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis

scientific article

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS.

scientific article

Paraoxonase 1 (PON1) organophosphate hydrolysis is not reduced in ALS.

scientific article

Paraoxonase gene mutations in amyotrophic lateral sclerosis

scientific article

Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis

scientific article published on 26 November 2020

Polymorphisms in the GluR2 gene are not associated with amyotrophic lateral sclerosis

scientific article

Prevalence of Huntington's disease gene CAG repeat alleles in sporadic amyotrophic lateral sclerosis patients

scientific article

Project MinE: study design and pilot analyses of a large-scale whole-genome sequencing study in amyotrophic lateral sclerosis

Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS

scientific article published on 01 July 2019

RNA processing pathways in amyotrophic lateral sclerosis

scientific article published on 27 March 2010

Rare variants in MYH15 modify amyotrophic lateral sclerosis risk

scientific article published on 01 July 2019

Reconsidering the causality of TIA1 mutations in ALS.

scientific article published on 13 December 2017

Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis

scientific journal article

Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress

scientific article published on 10 November 2012

SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models

scientific article published on 9 July 2016

Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and in frontotemporal dementia

scientific article published on 11 October 2012

Structural basis for mutation-induced destabilization of profilin 1 in ALS.

scientific article published on 8 June 2015

Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

scientific article published on 28 January 2022

TDP-43 and NOVA-1 RNA-binding proteins as competitive splicing regulators of the schizophrenia-associated TNIK gene

scientific article published on 02 August 2019

TUBA4A gene analysis in sporadic amyotrophic lateral sclerosis: identification of novel mutations.

scientific article

The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder

scientific article

The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1.

scientific article published on 28 February 2018

The Project MinE databrowser: bringing large-scale whole-genome sequencing in ALS to researchers and the public

The RNA-binding protein FUS/TLS undergoes calcium-mediated nuclear egress during excitotoxic stress and is required for GRIA2 mRNA processing

scientific article published on 15 May 2019

The distinct genetic pattern of ALS in Turkey and novel mutations.

scientific article published on 10 January 2015

The effect of SMN gene dosage on ALS risk and disease severity

scientific article published on 02 January 2021

The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci ⬇️

scientific article

The role of de novo mutations in the development of amyotrophic lateral sclerosis.

scientific article published on 17 July 2017

Transcription factor Pebbled/RREB1 regulates injury-induced axon degeneration

scientific article published on 2 January 2018

Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein ⬇️

scientific article published on August 15, 1997

Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

scientific article

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