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List of works by Lixin Wan

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination

scientific article

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction

scientific article

Acetylation-dependent regulation of Skp2 function

scientific article

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 01 May 2019

Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 28 August 2020

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

scientific article

Cdc20: a potential novel therapeutic target for cancer treatment

scientific article

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

scientific article published on 2 February 2016

Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways

scientific article published on 28 May 2009

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid

scientific article published on 29 April 2016

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

scientific article published on December 2011

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

scientific article

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction ⬇️

scientific article published on September 1, 2012

Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.

scientific article published on 15 January 2018

Emerging roles of the FBW7 tumour suppressor in stem cell differentiation ⬇️

scientific article published on December 23, 2011

Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis

scientific article

Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

scientific article published on 16 August 2019

MC1R is a potent regulator of PTEN after UV exposure in melanocytes

scientific article published on August 2013

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

scientific article

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

scientific article published on 01 May 2019

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction ⬇️

scientific article published on September 10, 2010

SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

scientific article published on December 2013

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

scientific article

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

scientific article

SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation

scientific article

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

scientific article

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

scientific article

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.

scientific article published on 22 August 2013

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 27 October 2013

Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 15 July 2020

Skp2 is a promising therapeutic target in breast cancer

scientific article published on January 2012

Skp2: A novel potential therapeutic target for prostate cancer ⬇️

scientific article published on September 22, 2011

Smurf1 regulation of DAB2IP controls cell proliferation and migration

scientific article published on 27 March 2016

Targeting Cdc20 as a novel cancer therapeutic strategy

scientific article published on 4 April 2015

The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function

scientific article published on 7 February 2017

The two faces of FBW7 in cancer drug resistance.

scientific article

Tumor suppressor functions of FBW7 in cancer development and progression ⬇️

scientific article published on March 21, 2012

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

scientific article

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