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List of works by Jun Chen

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

scientific article published on 07 September 2018

APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.

scientific article published on 06 June 2016

ATP induces mild hypothermia in rats but has a strikingly detrimental impact on focal cerebral ischemia.

scientific article published on 17 October 2012

Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia

scientific article published on 03 October 2013

Apurinic/apyrimidinic endonuclease 1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury

scientific article published on January 2015

Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation.

scientific article

Corrigendum to "Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation" [Redox Biol. 17 (2018) 323-337]

scientific article published on 21 December 2018

Delivery of neurotherapeutics across the blood brain barrier in stroke.

scientific article published on January 2012

Diabetes Mellitus Impairs White Matter Repair and Long-Term Functional Deficits After Cerebral Ischemia

scientific article published on 01 October 2018

Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke.

scientific article

Drug-induced hypothermia in stroke models: does it always protect?

scientific article

Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.

scientific article

Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury

scientific article

Expansion of Regulatory T cells with IL-2/IL-2 Antibody Complex Protects against Transient Ischemic Stroke

scientific article published on 05 October 2018

Fast free-of-acrylamide clearing tissue (FACT)-an optimized new protocol for rapid, high-resolution imaging of three-dimensional brain tissue

scientific article published on 29 August 2017

From apoplexy to stroke: historical perspectives and new research frontiers.

scientific article

Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury

scientific article

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis.

scientific article

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

scientific article published on 08 December 2020

Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury.

scientific article published on July 2017

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

scientific article published on 5 January 2016

Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2

scientific article published on 05 December 2019

Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia.

scientific article published on 28 August 2012

Microglial Responses to Brain Injury and Disease: Functional Diversity and New Opportunities

scientific article published on 31 October 2020

Microglial and macrophage polarization—new prospects for brain repair

scientific article

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

scientific article published on November 2012

Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair

scientific article

Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles

scientific article

Neurobiology of stroke: Research progress and perspectives

scientific article published on 01 April 2018

Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury

scientific article

Neuroprotection against stroke and CNS injury: new mechanisms, targets, and controversies

scientific article published on 01 May 2013

Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1.

scientific article published on January 2014

Omega-3 polyunsaturated fatty acid supplementation improves neurologic recovery and attenuates white matter injury after experimental traumatic brain injury.

scientific article published on 26 June 2013

Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke

scientific article

Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury

scientific article published on 24 February 2016

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

scientific article published on 8 November 2017

Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury.

scientific article published on 21 February 2013

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

scientific article published on 11 October 2017

Perspective for stroke and brain injury research: mechanisms and potential therapeutic targets

scientific article published in April 2015

Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.

scientific article published on 02 January 2014

Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases

scientific article published on 2 January 2017

Promises and limitations of immune cell-based therapies in neurological disorders

scientific article published on 01 September 2018

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke

scientific article published on 17 April 2019

RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke

scientific article published on 13 November 2019

Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury

scientific article published on 27 January 2016

Regulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological Disorders

scientific article

Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.

scientific article published on 22 May 2017

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia.

scientific article

ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury

scientific article published on 7 April 2017

Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT.

scientific article

TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia

scientific article published on 05 March 2019

The dynamics of the mitochondrial organelle as a potential therapeutic target

scientific article

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

scientific article published on 21 June 2019

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury

scientific article published on 10 September 2018

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals.

scientific article published on 13 January 2016

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke.

scientific article

n-3 PUFA supplementation benefits microglial responses to myelin pathology.

scientific article published on 12 December 2014

n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling.

scientific article

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