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List of works by Leonid Margolis

A common anti-cytomegalovirus drug, ganciclovir, inhibits HIV-1 replication in human tissues ex vivo

scientific article published on July 2017

A highly sensitive and dynamic immunofluorescent cytometric bead assay for the detection of HIV-1 p24.

scientific article published on 6 January 2009

A multi-targeted drug candidate with dual anti-HIV and anti-HSV activity

scientific article (publication date: 2013)

A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.

scientific article

A new class of dual-targeted antivirals: monophosphorylated acyclovir prodrug derivatives suppress both human immunodeficiency virus type 1 and herpes simplex virus type 2

scientific article

Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.

scientific article published on 8 February 2007

Activation of T lymphocytes in atherosclerotic plaques

scientific article published on 29 September 2011

Acyclovir is activated into a HIV-1 reverse transcriptase inhibitor in herpesvirus-infected human tissues

scientific article

Acyclovir: a new use for an old drug

scientific article published on December 2009

Addition of thrombin reduces the recovery of extracellular vesicles from blood plasma.

scientific article published in January 2016

An ex vivo Model of HIV-1 Infection in Human Lymphoid Tissue and Cervico-vaginal Tissue

scientific article published on January 2014

Antigenic composition of single nano-sized extracellular blood vesicles

scientific article published on 3 December 2014

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: a multicenter study

scientific article published on 17 May 2008

CD4+ T cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors

scientific article

CD63, MHC class 1, and CD47 identify subsets of extracellular vesicles containing distinct populations of noncoding RNAs.

scientific article published on 7 February 2018

CXCR4-tropic HIV-1 suppresses replication of CCR5-tropic HIV-1 in human lymphoid tissue by selective induction of CC-chemokines

scientific article published on 20 January 2004

Cervico-vaginal tissue ex vivo as a model to study early events in HIV-1 infection

scientific article published on 12 January 2011

Coinfecting viruses as determinants of HIV disease

scientific article

Complex extracellular matrices promote tissue-specific stem cell differentiation.

scientific article published on February 2005

Contrasting roles for TLR ligands in HIV-1 pathogenesis

scientific article

Cytomegalovirus-Productive Infection Is Associated With Acute Coronary Syndrome

scientific article published on 20 August 2016

Design and cellular kinetics of dansyl-labeled CADA derivatives with anti-HIV and CD4 receptor down-modulating activity

scientific article

Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides

scientific article

Determinants of protection among HIV‐exposed seronegative persons: an overview

scientific article

Differential pathogenesis of primary CCR5-using human immunodeficiency virus type 1 isolates in ex vivo human lymphoid tissue

scientific article published in September 2005

Distinct cytokine/chemokine network in semen and blood characterize different stages of HIV infection

scientific article published on 10 November 2015

Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue

scientific article published in October 2004

Dual-targeted anti-TB/anti-HIV heterodimers

scientific article

Dynamics of coagulopathy in patients with different COVID-19 severity

scientific article published on 04 July 2020

Evaluation of the maturation of individual Dengue virions with flow virometry

scientific article published on 16 November 2015

Evidence of perturbations of the cytokine network in preterm labor

scientific article

Evolution of CXCR4-using human immunodeficiency virus type 1 SF162 is associated with two unique envelope mutations

scientific article published on 3 January 2007

Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A.

scientific article published on 2 July 2009

Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin

scientific article published on 6 February 2012

Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

scientific article

Extracellular vesicles and viruses: Are they close relatives?

scientific article

Extracellular vesicles generated by placental tissues ex vivo: A transport system for immune mediators and growth factors

scholarly article by Wendy Fitzgerald et al published July 2018 in American Journal of Reproductive Immunology

Ex vivo culture of human atherosclerotic plaques: A model to study immune cells in atherogenesis

scientific article published on 7 October 2017

Flow Virometry to Analyze Antigenic Spectra of Virions and Extracellular Vesicles

scientific article published on 25 January 2017

Flow analysis of individual blood extracellular vesicles in acute coronary syndrome

scientific article published on 5 September 2016

Flow virometry analysis of envelope glycoprotein conformations on individual HIV virions

scientific article published on 19 April 2017

Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine

scientific article published on July 2017

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

scientific article

Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men.

scientific article published on 10 June 2015

HIV-1 expressing the envelopes of transmitted/founder or control/reference viruses have similar infection patterns of CD4 T-cells in human cervical tissue ex vivo

scientific article

HIV-1 imposes rigidity on blood and semen cytokine networks

scientific article published on 24 September 2012

HIV-1 induced activation of CD4+ T cells creates new targets for HIV-1 infection in human lymphoid tissue ex vivo

scientific article published in October 2007

HIV-1 pathogenesis differs in rectosigmoid and tonsillar tissues infected ex vivo with CCR5- and CXCR4-tropic HIV-1.

scientific article published on June 2007

HIV-1 vaginal transmission: cell-free or cell-associated virus?

scientific article published on 15 April 2014

Heterogeneous Conformation of HIV-1 Envelopes on Individual Virions.

scientific article published in October 2014

Histocultures (tissue explants) in human retrovirology

scientific article published in January 2014

Human cytomegalovirus-infected cells release extracellular vesicles that carry viral surface proteins

Immune suppression of human lymphoid tissues and cells in rotating suspension culture and onboard the International Space Station

scientific article published on December 2009

Immunoactivation at the crossroads of human disease

scientific article published on 28 January 2015

Inhibition of HIV-1 replication in human lymphoid tissues ex vivo by measles virus

scientific article published on 31 May 2005

Interleukin-7 facilitates HIV-1 transmission to cervico-vaginal tissue ex vivo

scientific article

Invasion of human tissue ex vivo by Borrelia burgdorferi

scientific article (publication date: 15 May 2005)

It Takes More Than Two for This Tango

scientific article published on January 16, 2013

Macrophage-derived HIV-1 carries bioactive TGF-beta

scientific article published on 13 December 2019

Mechanisms associated with HIV-1 resistance to acyclovir by the V75I mutation in reverse transcriptase

scientific article published on 09 June 2009

Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin

scientific article published on November 11, 2003

Microbicides: still a long road to success

scientific article published on June 15, 2012

Modulation of Immune Responses by Extracellular Vesicles From Retinal Pigment Epithelium

scientific article published on August 2016

Monocytes but Not Lymphocytes Carrying HIV-1 on Their Surface Transmit Infection to Human Tissue Ex Vivo.

scientific article published on 24 August 2016

Monocytes of Different Subsets in Complexes with Platelets in Patients with Myocardial Infarction

scientific article published on 09 October 2018

Multisite comparison of anti-human immunodeficiency virus microbicide activity in explant assays using a novel endpoint analysis

scientific article published on 02 September 2009

Nanoparticle-based flow virometry for the analysis of individual virions

scientific article published on 08 August 2013

Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo

scientific article published in July 2004

Pathogenic effects of human herpesvirus 6 in human lymphoid tissue ex vivo

scientific article published in August 2003

Real-time PCR assay of individual human immunodeficiency virus type 1 variants in coinfected human lymphoid tissues

scientific article published in May 2003

Selective transmission of R5 HIV-1 variants: where is the gatekeeper?

scientific article

Semen of HIV-1-infected individuals: local shedding of herpesviruses and reprogrammed cytokine network

scientific article published on 22 November 2011

Semen-derived amyloid fibrils drastically enhance HIV infection

scientific article

Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells.

scientific article published on 9 August 2007

Syncytin 1 dependent horizontal transfer of marker genes from retrovirally transduced cells.

scientific article published on 27 November 2019

The application of phosphoramidate protide technology to acyclovir confers anti-HIV inhibition.

scientific article published on September 2009

The biology of extracellular vesicles: The known unknowns

scientific article published on 18 July 2019

The cytokine network in women with an asymptomatic short cervix and the risk of preterm delivery.

scientific article published on 6 June 2017

The lymph node in HIV pathogenesis

scientific article

The nonnucleoside reverse transcriptase inhibitor UC-781 inhibits human immunodeficiency virus type 1 infection of human cervical tissue and dissemination by migratory cells

scientific article

Topical tenofovir, a microbicide effective against HIV, inhibits herpes simplex virus-2 replication

scientific article

Toxoplasma gondii inhibits R5 HIV-1 replication in human lymphoid tissues ex vivo

scientific article published on 09 August 2009

Unsung Hero Robert C. Gallo

scientific article

Use of human tissue explants to study human infectious agents

scientific article

Vaginal Lactobacillus Inhibits HIV-1 Replication in Human Tissues Ex Vivo

scientific article published on 19 May 2017

Valacyclovir Decreases Plasma HIV-1 RNA in HSV-2 Seronegative Individuals: A Randomized Placebo-Controlled Crossover Trial

scientific article published on 3 March 2015

Viral interactions in human lymphoid tissue: Human herpesvirus 7 suppresses the replication of CCR5-tropic human immunodeficiency virus type 1 via CD4 modulation

scientific article published on 25 October 2006

Virtual screening of acyclovir derivatives as potential antiviral agents: design, synthesis and biological evaluation of new acyclic nucleoside ProTides

scientific article

Vpr and Vpu are important for efficient human immunodeficiency virus type 1 replication and CD4+ T-cell depletion in human lymphoid tissue ex vivo

scientific article published in November 2004

War and peace between microbes: HIV-1 interactions with coinfecting viruses

scientific article