List of works - Andrzej Kutner

A novel convergent synthesis of the antiglaucoma PGF2α analogue bimatoprost.

scientific article published on 5 February 2013

ANTIPROLIFERATIVE AND CYTOTOXIC EFFECT OF SELECTED VITAMIN D ANALOGS ON NASAL POLYPS FIBROBLASTS AND OTHER CELLS WITH HIGHER PROLIFERATIVE POTENTIAL

scientific article published in September 2015

Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol

scientific article

Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D₂ Against Human Malignant Melanoma Cell Lines.

scientific article published on 8 January 2016

Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines

scientific article published on 20 May 2020

Antiproliferative activity of vitamin D compounds in combination with cytostatics

scientific article published on July 2006

Antitumor properties of diastereomeric and geometric analogs of vitamin D3.

scientific article published on April 2007

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D₂ as Potential Anti-Leukemic Agents.

scientific article published on February 2016

Biological evaluation of new vitamin D2 analogues

scientific article

Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours

scientific article published on 01 October 2019

Combined colonic cancer treatment with vitamin D analogs and irinotecan or oxaliplatin.

scientific article published on February 2013

Convergent synthesis of double point modified analogs of 1α,25-dihydroxyvitamin D2 for biological evaluation

scientific article published on 24 August 2015

Correlation between VDR expression and antiproliferative activity of vitamin D3 compounds in combination with cytostatics.

scientific article

Crystal structure and tautomerism of capecitabine

scientific article published on 30 December 2013

Derivatives of vitamins D2 and D3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 cells.

scientific article

Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations.

scientific article published on 31 October 2009

Differential interference of vitamin D analogs PRI-1906, PRI-2191, and PRI-2205 with the renewal of human colon cancer cells refractory to treatment with 5-fluorouracil.

scientific article

Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism

scientific article published on 18 July 2019

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model

scientific article published on 30 November 2018

Double point modified analogs of vitamin d as potent activators of vitamin D receptor

scientific article published in January 2015

Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat.

scientific article

First Experimental Quantitative Charge Density Studies of Advanced Intermediate of Vitamin D Analogues

scientific article published on 8 March 2022

Identification and characterization of potential impurities of quetiapine fumarate.

scientific article published in January 2009

Imatinib inhibits the regrowth of human colon cancer cells after treatment with 5-FU and cooperates with vitamin D analogue PRI-2191 in the downregulation of expression of stemness-related genes in 5-FU refractory cells.

scientific article

Inhibitory effects of 1,25-dihydroxyvitamin D3 and its low-calcemic analogues on staurosporine-induced apoptosis.

scientific article

Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D ⬇️

scientific article published on 26 August 2019

Involvement of PI3-K in neuroprotective effects of the 1,25-dihydroxyvitamin D3 analogue - PRI-2191.

scientific article published on November 2006

Low-oxidation-potential thiophene-carbazole monomers for electro-oxidative molecular imprinting: Selective chemosensing of aripiprazole

scientific article published on 03 September 2020

Metastability and instability of organic crystalline substances

scientific article

Monocytic differentiation induced by side-chain modified analogs of vitamin D in ex vivo cells from patients with acute myeloid leukemia.

scientific article published on 20 March 2014

Neuroprotection by co-treatment and post-treating with calcitriol following the ischemic and excitotoxic insult in vivo and in vitro.

scientific article

Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.

scientific article published on 10 September 2015

Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors

scientific article published on 17 October 2015

Physicochemical characteristics of sunitinib malate and its process-related impurities

scientific article published on 11 December 2012

Predicted structures of new Vitamin D Receptor agonists based on available X-ray structures.

scientific article

Prodifferentiation Activity of Novel Vitamin D₂ Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells

scientific article published on 5 July 2016

Relation Between Crystal Structures of Precursors and Final Products: Example of Vitamin D Intermediates

scientific article published on 14 April 2020

Retiferols - synthesis and biological activity of a conceptually novel class of vitamin D analogs.

scientific article published on 22 March 2014

Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential

scientific article published on 2 July 2008

Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells

scientific article published in January 2002

Studies on the mechanisms of superagonistic pro-differentiating activities of side-chain modified analogs of vitamin D2.

scientific article

Sunitinib: from charge-density studies to interaction with proteins

scientific article published on 29 April 2014

Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells

scientific article published on 31 October 2013

Synthesis and antiproliferative activity of side-chain unsaturated and homologated analogs of 1,25-dihydroxyvitamin D(2). (24E)-(1S)-24-Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners.

scientific article published on August 2002

Synthesis and crystal structure of anhydrous analog of 1,25-dihydroxyvitamin d3.

scientific article published on 14 August 2013

Synthesis and crystallographic study of 1,25-dihydroxyergocalciferol analogs.

scientific article published on 28 June 2013

Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics

scientific article published on 27 August 2015

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring

scientific article published on 18 January 2020

THE COMPARISON OF THE STABILITY INDICATING TWO HPLC METHODS AND THEIR APPLICATION FOR THE DETERMINATION OF BOSENTAN IN COATED TABLETS

Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase

scientific article published on 25 March 2019

The Effect of Analogues of 1α,25-Dihydroxyvitamin D₂ on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil.

scientific article published on 14 June 2016

The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice.

scientific article published in September 2007

The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics.

scientific article

The in-vitro antiproliferative effect of PRI-2191 and imatinib applied in combined treatment with cisplatin, idarubicin, or docetaxel on human leukemia cells.

scientific article published in January 2012

The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on alphavbeta3 integrin expression in cancer cell lines

scientific article published on October 2008

The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.

scientific article

The rationale for deltanoids in therapy for myeloid leukemia: role of KSR-MAPK-C/EBP pathway.

scientific article

The third multidisciplinary conference on drug research, Piła 2002. Effects of 1alpha,25-dihydroxyvitamin D3 and some putative steroid neuroprotective agents on the hydrogen peroxide-induced damage in neuroblastoma-glioma hybrid NG108-15 cells.

scientific article published on September 2003

Therapeutic uses of prostaglandin F2α analogues in ocular disease and novel synthetic strategies ⬇️

scientific article published on January 23, 2013

Toxicity and antineoplastic effect of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191).

scientific article published in September 2004

Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model

scientific article

Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer

scientific article published on 2 November 2017

Use of hyphenated LC-MS/MS technique for characterization of impurity profile of quetiapine during drug development

scientific article published on November 1, 2010

Vitamin D Analogs Potentiate the Antitumor Effect of Imatinib Mesylate in a Human A549 Lung Tumor Model.

scientific article

Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment.

scientific article

Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model

scientific article

Vitamin D derivatives potentiate the anticancer and anti-angiogenic activity of tyrosine kinase inhibitors in combination with cytostatic drugs in an A549 non-small cell lung cancer model.

scientific article published on 15 December 2017

Vitamins D: Relationship between Structure and Biological Activity.

scientific article published on 20 July 2018

List of works by Andrzej Kutner

A novel convergent synthesis of the antiglaucoma PGF2α analogue bimatoprost.

ANTIPROLIFERATIVE AND CYTOTOXIC EFFECT OF SELECTED VITAMIN D ANALOGS ON NASAL POLYPS FIBROBLASTS AND OTHER CELLS WITH HIGHER PROLIFERATIVE POTENTIAL

Antiproliferative Activity and in Vivo Toxicity of Double-Point Modified Analogs of 1,25-Dihydroxyergocalciferol

Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D₂ Against Human Malignant Melanoma Cell Lines.

Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines

Antiproliferative activity of vitamin D compounds in combination with cytostatics

Antitumor properties of diastereomeric and geometric analogs of vitamin D3.

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D₂ as Potential Anti-Leukemic Agents.

Biological evaluation of new vitamin D2 analogues

Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours

Combined colonic cancer treatment with vitamin D analogs and irinotecan or oxaliplatin.

Convergent synthesis of double point modified analogs of 1α,25-dihydroxyvitamin D2 for biological evaluation

Correlation between VDR expression and antiproliferative activity of vitamin D3 compounds in combination with cytostatics.

Crystal structure and tautomerism of capecitabine

Derivatives of vitamins D2 and D3 activate three MAPK pathways and upregulate pRb expression in differentiating HL60 cells.

Different susceptibilities to 1,25-dihydroxyvitamin D3-induced differentiation of AML cells carrying various mutations.

Differential interference of vitamin D analogs PRI-1906, PRI-2191, and PRI-2205 with the renewal of human colon cancer cells refractory to treatment with 5-fluorouracil.

Differential response of lung cancer cell lines to vitamin D derivatives depending on EGFR, KRAS, p53 mutation status and VDR polymorphism

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model

Double point modified analogs of vitamin d as potent activators of vitamin D receptor

Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat.

First Experimental Quantitative Charge Density Studies of Advanced Intermediate of Vitamin D Analogues

Identification and characterization of potential impurities of quetiapine fumarate.

Imatinib inhibits the regrowth of human colon cancer cells after treatment with 5-FU and cooperates with vitamin D analogue PRI-2191 in the downregulation of expression of stemness-related genes in 5-FU refractory cells.

Inhibitory effects of 1,25-dihydroxyvitamin D3 and its low-calcemic analogues on staurosporine-induced apoptosis.

Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D ⬇️

Involvement of PI3-K in neuroprotective effects of the 1,25-dihydroxyvitamin D3 analogue - PRI-2191.

Low-oxidation-potential thiophene-carbazole monomers for electro-oxidative molecular imprinting: Selective chemosensing of aripiprazole

Metastability and instability of organic crystalline substances

Monocytic differentiation induced by side-chain modified analogs of vitamin D in ex vivo cells from patients with acute myeloid leukemia.

Neuroprotection by co-treatment and post-treating with calcitriol following the ischemic and excitotoxic insult in vivo and in vitro.

Novel analogs of 1,25-dihydroxyvitamin D2 combined with a plant polyphenol as highly efficient inducers of differentiation in human acute myeloid leukemia cells.

Novel vitamin D analogues; cytotoxic and anti-proliferative activity against a diffuse large B-cell lymphoma cell line and B-cells from healthy donors

Physicochemical characteristics of sunitinib malate and its process-related impurities

Predicted structures of new Vitamin D Receptor agonists based on available X-ray structures.

Prodifferentiation Activity of Novel Vitamin D₂ Analogs PRI-1916 and PRI-1917 and Their Combinations with a Plant Polyphenol in Acute Myeloid Leukemia Cells

Relation Between Crystal Structures of Precursors and Final Products: Example of Vitamin D Intermediates

Retiferols - synthesis and biological activity of a conceptually novel class of vitamin D analogs.

Side-chain modified vitamin D analogs induce rapid accumulation of VDR in the cell nuclei proportionately to their differentiation-inducing potential

Side-chain modified vitamin D analogs require activation of both PI 3-K and erk1,2 signal transduction pathways to induce differentiation of human promyelocytic leukemia cells

Studies on the mechanisms of superagonistic pro-differentiating activities of side-chain modified analogs of vitamin D2.

Sunitinib: from charge-density studies to interaction with proteins

Synthesis and Biological Activity of Diastereomeric and Geometric Analogs of Calcipotriol, PRI-2202 and PRI-2205, Against Human HL-60 Leukemia and MCF-7 Breast Cancer Cells

Synthesis and antiproliferative activity of side-chain unsaturated and homologated analogs of 1,25-dihydroxyvitamin D(2). (24E)-(1S)-24-Dehydro-24a-homo-1,25-dihydroxyergocalciferol and congeners.

Synthesis and crystal structure of anhydrous analog of 1,25-dihydroxyvitamin d3.

Synthesis and crystallographic study of 1,25-dihydroxyergocalciferol analogs.

Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics

Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring

THE COMPARISON OF THE STABILITY INDICATING TWO HPLC METHODS AND THEIR APPLICATION FOR THE DETERMINATION OF BOSENTAN IN COATED TABLETS

Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by downregulating the thymidylate synthase

The Effect of Analogues of 1α,25-Dihydroxyvitamin D₂ on the Regrowth and Gene Expression of Human Colon Cancer Cells Refractory to 5-Fluorouracil.

The antitumor effect of lowered doses of cytostatics combined with new analogs of vitamin D in mice.

The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics.

The in-vitro antiproliferative effect of PRI-2191 and imatinib applied in combined treatment with cisplatin, idarubicin, or docetaxel on human leukemia cells.

The influence of 1,25-dihydroxyvitamin D3 and 1,24-dihydroxyvitamin D3 on alphavbeta3 integrin expression in cancer cell lines

The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.

The rationale for deltanoids in therapy for myeloid leukemia: role of KSR-MAPK-C/EBP pathway.

The third multidisciplinary conference on drug research, Piła 2002. Effects of 1alpha,25-dihydroxyvitamin D3 and some putative steroid neuroprotective agents on the hydrogen peroxide-induced damage in neuroblastoma-glioma hybrid NG108-15 cells.

Therapeutic uses of prostaglandin F2α analogues in ocular disease and novel synthetic strategies ⬇️

Toxicity and antineoplastic effect of (24R)-1,24-dihydroxyvitamin D3 (PRI-2191).

Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model

Unfavorable effect of calcitriol and its low-calcemic analogs on metastasis of 4T1 mouse mammary gland cancer

Use of hyphenated LC-MS/MS technique for characterization of impurity profile of quetiapine during drug development

Vitamin D Analogs Potentiate the Antitumor Effect of Imatinib Mesylate in a Human A549 Lung Tumor Model.

Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment.

Vitamin D analogs enhance the anticancer activity of 5-fluorouracil in an in vivo mouse colon cancer model

Vitamin D derivatives potentiate the anticancer and anti-angiogenic activity of tyrosine kinase inhibitors in combination with cytostatic drugs in an A549 non-small cell lung cancer model.

Vitamins D: Relationship between Structure and Biological Activity.