List of works - Darren J Baker

Age-related decline in BubR1 impairs adult hippocampal neurogenesis

scientific article published on 6 April 2017

Aging-associated vascular phenotype in mutant mice with low levels of BubR1.

scientific article published in February 2007

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging

scientific article published on 29 June 2017

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

scientific article

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

scientific article published on 16 August 2016

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

scientific article published on 20 June 2004

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

scientific article published on 01 January 2020

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

scientific article published on 01 November 2020

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

scientific article published on 16 November 2020

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

scientific article

Cellular Identification and Quantification of Senescence-Associated β-Galactosidase Activity In Vivo

Cellular Senescence and the Immune System in Cancer

scientific article published on 18 June 2019

Cellular senescence in aging and age-related disease: from mechanisms to therapy

scientific article

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

scientific article published on 19 February 2018

Cellular senescence in renal ageing and disease

scientific article published on 28 December 2016

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

scientific article published on 29 October 2019

Chromosome missegregation causes colon cancer by APC loss of heterozygosity

scientific article

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.

scientific article published on 31 December 2017

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

scientific article

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

scientific article published in Nature

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

scientific article

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

scientific article

Endonucleases: new tools to edit the mouse genome

scientific article

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

scientific article published on 16 March 2016

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

scientific article

FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer

scientific article published on 12 October 2020

Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1

scientific article published on 02 November 2021

Hypomorphic Mice ⬇️

scientific article published on 01 January 2011

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

scientific article

Insights from In Vivo Studies of Cellular Senescence

scientific article published on 13 April 2020

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

scientific article published on 24 April 2017

Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.

scientific article published in February 2004

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

scientific article published on 16 July 2017

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

scientific article (publication date: 11 February 2016)

Oncogenic senescence: a multi-functional perspective

scientific article

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

scientific article published on 30 May 2008

Pak2 kinase promotes cellular senescence and organismal aging

scientific article published on 17 June 2019

Probing the depths of cellular senescence

scientific article published on July 2013

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

scientific article

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

scientific article

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

scientific article

Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.

scientific article

Senescence and apoptosis: dueling or complementary cell fates?

scientific article

Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis

scientific article published on 02 August 2021

Senescent cells: an emerging target for diseases of ageing

scientific article

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

scientific article

Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice.

scientific article published in November 2005

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

scientific article

Spartan deficiency causes genomic instability and progeroid phenotypes

scientific article

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

scientific article

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.

scientific article published on 16 October 2017

The mitotic checkpoint in cancer and aging: what have mice taught us?

scientific article

The progeroid gene BubR1 regulates axon myelination and motor function

scientific article

The yin and yang of the Cdkn2a locus in senescence and aging

scientific article published on 28 September 2008

Therapy-Induced Senescence Drives Bone Loss

scientific article published on 13 January 2020

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

scientific article published on 16 February 2016

Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

scientific article published on 17 December 2015

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

scientific article

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice

scientific article published on 18 April 2013

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

scientific article published on 29 October 2021

List of works by Darren J Baker

Age-related decline in BubR1 impairs adult hippocampal neurogenesis

Aging-associated vascular phenotype in mutant mice with low levels of BubR1.

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

BubR1﻿﻿ allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

BubR1﻿﻿ allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis.

Cellular Identification and Quantification of Senescence-Associated β-Galactosidase Activity In Vivo

Cellular Senescence and the Immune System in Cancer

Cellular senescence in aging and age-related disease: from mechanisms to therapy

Cellular senescence in brain aging and neurodegenerative diseases: evidence and perspectives

Cellular senescence in renal ageing and disease

Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL

Chromosome missegregation causes colon cancer by APC loss of heterozygosity

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans.

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice

Endonucleases: new tools to edit the mouse genome

Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue.

Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism

FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer

Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1

Hypomorphic Mice ⬇️

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.

Insights from In Vivo Studies of Cellular Senescence

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.

NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

Oncogenic senescence: a multi-functional perspective

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

Pak2 kinase promotes cellular senescence and organismal aging

Probing the depths of cellular senescence

Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation

Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition.

Senescence and apoptosis: dueling or complementary cell fates?

Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis

Senescent cells: an emerging target for diseases of ageing

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice.

Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis

Spartan deficiency causes genomic instability and progeroid phenotypes

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

The Spindle Assembly Checkpoint Is Required for Hematopoietic Progenitor Cell Engraftment.

The mitotic checkpoint in cancer and aging: what have mice taught us?

The progeroid gene BubR1 regulates axon myelination and motor function

The yin and yang of the Cdkn2a locus in senescence and aging

Therapy-Induced Senescence Drives Bone Loss

Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown.

Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice

Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

p21 both attenuates and drives senescence and aging in BubR1 progeroid mice

p21 produces a bioactive secretome that places stressed cells under immunosurveillance

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome