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List of works by Michael Gekle

A rapid screening method to test apoptotic synergisms of ochratoxin A with other nephrotoxic substances

scientific article

Acidic environment leads to ROS-induced MAPK signaling in cancer cells

scientific article

Acidic priming enhances metastatic potential of cancer cells

scientific article

Acidosis induces multi-drug resistance in rat prostate cancer cells (AT1) in vitro and in vivo by increasing the activity of the p-glycoprotein via activation of p38.

scientific article

Activated mineralocorticoid receptor regulates micro-RNA-29b in vascular smooth muscle cells

scientific article published on 4 January 2016

Activity of drug efflux transporters in tumor cells under hypoxic conditions

scientific article

Albumin and glucose effects on cell growth parameters, albumin uptake and Na(+)/H(+)-exchanger Isoform 3 in OK cells

scientific article published in January 2003

Albumin induces NF-kappaB expression in human proximal tubule-derived cells (IHKE-1).

scientific article published in January 2002

Aldosterone interaction with epidermal growth factor receptor signaling in MDCK cells

scientific article published on April 2002

Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC)

scientific article published on 07 February 2006

Aldosterone stimulates epidermal growth factor receptor expression

scientific article

Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter

scientific article published on 20 February 2007

Aldosterone/NaCl-induced renal and cardiac fibrosis is modulated by TGF-β responsiveness of T cells

scientific article published on 24 February 2011

Altered collagen homeostasis in human aortic smooth muscle cells (HAoSMCs) induced by aldosterone

scientific article published on 23 January 2007

Answer to comment

scientific article published on 01 July 2015

Apical expression or expression in a non polarized cell of hOAT1 inverses regulation by epidermal growth factor (EGF) as compared to basolateral hOAT1.

scientific article published on January 2004

Ca2+ but not H2O2 modulates GRE-element activation by the human mineralocorticoid receptor in HEK cells.

scientific article published on 20 November 2006

Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy

scientific article published on 11 October 2006

Chloroacetaldehyde- and acrolein-induced death of human proximal tubule cells.

scientific article published on 3 November 2005

Cisplatin-induced apoptosis is enhanced by hypoxia and by inhibition of mitochondria in renal collecting duct cells.

scientific article published on 16 February 2005

Colocalization of mineralocorticoid and EGF receptor at the plasma membrane

scientific article published on 6 March 2010

Consequences of epidermal growth factor receptor (ErbB1) loss for vascular smooth muscle cells from mice with targeted deletion of ErbB1.

scientific article published on 21 April 2011

Consequences of postnatal vascular smooth muscle EGFR deletion on acute angiotensin II action

scientific article published on 5 October 2015

Cytotoxicity, metabolism and cellular uptake of the mycotoxin deoxynivalenol in human proximal tubule cells and lung fibroblasts in primary culture

scientific article published on 01 August 2007

Derangement of pH Homeostasis in the Renal Papilla: Ochratoxin A Increases pH in Vasa recta Blood ⬇️

scientific article published on 01 January 1997

Detailed mapping of ochratoxin A reabsorption along the rat nephron in vivo: the nephrotoxin can be reabsorbed in all nephron segments by different mechanisms ⬇️

scientific article published on 01 July 1998

Differential Stimulation of the Na+/H+ Exchanger Determines Chloroquine Uptake in Plasmodium falciparum ⬇️

scientific article published on January 26, 1998

Differential effect of COX1 and COX2 inhibitors on renal outcomes following ischemic acute kidney injury

scientific article published on 17 June 2014

Differential reduction of HCN channel activity by various types of lipopolysaccharide

scientific article published on 14 May 2011

Direct inhibition, but indirect sensitization of pacemaker activity to sympathetic tone by the interaction of endotoxin with HCN-channels

scientific article

Disturbed Ca2+-signaling by chloroacetaldehyde: a possible cause for chronic ifosfamide nephrotoxicity

scientific article published on November 2005

EF domains are sufficient for nongenomic mineralocorticoid receptor actions

scientific article

Effect of ochratoxin A on cell survival and collagen homeostasis in human mesangial cells in primary culture

scientific article

Effects of the mycotoxin deoxynivalenol on human primary hepatocytes

scientific article

Epithelial-fibroblast cross talk aggravates the impact of the nephrotoxin ochratoxin A

scientific article published on 12 August 2019

Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na+ reabsorption

scientific article published on 28 January 2004

Exposure to nephrotoxic ochratoxin A enhances collagen secretion in human renal proximal tubular cells

scientific article

Human epidermal growth factor receptor-1 expression renders Chinese hamster ovary cells sensitive to alternative aldosterone signaling

scientific article published on 19 September 2002

Human mineralocorticoid receptor expression renders cells responsive for nongenotropic aldosterone actions

scientific article

Hypoxia-induced extracellular acidosis increases p-glycoprotein activity and chemoresistance in tumors in vivo via p38 signaling pathway

scientific article published on January 2011

Identification and apoptotic potential of T-2 toxin metabolites in human cells

scientific article published on 24 May 2012

Identification of a novel lncRNA induced by the nephrotoxin ochratoxin A and expressed in human renal tumor tissue

scientific article

Impact of extracellular acidity on the activity of P-glycoprotein and the cytotoxicity of chemotherapeutic drugs

scientific article published on February 2006

Impact of extracellular acidosis on intracellular pH control and cell signaling in tumor cells

scientific article

Impact of hypoxia-related tumor acidosis on cytotoxicity of different chemotherapeutic drugs in vitro and in vivo

scientific article

Impact of hypoxic and acidic extracellular conditions on cytotoxicity of chemotherapeutic drugs

scientific article published on January 2007

Implementation of an in vitro model system for investigation of reperfusion damage after renal ischemia

scientific article

Influence of aldosterone and salt or ouabain in a10 rat aorta smooth muscle cells

scientific article published on 15 March 2012

Influence of miR-221/222 on cardiomyocyte calcium handling and function

scientific article published on 17 August 2021

Inhibition of cardiac pacemaker channel hHCN2 depends on intercalation of lipopolysaccharide into channel-containing membrane microdomains

scientific article

Inhibition of mitochondria and extracellular acidification enhance achratoxin A-induced apoptosis in renal collecting duct-derived MDCK-C7 cells

scientific article published on January 2004

Inhibition of mitochondria prevents cell death in kidney epithelial cells by intra- and extracellular acidification

scientific article published on May 2003

Interaction between mineralocorticoid receptor and cAMP/CREB signaling

scientific article

Interaction between mineralocorticoid receptor and epidermal growth factor receptor signaling

scientific article published on 29 July 2011

Knockout of vascular smooth muscle EGF receptor in a mouse model prevents obesity-induced vascular dysfunction and renal damage in vivo

scientific article published on 17 June 2020

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post‐acute sequelae of COVID‐19

scientific article published in 2022

Long-term application of the aldosterone antagonist spironolactone prevents stiff endothelial cell syndrome

scientific article published on 31 May 2013

Long-term effects of ochratoxin A on fibrosis and cell death in human proximal tubule or fibroblast cells in primary culture

article

Long-term protein exposure reduces albumin binding and uptake in proximal tubule-derived opossum kidney cells ⬇️

scientific article published on June 1, 1998

Loss of epidermal growth factor receptor in vascular smooth muscle cells and cardiomyocytes causes arterial hypotension and cardiac hypertrophy

scientific article published on 17 December 2012

Mechanism of cell death of rat cardiac fibroblasts induced by serum depletion

scientific article published on September 1, 2003

Mesna or cysteine prevents chloroacetaldehyde-induced cell death of human proximal tubule cells.

scientific article published on 2 February 2007

Metabolism and cytotoxic effects of T-2 toxin and its metabolites on human cells in primary culture

scientific article

Mineralocorticoid receptor inhibits CREB signaling by calcineurin activation

scientific article published on 26 January 2010

Mineralocorticoid receptor interaction with SP1 generates a new response element for pathophysiologically relevant gene expression

scientific article

Moderate inappropriately high aldosterone/NaCl constellation in mice: cardiovascular effects and the role of cardiovascular epidermal growth factor receptor

scientific article

Modulation of transcriptional mineralocorticoid receptor activity by casein kinase 2.

scientific article published on 10 November 2017

Modulation of transcriptional mineralocorticoid receptor activity by nitrosative stress

scientific article published on 26 June 2012

NHE3 Na+/H+ exchanger supports proximal tubular protein reabsorption in vivo

scientific journal article

NHE3 serves as a molecular tool for cAMP-mediated regulation of receptor-mediated endocytosis

scientific article

NOS1 induces NADPH oxidases and impairs contraction kinetics in aged murine ventricular myocytes.

scientific article

Nephrotoxicity of platinum complexes is related to basolateral organic cation transport

scientific article published on July 2004

Neurotoxic potential and cellular uptake of T-2 toxin in human astrocytes in primary culture

scientific article published on 14 February 2013

Non-classical actions of the mineralocorticoid receptor: misuse of EGF receptors?

scientific article

Nongenotropic aldosterone effects and the EGFR: interaction and biological relevance

scientific article

Non‐genomic action of the mineralocorticoid aldosterone on cytosolic sodium in cultured kidney cells ⬇️

scientific article published on August 15, 1998

Nuclear shuttling precedes dimerization in mineralocorticoid receptor signaling

scientific article

Ochratoxin A at nanomolar concentrations: a signal modulator in renal cells

scientific article

Ochratoxin A disturbs pH homeostasis in the kidney: increases in pH and HCO 3 - in the tubules and vasa recta ⬇️

scientific article published on 01 August 1997

PAH clearance after renal ischemia and reperfusion is a function of impaired expression of basolateral Oat1 and Oat3.

scientific article

Post-COVID recovery is faster after an infection with the SARS-CoV-2 Omicron variant: a population-based cohort study

scientific article published in 2024

Prostaglandin E2 inhibits its own renal transport by downregulation of organic anion transporters rOAT1 and rOAT3.

scientific article published on 7 December 2005

Protein uptake disturbs collagen homeostasis in proximal tubule-derived cells

scientific article published in May 2003

Rapid actions of aldosterone on cells from renal epithelium: the possible role of EGF-receptor signaling

scientific article published in May 2002

Regulation of Expression of Renal Organic Anion Transporters OAT1 and OAT3 in a Model of Ischemia/Reperfusion Injury

scientific article

Role of epidermal growth factor receptor in vascular structure and function

scientific article published on March 2014

Role of microRNA-29b in the ochratoxin A-induced enhanced collagen formation in human kidney cells

scientific article

Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells.

scientific article published on January 2007

Short-term regulation of basolateral organic anion uptake in proximal tubular OK cells: EGF acts via MAPK, PLA(2), and COX1.

scientific article published on August 2002

Short-term regulation of basolateral organic anion uptake in proximal tubular opossum kidney cells: prostaglandin E2 acts via receptor-mediated activation of protein kinase A.

scientific article published in December 2003

Structure-activity relationship of ochratoxin A and synthesized derivatives: importance of amino acid and halogen moiety for cytotoxicity

scientific article

Substance-specific importance of EGFR for vascular smooth muscle cells motility in primary culture.

scientific article

Synergistic action of the nephrotoxic mycotoxins ochratoxin A and citrinin at nanomolar concentrations in human proximal tubule-derived cells.

scientific article

Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation

scientific article published on 18 December 2021

The food contaminant and nephrotoxin ochratoxin A enhances Wnt1 inducible signaling protein 1 and tumor necrosis factor-α expression in human primary proximal tubule cells

scientific article

The mineralocorticoid aldosterone activates a proton conductance in cultured kidney cells ⬇️

scientific article published on November 1, 1997

The nephrotoxic Ifosfamide-metabolite chloroacetaldehyde interferes with renal extracellular matrix homeostasis

scientific article published on 09 April 2014

The nephrotoxin ochratoxin A induces key parameters of chronic interstitial nephropathy in renal proximal tubular cells.

scientific article published on January 2005

The phosphatase calcineurin PP2BAβ mediates part of mineralocorticoid receptor transcriptional activity

scientific article

The selective mineralcorticoid receptor (MR) antagonist eplerenon prevents decompensation of liver cirrhosis.

scientific article published on 22 April 2018

Transforming growth factor-beta1 reduces megalin- and cubilin-mediated endocytosis of albumin in proximal-tubule-derived opossum kidney cells

scientific article published in October 2003

Vitamin D Receptor Deficiency Does Not Affect Blood Pressure and Heart Function

scientific article published on 29 August 2019

miR-221 and -222 target CACNA1C and KCNJ5 leading to altered cardiac ion channel expression and current density

scientific article published on 16 July 2019

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