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List of works by Steven R Houser

A Characterization and Targeting of the Infarct Border Zone in a Swine Model of Myocardial Infarction ⬇️

scientific article published on June 26, 2012

A Feline HFpEF Model with Pulmonary Hypertension and Compromised Pulmonary Function

scientific article published on 29 November 2017

A Metric-Based System for Evaluating the Productivity of Preclinical Faculty at an Academic Medical Center in the Era of Clinical and Translational Science

scientific article published on 05 March 2015

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

scientific article published on 20 April 2016

A caveolae-targeted L-type Ca²+ channel antagonist inhibits hypertrophic signaling without reducing cardiac contractility

scientific article published on 2 February 2012

A low voltage activated Ca2+ current found in a subset of human ventricular myocytes

scientific article published on 01 December 2020

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

scientific journal article

Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion

scientific article published on 25 February 2020

Abnormal frequency-dependent responses represent the pathophysiologic signature of contractile failure in human myocardium

scientific article published on 01 January 2004

Acetylation of SERCA2a, Another Target for Heart Failure Treatment?

scientific article published on 01 April 2019

Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration.

scientific article published on 26 July 2016

Acute aerobic exercise increases exogenously infused bone marrow cell retention in the heart

scientific article published in October 2015

Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties

scientific article published in February 2007

Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808

scientific article published on 03 April 2008

Alterations in Early Action Potential Repolarization Causes Localized Failure of Sarcoplasmic Reticulum Ca 2+ Release

scientific article published on 10 February 2005

Altered myocardial Ca2+ cycling after left ventricular assist device support in the failing human heart

scientific article published in August 2004

Animal models of heart failure: a scientific statement from the American Heart Association

scientific article published on 17 May 2012

Are Resident c-Kit + Cardiac Stem Cells Really All That Are Needed to Mend a Broken Heart?

scientific article published on 01 October 2013

Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy

scientific article published on 11 February 2015

Beta1-adrenergic receptors promote focal adhesion signaling downregulation and myocyte apoptosis in acute volume overload ⬇️

scientific article published on May 15, 2012

Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation

scientific article published on 25 January 2013

Bone marrow cells adopt the cardiomyogenic fate in vivo

scientific article

Bone-Derived Stem Cells Repair the Heart After Myocardial Infarction Through Transdifferentiation and Paracrine Signaling Mechanisms ⬇️

scientific article published on June 25, 2013

Ca influx via the Na/Ca exchanger maintains sarcoplasmic reticulum Ca content in failing human myocytes

scientific article published on 01 November 2002

Ca(2+) influx through L-type Ca(2+) channels and transient receptor potential channels activates pathological hypertrophy signaling

scientific article published on 21 August 2012

Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes

scientific article published on 02 October 2008

Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes

scientific article published on 6 October 2005

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

scientific article published in September 2007

CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes

scientific article published on 16 July 2009

Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat.

scientific article published on 7 September 2007

Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes

scientific article published on March 2003

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy

scientific article published on 25 November 2010

Calcium influx via I(NCX) is favored in failing human ventricular myocytes

scientific article published on 01 November 2002

Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload

scientific article published on 27 January 2020

Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction

scientific article published on 10 April 2012

Cardiac-restricted overexpression of the A(2A)-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A(1)-adenosine receptor

scientific article

Cardiometabolic Heart Failure and HFpEF: Still Chasing Unicorns

scientific article published on 24 June 2019

Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart

scientific article published on 15 April 2019

Cardiomyocyte Regeneration: A Consensus Statement

scientific article published on 6 July 2017

Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair

scientific article

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart

scientific article published on 11 April 2017

Cellular basis of abnormal calcium transients of failing human ventricular myocytes

scientific article published on 20 February 2003

Challenges facing early career academic cardiologists.

scientific article

Chronic β1-adrenergic blockade enhances myocardial β3-adrenergic coupling with nitric oxide-cGMP signaling in a canine model of chronic volume overload: new insight into mechanisms of cardiac benefit with selective β1-blocker therapy.

scientific article published on 6 December 2014

Class I Histone Deacetylase Inhibition for the Treatment of Sustained Atrial Fibrillation

scientific article published on 27 June 2016

Cortical Bone Derived Stem Cells for Cardiac Wound Healing

scientific article published on 24 January 2019

Cortical Bone Stem Cell Therapy Preserves Cardiac Structure and Function After Myocardial Infarction

scientific article published on 14 September 2017

Cortical bone-derived stem cell therapy reduces apoptosis after myocardial infarction

scientific article published on 23 August 2019

Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice

scientific article published on December 2011

Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury

scientific article published on 22 June 2017

Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control

scientific article published on 30 October 2018

Differential effects of exercise training on skeletal muscle SERCA gene expression

scientific article published on 01 January 2003

Differential microRNA-21 and microRNA-221 Upregulation in the Biventricular Failing Heart Reveals Distinct Stress Responses of Right Versus Left Ventricular Fibroblasts

scientific article published on 09 January 2020

Does contractile Ca2+ control calcineurin-NFAT signaling and pathological hypertrophy in cardiac myocytes?

scientific article published on 24 June 2008

Dynamic regulation of sodium/calcium exchange function in human heart failure

scientific article published on 13 October 2003

Echocardiographic Strain Analysis for the Early Detection of Left Ventricular Systolic/Diastolic Dysfunction and Dyssynchrony in a Mouse Model of Physiological Aging

scientific article published on 01 March 2019

Effects of forskolin on inotropic performance and phospholamban phosphorylation in exercise-trained hypertensive myocardium

scientific article published on 2 November 2006

Embryonic stem cell-derived cardiac myocytes are not ready for human trials

scientific article

Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction

scientific article published on 22 April 2015

Enhanced acidotic myocardial Ca2+ responsiveness with training in hypertension

scientific article published in May 2006

Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity

scientific article

Examining prehospital intubation for penetrating trauma in a swine hemorrhagic shock model ⬇️

scientific article published on May 1, 2013

Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes

scientific article

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure

scientific article

GDF11 Decreases Pressure Overload-Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death

scientific article published on 01 November 2018

GDF11 does not rescue aging-related pathological hypertrophy

scientific article

GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity

scientific article

Gender differences in post-infarction hypertrophy in end-stage failing hearts

scientific article published on 01 January 2003

HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction

scientific article published on 01 January 2020

Hyperhomocysteinemia suppresses bone marrow CD34+/VEGF receptor 2+ cells and inhibits progenitor cell mobilization and homing to injured vasculature-a role of β1-integrin in progenitor cell migration and adhesion

scientific article published on 8 April 2015

Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction

scientific article published on 2 February 2012

Identification and Comparison of Hyperglycemia-Induced Extracellular Vesicle Transcriptome in Different Mouse Stem Cells

scientific article published on 15 September 2020

Imatinib activates pathological hypertrophy by altering myocyte calcium regulation

scientific article published on 16 June 2014

Impaired contractile reserve in severe mitral valve regurgitation with a preserved ejection fraction

scientific article published on 26 June 2007

Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension

scientific article published on 20 June 2005

Increased cardiac myocyte progenitors in failing human hearts

scientific article published on 21 July 2008

Increasing T-type calcium channel activity by β-adrenergic stimulation contributes to β-adrenergic regulation of heart rates

scientific article published on 23 December 2017

Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction

scientific article published on 29 July 2010

Inhibition of PKCα/β with ruboxistaurin antagonizes heart failure in pigs after myocardial infarction injury

scientific article published on 13 October 2011

Inhibition of angiotensin II Gq signaling augments beta-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure

scientific article published on 30 September 2008

Interaction of the Joining Region in Junctophilin-2 with the L-type Ca2+ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca2+ Dynamics

scientific article published on 23 October 2020

Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes

scientific article published on 29 September 2006

Intracoronary Cytoprotective Gene Therapy: A Study of VEGF-B167 in a Pre-Clinical Animal Model of Dilated Cardiomyopathy

scientific article published in July 2015

Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects?

scientific article

Is depressed myocyte contractility centrally involved in heart failure?

scientific article

L-type Ca(2+) currents overlapping threshold Na(+) currents: could they be responsible for the "slip-mode" phenomenon in cardiac myocytes?

scientific article published in March 2002

L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices

scientific article published in September 2002

LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation.

scientific article

Left ventricular remodeling with exercise in hypertension

scientific article published on 07 August 2009

Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure

scientific article published in March 2018

Loss of Protease-Activated Receptor 4 Prevents Inflammation Resolution and Predisposes the Heart to Cardiac Rupture after Myocardial Infarction

scientific article published on 03 June 2020

Loss of beta1D-integrin function in human ischemic cardiomyopathy.

scientific article

MCUR1 Is a Scaffold Factor for the MCU Complex Function and Promotes Mitochondrial Bioenergetics

scientific journal article

Modulation of contractility by myocyte-derived arginase in normal and hypertrophied feline myocardium

scientific article published on 3 December 2005

Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange.

scientific article

Myocardial hypoperfusion/reperfusion tolerance with exercise training in hypertension

scientific article published on 13 October 2005

Myocyte nitric oxide synthase 2 contributes to blunted beta-adrenergic response in failing human hearts by decreasing Ca2+ transients

scientific article published on 22 March 2004

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential

scientific article published on February 2002

Negative Regulation of miR-375 by Interleukin-10 Enhances Bone Marrow-Derived Progenitor Cell-Mediated Myocardial Repair and Function After Myocardial Infarction

scientific article

Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes

scientific article published on 25 January 2008

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy ⬇️

scientific article published in January 2017

New Myocyte Formation in the Adult Heart: Endogenous Sources and Therapeutic Implications

Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images

scientific article published on 23 March 2016

Obligatory role of neuronal nitric oxide synthase in the heart's antioxidant adaptation with exercise

scientific article

Outcomes Associated With a Strategy of Adjuvant Metolazone or High-Dose Loop Diuretics in Acute Decompensated Heart Failure: A Propensity Analysis

scientific article published on 01 September 2018

Peptidyl-Prolyl Isomerase 1 Regulates Ca2+ Handling by Modulating Sarco(Endo)Plasmic Reticulum Calcium ATPase and Na2+/Ca2+ Exchanger 1 Protein Levels and Function

scientific article published on 10 October 2017

Periostin and periostin-like factor in the human heart: possible therapeutic targets

scientific article published in January 2006

Pharmacological effects of ATI22-107 [2-(2-{2-[2-chloro-4-(6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenoxy]-acetylamino}-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester)], a novel dual pharmacoph

scientific article published on 18 November 2004

Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito.

scientific article published on 2 October 2003

Phosphorylation of phospholamban at threonine-17 reduces cardiac adrenergic contractile responsiveness in chronic pressure overload-induced hypertrophy

scientific article published on 01 July 2006

Pim-1 regulates cardiomyocyte survival downstream of Akt.

scientific article published on 25 November 2007

Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function.

scientific article

Pleiotropic effects of neutrophils on myocyte apoptosis and left ventricular remodeling during early volume overload

scientific article published on 28 August 2009

Post-surgery echocardiography can predict the amount of ischemia-reperfusion injury and the resultant scar size

scientific article published on 24 December 2020

Prior β-blocker treatment decreases leukocyte responsiveness to injury.

scientific article published on 28 March 2019

Prolyl Hydroxylase Domain Protein 2 Silencing Enhances the Survival and Paracrine Function of Transplanted Adipose-Derived Stem Cells in Infarcted Myocardium ⬇️

scientific article published on May 21, 2013

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach

scientific article published on 25 June 2009

Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium

scientific article

Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation

scientific article published on 21 March 2008

Reduced sarcoplasmic reticulum Ca(2+) load mediates impaired contractile reserve in right ventricular pressure overload

scientific article published on 6 September 2007

Regulated Overexpression of the A 1 -Adenosine Receptor in Mice Results in Adverse but Reversible Changes in Cardiac Morphology and Function

scientific article published on 06 November 2006

Regulation of L-type calcium channel by phospholemman in cardiac myocytes

scientific article

Relative systolic dysfunction in female spontaneously hypertensive rat myocardium

scientific article published on 12 April 2007

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model

scientific article published on 23 June 2017

Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells

scientific article published on 31 March 2011

Requirement of FADD, NEMO, and BAX/BAK for aberrant mitochondrial function in tumor necrosis factor alpha-induced necrosis

scientific article

Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.

scientific article

Response to Torella et al

article

Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction

scientific article published on 7 June 2017

SPG7 Is an Essential and Conserved Component of the Mitochondrial Permeability Transition Pore

scientific article

STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy

scientific article

Severe Hyperhomocysteinemia Promotes Bone Marrow–Derived and Resident Inflammatory Monocyte Differentiation and Atherosclerosis in LDLr/CBS-Deficient Mice ⬇️

scientific article published on May 24, 2012

Sex-based differences in myocardial contractile reserve

scientific article

Sodium and the heart: a hidden key factor in cardiac regulation

scientific article published on 01 March 2003

Sorafenib cardiotoxicity increases mortality after myocardial infarction.

scientific article

Sprint training improves postischemic, left ventricular diastolic performance

scientific article published on 21 July 2005

Stem cell therapy for heart failure

scientific article published on 01 August 2009

Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.

scientific article

T-type Ca²⁺ channels regulate the exit of cardiac myocytes from the cell cycle after birth.

scientific article published on 04 June 2013

Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle ⬇️

scientific article published on November 16, 2012

The Heart Failure Society of America in 2020: a vision for the future

scientific article published on February 2012

The Mitochondrial Calcium Uniporter Matches Energetic Supply with Cardiac Workload during Stress and Modulates Permeability Transition

scientific article published on 25 June 2015

The Na+/Ca2+ exchanger/SR Ca2+ ATPase transport capacity regulates the contractility of normal and hypertrophied feline ventricular myocytes

scientific article published on June 2005

The gut hormone ghrelin partially reverses energy substrate metabolic alterations in the failing heart.

scientific article

The inotropic effect of cardioactive glycosides in ventricular myocytes requires Na+-Ca2+ exchanger function

scientific article

The mitochondrial Na+/Ca2+ exchanger is essential for Ca2+ homeostasis and viability

scientific article

Thomas L. Force, MD: 1951-2020: A Brilliant Physician-Scientist Gone Too Soon

scientific article published on 07 January 2021

Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury

scientific article published on 09 April 2019

Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction

scientific article

Two-photon laser scanning microscopy of the transverse-axial tubule system in ventricular cardiomyocytes from failing and non-failing human hearts

scientific article

Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age

scientific article published on 10 September 2020

Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart

scientific article

Validation of transcatheter left ventricular electromechanical mapping for assessment of cardiac function and targeted transendocardial injection in a porcine ischemia-reperfusion model ⬇️

scientific article published on April 18, 2012

Voluntary wheel running and pacing-induced dysfunction in hypertension

scientific article

[Na+]i handling in the failing human heart

scientific article

alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice

scientific article published on 16 November 2009

c-Cbl Ubiquitin Ligase Regulates Focal Adhesion Protein Turnover and Myofibril Degeneration Induced by Neutrophil Protease Cathepsin G ⬇️

scientific article published on December 27, 2011

c-Cbl inhibition improves cardiac function and survival in response to myocardial ischemia

scientific article

c-Kit+ bone marrow stem cells differentiate into functional cardiac myocytes.

scientific article

microRNA in Cardiovascular Aging and Age-Related Cardiovascular Diseases

scientific article published on 12 June 2017

{beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways

scientific article

β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt.

scientific article

β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling

scientific article published on 9 September 2014

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