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List of works by Tim Heffernan

4-1BB Agonist Focuses CD8+ Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer.

scientific article

Allosteric SHP2 inhibitor IACS-13909 overcomes EGFR-dependent and EGFR-independent resistance mechanisms towards osimertinib

scientific article published on 14 September 2020

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy

scientific article published on 15 June 2022

Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity

scientific article published on 29 October 2020

BI-3406, a potent and selective SOS1::KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition

scientific article published on 19 August 2020

EGFR Amplification Induces Increased DNA Damage Response and Renders Selective Sensitivity to Talazoparib (PARP Inhibitor) in Glioblastoma

scientific article published on 18 December 2019

HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes

scientific article published on 6 September 2017

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy

scientific article published on 05 April 2018

Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy.

scientific article published on 8 December 2015

Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma

scientific article published on 01 May 2019

Oncogenic <i>KRAS</i> Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis

publication published on 10 April 2021

PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma

scientific article published on 30 July 2021

Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state

scientific article published on 01 April 2019

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer

scientific article published on 27 March 2019

Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.

scientific article published on 8 February 2017

Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition

scientific article published on 11 June 2021

Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression

scientific article

Targeting YAP-dependent MDSC infiltration impairs tumor progression.

scientific article

The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy.

scientific article published on 18 December 2017

The RNA-binding protein MEX3B mediates resistance to cancer immunotherapy by downregulating HLA-A expression

scientific article published in March 2018

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma

scientific article published on 01 November 2019

ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism

scientific article published on 01 March 2019

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