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List of works by Yae Kanai

5-aza-2'-deoxycytidine restores the E-cadherin system in E-cadherin-silenced cancer cells and reduces cancer metastasis

scientific article published on January 2004

A novel diagnostic biomarker for human uterine leiomyosarcoma: PSMB9/β1i.

scientific article published in April 2017

A paradoxical thrombogenic mutation in factor II at the target site of arthropod bleeding toxin

scientific article published on 04 June 2018

ADAM9 is over-expressed in human ovarian clear cell carcinomas and suppresses cisplatin-induced cell death

scientific article published on 16 December 2017

Aberrant DNA methylation results in altered gene expression in non-alcoholic steatohepatitis-related hepatocellular carcinomas

scientific article published on 19 July 2020

Ability of preoperative 3.0-Tesla magnetic resonance imaging to predict the absence of side-specific extracapsular extension of prostate cancer

scientific article published on 29 January 2013

Abstract 318: Hierarchical clustering analysis of array CGH data identifies clinicopathologically distinct groups of lymph-node-negative invasive breast cancer

scientific article published in 2011

Alterations of DNA methylation and clinicopathological diversity of human cancers

scientific article published on September 2008

Alterations of the spindle checkpoint pathway in clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas

scientific article published on 9 June 2015

An Integrated Prognostic Classifier for Stage I Lung Adenocarcinoma Based on mRNA, microRNA, and DNA Methylation Biomarkers

scientific article published in July 2015

Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy

scientific article published on 12 January 2017

Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer

scientific article

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer.

scientific article

Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung.

scientific article published in October 2005

Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs ⬇️

scientific article published on August 5, 2010

Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma.

scientific article published on 13 March 2014

Bile acids increase levels of microRNAs 221 and 222, leading to degradation of CDX2 during esophageal carcinogenesis.

scientific article published on 8 August 2013

Bile duct carcinoma involving the common channel associated with pancreaticobiliary maljunction shows an extension pattern similar to ductal carcinoma of the pancreas

scientific article published in August 2013

Biological characterization of soft tissue sarcomas

scientific article

CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation

scientific article published on 25 May 2010

CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma

scientific article published on 8 May 2008

CXCL17 and ICAM2 Are Associated With a Potential Anti-Tumor Immune Response in Early Intraepithelial Stages of Human Pancreatic Carcinogenesis ⬇️

scientific article published on October 16, 2010

Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage

scientific article published on 9 May 2011

Cell adhesion system and human cancer morphogenesis

scientific article

Characteristics of Leiomyosarcoma: Induction of Hematogenous Metastasis by Isolated Uterine Mesenchymal Tumor Stem-like Cells

scientific article published on 01 March 2020

Characteristics of lymph node metastases defining the outcome after radical cystectomy of urothelial bladder carcinoma

scientific article published on 22 August 2012

Clinical and endoscopic findings to assist the early detection of duodenal adenoma and adenocarcinoma

scientific article published on 03 December 2018

Clinical impact of c-Met expression and its gene amplification in hepatocellular carcinoma

scientific article

Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma: immunohistochemical analysis of 115 patients.

scientific article

Clinicopathological characterization of so-called "cholangiocarcinoma with intraductal papillary growth" with respect to "intraductal papillary neoplasm of bile duct (IPNB)"

scientific article

Clinicopathological impacts of DNA methylation alterations on pancreatic ductal adenocarcinoma: prediction of early recurrence based on genome-wide DNA methylation profiling

scientific article published on 26 February 2021

Cluster microRNAs miR-194 and miR-215 suppress the tumorigenicity of intestinal tumor organoids

scientific article

Combined functional genome survey of therapeutic targets for hepatocellular carcinoma

scientific article published on 13 April 2010

Comprehensive exploration of novel chimeric transcripts in clear cell renal cell carcinomas using whole transcriptome analysis

scientific article

Conditional abrogation of Atm in osteoclasts extends osteoclast lifespan and results in reduced bone mass

scientific article published on 28 September 2016

Cooperative participation of epigenomic and genomic alterations in the clinicopathological diversity of gastric adenocarcinomas: significance of cell adhesion and epithelial-mesenchymal transition-related signaling pathways

scientific article published on 25 July 2020

Copy number alterations in urothelial carcinomas: their clinicopathological significance and correlation with DNA methylation alterations

scientific article

Correlation of DNA hypomethylation at pericentromeric heterochromatin regions of chromosomes 16 and 1 with histological features and chromosomal abnormalities of human breast carcinomas

scientific article published on September 2002

Cytoplasmic p120ctn regulates the invasive phenotypes of E-cadherin-deficient breast cancer ⬇️

scientific article

DBTSS/DBKERO for integrated analysis of transcriptional regulation

scientific article published on 8 November 2017

DNA hypermethylation of the ZNF132 gene participates in the clinicopathological aggressiveness of "pan-negative"-type lung adenocarcinomas

scientific article published on 06 November 2020

DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.

scientific article

DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma

scientific article published on 27 March 2013

DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status

scientific article published on June 2010

DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma

scientific article

Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification

scientific article

Diagnostic markers of urothelial cancer based on DNA methylation analysis.

scientific article

Dicer is required for proper liver zonation

scientific article published in November 2009

Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis

scientific article

Downregulation and growth inhibitory effect of epithelial-type Krüppel-like transcription factor KLF4, but not KLF5, in bladder cancer

scientific article (publication date: 22 August 2003)

Dysadherin expression facilitates cell motility and metastatic potential of human pancreatic cancer cells

scientific article

Early venous return in hepatic angiomyolipoma due to an intratumoral structure resembling an arteriovenous fistula

scientific article

Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome

scientific article published on 4 March 2015

Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease

scientific article

Epigenetic instability and chromosomal instability in hepatocellular carcinoma

scientific article

Epigenome mapping of human normal purified hepatocytes: personal epigenome variation and genome–epigenome correlation

Establishment of Patient-Derived Organoids and Drug Screening for Biliary Tract Carcinoma

scientific article published on 01 April 2019

Establishment of diagnostic criteria for upper urinary tract urothelial carcinoma based on genome-wide DNA methylation analysis

scientific article published on 04 June 2020

Establishment of permutation for cancer risk estimation in the urothelium based on genome-wide DNA methylation analysis

scientific article published on 01 November 2019

Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment

scientific article

Evaluation of clinical formalin-fixed paraffin-embedded tissue quality for targeted-bisulfite sequencing

scientific article published on 17 December 2020

Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma

scientific article published on 03 July 2011

Expression of a splicing variant of the CADM1 specific to small cell lung cancer.

scientific article published on 15 May 2012

Familial adenomatous polyposis-associated and sporadic pyloric gland adenomas of the upper gastrointestinal tract share common genetic features.

scientific article published on 14 May 2015

Feasibility of methylome analysis using small amounts of genomic DNA from formalin-fixed paraffin-embedded tissue

scientific article published on 21 September 2018

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

scientific article

Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum

scientific article published on 04 February 2013

Frequent activating GNAS mutations in villous adenoma of the colorectum

scientific article published on 02 July 2012

Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer

scientific article published in July 2008

Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma

scientific article published on 28 January 2014

Genes involved in development and differentiation are commonly methylated in cancers derived from multiple organs: a single-institutional methylome analysis using 1007 tissue specimens

scientific article published on 09 January 2017

Genetic and epigenetic alterations during renal carcinogenesis.

scientific article

Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome

scientific article published in September 2008

Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome.

scientific article published on 5 July 2005

Genome-wide DNA methylation analysis during non-alcoholic steatohepatitis-related multistage hepatocarcinogenesis: comparison with hepatitis virus-related carcinogenesis

scientific article published in March 2017

Genome-wide DNA methylation profile of early-onset endometrial cancer: its correlation with genetic aberrations and comparison with late-onset endometrial cancer

scientific article published on 01 July 2019

Genome-wide DNA methylation profiles in precancerous conditions and cancers

scientific article published on October 2009

Genome-wide DNA methylation profiles in renal tumors of various histological subtypes and non-tumorous renal tissues.

scientific article published on 5 April 2011

Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome

scientific article

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

scientific article

Heat Shock Protein 90 Is a Potential Therapeutic Target in Cholangiocarcinoma

scientific article

Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers: a tricky aspect of a conditional knockout mouse model.

scientific article published on 7 January 2011

Higher-order chromatin regulation and differential gene expression in the human tumor necrosis factor/lymphotoxin locus in hepatocellular carcinoma cells

scientific article published on 21 February 2012

Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma.

scientific article

Human amniotic fluid stem cells have a unique potential to accelerate cutaneous wound healing with reduced fibrotic scarring like a fetus

scientific article published on 01 December 2018

Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Controls Endochondral Ossification through Hyaluronan Metabolism.

scientific article published on 8 March 2017

Hypermethylation of an E-cadherin (CDH1) promoter region in high grade transitional cell carcinoma of the bladder comprising carcinoma in situ.

scientific article

Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers

scientific article

Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.

scientific article

Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder

scientific article published on 01 December 2003

Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas ⬇️

scientific article published on 01 July 2003

Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system

scientific article published on 12 February 2018

Infiltration of tumor-associated macrophages is involved in tumor programmed death-ligand 1 expression in early lung adenocarcinoma

scientific article published on 06 January 2020

Inhibition of PDGFR signaling prevents muscular fatty infiltration after rotator cuff tear in mice

scientific article published on 31 January 2017

Intermittent Exposure to Cigarette Smoke Increases Lung Tumors and the Severity of Emphysema More Than Continuous Exposure

scientific article published on 14 February 2018

Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct.

scientific article published in January 2014

Invasive biliary cystic tumor without ovarian-like stroma.

scientific article published in December 2007

Involvement of proteasome β1i subunit, LMP2, on development of uterin leiomyosarcma.

scientific article published on September 2011

Laminin 5 beta3 and gamma2 chains are frequently coexpressed in cancer cells

scientific article published on 01 September 2004

Leiomyosarcoma of the renal vein: arterial encasement on contrast-enhanced dynamic computed tomography.

scientific article published in May 2006

Lipidomic Signatures and Associated Transcriptomic Profiles of Clear Cell Renal Cell Carcinoma

scientific article published on 30 June 2016

Liver atrophy after percutaneous transhepatic portal embolization occurs in two histological phases: Hepatocellular atrophy followed by apoptosis

scientific article

Lobular endocervical glandular hyperplasia is a neoplastic entity with frequent activating GNAS mutations

scientific article published on March 2014

Long‑term exposure to gefitinib induces acquired resistance through DNA methylation changes in the EGFR‑mutant PC9 lung cancer cell line

scientific article

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers

scientific article published on 26 February 2014

Loss of blood group A antigen expression in bladder cancer caused by allelic loss and/or methylation of the ABO gene

scientific article published on 01 July 2005

Lysine Demethylase LSD1 Coordinates Glycolytic and Mitochondrial Metabolism in Hepatocellular Carcinoma Cells.

scientific article published on 3 February 2015

Macroscopic features predict outcome in patients with pancreatic ductal adenocarcinoma

scientific article published on 05 October 2016

Methylation pattern of urinary DNA as a marker of kidney function decline in diabetes

scientific article published on 01 September 2020

Mice-lacking LMP2, immuno-proteasome subunit, as an animal model of spontaneous uterine leiomyosarcoma

scientific article published on 28 August 2010

Molecular Approach to Uterine Leiomyosarcoma: LMP2-Deficient Mice as an Animal Model of Spontaneous Uterine Leiomyosarcoma

scientific article

Molecular Pathology and Novel Clinical Therapy for Uterine Leiomyosarcoma

scientific article published on October 2016

Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity

scientific article published on 18 December 2007

Molecular mechanisms of uterine leiomyosarcomas: involvement of defect in LMP2 expression.

scientific article published on 22 July 2008

Morules in intraductal papillary mucinous neoplasm with an associated invasive carcinoma of the pancreas

scientific article published on 01 May 2012

Multilayer-omics analyses of human cancers: exploration of biomarkers and drug targets based on the activities of the International Human Epigenome Consortium

scientific article published on 14 February 2014

Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome

scientific article

Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.

scientific article

Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung.

scientific article

Novel method for DNA methylation analysis using high-performance liquid chromatography and its clinical application.

scientific article published on 9 March 2018

Overexpression of HDACs: a prognostic marker for gastric cancer identified by tissue microarray

scientific article published on 01 February 2008

Overexpression of KIT in chromophobe renal cell carcinoma

scientific article

Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis

scientific article

Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in gastric cancer

scientific article published on 16 December 2012

Overexpression of α-methylacyl-CoA racemase is associated with CTNNB1 mutations in hepatocellular carcinomas.

scientific article

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

scientific article

Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas

scientific article

Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma

scientific article published on 01 July 2013

Pancreatic metastasis from renal cell carcinoma extending into the main pancreatic duct: a case report

scientific article published on 01 August 2002

Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia

scientific article published on 25 April 2013

Potential biomarker for human uterine leiomyosarcoma

scientific article

Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1

scientific article published on 29 May 2012

Potential role of LMP2 as tumor-suppressor defines new targets for uterine leiomyosarcoma therapy.

scientific article published on 5 December 2011

Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours

scientific article published on 24 January 2013

Primary Peritoneal Low-grade Serous Carcinoma in a Patient With Lynch Syndrome: A Case Report

scientific article published on 03 July 2019

Primary adenocarcinoma of the rete testis with preceding diagnosis of pulmonary metastases

scientific article published on 01 December 2006

Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors

scientific article published on 27 July 2019

Prognostic implication of PTPRH hypomethylation in non-small cell lung cancer.

scientific article

Prognostic risk stratification of patients with urothelial carcinoma of the bladder with recurrence after radical cystectomy.

scientific article published on 30 October 2012

Prognostic significance of dysadherin expression in tongue cancer: immunohistochemical analysis of 91 cases

scientific article published on 01 December 2004

Prognostic significance of tissue factor in pancreatic ductal adenocarcinoma

scientific article

Prognostication of patients with clear cell renal cell carcinomas based on quantification of DNA methylation levels of CpG island methylator phenotype marker genes

scientific article

Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer

scientific article published on August 2007

Prophylactic therapy with human amniotic fluid stem cells improved survival in a rat model of lipopolysaccharide-induced neonatal sepsis through immunomodulation via aggregates with peritoneal macrophages

scientific article published on 20 July 2020

Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study)

scientific article published on 08 December 2018

Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis

scientific article published on 20 September 2011

Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues.

scientific article

SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas

scientific article published on 4 November 2015

SOX10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: a clue to the histogenesis for tumor diagnosis

scientific article published on 5 April 2013

Semiquantitative Evaluation of Muscle Repair by Diffusion Tensor Imaging in Mice

Sensitive detection of FGFR3 mutations in bladder cancer and urine sediments by peptide nucleic acid-mediated real-time PCR clamping

scientific article published on 27 August 2007

Serous cystic neoplasm in an intrapancreatic accessory spleen ⬇️

scientific article published on October 1, 2010

Significance of PGP9.5 expression in cancer-associated fibroblasts for prognosis of colorectal carcinoma

scientific article published on 01 July 2010

Silencing of microRNA-122 is an early event during hepatocarcinogenesis from non-alcoholic steatohepatitis

scientific article published on 25 September 2014

Simple prediction model for homologous recombination deficiency in breast cancers in adolescents and young adults

scientific article published on 03 June 2020

Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas

scientific article

Solid-pseudopapillary neoplasms of the pancreas in men and women: do they differ?

scientific article

Solitary hepatic lymphangioma: Report of a case ⬇️

scientific article published on August 26, 2010

Steatotic and nonsteatotic scirrhous hepatocellular carcinomas reveal distinct clinicopathological features

scientific article published on 28 December 2018

Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis.

scientific article

Stromal metalloproteinases: Crucial contributors to the tumor microenvironment

scientific article published on 19 October 2020

TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast

scientific article

The Japanese Society of Pathology Guidelines on the handling of pathological tissue samples for genomic research: Standard operating procedures based on empirical analyses

scientific article published in February 2018

The genomic and epigenomic landscape in thymic carcinoma

scientific article published on 01 October 2017

The tumor suppressor microRNA-29c is downregulated and restored by celecoxib in human gastric cancer cells.

scientific article

Tumour multifocality and grade predict intravesical recurrence after nephroureterectomy in patients with upper urinary tract urothelial carcinoma without a history of bladder cancer.

scientific article published on 12 February 2015

Use of quantitative shotgun proteomics to identify fibronectin 1 as a potential plasma biomarker for clear cell carcinoma of the kidney

scientific article published on 01 January 2011

Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency

scientific article

[The excision repair cross-complementation group 1]

β-Catenin Mutations Are Frequent in Calcifying Odontogenic Cysts, but Rare in Ameloblastomas ⬇️

scientific article published on November 1, 2003

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