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List of works by Brent A Orr

Active medulloblastoma enhancers reveal subgroup-specific cellular origins

scientific article published on 27 January 2016

An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling

scientific article published on 16 January 2020

An update on the central nervous system manifestations of Li-Fraumeni syndrome

scientific article published on 30 August 2019

Comprehensive molecular characterization of pediatric radiation-induced high-grade glioma

scientific article published on 20 September 2021

Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma ⬇️

scientific article published on July 19, 2012

EMBR-15. DIAGNOSTIC RE-EVALUATION AND POOLED CLINICAL DATA ANALYSIS OF PATIENTS WITH PREVIOUS DIAGNOSIS OF CNS-PNET

Establishment and characterization of a primary human chordoma xenograft model ⬇️

scientific article published on January 27, 2012

Expanded endonasal endoscopic approach for resection of a growth hormone-secreting pituitary macroadenoma coexistent with a cavernous carotid artery aneurysm ⬇️

scientific article published on July 25, 2012

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation

scientific article published on 20 August 2020

GENE-06. DISTINCT MOLECULAR SUBGROUPS OF TUMORS OF THE PINEAL REGION CORRELATE WITH CLINICAL PARAMETERS AND GENETIC ALTERATIONS

scientific article published on 23 April 2019

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

scientific article published on 01 April 2020

IgA/Kappa-restricted crystal storing histiocytosis involving the central nervous system characterized by proteomic analysis ⬇️

scientific article published on January 1, 2014

MBCL-44. THE MOLECULAR AND CLINICAL LANDSCAPE OF INFANT MEDULLOBLASTOMA (iMB): RESULTS AND MOLECULAR ANALYSIS FROM A PROSPECTIVE, MULTICENTER PHASE II TRIAL (SJYC07)

MBRS-07. BCOR LOSS IMPACTS SHH MEDULLOBLASTOMA FORMATION VIA TRANSCRIPTIONAL UP-REGULATION OF

MBRS-34. MOLECULAR CHARACTERIZATION OF RECURRENT MEDULLOBLASTOMA REVEALS AN UNEXPECTEDLY HIGH INCIDENCE OF SECONDARY MALIGNANCY.

scientific article published on 22 June 2018

MEDU-21. LOSS OF THE TRANSCRIPTIONAL CO-REPRESSOR BCOR LEADS TO OVEREXPRESSION OF THE GROWTH FACTOR IGF2 AND SHH MEDULLOBLASTOMA TUMOR FORMATION

MPTH-15MOLECULAR RECLASSIFICATION OF CNS-PRIMITIVE NEUROECTODERMAL TUMORS INTO WELL-KNOWN AND NOVEL TUMOR ENTITIES.

scientific article

Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations

scientific article published on 25 November 2019

Neoplastic cells are a rare component in human glioblastoma microvasculature ⬇️

scientific article published on January 1, 2012

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

scientific article

Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03)

scientific article published on 06 January 2021

PNR-21FOUR NEW BRAIN TUMOR ENTITIES EMERGE FROM MOLECULAR CLASSIFICATION OF CNS PNETs

scientific article published on 30 May 2016

Papillary tumor of the pineal region in a 15-month-old boy ⬇️

scientific article published on May 1, 2011

Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma

scientific article published on 02 July 2021

Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition

scientific article published on 17 April 2020

Primary Intramedullary Spinal Germ Cell Tumors ⬇️

scientific article published on 01 November 2011

Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following In Vivo Notch Blockade ⬇️

scientific article published on April 29, 2013

Resolving medulloblastoma cellular architecture by single-cell genomics

scientific article published on 24 July 2019

Retinoblastoma from human stem cell-derived retinal organoids

scientific article published on 27 July 2021

Risk-adapted therapy for young children with medulloblastoma (SJYC07): therapeutic and molecular outcomes from a multicentre, phase 2 trial

scientific article published on 16 May 2018

SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression

scientific article published on 18 June 2021

St. Jude Cloud-a Pediatric Cancer Genomic Data Sharing Ecosystem

scientific article published on 06 January 2021

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

Unbiased Metabolic Profiling Predicts Sensitivity of High MYC-Expressing Atypical Teratoid/Rhabdoid Tumors to Glutamine Inhibition with 6-Diazo-5-Oxo-L-Norleucine

scientific article published on 12 July 2019

Yes-Associated Protein 1 Is Widely Expressed in Human Brain Tumors and Promotes Glioblastoma Growth ⬇️

scientific article published on July 1, 2011

Yes-associated protein 1 is activated and functions as an oncogene in meningiomas

scientific article

cMYC expression in infiltrating gliomas: associations with IDH1 mutations, clinicopathologic features and outcome ⬇️

scientific article published on August 11, 2013

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