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List of works by Clark T Hung

* Constrained Cage Culture Improves Engineered Cartilage Functional Properties by Enhancing Collagen Network Stability

scientific article published on 14 February 2017

A Functional Tissue-Engineered Synovium Model to Study Osteoarthritis Progression and Treatment

scientific article published on 31 October 2018

A layered agarose approach to fabricate depth-dependent inhomogeneity in chondrocyte-seeded constructs.

scientific article published in January 2005

A mixture theory analysis for passive transport in osmotic loading of cells

scientific article

A novel system improves preservation of osteochondral allografts

scientific article

A paradigm for functional tissue engineering of articular cartilage via applied physiologic deformational loading.

scientific article published on January 2004

A puzzle assembly strategy for fabrication of large engineered cartilage tissue constructs

scientific article

A tissue level tolerance criterion for living brain developed with an in vitro model of traumatic mechanical loading

scientific article published in October 2003

Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage.

scientific article published on April 2013

An automated approach for direct measurement of two-dimensional strain distributions within articular cartilage under unconfined compression

scientific article published on October 2002

Anatomically shaped osteochondral constructs for articular cartilage repair.

scientific article published in December 2003

Anisotropic strain-dependent material properties of bovine articular cartilage in the transitional range from tension to compression

scientific article

Applied osmotic loading for promoting development of engineered cartilage

scientific article published on 30 August 2013

Articular cartilage wear characterization with a particle sizing and counting analyzer

scientific article published on February 2013

Bioactive glass 13-93 as a subchondral substrate for tissue-engineered osteochondral constructs: a pilot study.

scientific article published on October 2011

Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair

scientific article

Biocompatibility of polysebacic anhydride microparticles with chondrocytes in engineered cartilage

scientific article published on 28 August 2015

Biphasic Analysis of Cartilage Stresses in the Patellofemoral Joint

scientific article published on 7 December 2015

Cartilage Wear Particles Induce an Inflammatory Response Similar to Cytokines in Human Fibroblast-Like Synoviocytes

scientific article published on 17 May 2019

Cartilage interstitial fluid load support in unconfined compression following enzymatic digestion.

scientific article published on December 2004

Characterization of the Concentration-Dependence of Solute Diffusivity and Partitioning in a Model Dextran-Agarose Transport System

scientific article

Characterization of the mechanical properties and mineral distribution of the anterior cruciate ligament-to-bone insertion site

scientific article

Characterization of the structure-function relationship at the ligament-to-bone interface.

scientific article

Chondrocyte nuclear response to osmotic loading

scientific article published on 01 January 2006

Chondrogenic properties of collagen type XI, a component of cartilage extracellular matrix

scientific article published on 03 May 2018

Chondroitin sulfate reduces the friction coefficient of articular cartilage

scientific article published on 3 November 2006

Clinically relevant strategies for treating cartilage and meniscal pathology: editorial comment

scientific article published on October 2011

Coculture of engineered cartilage with primary chondrocytes induces expedited growth

scientific article

Concise Review: Mesenchymal Stem Cells for Functional Cartilage Tissue Engineering: Taking Cues from Chondrocyte-Based Constructs

scientific article

Continuum modeling of biological tissue growth by cell division, and alteration of intracellular osmolytes and extracellular fixed charge density

scientific article

Continuum theory of fibrous tissue damage mechanics using bond kinetics: application to cartilage tissue engineering

scientific article

Culture duration modulates collagen hydrolysate-induced tissue remodeling in chondrocyte-seeded agarose hydrogels

scientific article published on 25 August 2007

Current strategies for integrative cartilage repair

scientific article published on 6 September 2016

Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult

scientific article

Dependence of zonal chondrocyte water transport properties on osmotic environment

scientific article published on December 2008

Development of a whole organ culture model for intervertebral disc disease.

scientific article published on 29 August 2015

Dexamethasone Release from Within Engineered Cartilage as a Chondroprotective Strategy Against Interleukin-1α.

scientific article published on 9 March 2016

Differences in interleukin-1 response between engineered and native cartilage.

scientific article published in October 2008

Direct Osmotic Pressure Measurements in Articular Cartilage Demonstrate Non-Ideal and Concentration-Dependent Phenomena

scientific article published on 19 November 2020

Direct measurement of osmotic pressure of glycosaminoglycan solutions by membrane osmometry at room temperature.

scientific article

Disparate aggrecan gene expression in chondrocytes subjected to hypotonic and hypertonic loading in 2D and 3D culture

scientific article published on 01 January 2003

Duty Cycle of Deformational Loading Influences the Growth of Engineered Articular Cartilage

scientific article

Dynamic deformational loading results in selective application of mechanical stimulation in a layered, tissue-engineered cartilage construct.

scientific article published in January 2006

Dynamic loading of deformable porous media can induce active solute transport.

scientific article published on 14 October 2008

Dynamic loading of immature epiphyseal cartilage pumps nutrients out of vascular canals

scientific article

Dynamic mechanical compression of devitalized articular cartilage does not activate latent TGF-β.

scientific article published on 27 March 2013

Dynamic mechanical loading enhances functional properties of tissue-engineered cartilage using mature canine chondrocytes

scientific article

Effect of dynamic loading on the transport of solutes into agarose hydrogels.

scientific article published on August 2009

Effect of glutaraldehyde fixation on the frictional response of immature bovine articular cartilage explants

scientific article published on December 2013

Effects of applied DC electric field on ligament fibroblast migration and wound healing

scientific article published in January 2007

Effects of dexamethasone on the functional properties of cartilage explants during long-term culture

scientific article

Effects of enzymatic degradation on the frictional response of articular cartilage in stress relaxation

scientific article

Effects of hypertonic (NaCl) two-dimensional and three-dimensional culture conditions on the properties of cartilage tissue engineered from an expanded mature bovine chondrocyte source

scientific article

Electric field-induced polarization of charged cell surface proteins does not determine the direction of galvanotaxis

scientific article published on November 2007

Electrostatic and non-electrostatic contributions of proteoglycans to the compressive equilibrium modulus of bovine articular cartilage

scientific article

Fabrication of tissue engineered osteochondral grafts for restoring the articular surface of diarthrodial joints

scientific article

Fibroblast-like synoviocyte mechanosensitivity to fluid shear is modulated by interleukin-1α.

scientific article published on 28 June 2017

Frictional response of bovine articular cartilage under creep loading following proteoglycan digestion with chondroitinase ABC.

scientific article

Functional tissue engineering of chondral and osteochondral constructs.

scientific article published in January 2004

Genipin enhances the mechanical properties of tissue-engineered cartilage and protects against inflammatory degradation when used as a medium supplement

scientific article

Glutaraldehyde Fixation of Bovine Humeral Head Articular Cartilage Maintains Functional Frictional Response

Grading of osteoarthritic cartilage: Correlations between histology and biomechanics.

scientific article published on 22 December 2015

Growth factor priming differentially modulates components of the extracellular matrix proteome in chondrocytes and synovium-derived stem cells

scientific article (publication date: 2014)

Growth factor priming of synovium-derived stem cells for cartilage tissue engineering

scientific article

Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β

scientific article

Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β.

scientific article

High intensity focused ultrasound as a tool for tissue engineering: Application to cartilage.

scientific article

High seeding density of human chondrocytes in agarose produces tissue-engineered cartilage approaching native mechanical and biochemical properties.

scientific article published on 10 May 2016

Human chondrocyte migration behaviour to guide the development of engineered cartilage.

scientific article

Immature bovine cartilage wear by fatigue failure and delamination

scientific article published on 19 May 2020

Improved Preservation of Fresh Osteochondral Allografts for Clinical Use

Improved preservation of fresh osteochondral allografts for clinical use.

scientific article published in May 2012

In-situ measurements of chondrocyte deformation under transient loading.

scientific article published on 31 May 2007

Influence of chondroitin sulfate on the biochemical, mechanical and frictional properties of cartilage explants in long-term culture

scientific article

Influence of seeding density and dynamic deformational loading on the developing structure/function relationships of chondrocyte-seeded agarose hydrogels

scientific article published on 01 September 2002

Influence of temporary chondroitinase ABC-induced glycosaminoglycan suppression on maturation of tissue-engineered cartilage

scientific article published on August 2009

Influence of the partitioning of osmolytes by the cytoplasm on the passive response of cells to osmotic loading

scientific article published on December 2009

Insulin, ascorbate, and glucose have a much greater influence than transferrin and selenous acid on the in vitro growth of engineered cartilage in chondrogenic media

scientific article published on 30 May 2013

Intrinsically superparamagnetic Fe-hydroxyapatite nanoparticles positively influence osteoblast-like cell behaviour

scientific article

Label-free protein profiling of adipose-derived human stem cells under hyperosmotic treatment

scientific article

Long-term storage and preservation of tissue engineered articular cartilage

scientific article

Low-serum media and dynamic deformational loading in tissue engineering of articular cartilage.

scientific article published on 26 February 2008

Magnetic hydroxyapatite bone substitutes to enhance tissue regeneration: evaluation in vitro using osteoblast-like cells and in vivo in a bone defect

scientific article

Matrix Production in Large Engineered Cartilage Constructs Is Enhanced by Nutrient Channels and Excess Media Supply

scientific article published on 3 April 2015

Mechanics of Cell Growth

scientific article

Microbubbles as biocompatible porogens for hydrogel scaffolds.

scientific article published on 3 August 2012

Migration responses of outer and inner meniscus cells to applied direct current electric fields.

scientific article

Modeling of active transmembrane transport in a mixture theory framework

scientific article

Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering.

scientific article

Modeling the matrix of articular cartilage using a continuous fiber angular distribution predicts many observed phenomena.

scientific article

Musculoskeletal mechanobiology: A new era for MechanoMedicine

scientific article published on 6 February 2018

Nutrient Channels Aid the Growth of Articular Surface-Sized Engineered Cartilage Constructs

scientific article published on August 2016

Nutrient channels and stirring enhanced the composition and stiffness of large cartilage constructs

scientific article

Optical determination of anisotropic material properties of bovine articular cartilage in compression

scientific article

Optimizing nutrient channel spacing and revisiting TGF-beta in large engineered cartilage constructs

scientific article published on 21 May 2016

Osmotic loading of spherical gels: a biomimetic study of hindered transport in the cell protoplasm

scientific article

Osteoblast elastic modulus measured by atomic force microscopy is substrate dependent

scientific article

Osteocyte viability and regulation of osteoblast function in a 3D trabecular bone explant under dynamic hydrostatic pressure.

scientific article published in June 2004

Passaged adult chondrocytes can form engineered cartilage with functional mechanical properties: a canine model

scientific article

Patellofemoral joint biomechanics and tissue engineering

scientific article

Physiologic deformational loading does not counteract the catabolic effects of interleukin-1 in long-term culture of chondrocyte-seeded agarose constructs.

scientific article published on 26 September 2008

Porous titanium bases for osteochondral tissue engineering.

scientific article published on 27 August 2015

Pulsed electromagnetic fields promote repair of focal articular cartilage defects with engineered osteochondral constructs

scientific article published on 05 February 2020

Role of cell-associated matrix in the development of free-swelling and dynamically loaded chondrocyte-seeded agarose gels.

scientific article published in January 2004

Silk microfiber-reinforced silk hydrogel composites for functional cartilage tissue repair

scientific article

Spatial and temporal development of chondrocyte-seeded agarose constructs in free-swelling and dynamically loaded cultures

scientific article published on 28 June 2005

Spatially varying material properties of the rat caudal intervertebral disc

scientific article

Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair

scientific article published on 02 December 2019

Synergistic action of growth factors and dynamic loading for articular cartilage tissue engineering.

scientific article published in August 2003

Synthesis rates and binding kinetics of matrix products in engineered cartilage constructs using chondrocyte-seeded agarose gels

scientific article

The correspondence between equilibrium biphasic and triphasic material properties in mixture models of articular cartilage

scientific article

The effect of applied compressive loading on tissue-engineered cartilage constructs cultured with TGF-beta3.

scientific article published in January 2006

The effect of devitalized trabecular bone on the formation of osteochondral tissue-engineered constructs

scientific article published on 20 August 2008

The friction coefficient of shoulder joints remains remarkably low over 24 h of loading

scientific article

The functional environment of chondrocytes within cartilage subjected to compressive loading: a theoretical and experimental approach.

scientific article published on January 2002

Tissue-engineered articular cartilage exhibits tension-compression nonlinearity reminiscent of the native cartilage

scientific article published on 21 June 2013

Toward engineering a biological joint replacement.

scientific article published on July 2012

Transient expression of the diseased phenotype of osteoarthritic chondrocytes in engineered cartilage

scientific article published on 16 May 2016

Transient supplementation of anabolic growth factors rapidly stimulates matrix synthesis in engineered cartilage.

scientific article

Trimethylamine N-oxide as a media supplement for cartilage tissue engineering

scientific article

Two-dimensional strain fields on the cross-section of the bovine humeral head under contact loading

scientific article published on 25 October 2008

Two-dimensional strain fields on the cross-section of the human patellofemoral joint under physiological loading.

scientific article

Validation of theoretical framework explaining active solute uptake in dynamically loaded porous media

scientific article

Wear and damage of articular cartilage with friction against orthopedic implant materials.

scientific article published on 15 April 2015

Zonal chondrocytes seeded in a layered agarose hydrogel create engineered cartilage with depth-dependent cellular and mechanical inhomogeneity

scientific article published on September 2009

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