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List of works by Christoph Hölscher

9- and 11-Substituted 4-azapaullones are potent and selective inhibitors of African trypanosoma

scientific article

A Mutation in IL4RA Is Associated with the Degree of Pathology in Human TB Patients

scientific article published on 10 February 2016

Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation

scientific article

Alternative Macrophage Activation Is Essential for Survival during Schistosomiasis and Downmodulates T Helper 1 Responses and Immunopathology

article

Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

scientific article published in May 2004

Alternatively activated macrophages express the IL-27 receptor alpha chain WSX-1

scientific article published on 05 July 2006

An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer

scientific article published on 3 December 2012

Analyzing classical and alternative macrophage activation in macrophage/neutrophil-specific IL-4 receptor-alpha-deficient mice

scientific article

Arginase-1 Is Responsible for IL-13-Mediated Susceptibility to Trypanosoma cruzi Infection

scientific article published on 29 November 2018

Autocrine IL-10 induces hallmarks of alternative activation in macrophages and suppresses antituberculosis effector mechanisms without compromising T cell immunity

scientific article published on 26 June 2009

Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.

scientific article published on 18 April 2019

Cell-autonomous hepatocyte-specific GP130 signalling is sufficient to trigger a robust innate immune response in mice

scientific article published on 25 September 2020

Chemical p38 MAP kinase inhibition constrains tissue inflammation and improves antibiotic activity in Mycobacterium tuberculosis-infected mice

scientific article published on 12 August 2020

Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL/Fas pathway

scientific article published in January 2003

Containment of aerogenic Mycobacterium tuberculosis infection in mice does not require MyD88 adaptor function for TLR2, -4 and -9.

scientific article

Corticosteroids inhibit Mycobacterium tuberculosis-induced necrotic host cell death by abrogating mitochondrial membrane permeability transition

scientific article published in Nature Communications

Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis

scientific article published in October 2002

DAP10 contributes to CD8+ T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection

scientific article published on 24 September 2010

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages

scientific article published on 5 April 2018

Defective Nitric Oxide Effector Functions Lead to Extreme Susceptibility ofTrypanosoma cruzi-Infected Mice Deficient in Gamma Interferon Receptor or Inducible Nitric Oxide Synthase ⬇️

scientific article published on March 1, 1998

Deletion of IL-4Ralpha on CD4 T cells renders BALB/c mice resistant to Leishmania major infection.

scientific article

Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice

scientific article published on 01 June 2007

Differing Outcome of Experimental Autoimmune Encephalitis in Macrophage/Neutrophil- and T Cell-Specific gp130-Deficient Mice.

scientific article

During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection

scientific article published on 21 September 2016

Epstein-Barr virus-induced gene 3 suppresses T helper type 1, type 17 and type 2 immune responses after Trypanosoma cruzi infection and inhibits parasite replication by interfering with alternative macrophage activation

scientific article published on 23 December 2015

Fucosyltransferase IV and VII-directed selectin ligand function determines long-term survival in experimental tuberculosis.

scientific article published in January 2009

Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages

scientific article published on 30 October 2021

IL-10-producing Tfh cells accumulate with age and link inflammation with age-related immune suppression

scientific article published on 29 July 2020

IL-17A is produced by Th17, gammadelta T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance

scientific article published on 3 July 2008

IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment

scientific article published on 26 October 2012

IL-22 is mainly produced by IFNγ-secreting cells but is dispensable for host protection against Mycobacterium tuberculosis infection

scientific article

IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage

scientific article

IL-4 receptor signaling in Clara cells is required for allergen-induced mucus production

scientific article published in September 2005

IL-6 is not Absolutely Essential for the Development of a TH17 Immune Response after an Aerosol Infection with Mycobacterium Tuberculosis H37rv

scientific article published on 22 December 2020

IgG Fc sialylation is regulated during the germinal center reaction upon immunization with different adjuvants

scientific article published on 20 May 2020

Immunosuppression in Experimental Chagas Disease Is Mediated by an Alteration of Bone Marrow Stromal Cell Function During the Acute Phase of Infection

Impairment of alternative macrophage activation delays cutaneous leishmaniasis in nonhealing BALB/c mice

scientific article

Integrating high resolution MALDI imaging into the development pipeline of anti-tuberculosis drugs

scientific article published on 23 September 2020

Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17.

scientific article

Interleukin-12p40 mediates transient protection against Mycobacterium avium infection in the absence of interleukin-12.

scientific article published in January 2005

Interleukin-15 mediates protection against experimental tuberculosis: a role for NKG2D-dependent effector mechanisms of CD8+ T cells

scientific article published on 01 May 2006

Interleukin-23 instructs protective multifunctional CD4 T cell responses after immunization with the Mycobacterium tuberculosis subunit vaccine H1 DDA/TDB independently of interleukin-17A

scientific article

Mincle is not essential for controlling Mycobacterium tuberculosis infection.

scientific article published on 21 June 2012

MyD88/IL-18-dependent pathways rather than TLRs control early parasitaemia in non-lethal Plasmodium yoelii infection

scientific article published on 22 July 2008

MyDths and un-TOLLed truths: sensor, instructive and effector immunity to tuberculosis.

scientific article published on 26 December 2007

NALP3 is not necessary for early protection against experimental tuberculosis

scientific article published on 4 June 2010

Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke

scientific article published on 13 September 2012

No inhibition of IL-27 signaling by soluble gp130.

scientific article

Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression

scientific article published on 01 November 2009

Poly(inosinic-cytidylic) acid-triggered exacerbation of experimental asthma depends on IL-17A produced by NK cells

scientific article published on 13 May 2015

Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17.

scientific article published in December 2008

Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity

scientific article

Selectin ligand-independent priming and maintenance of T cell immunity during airborne tuberculosis

scientific article published on 01 January 2006

Suppressor of Cytokine Signaling 3 in Macrophages Prevents Exacerbated Interleukin-6-Dependent Arginase-1 Activity and Early Permissiveness to Experimental Tuberculosis.

scientific article published on 10 November 2017

Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages

scientific journal article

TGF-β-responsive myeloid cells suppress type 2 immunity and emphysematous pathology after hookworm infection

scientific article

TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes

scientific article (publication date: 2012)

Targeting IL-23 in autoimmunity.

scientific article

The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology

scientific article published on 6 August 2014

The IL-23/Th17 axis contributes to renal injury in experimental glomerulonephritis

scientific article published on April 2009

The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis

scientific article published on 01 March 2005

The Role of gp130 Cytokines in Tuberculosis

scientific article published on 15 December 2020

The increased protection and pathology in Mycobacterium tuberculosis-infected IL-27R-alpha-deficient mice is supported by IL-17A and is associated with the IL-17A-induced expansion of multifunctional T cells.

scientific article

The lymphotoxin beta receptor is critically involved in controlling infections with the intracellular pathogens Mycobacterium tuberculosis and Listeria monocytogenes

scientific article published in May 2003

The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases

scientific article

Therapeutic targeting of interleukin-6 trans-signaling does not affect the outcome of experimental tuberculosis

scientific article published on 20 January 2012

gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis

scientific article published on 08 December 2010

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