List of works - Maria Valeria D'Auria

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

scientific article published on 20 January 2012

Amphiasterins: a new family of cytotoxic metabolites from the marine sponge Plakortis quasiamphiaster

Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

scientific article published on 23 July 2015

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

scientific article

Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensis

scientific article

Callipeltin A: sodium ionophore effect and tension development in vascular smooth muscle

scientific article published in October 2004

Callipeltins F–I: new antifungal peptides from the marine sponge Latrunculia sp

Characterization of a New Mixture of Mono-Rhamnolipids Produced by Pseudomonas gessardii Isolated from Edmonson Point (Antarctica)

scientific article published on 20 May 2020

Concise Synthesis of All Stereoisomers of β-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A

scientific article published on 01 August 2005

Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

scientific article

Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties

article published in 2009

Crellastatin A: A Cytotoxic Bis-Steroid Sulfate from the Vanuatu Marine SpongeCrellasp.†

scholarly article by Maria Valeria D'Auria et al published October 1998 in Journal of Organic Chemistry

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

scientific article published on 17 January 2014

Dihydroauroglaucin Isolated from the Mediterranean Sponge Grantia compressa Endophyte Marine Fungus Eurotium chevalieri Inhibits Migration of Human Neuroblastoma Cells

scientific article published in 2022

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

scientific article (publication date: 2012)

Genomics-Metabolomics Profiling Disclosed Marine Vibrio spartinae 3.6 as a Producer of a New Branched Side Chain Prodigiosin ⬇️

scientific article published on 10 April 2020

Gracilioethers E–J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris

article

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

scientific article published in January 2014

Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

scientific article

Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

scientific article published on 22 July 2009

Identification of a Sorbicillinoid-Producing Aspergillus Strain with Antimicrobial Activity Against Staphylococcus aureus: a New Polyextremophilic Marine Fungus from Barents Sea.

scientific article published on 12 April 2018

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

scientific article

Isolation and Structural Elucidation of Crellastatins B–H: Cytotoxic Bis(steroid) Derivatives from the Vanuatu Marine SpongeCrella sp.

scientific article published in December 2005

Isolation and structural elucidation of callipeltins J–M: antifungal peptides from the marine sponge Latrunculia sp

Isolation and structural elucidation of the crellastatins I-M: cytotoxic bis-steroid derivatives from the vanuatu marine sponge Crella sp

scholarly article by Clelia Giannini et al published November 1999 in Tetrahedron

Isolation of Plakinamine I: A New Steroidal Alkaloid from the Marine SpongeCorticiumsp. and Synthesis of an Analogue Model Compound

Isolation of callipeltins A–C and of two new open-chain derivatives of callipeltin A from the marine sponge Latrunculia sp. A revision of the stereostructure of callipeltins

Jaspamides H–L, new actin-targeting depsipeptides from the sponge Jaspis splendans

Jaspamides M–P: new tryptophan modified jaspamide derivatives from the sponge Jaspis splendans

Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation

scientific article

Marine sponge steroids as nuclear receptor ligands.

scientific article

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

scientific article

Modulatory effect of bolinaquinone, a marine sesquiterpenoid, on acute and chronic inflammatory processes

scientific article published in March 2003

Molecular Network and Culture Media Variation Reveal a Complex Metabolic Profile in Pantoea cf. eucrina D2 Associated with an Acidified Marine Sponge

scientific article published on 31 August 2020

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.

scientific article

Natural ligands for nuclear receptors: biology and potential therapeutic applications.

scientific article published on January 2012

New Jaspamide Derivatives from the Marine SpongeJaspis splendansCollected in Vanuatu1

New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.

scientific article published on 2 July 2013

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Pharmacological evaluation of the semi-purified fractions from the soft coral Eunicella singularis and isolation of pure compounds

scientific article

Phytochemical and Biological Studies of Nepeta asterotricha Rech. f. (Lamiaceae): Isolation of Nepetamoside.

scientific article

Plakilactones G and H from a marine sponge. Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of (13)C chemical shifts

scientific article published on 30 December 2013

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

scientific article

Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei

scientific article published on 5 November 2012

Protection against 2,4,6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongiolide M.

scientific article published in May 2005

Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei

scientific article published on 23 January 2012

Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

scientific article

Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei.

scientific article published on 22 February 2011

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.

scientific article published on 24 December 2013

Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity

scientific article published on 9 December 2010

Stereochemical assignment of the C23–C35 portion of sphinxolide/reidispongiolide class of natural products by asymmetric synthesis

Stereoselective synthesis of (2R,3R,4R)-3-hydroxy-2,4,6-trimethylheptanoic acid and determination of the absolute stereochemistry of the natural product from callipeltin A

Steroids from the starfish Euretaster insignis: a novel group of sulphated 3β,21-dihydroxysteroids

scientific article published on 26 April 2004

Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists.

scientific article published on 4 December 2013

Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity

scientific article

Studies towards the synthesis of superstolide A. Synthesis and stereochemical assignment of the C(21)C(26) fragment of superstolide A

Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei

scientific article published on 22 June 2011

Synthetic studies on callipeltin A: stereoselective synthesis of (2 R ,3 R ,4 S )-3-hydroxy-2,4,6-trimethylheptanoic acid

Synthetic studies on homophymine A: stereoselective synthesis of (2R,3R,4R,6R)-3-hydroxy-2,4,6-trimethyloctanoic acid

The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist

The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling.

scientific article published on 3 May 2016

The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone

scientific article published on 01 June 2006

Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.

scientific article

Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity

scientific article published on 3 June 2011

Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

scientific article published on 16 May 2011

Unusual sulfated marine steroids from the ophiuroid ophioderma longicaudum

scientific article published on 25 July 2002

List of works by Maria Valeria D'Auria

4-Methylenesterols from Theonella swinhoei sponge are natural pregnane-X-receptor agonists and farnesoid-X-receptor antagonists that modulate innate immunity

Amphiasterins: a new family of cytotoxic metabolites from the marine sponge Plakortis quasiamphiaster

Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

Binding mechanism of the farnesoid X receptor marine antagonist suvanine reveals a strategy to forestall drug modulation on nuclear receptors. Design, synthesis, and biological evaluation of novel ligands.

Bioactive cembrane derivatives from the Indian Ocean soft coral, Sinularia kavarattiensis

Callipeltin A: sodium ionophore effect and tension development in vascular smooth muscle

Callipeltins F–I: new antifungal peptides from the marine sponge Latrunculia sp

Characterization of a New Mixture of Mono-Rhamnolipids Produced by Pseudomonas gessardii Isolated from Edmonson Point (Antarctica)

Concise Synthesis of All Stereoisomers of β-Methoxytyrosine and Determination of the Absolute Configuration of the Residue in Callipeltin A

Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.

Coscinolactams A and B: new nitrogen-containing sesterterpenoids from the marine sponge Coscinoderma mathewsi exerting anti-inflammatory properties

Crellastatin A: A Cytotoxic Bis-Steroid Sulfate from the Vanuatu Marine SpongeCrellasp.†

Design, synthesis, and biological evaluation of potent dual agonists of nuclear and membrane bile acid receptors.

Dihydroauroglaucin Isolated from the Mediterranean Sponge Grantia compressa Endophyte Marine Fungus Eurotium chevalieri Inhibits Migration of Human Neuroblastoma Cells

Discovery that theonellasterol a marine sponge sterol is a highly selective FXR antagonist that protects against liver injury in cholestasis

Genomics-Metabolomics Profiling Disclosed Marine Vibrio spartinae 3.6 as a Producer of a New Branched Side Chain Prodigiosin ⬇️

Gracilioethers E–J, new oxygenated polyketides from the marine sponge Plakinastrella mamillaris

Heteronemin, a marine sponge terpenoid, targets TDP-43, a key factor in several neurodegenerative disorders

Homophymine A, an anti-HIV cyclodepsipeptide from the sponge Homophymia sp.

Homophymines B-E and A1-E1, a family of bioactive cyclodepsipeptides from the sponge Homophymia sp.

Identification of a Sorbicillinoid-Producing Aspergillus Strain with Antimicrobial Activity Against Staphylococcus aureus: a New Polyextremophilic Marine Fungus from Barents Sea.

Insights on pregnane-X-receptor modulation. Natural and semisynthetic steroids from Theonella marine sponges.

Isolation and Structural Elucidation of Crellastatins B–H: Cytotoxic Bis(steroid) Derivatives from the Vanuatu Marine SpongeCrella sp.

Isolation and structural elucidation of callipeltins J–M: antifungal peptides from the marine sponge Latrunculia sp

Isolation and structural elucidation of the crellastatins I-M: cytotoxic bis-steroid derivatives from the vanuatu marine sponge Crella sp

Isolation of Plakinamine I: A New Steroidal Alkaloid from the Marine SpongeCorticiumsp. and Synthesis of an Analogue Model Compound

Isolation of callipeltins A–C and of two new open-chain derivatives of callipeltin A from the marine sponge Latrunculia sp. A revision of the stereostructure of callipeltins

Jaspamides H–L, new actin-targeting depsipeptides from the sponge Jaspis splendans

Jaspamides M–P: new tryptophan modified jaspamide derivatives from the sponge Jaspis splendans

Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation

Marine sponge steroids as nuclear receptor ligands.

Modification in the side chain of solomonsterol A: discovery of cholestan disulfate as a potent pregnane-X-receptor agonist.

Modulatory effect of bolinaquinone, a marine sesquiterpenoid, on acute and chronic inflammatory processes

Molecular Network and Culture Media Variation Reveal a Complex Metabolic Profile in Pantoea cf. eucrina D2 Associated with an Acidified Marine Sponge

Molecular decodification of gymnemic acids from Gymnema sylvestre. Discovery of a new class of liver X receptor antagonists.

Natural ligands for nuclear receptors: biology and potential therapeutic applications.

New Jaspamide Derivatives from the Marine SpongeJaspis splendansCollected in Vanuatu1

New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Oxygenated polyketides from Plakinastrella mamillaris as a new chemotype of PXR agonists.

Perthamides C and D, two new potent anti-inflammatory cyclopeptides from a Solomon Lithistid sponge Theonella swinhoei

Pharmacological evaluation of the semi-purified fractions from the soft coral Eunicella singularis and isolation of pure compounds

Phytochemical and Biological Studies of Nepeta asterotricha Rech. f. (Lamiaceae): Isolation of Nepetamoside.

Plakilactones G and H from a marine sponge. Stereochemical determination of highly flexible systems by quantitative NMR-derived interproton distances combined with quantum mechanical calculations of (13)C chemical shifts

Plakilactones from the marine sponge Plakinastrella mamillaris. Discovery of a new class of marine ligands of peroxisome proliferator-activated receptor γ.

Preliminary structure-activity relationship on theonellasterol, a new chemotype of FXR antagonist, from the marine sponge Theonella swinhoei

Protection against 2,4,6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongiolide M.

Quantitative NMR-derived interproton distances combined with quantum mechanical calculations of 13C chemical shifts in the stereochemical determination of conicasterol F, a nuclear receptor ligand from Theonella swinhoei

Scalarane sesterterpenes from Thorectidae sponges as inhibitors of TDP-43 nuclear factor

Solomonamides A and B, new anti-inflammatory peptides from Theonella swinhoei.

Solomonsterol A, a marine pregnane-X-receptor agonist, attenuates inflammation and immune dysfunction in a mouse model of arthritis.

Solomonsterols A and B from Theonella swinhoei. The first example of C-24 and C-23 sulfated sterols from a marine source endowed with a PXR agonistic activity

Stereochemical assignment of the C23–C35 portion of sphinxolide/reidispongiolide class of natural products by asymmetric synthesis

Stereoselective synthesis of (2R,3R,4R)-3-hydroxy-2,4,6-trimethylheptanoic acid and determination of the absolute stereochemistry of the natural product from callipeltin A

Steroids from the starfish Euretaster insignis: a novel group of sulphated 3β,21-dihydroxysteroids

Structural insights into Estrogen Related Receptor-β modulation: 4-methylenesterols from Theonella swinhoei sponge as the first example of marine natural antagonists.

Structures of microfilament destabilizing toxins bound to actin provide insight into toxin design and activity

Studies towards the synthesis of superstolide A. Synthesis and stereochemical assignment of the C(21)C(26) fragment of superstolide A

Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei

Synthetic studies on callipeltin A: stereoselective synthesis of (2 R ,3 R ,4 S )-3-hydroxy-2,4,6-trimethylheptanoic acid

Synthetic studies on homophymine A: stereoselective synthesis of (2R,3R,4R,6R)-3-hydroxy-2,4,6-trimethyloctanoic acid

The First Total Synthesis of Solomonsterol B, a Marine Pregnane X Receptor Agonist

The antimicrobial potential of algicolous marine fungi for counteracting multidrug-resistant bacteria: phylogenetic diversity and chemical profiling.

The molecular mechanism of bee venom phospholipase A2 inactivation by bolinaquinone

Theonellasterols and conicasterols from Theonella swinhoei. Novel marine natural ligands for human nuclear receptors.

Total synthesis and pharmacological characterization of solomonsterol A, a potent marine pregnane-X-receptor agonist endowed with anti-inflammatory activity

Towards new ligands of nuclear receptors. Discovery of malaitasterol A, an unique bis-secosterol from marine sponge Theonella swinhoei

Unusual sulfated marine steroids from the ophiuroid ophioderma longicaudum