List of works - Karim Asehnoune

A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury

scientific article published on 12 May 2020

A multi-faceted strategy to reduce ventilation-associated mortality in brain-injured patients. The BI-VILI project: a nationwide quality improvement project.

scientific article published on 18 March 2017

A new way of thinking: hydrocortisone in traumatic brain-injured patients

scientific article

A retrospective study about cerebral near-infrared spectroscopy monitoring during paediatric cardiac surgery and intra-operative patient blood management

scientific article

Alterations of the iNKT cell compartment in brain-injured patients

scientific article published on 28 June 2019

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

scientific article published on 18 May 2020

An in vitro model of mycobacterial granuloma to investigate the immune response in brain-injured patients

scientific article published in January 2013

An opioid-free anaesthetic using nerve blocks enhances rapid recovery after minor hand surgery in children

scientific article

Analysis of autofluorescence in polymorphonuclear neutrophils: a new tool for early infection diagnosis.

scientific article

Association between continuous hyperosmolar therapy and survival in patients with traumatic brain injury - a multicentre prospective cohort study and systematic review.

scientific article published on 28 December 2017

Author Correction: Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

scientific article published on 24 June 2020

Baclofen to prevent agitation in alcohol-addicted patients in the ICU: study protocol for a randomised controlled trial

scientific article published on 19 August 2016

Balanced versus chloride-rich solutions for fluid resuscitation in brain-injured patients: a randomised double-blind pilot study.

scientific article

CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.

scientific article

COBI (COntinuous hyperosmolar therapy for traumatic Brain-Injured patients) trial protocol: a multicentre randomised open-label trial with blinded adjudication of primary outcome

scientific article published on 24 September 2017

Continuous controlled-infusion of hypertonic saline solution in traumatic brain-injured patients: a 9-year retrospective study

scientific article published on 28 October 2011

Corticotherapy for traumatic brain-injured patients--the Corti-TC trial: study protocol for a randomized controlled trial

scientific article published on 14 October 2011

Cortisol total/CRP ratio for the prediction of hospital-acquired pneumonia and initiation of corticosteroid therapy in traumatic brain-injured patients

scientific article published on 05 December 2019

CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia

scientific article

Depletion of natural killer cells increases mice susceptibility in a Pseudomonas aeruginosa pneumonia model

scientific article

Dobutamine-induced high cardiac index did not prevent vasospasm in subarachnoid hemorrhage patients: a randomized controlled pilot study

scientific article published in October 2012

Effect of oropharyngeal povidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial.

scientific article published in January 2014

Effects of etomidate on complications related to intubation and on mortality in septic shock patients treated with hydrocortisone: a propensity score analysis

scientific article published on 21 November 2012

Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children.

scientific article

Effects of tight computerized glucose control on neurological outcome in severely brain injured patients: a multicenter sub-group analysis of the randomized-controlled open-label CGAO-REA study

scientific article

Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response

scientific article published on 30 August 2012

Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.

scientific article

Empiric antimicrobial therapy for ventilator-associated pneumonia after brain injury

scientific article

Escherichia coli-induced productions of pro-inflammatory cytokines are regulated by MAP kinases and G-protein but not by Akt: Relationship with phylogenetic groups and resistance patterns

scientific article published on 18 July 2011

Exoenzyme T Plays a Pivotal Role in the IFN-γ Production after Pseudomonas Challenge in IL-12 Primed Natural Killer Cells

scientific article published on 10 October 2017

Extubation Success Prediction in a Multicentric Cohort of Patients with Severe Brain Injury

scientific article published on 21 June 2017

High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.

scientific article published on 27 October 2014

High-flow Nasal Cannulae Versus Non-invasive Ventilation for Preoxygenation of Obese Patients: The PREOPTIPOP Randomized Trial ⬇️

scientific article published on 05 June 2019

Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial

scientific article published on 24 July 2014

Hydrocortisone prevents immunosuppression by interleukin-10+ natural killer cells after trauma-hemorrhage

scientific article published on December 2014

Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study

scientific article published on March 2011

Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa.

scientific article

Immune discrepancies during in vitro granuloma formation in response to Cutibacterium (formerly Propionibacterium) acnes infection.

scientific article

Impact of Low-Dose Hydrocortisone on the Incidence of Atrial Fibrillation in Patients With Septic Shock

scientific article published on 01 January 2017

Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2).

scientific article

Impaired blood dendritic cell numbers and functions after aneurysmal subarachnoid hemorrhage

scientific article

Implementation of French recommendations for the prevention and the treatment of hospital-acquired pneumonia: a cluster-randomized trial

scientific article published on 24 September 2020

Implementation of an evidence-based extubation readiness bundle in 499 brain-injured patients. a before-after evaluation of a quality improvement project

scientific article published in October 2013

Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study

scientific article published on 3 February 2011

Innate immune dysfunction in trauma patients: from pathophysiology to treatment

scientific article published on August 2012

Interaction of Cutibacterium ( formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development

scientific article

Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model.

scientific article published on 8 September 2017

Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in Intensive Care Unit: an observational study.

scientific article published on 12 February 2013

Linezolid dampens neutrophil-mediated inflammation in methicillin-resistant Staphylococcus aureus-induced pneumonia and protects the lung of associated damages

scientific article

Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals.

scientific article

Multicentre randomised controlled trial to investigate the usefulness of continuous pneumatic regulation of tracheal cuff pressure for reducing ventilator-associated pneumonia in mechanically ventilated severe trauma patients: the AGATE study protoc

scientific article

PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study

Pathogenic potential of Escherichia coli clinical strains from orthopedic implant infections towards human osteoblastic cells

scientific article published on September 2015

Patient factors and outcomes associated with the withdrawal or withholding of life-sustaining therapies in mechanically ventilated brain-injured patients: An observational multicentre study

scientific article published on 3 February 2018

Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

scientific article published on 06 August 2019

Pharmacodynamics of cisatracurium in the intensive care unit: an observational study

scientific article published on 11 February 2014

Phenotype and functions of B cells in patients with acute brain injuries.

scientific article published on 9 September 2015

Plasma PCSK9 is a late biomarker of severity in patients with severe trauma injury

scientific article published on 28 February 2013

Pneumonia prevention to decrease mortality in intensive care unit: a systematic review and meta-analysis

scientific article

Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment

scientific article published on 01 January 2019

Prediction Score for Postoperative Neurologic Complications after Brain Tumor Craniotomy: A Multicenter Observational Study

scientific article published on 01 December 2018

Preoperative moderate renal impairment is an independent risk factor of transfusion in elderly patients undergoing hip fracture surgery and receiving low-molecular-weight heparin for thromboprophylaxis

scientific article published on 22 May 2012

Preoxygenation in difficult airway management: high-flow oxygenation by nasal cannula versus face mask (the PREOPTIDAM study). Protocol for a single-centre randomised study

article by Mickael Vourc'h et al published 25 April 2019 in BMJ Open

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study.

scientific article published on 21 March 2014

Prevalence of iron deficiency on ICU discharge and its relation with fatigue: a multicenter prospective study.

scientific article

Prevention of early ventilation-acquired pneumonia (VAP) in comatose brain-injured patients by a single dose of ceftriaxone: PROPHY-VAP study protocol, a multicentre, randomised, double-blind, placebo-controlled trial

article published in 2018

Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

scientific article

Protease-activated receptor-1: key player in the sepsis coagulation-inflammation crosstalk

scientific article published on 26 February 2013

Pulse pressure variations to guide fluid therapy in donors: a multicentric echocardiographic observational study

scientific article

Pupillary reflex measurement predicts insufficient analgesia before endotracheal suctioning in critically ill patients

scientific article

Retrospective analysis of the risk factors and pathogens associated with early-onset ventilator-associated pneumonia in surgical-ICU head-trauma patients

scientific article published in January 2010

Risk factors and outcomes for airway failure versus non-airway failure in the intensive care unit: a multicenter observational study of 1514 extubation procedures

Risk factors and outcomes for prolonged versus brief fever: a prospective cohort study

scientific article

Risk factors for prolonged duration of mechanical ventilation in acute traumatic tetraplegic patients--a retrospective cohort study.

scientific article

Risk factors for ventilator-associated pneumonia due to Staphylococcus aureus in patients with severe brain injury: A multicentre retrospective cohort study

scientific article published on 26 November 2020

Role of IL-12 in overcoming the low responsiveness of NK cells to missing self after traumatic brain injury

scientific article published on 17 September 2015

Screening of patients with augmented renal clearance in ICU: taking into account the CKD-EPI equation, the age, and the cause of admission.

scientific article

Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial.

scientific article

Speckle tracking analysis allows sensitive detection of stress cardiomyopathy in severe aneurysmal subarachnoid hemorrhage patients

scientific article published on 26 October 2015

Speckle-Tracking analysis of left ventricular systolic function in the intensive care unit

scientific article published on 20 November 2015

The Effect of an Accelerated Renal Replacement Therapy Initiation Is Not Modified by Baseline Risk

scientific article published in 2022

The Microbiology of Community-acquired Peritonitis in Children.

scientific article published in February 2011

The Script Concordance Test in anesthesiology: Validation of a new tool for assessing clinical reasoning.

scientific article published on February 2015

The effects of spinal anesthesia on cerebral blood flow in the very elderly.

scientific article

Toll-like receptor-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells

scientific article

What's new in management of traumatic coagulopathy?

scientific article published on 08 July 2014

List of works by Karim Asehnoune

A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury

A multi-faceted strategy to reduce ventilation-associated mortality in brain-injured patients. The BI-VILI project: a nationwide quality improvement project.

A new way of thinking: hydrocortisone in traumatic brain-injured patients

A retrospective study about cerebral near-infrared spectroscopy monitoring during paediatric cardiac surgery and intra-operative patient blood management

Alterations of the iNKT cell compartment in brain-injured patients

Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

An in vitro model of mycobacterial granuloma to investigate the immune response in brain-injured patients

An opioid-free anaesthetic using nerve blocks enhances rapid recovery after minor hand surgery in children

Analysis of autofluorescence in polymorphonuclear neutrophils: a new tool for early infection diagnosis.

Association between continuous hyperosmolar therapy and survival in patients with traumatic brain injury - a multicentre prospective cohort study and systematic review.

Author Correction: Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis

Baclofen to prevent agitation in alcohol-addicted patients in the ICU: study protocol for a randomised controlled trial

Balanced versus chloride-rich solutions for fluid resuscitation in brain-injured patients: a randomised double-blind pilot study.

CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.

COBI (COntinuous hyperosmolar therapy for traumatic Brain-Injured patients) trial protocol: a multicentre randomised open-label trial with blinded adjudication of primary outcome

Continuous controlled-infusion of hypertonic saline solution in traumatic brain-injured patients: a 9-year retrospective study

Corticotherapy for traumatic brain-injured patients--the Corti-TC trial: study protocol for a randomized controlled trial

Cortisol total/CRP ratio for the prediction of hospital-acquired pneumonia and initiation of corticosteroid therapy in traumatic brain-injured patients

CpG-ODN and MPLA prevent mortality in a murine model of post-hemorrhage-Staphyloccocus aureus pneumonia

Depletion of natural killer cells increases mice susceptibility in a Pseudomonas aeruginosa pneumonia model

Dobutamine-induced high cardiac index did not prevent vasospasm in subarachnoid hemorrhage patients: a randomized controlled pilot study

Effect of oropharyngeal povidone-iodine preventive oral care on ventilator-associated pneumonia in severely brain-injured or cerebral hemorrhage patients: a multicenter, randomized controlled trial.

Effects of etomidate on complications related to intubation and on mortality in septic shock patients treated with hydrocortisone: a propensity score analysis

Effects of perioperative intravenous low dose of ketamine on postoperative analgesia in children.

Effects of tight computerized glucose control on neurological outcome in severely brain injured patients: a multicenter sub-group analysis of the randomized-controlled open-label CGAO-REA study

Efficacy of ceftolozane in a murine model of Pseudomonas aeruginosa acute pneumonia: in vivo antimicrobial activity and impact on host inflammatory response

Elevated Plasma Levels of sRAGE Are Associated With Nonfocal CT-Based Lung Imaging in Patients With ARDS: A Prospective Multicenter Study.

Empiric antimicrobial therapy for ventilator-associated pneumonia after brain injury

Escherichia coli-induced productions of pro-inflammatory cytokines are regulated by MAP kinases and G-protein but not by Akt: Relationship with phylogenetic groups and resistance patterns

Exoenzyme T Plays a Pivotal Role in the IFN-γ Production after Pseudomonas Challenge in IL-12 Primed Natural Killer Cells

Extubation Success Prediction in a Multicentric Cohort of Patients with Severe Brain Injury

High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis.

High-flow Nasal Cannulae Versus Non-invasive Ventilation for Preoxygenation of Obese Patients: The PREOPTIPOP Randomized Trial ⬇️

Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial

Hydrocortisone prevents immunosuppression by interleukin-10+ natural killer cells after trauma-hemorrhage

Hydrocortisone therapy for patients with multiple trauma: the randomized controlled HYPOLYTE study

Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa.

Immune discrepancies during in vitro granuloma formation in response to Cutibacterium (formerly Propionibacterium) acnes infection.

Impact of Low-Dose Hydrocortisone on the Incidence of Atrial Fibrillation in Patients With Septic Shock

Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2).

Impaired blood dendritic cell numbers and functions after aneurysmal subarachnoid hemorrhage

Implementation of French recommendations for the prevention and the treatment of hospital-acquired pneumonia: a cluster-randomized trial

Implementation of an evidence-based extubation readiness bundle in 499 brain-injured patients. a before-after evaluation of a quality improvement project

Increased creatinine clearance in polytrauma patients with normal serum creatinine: a retrospective observational study

Innate immune dysfunction in trauma patients: from pathophysiology to treatment

Interaction of Cutibacterium ( formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development

Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model.

Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in Intensive Care Unit: an observational study.

Linezolid dampens neutrophil-mediated inflammation in methicillin-resistant Staphylococcus aureus-induced pneumonia and protects the lung of associated damages

Modulation of dendritic cell antigen presentation by pathogens, tissue damage and secondary inflammatory signals.

Multicentre randomised controlled trial to investigate the usefulness of continuous pneumatic regulation of tracheal cuff pressure for reducing ventilator-associated pneumonia in mechanically ventilated severe trauma patients: the AGATE study protoc

PACMAN trial protocol, Perioperative Administration of Corticotherapy on Morbidity and mortality After Non-cardiac major surgery: a randomised, multicentre, double-blind, superiority study

Pathogenic potential of Escherichia coli clinical strains from orthopedic implant infections towards human osteoblastic cells

Patient factors and outcomes associated with the withdrawal or withholding of life-sustaining therapies in mechanically ventilated brain-injured patients: An observational multicentre study

Personalised mechanical ventilation tailored to lung morphology versus low positive end-expiratory pressure for patients with acute respiratory distress syndrome in France (the LIVE study): a multicentre, single-blind, randomised controlled trial

Pharmacodynamics of cisatracurium in the intensive care unit: an observational study

Phenotype and functions of B cells in patients with acute brain injuries.

Plasma PCSK9 is a late biomarker of severity in patients with severe trauma injury

Pneumonia prevention to decrease mortality in intensive care unit: a systematic review and meta-analysis

Population pharmacokinetics of daptomycin in critically ill patients with various degrees of renal impairment

Prediction Score for Postoperative Neurologic Complications after Brain Tumor Craniotomy: A Multicenter Observational Study

Preoperative moderate renal impairment is an independent risk factor of transfusion in elderly patients undergoing hip fracture surgery and receiving low-molecular-weight heparin for thromboprophylaxis

Preoxygenation in difficult airway management: high-flow oxygenation by nasal cannula versus face mask (the PREOPTIDAM study). Protocol for a single-centre randomised study

Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study.

Prevalence of iron deficiency on ICU discharge and its relation with fatigue: a multicenter prospective study.

Prevention of early ventilation-acquired pneumonia (VAP) in comatose brain-injured patients by a single dose of ceftriaxone: PROPHY-VAP study protocol, a multicentre, randomised, double-blind, placebo-controlled trial

Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Protease-activated receptor-1: key player in the sepsis coagulation-inflammation crosstalk

Pulse pressure variations to guide fluid therapy in donors: a multicentric echocardiographic observational study

Pupillary reflex measurement predicts insufficient analgesia before endotracheal suctioning in critically ill patients

Retrospective analysis of the risk factors and pathogens associated with early-onset ventilator-associated pneumonia in surgical-ICU head-trauma patients

Risk factors and outcomes for airway failure versus non-airway failure in the intensive care unit: a multicenter observational study of 1514 extubation procedures

Risk factors and outcomes for prolonged versus brief fever: a prospective cohort study

Risk factors for prolonged duration of mechanical ventilation in acute traumatic tetraplegic patients--a retrospective cohort study.

Risk factors for ventilator-associated pneumonia due to Staphylococcus aureus in patients with severe brain injury: A multicentre retrospective cohort study

Role of IL-12 in overcoming the low responsiveness of NK cells to missing self after traumatic brain injury

Screening of patients with augmented renal clearance in ICU: taking into account the CKD-EPI equation, the age, and the cause of admission.

Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial.

Speckle tracking analysis allows sensitive detection of stress cardiomyopathy in severe aneurysmal subarachnoid hemorrhage patients