List of works - Thorsten Schinke

Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice

scientific article

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus

scientific article published on 25 April 2016

BMP-7-induced ectopic bone formation and fracture healing is impaired by systemic NSAID application in C57BL/6-mice

scientific article published in June 2010

CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals

scientific article published in April 2014

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

scientific article

Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice

scientific article published on 03 August 2017

Can we induce osteoporosis in animals comparable to the human situation?

scientific article

Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts

scientific article

Control of bone formation by the serpentine receptor Frizzled-9 ⬇️

scientific journal article

Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.

scientific article published on 15 October 2013

Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide

scientific journal article

Deficiency of Thrombospondin-4 in Mice Does Not Affect Skeletal Growth or Bone Mass Acquisition, but Causes a Transient Reduction of Articular Cartilage Thickness

scientific article published on 2 December 2015

Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase

scientific article published on 17 July 2019

Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL.

scientific article

Differential effects of Calca-derived peptides in male mice with diet-induced obesity

scientific article

Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay

scientific article

Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone ⬇️

scientific article published on February 27, 2012

Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins

scientific article

Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts

scientific article

Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production ⬇️

scientific article

Gene disruption of Spred-2 causes dwarfism

scientific article

Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency

scientific article published on 05 December 2019

Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton.

scientific article published on 04 March 2016

Impaired gastric acidification negatively affects calcium homeostasis and bone mass.

scientific article published in June 2009

Increased bone formation in mice lacking apolipoprotein E.

scientific article published in November 2004

Increased osteoclastogenesis in mice lacking the carcinoembryonic antigen-related cell adhesion molecule 1

scientific journal article

Inhibition of Midkine Augments Osteoporotic Fracture Healing.

scientific article

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells ⬇️

scientific article published on April 1, 2011

Mannose 6-phosphate-dependent targeting of lysosomal enzymes is required for normal craniofacial and dental development

scientific article published on 27 May 2016

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

scientific article published on 01 June 2022

Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone-specific phenotype

scientific article published on 05 May 2020

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice

scientific article

Mouse models in skeletal physiology and osteoporosis: experiences and data on 14,839 cases from the Hamburg Mouse Archives

scientific article

Mutations in WNT1 cause different forms of bone fragility

scientific article

Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.

scientific article

Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice

scientific article

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing

scientific article

Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism

scientific article published on 29 September 2009

Pharmacological Estrogen Administration Causes a FSH-Independent Osteo-Anabolic Effect Requiring ER Alpha in Osteoblasts ⬇️

scientific article published on November 27, 2012

Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation

scientific article published on 12 November 2020

Relevance of Wnt signaling for osteoanabolic therapy

scientific article published on 14 July 2014

Resorbability of bone substitute biomaterials by human osteoclasts

scientific article published on August 2004

Severe bone loss and multiple fractures in SCN8A-related epileptic encephalopathy

scientific article

Short-Term Application of Dexamethasone Enhances Bone Morphogenetic Protein-7-Induced Ectopic Bone Formation In Vivo ⬇️

scientific article published on December 1, 2010

The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans

scientific article published on 06 May 2017

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice

scientific article published on 11 September 2015

The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing

scientific journal article

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta

scientific article published on 5 May 2017

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

scientific article

The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation

scientific journal article

The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice

scientific article

The role of Apolipoprotein E in bone metabolism ⬇️

scientific article published on July 23, 2011

The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation

scientific article published on 16 February 2008

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification

scientific article

The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors

scientific article

p65-Dependent production of interleukin-1β by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts

scientific article

List of works by Thorsten Schinke

Accelerated growth plate mineralization and foreshortened proximal limb bones in fetuin-A knockout mice

Antagonizing midkine accelerates fracture healing in mice by enhanced bone formation in the fracture callus

BMP-7-induced ectopic bone formation and fracture healing is impaired by systemic NSAID application in C57BL/6-mice

CLCN7 and TCIRG1 mutations differentially affect bone matrix mineralization in osteopetrotic individuals

Calcitonin controls bone formation by inhibiting the release of sphingosine 1-phosphate from osteoclasts

Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice

Can we induce osteoporosis in animals comparable to the human situation?

Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts

Control of bone formation by the serpentine receptor Frizzled-9 ⬇️

Decreased bone formation and increased osteoclastogenesis cause bone loss in mucolipidosis II.

Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide

Deficiency of Thrombospondin-4 in Mice Does Not Affect Skeletal Growth or Bone Mass Acquisition, but Causes a Transient Reduction of Articular Cartilage Thickness

Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase

Denosumab mimics the natural decoy receptor osteoprotegerin by interacting with its major binding site on RANKL.

Differential effects of Calca-derived peptides in male mice with diet-induced obesity

Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay

Estradiol increases hematopoietic stem and progenitor cells independent of its actions on bone ⬇️

Extracellular matrix mineralization is regulated locally; different roles of two gla-containing proteins

Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts

Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production ⬇️

Gene disruption of Spred-2 causes dwarfism

Human Heterozygous ENPP1 Deficiency Is Associated With Early Onset Osteoporosis, a Phenotype Recapitulated in a Mouse Model of Enpp1 Deficiency

Hypochlorhydria-induced calcium malabsorption does not affect fracture healing but increases post-traumatic bone loss in the intact skeleton.

Impaired gastric acidification negatively affects calcium homeostasis and bone mass.

Increased bone formation in mice lacking apolipoprotein E.

Increased osteoclastogenesis in mice lacking the carcinoembryonic antigen-related cell adhesion molecule 1

Inhibition of Midkine Augments Osteoporotic Fracture Healing.

Interleukin-33 is expressed in differentiated osteoblasts and blocks osteoclast formation from bone marrow precursor cells ⬇️

Mannose 6-phosphate-dependent targeting of lysosomal enzymes is required for normal craniofacial and dental development

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

Mice carrying a ubiquitous R235W mutation of Wnt1 display a bone-specific phenotype

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice

Mouse models in skeletal physiology and osteoporosis: experiences and data on 14,839 cases from the Hamburg Mouse Archives

Mutations in WNT1 cause different forms of bone fragility

Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.

Osteoblast-specific Krm2 overexpression and Lrp5 deficiency have different effects on fracture healing in mice

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing

Osteolytic prostate cancer cells induce the expression of specific cytokines in bone-forming osteoblasts through a Stat3/5-dependent mechanism

Pharmacological Estrogen Administration Causes a FSH-Independent Osteo-Anabolic Effect Requiring ER Alpha in Osteoblasts ⬇️

Piezo1 Inactivation in Chondrocytes Impairs Trabecular Bone Formation

Relevance of Wnt signaling for osteoanabolic therapy

Resorbability of bone substitute biomaterials by human osteoclasts

Severe bone loss and multiple fractures in SCN8A-related epileptic encephalopathy

Short-Term Application of Dexamethasone Enhances Bone Morphogenetic Protein-7-Induced Ectopic Bone Formation In Vivo ⬇️

The Lrp4R1170Q Homozygous Knock-In Mouse Recapitulates the Bone Phenotype of Sclerosteosis in Humans

The Protein Tyrosine Phosphatase Rptpζ Suppresses Osteosarcoma Development in Trp53-Heterozygous Mice

The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation

The impact of low-magnitude high-frequency vibration on fracture healing is profoundly influenced by the oestrogen status in mice

The role of Apolipoprotein E in bone metabolism ⬇️

The role of calcitonin and alpha-calcitonin gene-related peptide in bone formation

The serum protein alpha 2-Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification

The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors

p65-Dependent production of interleukin-1β by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts