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List of works by Takashi Kojima

A Novel Drug Delivery System for the Human Nasal Epithelium

scientific article published on 26 April 2016

A novel monoclonal antibody against the second extracellular loop of occludin disrupts epithelial cell polarity

scientific article published on 19 March 2007

A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells ⬇️

scientific article published on May 11, 2011

ASPP2 suppression promotes malignancy via LSR and YAP in human endometrial cancer

scientific article published on 07 April 2020

Aberrant expression of claudin-4 and -7 in hepatocytes in the cirrhotic human liver

scientific article published on 16 April 2014

Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4alpha

scientific journal article

Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma

scientific article published on 11 April 2011

Behavior of Primary Cilia and Tricellular Tight Junction Proteins during Differentiation in Temperature-Sensitive Mouse Cochlear Precursor Hair Cells

scientific article published on 26 April 2016

Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4alpha-induced epithelial polarization

scientific article published on October 2005

Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions ⬇️

scientific article published on October 17, 2012

Cellular networks of human thymic medullary stromas coordinated by p53-related transcription factors

scientific article published on 21 August 2006

Cellular retinoic acid bioavailability determines epithelial integrity: Role of retinoic acid receptor alpha agonists in colitis

scientific article published on 11 October 2006

Changes of Tight Junction Protein Claudins in Small Intestine and Kidney Tissues of Mice Fed a DDC Diet

scientific article published on 26 December 2013

Changes of gap and tight junctions during differentiation of human nasal epithelial cells using primary human nasal epithelial cells and primary human nasal fibroblast cells in a noncontact coculture system

scientific article published on 11 July 2007

Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung

scientific article published on 27 September 2018

Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3.

scientific article published on 25 July 2016

Claudin-4 binder C-CPE 194 enhances effects of anticancer agents on pancreatic cancer cell lines via a MAPK pathway

scientific article published on 20 December 2015

Claudin-binder C-CPE mutants enhance permeability of insulin across human nasal epithelial cells

scientific article published on 2 June 2015

Claudin‐4‐targeted therapy using Clostridium perfringens enterotoxin for prostate cancer ⬇️

scientific article published on June 8, 2011

Cobalt inhibits motility of axonal mitochondria and induces axonal degeneration in cultured dorsal root ganglion cells of rat.

scientific article published on 27 June 2017

Connexin 26 expression prevents down-regulation of barrier and fence functions of tight junctions by Na+/K+-ATPase inhibitor ouabain in human airway epithelial cell line Calu-3.

scientific article published on 23 August 2006

Connexins induce and maintain tight junctions in epithelial cells

scientific article published on 14 June 2007

Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells

scientific article

Cx32 formation and/or Cx32-mediated intercellular communication induces expression and function of tight junctions in hepatocytic cell line

scientific article

Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood-brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways

scientific article

Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine

scientific journal article

Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro

scientific article published on October 2005

Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer

scientific article published on 22 September 2017

Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial–mesenchymal transition in human pancreatic cancer cells ⬇️

scientific article published on July 8, 2011

Dysregulation of junctional adhesion molecule-A via p63/GATA-3 in head and neck squamous cell carcinoma

scientific article published on 28 March 2016

Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells ⬇️

scientific article published on May 13, 2011

Effects of atelocollagen formulation containing oligonucleotide on endothelial permeability

scientific article published on 8 March 2012

Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines ⬇️

scientific article published on April 29, 2012

Epigenetic inactivation of CHFR and sensitivity to microtubule inhibitors in gastric cancer

scientific article (publication date: 15 December 2003)

Epigenetic silencing of claudin-6 promotes anchorage-independent growth of breast carcinoma cells

scientific article published on 23 July 2007

Epigenetic silencing of occludin promotes tumorigenic and metastatic properties of cancer cells via modulations of unique sets of apoptosis-associated genes

scientific article published on September 2006

Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids ⬇️

scientific article published on November 9, 2010

Epithelial barrier dysfunction and cell migration induction via JNK/cofilin/actin by angubindin-1

scientific article published on 29 November 2019

Experimental effect of retinoic acids on apoptosis during the development of diabetic retinopathy

scientific article

Expression and Function of Claudins in Hepatocytes ⬇️

scientific article published on January 1, 2011

Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.

scientific article published in December 2004

Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.

scientific article published on 24 December 2009

Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro

scientific article

Expression of tricellulin in epithelial cells and non-epithelial cells

scientific article published on 13 June 2013

Expression patterns of claudin family of tight-junction proteins in the mouse prostate

scientific article published on 27 January 2007

Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes

scientific article published on 4 May 2004

FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells

scientific article published in 2022

Fibroblastic foci, covered with alveolar epithelia exhibiting epithelial-mesenchymal transition, destroy alveolar septa by disrupting blood flow in idiopathic pulmonary fibrosis

scientific article published on 12 December 2016

Fluid shear stress remodels expression and function of junctional proteins in cultured bone cells

Glial cell-derived cytokines attenuate the breakdown of vascular integrity in diabetic retinopathy

scientific article published on May 2007

Glucose-Dependent FOXM1 Promotes Epithelial-to-Mesenchymal Transition Via Cellular Metabolism and Targeting Snail in Human Pancreatic Cancer

scientific article published on 01 February 2020

Glyceraldehyde-derived advanced glycation end-products preferentially induce VEGF expression and reduce GDNF expression in human astrocytes

scientific article

Guanylate binding protein-1-mediated epithelial barrier in human salivary gland duct epithelium

scientific article published on 22 July 2018

HLA-DR- and CD11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis

scientific article

HMGB1 enhances epithelial permeability via p63/TGF-β signaling in lung and terminal bronchial epithelial cells

scientific article published on 28 August 2020

HMGB1-downregulated angulin-1/LSR induces epithelial barrier disruption via claudin-2 and cellular metabolism via AMPK in airway epithelial Calu-3 cells

scientific article published on 15 May 2020

Hepatocyte nuclear factor (HNF)-4alpha induces expression of endothelial Fas ligand (FasL) to prevent cancer cell transmigration: a novel defense mechanism of endothelium against cancer metastasis

scientific article

Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells ⬇️

scientific article published on June 10, 2003

Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells

scientific article

Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells.

scientific article

Humulone suppresses replication of respiratory syncytial virus and release of IL-8 and RANTES in normal human nasal epithelial cells

scientific article published on 5 February 2013

IGF-I regulates tight-junction protein claudin-1 during differentiation of osteoblast-like MC3T3-E1 cells via a MAP-kinase pathway

scientific article published on 15 October 2008

IL-1beta regulates expression of Cx32, occludin, and claudin-2 of rat hepatocytes via distinct signal transduction pathways

scientific article published in October 2004

Impaired cutaneous wound healing in mice lacking tetranectin

scientific article published in January 2009

Increase in Epithelial Permeability and Cell Metabolism by High Mobility Group Box 1, Inflammatory Cytokines and TPEN in Caco-2 Cells as a Novel Model of Inflammatory Bowel Disease

scientific article published on 10 November 2020

Induction of JAM-A during differentiation of human THP-1 dendritic cells

scientific article

Induction of airway progenitor cells via p63 and KLF11 by Rho-kinase inhibitor Y27632 in hTERT-human nasal epithelial cells

Induction of claudins in passaged hTERT-transfected human nasal epithelial cells with an extended life span

scientific article published on 14 August 2007

Inhibition of MAP kinase activity moderates changes in expression and function of Cx32 but not claudin-1 during DNA synthesis in primary cultures of rat hepatocytes

scientific article

Inhibitory effects of retinoic acid receptor alpha stimulants on murine cataractogenesis through suppression of deregulated calpains

scientific article published on 01 May 2007

Interferon-gamma increased epithelial barrier function via upregulating claudin-7 expression in human submandibular gland duct epithelium.

scientific article published on 8 March 2016

Irsogladine maleate regulates gap junctional intercellular communication-dependent epithelial barrier in human nasal epithelial cells

scientific article published on 5 February 2015

Junctional Adhesion Molecule-A in Head and Neck Squamous Cell Carcinoma.

scientific article

Knockdown of tight junction protein claudin-2 prevents bile canalicular formation in WIF-B9 cells

scientific article

Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells

scientific article published on 29 October 2019

Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer

scientific article published on 10 January 2017

Marked induction of matrix metalloproteinase-10 by respiratory syncytial virus infection in human nasal epithelial cells

scientific article published on 5 September 2013

Mechanism of fibrogenesis in submandibular glands in patients with IgG4-RD

scientific article published on 24 September 2018

Mucosal immune barrier and antigen-presenting system in human nasal epithelial cells

scientific article published on August 18, 2011

Mumps Virus Induces Protein-Kinase-R-Dependent Stress Granules, Partly Suppressing Type III Interferon Production

scientific article published on 25 August 2016

Nuclear localization of tricellulin promotes the oncogenic property of pancreatic cancer

scientific article published on 19 September 2016

Occludin induces microvillus formation via phosphorylation of ezrin in a mouse hepatic cell line

scientific article published on 16 March 2018

Occludin-mediated premature senescence is a fail-safe mechanism against tumorigenesis in breast carcinoma cells

scientific article published on 24 April 2007

Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line

scientific article published on 12 August 2004

Oncostatin M induces upregulation of claudin-2 in rodent hepatocytes coinciding with changes in morphology and function of tight junctions

scientific article published on 20 March 2007

PPARgamma agonists upregulate the barrier function of tight junctions via a PKC pathway in human nasal epithelial cells

scientific article published on 19 March 2010

Pancreatic regeneration: basic research and gene regulation

scientific article published on 07 July 2015

Phosphorylation of ezrin enhances microvillus length via a p38 MAP-kinase pathway in an immortalized mouse hepatic cell line

scientific article published on 4 November 2005

Poly(I:C) induced microRNA-146a regulates epithelial barrier and secretion of proinflammatory cytokines in human nasal epithelial cells.

scientific article

Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells ⬇️

scientific article published on October 7, 2010

Possibility of Targeting Claudin-2 in Therapy for Human Endometrioid Endometrial Carcinoma

scientific article published on 16 June 2020

Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

scientific article published on July 2006

Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype

scientific article published on 11 January 2016

Protein kinase C enhances tight junction barrier function of human nasal epithelial cells in primary culture by transcriptional regulation

scientific article published on 13 May 2008

Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.

scientific article

Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer.

scientific article published on 6 February 2013

Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells

scientific article published on 18 February 2014

Pulmonary Collectins Play Distinct Roles in Host Defense against Mycobacterium avium ⬇️

scientific article published on August 5, 2011

Pulmonary collectins protect macrophages against pore-forming activity of Legionella pneumophila and suppress its intracellular growth

scientific article

Regulation of claudin-4 via p63 in human epithelial cells

scientific article published on 30 August 2017

Regulation of interleukin‐33 and thymic stromal lymphopoietin in human nasal fibroblasts by proinflammatory cytokines ⬇️

scientific article published on March 27, 2012

Regulation of the blood?biliary barrier: interaction between gap and tight junctions in hepatocytes ⬇️

scientific article published on September 1, 2003

Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano

scientific article published on 3 July 2013

Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells ⬇️

scientific article published on June 1, 2012

Regulation of tight junctions in upper airway epithelium

scientific article published on 29 December 2012

Respiratory syncytial virus infection and the tight junctions of nasal epithelial cells

scientific article published on 18 August 2011

Rho-kinase and PKCα Inhibition Induces Primary Cilia Elongation and Alters the Behavior of Undifferentiated and Differentiated Temperature-sensitive Mouse Cochlear Cells

scientific article published on 27 March 2019

Role of Tricellular Tight Junction Protein Lipolysis-Stimulated Lipoprotein Receptor (LSR) in Cancer Cells

scientific article published on 20 July 2019

Role of the p38 MAP-kinase signaling pathway for Cx32 and claudin-1 in the rat liver

scientific article published in July 2003

Role of tight junctions in signal transduction: an update.

scientific article published on 13 October 2014

Role of tight junctions in the epithelial-to-mesenchymal transition of cancer cells

scientific article published on 12 November 2020

Sorting nexin 5 of a new diagnostic marker of papillary thyroid carcinoma regulates Caspase‐2 ⬇️

scientific article published on 04 June 2012

Staurosporine induces formation of two types of extra-long cell protrusions: actin-based filaments and microtubule-based shafts

scientific article

Targeting claudin-4 in human pancreatic cancer ⬇️

scientific article published on July 16, 2012

Targeting tight junctions during epithelial to mesenchymal transition in human pancreatic cancer.

scientific article

The Behavior and Role of Lipolysis-stimulated Lipoprotein Receptor, a Component of Tricellular Tight Junctions, in Head and Neck Squamous Cell Carcinomas

scientific article published on November 2016

The acid-sensing ion channel 2 (ASIC2) of ciliated cells in the developing rat nasal septum ⬇️

scientific article published on January 1, 2010

The bicellular tensile force sorts the localization of LSRs in bicellular and tricellular junctions

scientific article

The nuclear receptor hepatocyte nuclear factor 4alpha acts as a morphogen to induce the formation of microvilli

scientific journal article

The p53 family member genes are involved in the Notch signal pathway

scientific article

The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells

scientific article published on 7 September 2017

The roles of tricellular tight junction protein lipolysis-stimulated lipoprotein receptor in malignancy of human endometrial cancer cells

scientific article published on 28 March 2016

The significance of interferon-gamma-triggered internalization of tight-junction proteins in inflammatory bowel disease

scientific article

Thr(207) of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP.

scientific article published on October 2004

Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions

scientific article

Thymic stromal lymphopoietin enhances tight-junction barrier function of human nasal epithelial cells

scientific article published on 09 September 2009

Thymic stromal lymphopoietin induces tight junction protein claudin-7 via NF-kappaB in dendritic cells.

scientific article published in March 2010

Tight junction protein MAGI-1 is up-regulated by transfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis

scientific article

Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.

scientific article published on 4 November 2014

Tight junction proteins and signal transduction pathways in hepatocytes

scientific article

Tight junction proteins claudin-2 and -12 are critical for vitamin D-dependent Ca2+ absorption between enterocytes.

scientific article published on 20 February 2008

Tight junctions and human diseases ⬇️

scientific article published on September 1, 2003

Tight junctions in human pancreatic duct epithelial cells

scientific article

Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells

scientific article

Transcriptional regulation of claudin‐18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancer cells ⬇️

scientific article published on July 1, 2011

Transforming growth factor-beta induces epithelial to mesenchymal transition by down-regulation of claudin-1 expression and the fence function in adult rat hepatocytes

scientific journal article

Transmembrane proteins of tight junctions

scientific article published on 04 September 2007

Tricellular tight junction protein LSR/angulin-1 contributes to the epithelial barrier and malignancy in human pancreatic cancer cell line

scientific article published on 24 October 2019

Tricellulin is expressed in autotypic tight junctions of peripheral myelinating Schwann cells ⬇️

scientific article published on December 1, 2010

Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells ⬇️

scientific article published on July 26, 2011

c-Jun N-terminal kinase inhibitor SP600125 enhances barrier function and elongation of human pancreatic cancer cell line HPAC in a Ca-switch model

scientific article published on 16 December 2014

c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells

scientific article

p38 MAP-kinase regulates function of gap and tight junctions during regeneration of rat hepatocytes

scientific journal article

p73 is expressed in human thymic epithelial cells

scientific article published on April 2002

ΔNp63 controls a TLR3-mediated mechanism that abundantly provides thymic stromal lymphopoietin in atopic dermatitis

scientific article

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