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List of works by Young-Joon Surh

(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells

scientific article

15-Deoxy-Delta(12,14)-prostaglandin J(2) rescues PC12 cells from H2O2-induced apoptosis through Nrf2-mediated upregulation of heme oxygenase-1: potential roles of Akt and ERK1/2.

scientific article

15-Deoxy-Delta12,14-prostaglandin J(2) protects against nitrosative PC12 cell death through up-regulation of intracellular glutathione synthesis

scientific article

15-Deoxy-Delta12,14-prostaglandin J2 induces COX-2 expression through Akt-driven AP-1 activation in human breast cancer cells: a potential role of ROS.

scientific article published on 12 January 2008

15-Deoxy-Delta12,14-prostaglandin J2 upregulates the expression of heme oxygenase-1 and subsequently matrix metalloproteinase-1 in human breast cancer cells: possible roles of iron and ROS.

scientific article published on 9 January 2009

15-Deoxy-delta 12, 14-prostaglandin J2 induces upregulation of multidrug resistance-associated protein 1 via Nrf2 activation in human breast cancer cells

scientific article

15-Deoxy-Δ12,14-Prostaglandin J2 Exerts Proresolving Effects Through Nuclear Factor E2-Related Factor 2-Induced Expression of CD36 and Heme Oxygenase-1.

scientific article published in March 2017

15-Deoxy-Δ12,14-prostaglandin J2 Induces Apoptosis in Ha-ras-transformed Human Breast Epithelial Cells by Targeting IκB kinase-NF-κB Signaling

scientific article published on 01 June 2020

15-Deoxy-Δ12,14-prostaglandin J2 Induces Epithelial-to-mesenchymal Transition in Human Breast Cancer Cells and Promotes Fibroblast Activation

scientific article published on 01 September 2020

15-Deoxy-Δ12,14-prostaglandin J2 activates PI3K-Akt signaling in human breast cancer cells through covalent modification of the tumor suppressor PTEN at cysteine 136.

scientific article published on 14 March 2018

15-Deoxy-Δ12,14-prostaglandin J2 induces expression of 15-hydroxyprostaglandin dehydrogenase through Elk-1 activation in human breast cancer MDA-MB-231 cells

scientific article

15-Deoxy-Δ12,14-prostaglandin J2 stabilizes hypoxia inducible factor-1α through induction of heme oxygenase-1 and direct modification ofprolyl-4-hydroxylase 2.

scientific article published on 6 September 2016

15-Deoxy-Δ12,14-prostaglandin J2 up-regulates the expression of 15-hydroxyprostaglandin dehydrogenase through DNA methyltransferase 1 inactivation

scientific article published on 01 March 2019

15-Deoxy-Δ12,14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling ⬇️

scientific article published on August 6, 2011

15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy ⬇️

scientific article published on August 11, 2011

15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells

scientific article published on 24 December 2019

15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression

scientific article published on 28 March 2019

15-deoxy-Delta12,14-prostaglandin J2 as a potential endogenous regulator of redox-sensitive transcription factors

scientific article published on 20 September 2006

17-Oxo-docosahexaenoic acid induces Nrf2-mediated expression of heme oxygenase-1 in mouse skin in vivo and in cultured murine epidermal cells

scientific article published on 17 October 2019

17-β estradiol exerts anti-inflammatory effects through activation of Nrf2 in mouse embryonic fibroblasts

scientific article published on 23 August 2019

17β-Estradiol Strongly Inhibits Azoxymethane/Dextran Sulfate Sodium-induced Colorectal Cancer Development in Nrf2 Knockout Male Mice

scientific article published on 14 October 2020

17β-Estradiol reduces inflammation and modulates antioxidant enzymes in colonic epithelial cells

scientific article published on 22 October 2018

17β-Estradiol supplementation changes gut microbiota diversity in intact and colorectal cancer-induced ICR male mice

scientific article published on 23 July 2020

2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells

scientific article published in December 2004

4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression

scientific article published on 09 July 2016

4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK.

scientific article

4-hydroxyestradiol induces anchorage-independent growth of human mammary epithelial cells via activation of IkappaB kinase: potential role of reactive oxygen species

scientific article published on 10 March 2009

A formulated red ginseng extract rescues PC12 cells from PCB-induced oxidative cell death through Nrf2-mediated upregulation of heme oxygenase-1 and glutamate cysteine ligase

scientific article published on 22 April 2010

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

scientific article published on 30 September 2009

A special issue of SFRR Asia: cross talk between free radicals and mitochondria in health and disease

scientific article published on 01 December 2018

AP-1 mediates beta-amyloid-induced iNOS expression in PC12 cells via the ERK2 and p38 MAPK signaling pathways

scientific article

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

scientific journal article

Activation of caspase-8 contributes to 3,3'-Diindolylmethane-induced apoptosis in colon cancer cells

scientific article published on January 2007

Ajoene, a Major Organosulfide Found in Crushed Garlic, Induces NAD(P)H:quinone Oxidoreductase Expression Through Nuclear Factor E2-related Factor-2 Activation in Human Breast Epithelial Cells

scientific article published on 30 June 2019

Amelioration of UVB-induced oxidative stress and inflammation in fat-1 transgenic mouse skin

scientific article published on 25 May 2018

An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H-Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target

scientific article published on 12 October 2020

Anti-inflammatory effects of docosahexaenoic acid: Implications for its cancer chemopreventive potential

scientific article

Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review

scientific article

Anticancer activity of a novel small molecule tubulin inhibitor STK899704

scientific article

Antitumor promotional effects of a novel intestinal bacterial metabolite (IH-901) derived from the protopanaxadiol-type ginsenosides in mouse skin.

scientific article published on 21 October 2004

Aschantin targeting on the kinase domain of mammalian target of rapamycin suppresses epidermal growth factor-induced neoplastic cell transformation

scientific article published on 4 August 2015

Asymmetric Total Synthesis of (+)-(3E)-Pinnatifidenyne via Abnormally Regioselective Pd(0)-Catalyzed Endocyclization.

scientific article published on 12 January 2018

Attenuation of Abeta-induced apoptosis of plant extract (Saengshik) mediated by the inhibition of mitochondrial dysfunction and antioxidative effect

scientific article published in January 2007

Axin inhibits extracellular signal-regulated kinase pathway by Ras degradation via beta-catenin.

scientific article published on 20 March 2007

Açaí Berries Inhibit Colon Tumorigenesis in Azoxymethane/Dextran Sulfate Sodium-Treated Mice

scientific article published on 16 December 2016

Baicalein Inhibits Dextran Sulfate Sodium-induced Mouse Colitis

scientific article published on 30 June 2019

Bcl-2 attenuation of oxidative cell death is associated with up-regulation of gamma-glutamylcysteine ligase via constitutive NF-kappaB activation

scientific article published on 18 June 2004

Bcl-2 overexpression prevents daunorubicin-induced apoptosis through inhibition of XIAP and Akt degradation ⬇️

scientific article published on November 1, 2003

Bcl-2 protects against Abeta(25-35)-induced oxidative PC12 cell death by potentiation of antioxidant capacity

scientific article published in July 2004

Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway

scientific article published on 24 March 2005

Breaking the NF-κB and STAT3 Alliance Inhibits Inflammation and Pancreatic Tumorigenesis ⬇️

scientific article published on October 26, 2010

Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals

scientific article

Breast Cancer Cell-Derived Soluble CD44 Promotes Tumor Progression by Triggering Macrophage IL1β Production

scientific article published on 22 January 2020

Breast cancer cell debris diminishes therapeutic efficacy through heme oxygenase-1-mediated inactivation of M1-like tumor-associated macrophages

scientific article published on 07 October 2020

CO ameliorates cellular senescence and aging by modulating the miR-34a/Sirt1 pathway

scientific article published on 31 March 2020

Cancer Chemopreventive and Therapeutic Potential of Guggulsterone ⬇️

scientific article published on January 1, 2013

Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives

scientific article published on 11 June 2008

Cancer chemopreventive effects of curcumin

scientific article published on January 2007

Cancer prevention with natural compounds

scientific article

Cancer preventive phytochemicals as speed breakers in inflammatory signaling involved in aberrant COX-2 expression

scientific article published on August 2007

Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2.

scientific article published on 27 October 2006

Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target

scientific article published on December 2007

Carbon monoxide ameliorates acetaminophen-induced liver injury by increasing hepatic HO-1 and Parkin expression

scientific article published on 23 October 2019

Carbon monoxide produced by heme oxygenase-1 in response to nitrosative stress induces expression of glutamate-cysteine ligase in PC12 cells via activation of phosphatidylinositol 3-kinase and Nrf2 signaling

scientific article

Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential.

scientific article

Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway

scientific article published on 31 May 2017

Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury

scientific article published on 17 October 2018

Celecoxib induces apoptosis in cervical cancer cells independent of cyclooxygenase using NF-kappaB as a possible target

scientific article published on 10 June 2004

Celecoxib inhibits phorbol ester-induced expression of COX-2 and activation of AP-1 and p38 MAP kinase in mouse skin

scientific article

Cellular adaptation mediated through Nrf2-induced glutamate cysteine ligase up-regulation against oxidative stress caused by iron overload in β-thalassemia/HbE patients

scientific article published on 04 July 2019

Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?

scientific article

Chemopreventive effects of the standardized extract (DA-9601) of Artemisia asiatica on azoxymethane-initiated and dextran sulfate sodium-promoted mouse colon carcinogenesis

scientific article published in January 2008

Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies

scientific article published on April 2004

Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo

scientific article

Comparative Effects of Curcumin and Tetrahydrocurcumin on Dextran Sulfate Sodium-induced Colitis and Inflammatory Signaling in Mice

scientific article published on 30 March 2018

Constitutive ω-3 fatty acid production in fat-1 transgenic mice and docosahexaenoic acid administration to wild type mice protect against 2,4,6-trinitrobenzene sulfonic acid-induced colitis

scientific article published on 26 April 2017

Construction of the Azacyclic Core of Tabernaemontanine-Related Alkaloids via Tandem Reformatsky-Aza-Claisen Rearrangement

scientific article

Correction: 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression

Correlation between macrophage migration inhibitory factor and autophagy in Helicobacter pylori-associated gastric carcinogenesis

Corrigendum to 'Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice' [Biochem. Pharmacol. 164 (2019) 139-151]

scientific article published on 01 August 2019

Curcumin Inhibits STAT3 Signaling in the Colon of Dextran Sulfate Sodium-treated Mice

scientific article

Curcumin Prevents Palmitoylation of Integrin β4 in Breast Cancer Cells

scientific article published on 4 May 2015

Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1.

scientific article published on 26 September 2007

Curcumin induces expression of 15-hydroxyprostaglandin dehydrogenase in gastric mucosal cells and mouse stomach in vivo: AP-1 as a potential target

scientific article published on 28 July 2020

Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification

scientific article published on 20 January 2020

Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-kappaB activation

scientific article published on 4 July 2003

Curcumin inhibits phorbol ester-induced up-regulation of cyclooxygenase-2 and matrix metalloproteinase-9 by blocking ERK1/2 phosphorylation and NF-kappaB transcriptional activity in MCF10A human breast epithelial cells.

scientific article published on November 2005

Curcumin interacts directly with the Cysteine 259 residue of STAT3 and induces apoptosis in H-Ras transformed human mammary epithelial cells.

scientific article published on 23 April 2018

Curcumin suppresses activation of NF-kappaB and AP-1 induced by phorbol ester in cultured human promyelocytic leukemia cells

scientific article published in May 2002

Curcumin suppresses oncogenicity of human colon cancer cells by covalently modifying the cysteine 67 residue of SIRT1

scientific article published on 26 May 2018

Diallyl trisulfide induces apoptosis in human breast cancer cells through ROS-mediated activation of JNK and AP-1 ⬇️

scientific article published on September 6, 2012

Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling

scientific article published on 23 February 2010

Diallyl trisulfide suppresses dextran sodium sulfate-induced mouse colitis: NF-κB and STAT3 as potential targets

scientific article published on 26 June 2013

Dietary and medicinal antimutagens and anticarcinogens: molecular mechanisms and chemopreventive potential--highlights of a symposium

scientific article published on 01 February 2003

Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response.

scientific article

Direct targeting of MEK1/2 and RSK2 by silybin induces cell-cycle arrest and inhibits melanoma cell growth.

scientific article published on 27 February 2013

Docosahexaenoic Acid Induces Expression of Heme Oxygenase-1 and NAD(P)H:quinone Oxidoreductase through Activation of Nrf2 in Human Mammary Epithelial Cells.

scientific article published on 10 June 2017

Docosahexaenoic Acid Inhibits UVB-Induced Activation of NF-κB and Expression of COX-2 and NOX-4 in HR-1 Hairless Mouse Skin by Blocking MSK1 Signaling ⬇️

scientific article published on November 28, 2011

Docosahexaenoic acid induces M2 macrophage polarization through peroxisome proliferator-activated receptor γ activation

scientific article

Docosahexaenoic acid inhibits Helicobacter pylori-induced STAT3 phosphorylation through activation of PPARγ.

scientific article published on 15 April 2016

Docosahexaenoic acid inhibits insulin-induced activation of sterol regulatory-element binding protein 1 and cyclooxygenase-2 expression through upregulation of SIRT1 in human colon epithelial cells

scientific article published on 06 September 2014

Dual Roles of Pin1 in Cancer Development and Progression

scientific article published on 3 July 2017

ET-18-O-CH3-induced apoptosis is causally linked to COX-2 upregulation in H-ras transformed human breast epithelial cells

scientific article published on 14 October 2005

Editorial

Effect of Estradiol in an Azoxymethane/Dextran Sulfate Sodium-Treated Mouse Model of Colorectal Cancer: Implication for Sex Difference in Colorectal Cancer Development

scientific article published on 01 August 2018

Effects of 15-deoxy-delta 12, 14-prostaglandin J2 on the expression of p53 in MCF-7 cells

scientific article

Effects of 17β-Estradiol on Colonic Permeability and Inflammation in an Azoxymethane/Dextran Sulfate Sodium-Induced Colitis Mouse Model

scientific article published on 01 November 2018

Effects of 17β-estradiol on colorectal cancer development after azoxymethane/dextran sulfate sodium treatment of ovariectomized mice

scientific article published on 11 April 2019

Effects of Genetic and Pharmacologic Inhibition of COX-2 on Colitis-associated Carcinogenesis in Mice

scientific article published on 01 March 2020

Effects of cyclopentenone prostaglandins on the expression of heme oxygenase-1 in MCF-7 cells.

scientific article published on December 2004

Effects of exercise on cyclooxygenase-2 expression and nuclear factor-kappaB DNA binding in human peripheral blood mononuclear cells

scientific article

Effects of selected ginsenosides on phorbol ester-induced expression of cyclooxygenase-2 and activation of NF-kappaB and ERK1/2 in mouse skin

scientific article

Effects of yakuchinone A and yakuchinone B on the phorbol ester-induced expression of COX-2 and iNOS and activation of NF-kappaB in mouse skin.

scientific article published in January 2002

Emerging avenues linking inflammation and cancer ⬇️

scientific article published on 03 March 2012

Endogenous ω-3 Fatty Acid Production by fat-1 Transgene and Topically Applied Docosahexaenoic Acid Protect against UVB-induced Mouse Skin Carcinogenesis

scientific article published on 14 September 2017

Endoplasmic reticulum stress-induced IRE1α activation mediates cross-talk of GSK-3β and XBP-1 to regulate inflammatory cytokine production

scientific article

Epigallocatechin gallate inhibits phorbol ester-induced activation of NF-kappa B and CREB in mouse skin: role of p38 MAPK.

scientific article published in January 2007

Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death

scientific article

Esculetin suppresses proliferation of human colon cancer cells by directly targeting β-catenin

scientific article

Essential role of mitochondrial permeability transition in vanilloid receptor 1-dependent cell death of sensory neurons ⬇️

scientific article published on September 1, 2003

Eupatilin inhibits proliferation of ras-transformed human breast epithelial (MCF-10A-ras) cells

scientific article published on January 2005

Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells

scientific article

Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes

scientific article

Fibroblast growth factor-2, derived from cancer-associated fibroblasts, stimulates growth and progression of human breast cancer cells via FGFR1 signaling

scientific article published on 18 June 2020

Functional inactivation of triosephosphate isomerase through phosphorylation during etoposide-induced apoptosis in HeLa cells: potential role of Cdk2.

scientific article

GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative Activity in human neuroblastoma cells

scientific article published on 06 July 2020

Genetic ablation of caspase-7 promotes solar-simulated light-induced mouse skin carcinogenesis: the involvement of keratin-17

scientific article published on 12 August 2015

Genistein Inhibits Proliferation of BRCA1 Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target

scientific article published on 30 December 2019

Genistein inhibits phorbol ester-induced NF-κB transcriptional activity and COX-2 expression by blocking the phosphorylation of p65/RelA in human mammary epithelial cells

scientific article published on 15 April 2014

Ginger-derived phenolic substances with cancer preventive and therapeutic potential

scientific article published on 07 April 2009

Ginsenoside Rg3 Induces Apoptosis of Human Breast Cancer (MDA-MB-231) Cells

scientific article

Ginsenoside Rg3 Inhibits Constitutive Activation of NF-κB Signaling in Human Breast Cancer (MDA-MB-231) Cells: ERK and Akt as Potential Upstream Targets

scientific article

Gremlin-1 Promotes Metastasis of Breast Cancer Cells by Activating STAT3-MMP13 Signaling Pathway

scientific article published on 03 December 2020

Gremlin-1 augments the oestrogen-related receptor α signalling through EGFR activation: implications for the progression of breast cancer

scientific article published on 23 June 2020

Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target ⬇️

scientific article published on November 17, 2011

H-Ras induces Nrf2-Pin1 interaction: Implications for breast cancer progression

scientific article published on 01 July 2020

H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells

scientific article published on October 2006

Heat-processed neoginseng, KG-135, down-regulates G1 Cyclin-dependent kinase through the proteasome-mediated pathway in HeLa cells.

scientific article published in February 2009

Helicobacter pylori Activates IL-6-STAT3 Signaling in Human Gastric Cancer Cells: Potential Roles for Reactive Oxygen Species

scientific article published on 23 February 2016

Helicobacter pylori induces Snail expression through ROS-mediated activation of Erk and inactivation of GSK-3β in human gastric cancer cells

scientific article published on 25 January 2016

Helicobacter pylori infection induces STAT3 phosphorylation on Ser727 and autophagy in human gastric epithelial cells and mouse stomach

scientific article published on 24 September 2020

Helicobacter pylori infection promotes autophagy through Nrf2-mediated heme oxygenase upregulation in human gastric cancer cells

scientific article published on 04 February 2019

Heme oxygenase-1 as a potential therapeutic target for hepatoprotection

scientific article published on September 2006

Heme oxygenase-1 determines the differential response of breast cancer and normal cells to piperlongumine.

scientific article

Hirsutenone inhibits phorbol ester-induced upregulation of COX-2 and MMP-9 in cultured human mammary epithelial cells: NF-kappaB as a potential molecular target

scientific article published on 19 December 2005

Humulone inhibits phorbol ester-induced COX-2 expression in mouse skin by blocking activation of NF-kappaB and AP-1: IkappaB kinase and c-Jun-N-terminal kinase as respective potential upstream targets

scientific article

Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9.

scientific article published on 21 November 2017

Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells ⬇️

scientific article published on April 8, 2011

Identification and Structural Analysis of New Nrf2 Activators by Mechanism-Based Chemical Transformation of 15-Deoxy-Δ12, 14 -PGJ2.

scientific article published on 25 July 2016

Identification of small molecule inhibitors of the STAT3 signaling pathway: Insights into their structural features and mode of action.

scientific article published on 26 July 2015

In vitro evidence of the role of COX-2 in attenuating gastric inflammation and promoting gastric carcinogenesis.

scientific article published in January 2002

Induction of apoptosis and caspase-3 activation by chemopreventive [6]-paradol and structurally related compounds in KB cells

scientific article published on March 2002

Induction of apoptosis by quercetin is mediated through AMPKalpha1/ASK1/p38 pathway

scientific article

Induction of apoptosis in HT-29 colon cancer cells by phloretin

scientific article published in December 2007

Induction of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma during nitric oxide-induced apoptotic PC12 cell death

scientific article published in December 2003

Induction of cyclooxygenase-2 in Ras-transformed human mammary epithelial cells undergoing apoptosis

scientific article published on November 2002

Induction of endoplasmic reticulum stress under endotoxin tolerance increases inflammatory responses and decreases Pseudomonas aeruginosa pneumonia

scientific article published on 20 June 2018

Inflammation: gearing the journey to cancer

scientific article published on 16 March 2008

Inhibition of Phorbol Ester–Induced COX-2 Expression by Epigallocatechin Gallate in Mouse Skin and Cultured Human Mammary Epithelial Cells ⬇️

scientific article published on November 1, 2003

Inhibition of cyclooxygenase-2 expression and restoration of gap junction intercellular communication in H-ras-transformed rat liver epithelial cells by caffeic acid phenethyl ester

scientific article

Inhibition of human breast cancer growth by GCP (genistein combined polysaccharide) in xenogeneic athymic mice: involvement of genistein biotransformation by beta-glucuronidase from tumor tissues.

scientific article published in February 2003

Inhibition of mouse skin tumor promotion by anti-inflammatory diarylheptanoids derived from Alpinia oxyphylla Miquel (Zingiberaceae).

scientific article published in January 2002

Inhibition of phorbol ester-induced COX-2 expression by some edible African plants.

scientific article

Inhibition of phorbol ester-induced mouse skin tumor promotion and COX-2 expression by celecoxib: C/EBP as a potential molecular target

scientific article published on 30 June 2006

Inhibitory Effects of Dried Longan (Euphoria longana Lam.) Seed Extract on Invasion and Matrix Metalloproteinases of Colon Cancer Cells ⬇️

scientific article published on April 3, 2013

Inhibitory effects of 7-carboxymethyloxy-3',4',5-trimethoxyflavone (DA-6034) on Helicobacter pylori-induced NF-kappa B activation and iNOS expression in AGS cells

scientific article published on January 2007

Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin

scientific article published in January 2004

Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-kappaB and C/EBP as potential targets

scientific article

Inhibitory effects of the extracts of Sutherlandia frutescens (L.) R. Br. and Harpagophytum procumbens DC. on phorbol ester-induced COX-2 expression in mouse skin: AP-1 and CREB as potential upstream targets.

scientific article published in January 2005

Inhibitory effects of the ginsenoside Rg3 on phorbol ester-induced cyclooxygenase-2 expression, NF-kappaB activation and tumor promotion

scientific article published in February 2003

Inhibitory effects of the standardized extract (DA-9601) of Artemisia asiatica Nakai on phorbol ester-induced ornithine decarboxylase activity, papilloma formation, cyclooxygenase-2 expression, inducible nitric oxide synthase expression and nuclear

scientific article published on 01 August 2002

Interaction between Peptidyl-prolyl <i>Cis</i>-<i>trans</i> Isomerase NIMA-interacting 1 and GTP-H-Ras: Implications for Aggressiveness of Human Mammary Epithelial Cells and Drug Resistance

scientific article published on 01 December 2020

Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression

scientific article published on 02 December 2020

Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate

scientific article

Introduction to Nutrition and Physical Activity in Aging, Obesity, and Cancer ⬇️

scientific article published on 01 July 2011

Iron enhancement of oxidative DNA damage and neuronal cell death induced by salsolinol

scientific article

Isoflavone intake on the risk of overall breast cancer and molecular subtypes in women at high risk for hereditary breast cancer

scientific article published on 17 October 2020

JNK-mediated Ser27 phosphorylation and stabilization of SIRT1 promote growth and progression of colon cancer through deacetylation-dependent activation of Snail

scientific article published on 04 January 2022

Jaceosidin induces apoptosis in ras-transformed human breast epithelial cells through generation of reactive oxygen species

scientific article published on January 2007

Janus‐faced role of SIRT1 in tumorigenesis ⬇️

scientific article published on October 1, 2012

KG-135 inhibits COX-2 expression by blocking the activation of JNK and AP-1 in phorbol ester-stimulated human breast epithelial cells

scientific article published on January 2007

Keap1 cysteine 288 as a potential target for diallyl trisulfide-induced Nrf2 activation

scientific article published on 28 January 2014

Kolaviron inhibits dimethyl nitrosamine-induced liver injury by suppressing COX-2 and iNOS expression via NF-kappaB and AP-1.

scientific article

L-ascorbic acid represses constitutive activation of NF-kappaB and COX-2 expression in human acute myeloid leukemia, HL-60.

scientific article published in October 2004

Leptin induces SIRT1 expression through activation of NF-E2-related factor 2: Implications for obesity-associated colon carcinogenesis

scientific article published on 7 February 2018

MAPK regulation and caspase activation are required in DMNQ S-52 induced apoptosis in Lewis lung carcinoma cells

scientific article published in February 2006

Magnolin inhibits cell migration and invasion by targeting the ERKs/RSK2 signaling pathway

scientific article published on 8 August 2015

Metabolic signaling functions of the heme oxygenase/CO system in metabolic diseases

scientific article published on 28 May 2018

Metabolism and cancer: old and new players

scientific article published on 23 June 2013

Methylseleninic acid induces NAD(P)H:quinone oxidoreductase-1 expression through activation of NF-E2-related factor 2 in Chang liver cells

scientific article published on 25 June 2016

Modulation of Cancer Cell Growth and Progression by Caveolin-1 in the Tumor Microenvironment

scientific article published on 01 January 2020

Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG.

scientific article published on 17 October 2007

Modulation of tumor microenvironment by chemopreventive natural products

scientific article

Molecular basis of chemoprevention by resveratrol: NF-kappaB and AP-1 as potential targets

scientific article published in November 2004

Molecular basis of heme oxygenase-1 induction: implications for chemoprevention and chemoprotection.

scientific article

More than spice: capsaicin in hot chili peppers makes tumor cells commit suicide

scientific article

Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis

scientific article published on 21 July 2009

Multidrug Resistance-Associated Protein 1 Mediates 15-Deoxy-Δ12,14-prostaglandin J2-Induced Expression of Glutamate Cysteine Ligase Expression via Nrf2 Signaling in Human Breast Cancer Cells ⬇️

scientific article published on July 25, 2011

Myc-nick promotes efferocytosis through M2 macrophage polarization during resolution of inflammation

scientific article published on 2 May 2018

Myricetin is a novel natural inhibitor of neoplastic cell transformation and MEK1.

scientific article

NF-kappa B and Nrf2 as potential chemopreventive targets of some anti-inflammatory and antioxidative phytonutrients with anti-inflammatory and antioxidative activities

scientific article published on January 2008

NF-kappaB and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals

scientific article published on February 2008

Neurotoxic effects of tetrahydroisoquinolines and underlying mechanisms

scientific article published on 30 September 2010

Ninjurin1 deficiency aggravates colitis development by promoting M1 macrophage polarization and inducing microbial imbalance

scientific article published on 08 May 2020

Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells ⬇️

scientific article published on June 15, 2011

Nitric oxide induces apoptosis via AP-1-driven upregulation of COX-2 in rat pheochromocytoma cells

scientific article

Nitric oxide induces expression of cyclooxygenase-2 in mouse skin through activation of NF-kappaB.

scientific article published on 21 November 2003

Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model

scientific article published on 21 April 2005

Nrf2 Mutagenic Activation Drives Hepatocarcinogenesis

scientific article published on 27 June 2017

Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals

scientific article published on 20 October 2008

Nrf2 as a novel molecular target for chemoprevention

scientific article

Nrf2-Keap1 signaling as a potential target for chemoprevention of inflammation-associated carcinogenesis

scientific article published on 31 March 2010

Nrf2-Mediated heme oxygenase-1 upregulation as adaptive survival response to glucose deprivation-induced apoptosis in HepG2 cells

scientific article published on 23 August 2010

Nrf2-mediated heme oxygenase-1 induction confers adaptive survival response to tetrahydropapaveroline-induced oxidative PC12 cell death

scientific article published in December 2007

Nuclear Factor Erythroid-Derived 2-Like 2-Induced Reductive Stress Favors Self-Renewal of Breast Cancer Stem-Like Cells via the FoxO3a-Bmi-1 Axis

scientific article published on 08 January 2020

Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin--AP-1 and C/EBP as potential upstream targets

scientific article published on 23 January 2008

Oligonol inhibits dextran sulfate sodium-induced colitis and colonic adenoma formation in mice

scientific article published on 15 May 2013

Oncogenic potential of Nrf2 and its principal target protein heme oxygenase-1.

scientific article

Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline

scientific article

Penta-O-galloyl-beta-D-glucose suppresses tumor growth via inhibition of angiogenesis and stimulation of apoptosis: roles of cyclooxygenase-2 and mitogen-activated protein kinase pathways

scientific article

Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α.

scientific article published on 19 January 2016

Perilla frutescens Extracts Protects against Dextran Sulfate Sodium-Induced Murine Colitis: NF-κB, STAT3, and Nrf2 as Putative Targets

scientific article published on 8 August 2017

Peroxisome proliferator-activated receptor γ (PPARγ) ligands as bifunctional regulators of cell proliferation ⬇️

scientific article published on October 15, 2003

Peroxynitrite induces HO-1 expression via PI3K/Akt-dependent activation of NF-E2-related factor 2 in PC12 cells

scientific article published on 03 July 2006

PharmDB-K: Integrated Bio-Pharmacological Network Database for Traditional Korean Medicine

scientific article

Phloretin Inhibits Phorbol Ester–Induced Tumor Promotion and Expression of Cyclooxygenase-2 in Mouse Skin: Extracellular Signal-Regulated Kinase and Nuclear Factor-κB as Potential Targets ⬇️

scientific article published on December 19, 2011

Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling

scientific article published on 15 June 2010

Piceatannol inhibits phorbol ester-induced NF-kappa B activation and COX-2 expression in cultured human mammary epithelial cells

scientific article

Piceatannol inhibits phorbol ester-induced expression of COX-2 and iNOS in HR-1 hairless mouse skin by blocking the activation of NF-κB and AP-1.

scientific article published on 6 November 2014

Piceatannol, a catechol-type polyphenol, inhibits phorbol ester-induced NF-{kappa}B activation and cyclooxygenase-2 expression in human breast epithelial cells: cysteine 179 of IKK{beta} as a potential target. ⬇️

scientific article published on 27 June 2010

Possible role of NF-kappaB in Bcl-X(L) protection against hydrogen peroxide-induced PC12 cell death

scientific article

Potential Role of Heme Oxygenase-1 in the Resolution of Experimentally Induced Colitis through Regulation of Macrophage Polarization

scientific article published on 01 March 2022

Potential roles of NF-kappaB and ERK1/2 in cytoprotection against oxidative cell death induced by tetrahydropapaveroline

scientific article published in May 2004

Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function ⬇️

scientific article published on October 15, 2003

Potentiation of etoposide-induced apoptosis in HeLa cells by co-treatment with KG-135, a quality-controlled standardized ginsenoside formulation

scientific article published on 11 March 2010

Preventive effects of Korean red ginseng on experimentally induced colitis and colon carcinogenesis

scientific article published on 25 April 2020

Progress in heme oxygenase research

scientific article published on 24 February 2020

Protective Effects of Silibinin on <i>Helicobacter pylori</i>-induced Gastritis: NF-κB and STAT3 as Potential Targets

scientific article published on 01 June 2021

Protective effect of resveratrol on beta-amyloid-induced oxidative PC12 cell death

scientific article published in April 2003

Protective effects of green tea polyphenol extracts against ethanol-induced gastric mucosal damages in rats: stress-responsive transcription factors and MAP kinases as potential targets

scientific article published on 10 August 2005

Protective effects of oligomers of grape seed polyphenols against beta-amyloid-induced oxidative cell death

scientific article published in December 2004

Pterostilbene 4′-β-Glucoside Attenuates LPS-Induced Acute Lung Injury via Induction of Heme Oxygenase-1

scientific article published on 23 October 2018

Puerarin suppresses AGEs-induced inflammation in mouse mesangial cells: a possible pathway through the induction of heme oxygenase-1 expression

scientific article

Redox modulation of p53: Mechanisms and functional significance ⬇️

scientific article published on April 1, 2011

Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals

scientific article

Regulation of the tumor suppressor PTEN by natural anticancer compounds

scientific article published in August 2017

Resolution of inflammation as a novel chemopreventive strategy

scientific article published on 31 January 2013

Resolvin D1 stimulates efferocytosis through p50/p50-mediated suppression of tumor necrosis factor-α expression

scientific article published on 20 June 2013

Resolvin D1-mediated NOX2 inactivation rescues macrophages undertaking efferocytosis from oxidative stress-induced apoptosis

scientific article published on 12 July 2013

Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells

scientific article

Resveratrol and piceatannol inhibit iNOS expression and NF-kappaB activation in dextran sulfate sodium-induced mouse colitis

scientific article published in January 2009

Resveratrol inhibits TCDD-induced expression of CYP1A1 and CYP1B1 and catechol estrogen-mediated oxidative DNA damage in cultured human mammary epithelial cells

scientific article

Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets

scientific article published in January 2004

Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity

scientific article published on 12 February 2006

Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets

scientific article published on 26 September 2006

Resveratrol suppresses 4-hydroxyestradiol-induced transformation of human breast epithelial cells by blocking IκB kinaseβ-NF-κB signalling

scientific article published on 9 May 2012

Resveratrol suppresses gastric cancer cell proliferation and survival through inhibition PIM-1 kinase activity

scientific article published on 27 May 2020

Resveratrol suppresses growth of human ovarian cancer cells in culture and in a murine xenograft model: eukaryotic elongation factor 1A2 as a potential target

scientific article published on 8 September 2009

Resveratrol suppresses migration, invasion and stemness of human breast cancer cells by interfering with tumor-stromal cross-talk

scientific article published on 15 March 2018

Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells

scientific article published in June 2005

Reverse pharmacology applicable for botanical drug development - inspiration from the legacy of traditional wisdom.

scientific article published on October 2011

Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress

scientific article published on 29 August 2009

Role of heme oxygenase-1 and its reaction product, carbon monoxide, in manifestation of breast cancer stem cell-like properties: Notch-1 as a putative target

scientific article published on 21 September 2018

Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis

scientific article published on 09 February 2018

Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-kappaB activation and COX-2 expression in human breast epithelial cells.

scientific article published on 26 July 2007

Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells

scientific article published on February 2003

Rutin inhibits UVB radiation-induced expression of COX-2 and iNOS in hairless mouse skin: p38 MAP kinase and JNK as potential targets

scientific article published on 26 May 2014

RvD1 inhibits TNFα-induced c-Myc expression in normal intestinal epithelial cells and destabilizes hyper-expressed c-Myc in colon cancer cells

scientific article published on 3 January 2018

STAT3 Stabilizes IKKα Protein through Direct Interaction in Transformed and Cancerous Human Breast Epithelial Cells

scientific article published on 30 December 2020

Selenium regulates cyclooxygenase-2 and extracellular signal-regulated kinase signaling pathways by activating AMP-activated protein kinase in colon cancer cells

scientific article published in October 2006

Signal transduction network leading to COX-2 induction: a road map in search of cancer chemopreventives

scientific article

Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention

scientific article published in September 2004

Similarities and Distinctions in the Effects of Metformin and Carbon Monoxide in Immunometabolism

Special issue for the 7th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia 2015 Thailand).

scientific article

Src-mediated phosphorylation, ubiquitination and degradation of Caveolin-1 promotes breast cancer cell stemness

scientific article published on 20 January 2019

Sulforaphane inhibits phorbol ester-stimulated IKK-NF-κB signaling and COX-2 expression in human mammary epithelial cells by targeting NF-κB activating kinase and ERK.

scientific article published on 18 April 2014

Suppression of mTOR via Akt-dependent and -independent mechanisms in selenium-treated colon cancer cells: involvement of AMPKalpha1.

scientific article published on 17 February 2010

Suppression of phorbol ester-induced NF-kappaB activation by capsaicin in cultured human promyelocytic leukemia cells

scientific article

TNF-α induces expression of urokinase-type plasminogen activator and β-catenin activation through generation of ROS in human breast epithelial cells

scientific article published on 9 September 2010

Targeting Nrf2-Keap1 signaling for chemoprevention of skin carcinogenesis with bioactive phytochemicals

scientific article published on 27 May 2014

Taurine Chloramine Stimulates Efferocytosis Through Upregulation of Nrf2-Mediated Heme Oxygenase-1 Expression in Murine Macrophages: Possible Involvement of Carbon Monoxide

scientific article published in July 2015

Taurine chloramine potentiates phagocytic activity of peritoneal macrophages through up-regulation of dectin-1 mediated by heme oxygenase-1-derived carbon monoxide

scientific article published on 15 December 2017

The 50-Year War on Cancer Revisited: Should We Continue to Fight the Enemy Within?

scientific article published on 06 January 2022

The Role of Nrf2 in Cellular Innate Immune Response to Inflammatory Injury

scientific article published on 30 December 2009

The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.

scientific article

The peptidyl prolyl isomerase, PIN1 induces angiogenesis through direct interaction with HIF-2α

scientific article published on 01 October 2020

The positive feedback loop between Nrf2 and phosphogluconate dehydrogenase stimulates proliferation and clonogenicity of human hepatoma cells

scientific article published on 27 April 2020

The role of 15-deoxy-delta(12,14)-prostaglandin J(2), an endogenous ligand of peroxisome proliferator-activated receptor gamma, in tumor angiogenesis

scientific article published on 14 August 2008

The role of beta-glucuronidase in induction of apoptosis by genistein combined polysaccharide (GCP) in xenogeneic mice bearing human mammary cancer cells.

scientific article published in December 2003

The role of nutrition in influencing mechanisms involved in environmentally mediated diseases

scientific article published on 30 January 2018

The second annual conference of International ovarian cancer consortium and the symposium on tumor microenvironment and therapeutic resistance.

scientific article

The standardized Korean Red Ginseng extract and its ingredient ginsenoside Rg3 inhibit manifestation of breast cancer stem cell-like properties through modulation of self-renewal signaling

scientific article published on 17 May 2018

Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases

scientific article published on January 2016

Therapeutic potential of resolvins in the prevention and treatment of inflammatory disorders ⬇️

scientific article published on November 15, 2012

Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo

scientific article published in August 2013

Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals

scientific article

Transcription factors in the cellular signaling network as prime targets of chemopreventive phytochemicals

scientific article

Transcriptional regulation via cysteine thiol modification: a novel molecular strategy for chemoprevention and cytoprotection

scientific article

Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor

scientific article published on 20 April 2007

Tumor suppressor p16 inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction

scientific article published in 2013

Tumor suppressor p16(INK4a) inhibits cancer cell growth by downregulating eEF1A2 through a direct interaction.

scientific article published on 26 February 2013

Ultraviolet B radiation activates NF‐κB and induces iNOS expression in HR‐1 hairless mouse skin: Role of IκB kinase‐β ⬇️

scientific article published on April 1, 2011

Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt

scientific article

Upregulation of VEGF by 15-deoxy-Delta12,14-prostaglandin J2 via heme oxygenase-1 and ERK1/2 signaling in MCF-7 cells

scientific article published on December 2006

Vitamin C and cancer chemoprevention: reappraisal

scientific article published on December 2003

Walnut polyphenol extracts inhibit <i>Helicobacter pylori</i>-induced STAT3<sup>Tyr705</sup> phosphorylation through activation of PPAR-γ and SOCS1 induction

scientific article published on 30 September 2020

What is new for an old molecule? Systematic review and recommendations on the use of resveratrol

scientific article

Xenohormesis mechanisms underlying chemopreventive effects of some dietary phytochemicals ⬇️

scientific article published on July 1, 2011

Zerumbone induces heme oxygenase-1 expression in mouse skin and cultured murine epidermal cells through activation of Nrf2.

scientific article published on 2 March 2011

Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice

scientific article

[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin

scientific article published in April 2005

[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo

scientific article published on May 2007

[6]-shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2.

scientific article

beta-Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase

scientific article published on 01 November 2002

beta-Catenin-mediated signaling: a novel molecular target for chemoprevention with anti-inflammatory substances

scientific article

cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt

scientific article published on 31 August 2006

eEF1A2 as a putative oncogene

scientific article published on August 2009

hYSK1 promotes cancer cell proliferation and migration through negative regulation of p16INK4a under hypoxic conditions

scientific article published on 6 October 2017

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